orai1 protein


Summary: The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium depletion.

Top Publications

  1. Tolios A, Gatidis S, Münzer P, Liu G, Towhid S, Karathanos A, et al. Increased platelet Ca2+ channel Orai1 expression upon platelet activation and in patients with acute myocardial infarction. Thromb Haemost. 2013;110:386-9 pubmed publisher
  2. Gudermann T, Steinritz D. A Correction to the Perspective Titled: “STIMulating Stress Fibers in Endothelial Cells". Sci Signal. 2013;6:er2 pubmed
  3. Chou J, Badran Y, Yee C, Bainter W, Ohsumi T, Al Hammadi S, et al. A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function. J Allergy Clin Immunol. 2015;136:479-482.e1 pubmed publisher
  4. Takei K, Denda S, Nagayama M, Denda M. Role of STIM1-Orai1 system in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes. Exp Dermatol. 2016;25:323-5 pubmed publisher
  5. Zhang L, Wang L, Li S, Xue J, Luo D. Calsequestrin-1 Regulates Store-Operated Ca2+ Entry by Inhibiting STIM1 Aggregation. Cell Physiol Biochem. 2016;38:2183-93 pubmed publisher
    ..Our results demonstrate that CSQ1 monomers suppress SOCE by interacting with STIM1 and attenuating STIM1 aggregation via its C-terminal amino acid 362-396. ..
  6. Ben Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk J, Zhou Y, et al. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. EMBO J. 2017;36:797-815 pubmed publisher
    ..Our findings identify a hitherto unknown NCLX-mediated pathway that coordinates Na+ and Ca2+ signals to effect mitochondrial redox control over SOCE. ..
  7. Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, et al. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017;153:1148-1159 pubmed publisher
    ..Our findings reveal that correcting ductal function is sufficient to rescue acinar cell function and suggests that CFTR correctors are strong candidates for the treatment of Sjögren's syndrome and pancreatitis. ..
  8. Chaudhari S, Li W, Wang Y, Jiang H, Ma Y, Davis M, et al. Store-operated calcium entry suppressed the TGF-?1/Smad3 signaling pathway in glomerular mesangial cells. Am J Physiol Renal Physiol. 2017;313:F729-F739 pubmed publisher
    ..Taken together, our results indicate that SOCE in MCs negatively regulates the TGF-?1/Smad3 signaling pathway. ..
  9. Li Y, Lou C, Wang W. STIM1 deficiency protects the liver from ischemia/reperfusion injury in mice. Biochem Biophys Res Commun. 2018;496:422-428 pubmed publisher
    ..STIM1 could be considered as a potential therapeutic target to ameliorate I/R injury. ..

More Information


  1. Sahu I, Pelzl L, Sukkar B, Fakhri H, Al Maghout T, Cao H, et al. NFAT5-sensitive Orai1 expression and store-operated Ca2+ entry in megakaryocytes. FASEB J. 2017;31:3439-3448 pubmed publisher
    ..In the mice, dehydration increased NFAT5 and Orai1 protein abundance in megakaryocytes and NFAT5, Orai1, and Orai2 abundance in platelets...
  2. Chen Y, Chang C, Lee W, Liou J. RASSF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2. J Cell Biol. 2017;216:2011-2025 pubmed publisher
    ..Overall, our study suggests that RASSF4 controls SOCE and ER-PM junctions through ARF6-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes. ..
  3. Stagno M, Zacharopoulou N, Bochem J, Tsapara A, Pelzl L, Al Maghout T, et al. Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells. Cell Physiol Biochem. 2017;42:1366-1376 pubmed publisher
    ..Istaroxime further decreased Orai1 and Stim1 transcript levels and downregulated Orai1 protein expression. Moreover, SOCE was significantly decreased upon istaroxime treatment...
  4. Apolikhin O, Sivkov A, Konstantinova O, Slominskii P, Tupitsyna T, Kalinichenko D. [Early diagnosis of risk for developing calcium oxalate urolithiasis]. Urologiia. 2017;:5-8 pubmed