large conductance calcium activated potassium channel beta subunits


Summary: The regulatory subunits of large-conductance calcium-activated potassium channels.

Top Publications

  1. Borbouse L, Dick G, Asano S, Bender S, Dincer U, Payne G, et al. Impaired function of coronary BK(Ca) channels in metabolic syndrome. Am J Physiol Heart Circ Physiol. 2009;297:H1629-37 pubmed publisher
    ..Coronary vascular dysfunction in MetS is related to impaired BK(Ca) channel function and is accompanied by significant increases in L-type Ca(2+) channel-mediated coronary vasoconstriction. ..
  2. Holtzclaw J, Grimm P, Sansom S. Intercalated cell BK-alpha/beta4 channels modulate sodium and potassium handling during potassium adaptation. J Am Soc Nephrol. 2010;21:634-45 pubmed publisher
    ..These changes streamline flow across the principal cells, producing gradients more favorable for potassium secretion and less favorable for sodium reabsorption. ..
  3. Lee U, Cui J. {beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia. J Physiol. 2009;587:1481-98 pubmed publisher
    ..Additionally, these results also have implications on physiological processes in tissues other than the brain where BK channels play an important role. ..
  4. Hammami S, Willumsen N, Olsen H, Morera F, Latorre R, Klaerke D. Cell volume and membrane stretch independently control K+ channel activity. J Physiol. 2009;587:2225-31 pubmed publisher
    ..We conclude that stretch and volume sensitivity can be considered two independent regulatory mechanisms. ..
  5. Wulf Johansson H, Amrutkar D, Hay Schmidt A, Poulsen A, Klaerke D, Olesen J, et al. Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino-neuronal pathway. Neuroscience. 2010;167:1091-102 pubmed publisher
    ..Iberiotoxin induced an increase in CGRP release from the TNC that was attenuated by NS11021. Thus, BK(Ca) channels might have a role in trigeminovascular pain transmission. ..
  6. Albarwani S, Al Siyabi S, Baomar H, Hassan M. Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries. Exp Physiol. 2010;95:746-55 pubmed publisher
    ..We conclude that low-intensity ET may be beneficial in restoring age-related decline in coronary vasodilatory properties mediated by BK(Ca) channels. ..
  7. Long X, Tharp D, Georger M, Slivano O, Lee M, Wamhoff B, et al. The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. J Biol Chem. 2009;284:33671-82 pubmed publisher
    ..These results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. ..
  8. Tong M, Duncan R. Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation. Am J Physiol Cell Physiol. 2009;297:C75-85 pubmed publisher
  9. Wulf Johansson H, Hay Schmidt A, Poulsen A, Klaerke D, Olesen J, Jansen Olesen I. Expression of BK Ca channels and the modulatory beta-subunits in the rat and porcine trigeminal ganglion. Brain Res. 2009;1292:1-13 pubmed publisher
    ..The present study showed BK(Ca) channel expression in rat and porcine TG. The main modulatory beta-subunits detected in TG of both species were beta2- and beta 4-subunits. ..

