cd30 ligand


Summary: A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.

Top Publications

  1. Sato K, Kato A, Sekai M, Hamazaki Y, Minato N. Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells. J Immunol. 2017;199:138-148 pubmed publisher
    ..SA-T cells may provide a suitable biomarker of immune aging, as well as a potential target for controlling aging-related disorders. ..
  2. Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley D, et al. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways. J Immunol. 2017;199:477-488 pubmed publisher
    ..These pathways may be targets for new strategies to modulate T cell immune responses in BM failure. ..
  3. Nawaf M, Ulvmar M, Withers D, McConnell F, Gaspal F, Webb G, et al. Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity. J Immunol. 2017;199:974-981 pubmed publisher
    ..By dissociating autoimmune side effects from anticancer immune responses, this potentially shifts this antitumor approach to patients with far less advanced disease. ..