atp binding cassette transporter 1

Summary

Summary: A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE characterized by accumulation of cholesteryl ester in various tissues.

Top Publications

  1. Schippling S, Orth M, Beisiegel U, Rosenkranz T, Vogel P, Munchau A, et al. Severe Tangier disease with a novel ABCA1 gene mutation. Neurology. 2008;71:1454-5 pubmed publisher
  2. Ng D, Saw N. The role of HDL and its modulators in the development of diabetes. Curr Opin Lipidol. 2012;23:167-8 pubmed publisher
  3. Demina E, Miroshnikova V, MaÄ­orov N, Davydenko V, Shvartsman A. [ABCA1 mRNA and protein levels in M-CSF-activated macrophages from patients with arterial stenosis]. Tsitologiia. 2013;55:580-5 pubmed
    ..01. Our results suggest that the level of ABCA1 mRNA and level of ABCA1 protein in macrophages may be important factors in the development of atherosclerosis. ..
  4. Darabi M, Ani M, Movahedian A, Rabbani M, Zarean E, Panjehpour M. Lack of association between circulating levels of oxidized LDL/beta2-glycoprotein I complexes and leukocyte ABCA1 gene expression. Ann Clin Biochem. 2011;48:291-2 pubmed publisher
  5. Yang Y, Li X, Peng L, An L, Sun N, Hu X, et al. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. Biochim Biophys Acta Mol Basis Dis. 2018;1864:882-890 pubmed publisher
    ..These observations suggest that Tan C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis. ..
  6. Bobin Dubigeon C, Chauvin A, Brillaud Meflah V, Boiffard F, Joalland M, Bard J. Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity. Anticancer Res. 2017;37:5495-5498 pubmed
    ..Liver X receptor [LXR; nuclear receptor subfamily 1, group H, member 2 (NR1H2, alias LXRB)] can inhibit proliferation and induce apoptosis of cancer cells. Its relationship with disease severity is not known...
  7. Monzel J, Budde T, Meyer zu Schwabedissen H, Schwebe M, Bien Möller S, Lutjohann D, et al. Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters. Biochem Pharmacol. 2017;144:108-119 pubmed publisher
    ..In this context, the cytotoxic effects of oxysterols and their impact on cardiac gene expression should be considered as an important factor in doxorubicin-induced cardiotoxicity. ..
  8. Borja M, Hammerson B, Tang C, Savinova O, Shearer G, Oda M. Apolipoprotein A-I exchange is impaired in metabolic syndrome patients asymptomatic for diabetes and cardiovascular disease. PLoS ONE. 2017;12:e0182217 pubmed publisher
    ..HAE and CEC are inhibited in MetSyn patients over a broad range of absolute apoA-I and HDL particle levels, supporting the observation that this patient population bears significant residual cardiovascular disease risk. ..
  9. Suzuki M, Takeda S, Teraoka Nishitani N, Yamagata A, Tanaka T, Sasaki M, et al. Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness. Toxicology. 2017;382:16-23 pubmed publisher
    ..Together, the current results suggest that the cadmium-mediated enhanced cell invasion is linked to down-regulation of ApoE during malignant transformation these liver cells. ..