More Information


  1. Rosenfeld C, Liu X, Despain K. Pregnancy modifies the large conductance Ca2+-activated K+ channel and cGMP-dependent signaling pathway in uterine vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2009;296:H1878-87 pubmed publisher
  2. Asano S, Tune J, Dick G. Bisphenol A activates Maxi-K (K(Ca)1.1) channels in coronary smooth muscle. Br J Pharmacol. 2010;160:160-70 pubmed publisher
    ..Our data indicate that BPA increased the activity of Maxi-K channels and may represent a basis for some potential toxicological effects. ..
  3. Bautista L, Castro M, Lopez Barneo J, Castellano A. Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning. Circ Res. 2009;104:1364-72 pubmed publisher
    ..Our work provides new perspectives for research on cardiac preconditioning. ..
  4. Köhler R. Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease. Pflugers Arch. 2010;460:343-51 pubmed publisher
    ..These findings from sequence analysis of human KCa genes, and epidemiological studies thus provide evidence that genetic variations and mutations in KCa channel genes contribute to human cardiovascular disease. ..
  5. Bukiya A, Vaithianathan T, Toro L, Dopico A. Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate. Biochem Biophys Res Commun. 2009;390:995-1000 pubmed publisher
    ..Our study indicates that LC represents a unique tool to probe the presence of functional beta1-subunits and selectively activate BK channels in tissues that highly express KCNMB1. ..
  6. Bukiya A, Liu J, Dopico A. The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction. FEBS Lett. 2009;583:2779-84 pubmed publisher
    ..Knocking-down KCNMB1 suppresses EtOH-reduction of arterial myocyte BK current and vessel diameter. Therefore, BK beta(1) is the molecular effector of alcohol-induced BK current inhibition and cerebrovascular constriction. ..
  7. Chang T, Wu L, Wang R. Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats. Am J Hypertens. 2006;19:678-85 pubmed
    ..Expression of BK beta1 in mesenteric arteries is closely correlated with BP in SHR. Increased BK beta1 expression in mesenteric arteries may represent a compensatory reaction to limit the development of hypertension. ..
  8. Grimm P, Irsik D, Liu L, Holtzclaw J, Sansom S. Role of BKbeta1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice. Am J Physiol Renal Physiol. 2009;297:F420-8 pubmed publisher
    ..We conclude that part of the mechanism to maximize Na(+) reabsorption during Na(+) deficiency is the placement of BKalpha/beta1 channels in the BSM of CCD PCs...
  9. Chen M, Petkov G. Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J Urol. 2009;182:374-81 pubmed publisher
    ..New drugs targeting specific BK channel subunits in human bladder smooth muscle may prove useful for overactive bladder. ..
  10. Li J, Deng C, Gao F, Cheng J, Yu Z, Liu L, et al. Coexpression and characterization of the human large-conductance Ca(2+)-activated K (+) channel alpha + beta1 subunits in HEK293 cells. Mol Cell Biochem. 2009;331:117-26 pubmed publisher
  11. Chang S, Gomes C, Hypolite J, Marx J, Alanzi J, Zderic S, et al. Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. Am J Physiol Renal Physiol. 2010;298:F1416-23 pubmed publisher
    ..Furthermore, downregulation of the BK channel may contribute to DO by increasing the basal level of MLC(20) phosphorylation. ..
  12. Wynne P, Puig S, Martin G, Treistman S. Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system. J Pharmacol Exp Ther. 2009;329:978-86 pubmed publisher
    ..This hypothesis is supported immunohistochemically by the appearance of distinct punctate beta1 or beta4 channel clusters in the membrane of somatic and dendritic or nerve terminal compartments, respectively. ..
  13. LE SOUEF P. Gene-environmental interaction in the development of atopic asthma: new developments. Curr Opin Allergy Clin Immunol. 2009;9:123-7 pubmed publisher
    ..Advances in knowledge of the genetics of viral defence have contributed to improved insight into asthma in children and could lead to effective new antiviral asthma therapies. ..
  14. Holtzclaw J, Liu L, Grimm P, Sansom S. Shear stress-induced volume decrease in C11-MDCK cells by BK-alpha/beta4. Am J Physiol Renal Physiol. 2010;299:F507-16 pubmed publisher
    ..Furthermore, these results support the use of C11 cells as in vitro models for studying BK-related functions in IC of the kidney. ..
  15. Grimm P, Irsik D, Settles D, Holtzclaw J, Sansom S. Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism. Proc Natl Acad Sci U S A. 2009;106:11800-5 pubmed publisher
    ..6% K) and increased significantly more than wild type when fed the HK diet. We conclude that the majority of the hypertension of Kcnmb1(-/-) is due to aldosteronism, resulting from renal potassium retention and hyperkalemia. ..
  16. Xie M, Ma Y, Gao F, Bai Y, Cheng J, Chang Y, et al. Activation of BKCa channel is associated with increased apoptosis of cerebrovascular smooth muscle cells in simulated microgravity rats. Am J Physiol Cell Physiol. 2010;298:C1489-500 pubmed publisher
    ..In conclusion, activation of BK(Ca) channels is associated with increased apoptosis in cerebral VSMCs of simulated microgravity rats. ..
  17. Yang C, Zeng X, Xia X, Lingle C. Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS ONE. 2009;4:e6135 pubmed publisher
  18. Gao L, Cong B, Zhang L, Ni X. Expression of the calcium-activated potassium channel in upper and lower segment human myometrium during pregnancy and parturition. Reprod Biol Endocrinol. 2009;7:27 pubmed publisher
    ..Our results suggest that expression of BKCa alpha- and beta-subunit in pregnant myometrium is reduced during labour, which is consistent with the myometrial activity at the onset of parturition. ..
  19. Wulf H, Hay Schmidt A, Poulsen A, Klaerke D, Olesen J, Jansen Olesen I. Molecular investigations of BK(Ca) channels and the modulatory beta-subunits in porcine basilar and middle cerebral arteries. J Mol Histol. 2009;40:87-97 pubmed publisher
    ..The mRNA transcript for beta1-, beta2- and beta4-subunit were shown by RT-PCR in porcine basilar and middle cerebral arteries. However, at the protein level, only, the beta1-subunit protein was found by western blotting. ..
  20. Foutz R, Grimm P, Sansom S. Insulin increases the activity of mesangial BK channels through MAPK signaling. Am J Physiol Renal Physiol. 2008;294:F1465-72 pubmed publisher
    ..These results indicate that insulin activates BK in the plasma membrane of MC and stimulates, via MAPK, an increase in cellular and plasma membrane BK-alpha. ..