Genomes and Genes
Summary: The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium depletion.
- Sahu I, Pelzl L, Sukkar B, Fakhri H, Al Maghout T, Cao H, et al. NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes. FASEB J. 2017;31:3439-3448 pubmed publisher..In the mice, dehydration increased NFAT5 and Orai1 protein abundance in megakaryocytes and NFAT5, Orai1, and Orai2 abundance in platelets...
- Chen Y, Chang C, Lee W, Liou J. RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2. J Cell Biol. 2017;216:2011-2025 pubmed publisher..Overall, our study suggests that RASSF4 controls SOCE and ER-PM junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. ..
- Stagno M, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al Maghout T, et al. Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells. Cell Physiol Biochem. 2017;42:1366-1376 pubmed publisher..Istaroxime further decreased Orai1 and Stim1 transcript levels and downregulated Orai1 protein expression. Moreover, SOCE was significantly decreased upon istaroxime treatment...
- Apolikhin O, Sivkov A, Konstantinova O, Slominskii P, Tupitsyna T, Kalinichenko D. [Early diagnosis of risk for developing calcium oxalate urolithiasis]. Urologiia. 2017;:5-8 pubmed