More Information

Publications30

  1. Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, et al. ABCG1 is involved in vitamin E efflux. Biochim Biophys Acta. 2014;1841:1741-51 pubmed
    ..Overall, the present study reveals for the first time that ABCG1 is involved in cellular vitamin E efflux. ..
  2. Singaraja R, Tietjen I, Hovingh G, Franchini P, Radomski C, Wong K, et al. Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans. J Lipid Res. 2014;55:1693-701 pubmed publisher
    ..Taken together, we have identified mutations in four novel genes that may play a role in regulating HDLc levels in humans. ..
  3. Frikke Schmidt R. Genetic variation in ABCA1 and risk of cardiovascular disease. Atherosclerosis. 2011;218:281-2 pubmed publisher
  4. Fond A, Lee C, Schulman I, Kiss R, Ravichandran K. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest. 2015;125:2748-58 pubmed publisher
    ..Collectively, these data identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes and with functional consequences in vivo. ..
  5. Heinecke J. Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL. Circ Res. 2015;116:1101-3 pubmed publisher
  6. He J, Zhang G, Pang Q, Yu C, Xiong J, Zhu J, et al. SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition. FEBS J. 2017;284:1324-1337 pubmed publisher
    ..These data imply that SIRT6 plays an essential role in protecting against atherosclerosis by reducing foam cell formation through an autophagy-dependent pathway. ..
  7. Zakrzewicz A. LDL is out again - through the crosstalk of two atheroprotective mechanisms: ABCA1 of macrophages and NO? from endothelial cells. Acta Physiol (Oxf). 2014;210:708-9 pubmed publisher
  8. Zhang H, Shi J, Hachet M, Xue C, Bauer R, Jiang H, et al. CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37:2156-2160 pubmed publisher
    ..CRISPR/Cas9 and IPSDM provide important tools to study human macrophage biology and more broadly for future studies of disease-associated LIPA genetic variation in human macrophages. ..
  9. Zhu R, Sun Y, Hou Y, Fan J, Chen G, Li T. Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice. Chem Biol Interact. 2017;272:153-159 pubmed publisher
  10. Sviridov D. Many ABCs make light work with cholesterol. Aging (Albany NY). 2013;5:637-8 pubmed
  11. Morizawa Y, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, et al. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017;8:28 pubmed publisher
    ..Here the authors show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway. ..
  12. Brichacek B, Darwish C, Popratiloff A, Dubrovsky L, Bukrinsky M. HIV-1 infection of macrophages induces retention of cholesterol transporter ABCA1 in the endoplasmic reticulum. AIDS Res Hum Retroviruses. 2014;30:947-8 pubmed publisher
  13. Halalkhor S, Mesbah Namin S, Daneshpour M, Hedayati M, Azizi F. Association of ATP-binding cassette transporter-A1 polymorphism with apolipoprotein AI level in Tehranian population. J Genet. 2011;90:129-32 pubmed
  14. Zhao G, Tang S, Lv Y, Ouyang X, He P, Yao F, et al. NF-?B suppresses the expression of ATP-binding cassette transporter A1/G1 by regulating SREBP-2 and miR-33a in mice. Int J Cardiol. 2014;171:e93-5 pubmed publisher
  15. Marinozzi M, Castro Navas F, Maggioni D, Carosati E, Bocci G, Carloncelli M, et al. Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. J Med Chem. 2017;60:6548-6562 pubmed publisher
    ..51 ?M). Interestingly, 13, 19, 20, and 25 showed to be LXR target gene-selective modulators, by strongly inducing the expression of ABCA1, while poorly or not activating the lipogenic genes SREBP1 and SCD1 or FASN, respectively. ..
  16. Minuz P, Meneguzzi A, Femia E, Fava C, Calabria S, Scavone M, et al. Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations. Clin Sci (Lond). 2017;131:2095-2107 pubmed publisher
    ..In conclusion, three patients carrying ABCA1 genetic variants had low platelet count, with the lowest values observed in TD, not associated with major alterations in platelet morphology and response to agonists or bleeding. ..
  17. Liang B, Wang X, Song X, Bai R, Yang H, Yang Z, et al. MicroRNA-20a/b regulates cholesterol efflux through post-transcriptional repression of ATP-binding cassette transporter A1. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:929-938 pubmed publisher
    ..miR-20 is a new miRNA capable of targeting ABCA1 and regulating ABCA1 expression. Therefore, miR-20 inhibition constitutes a new strategy for ABCA1-based treatment of atherosclerosis. ..
  18. Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169:1228-1239.e10 pubmed publisher
    ..Structural-based analysis suggests a plausible "lateral access" mechanism for ABCA1-mediated lipid export that may be distinct from the conventional alternating-access paradigm. ..
  19. Cukier A, Therond P, Didichenko S, Guillas I, Chapman M, Wright S, et al. Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:890-900 pubmed publisher
  20. Villalobos Comparan M, Antuna Puente B, Villarreal Molina M, Canizales Quinteros S, Velázquez Cruz R, León Mimila P, et al. Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population. BMC Med Genet. 2017;18:46 pubmed publisher
    ..This is the first report showing evidence of FTO and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences. Further studies are needed to confirm this interaction. ..
  21. Lee S, Tontonoz P. Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis. 2015;242:29-36 pubmed publisher