gp100 melanoma antigen


Summary: A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.

Top Publications

  1. Bol K, van den Bosch T, Schreibelt G, Mensink H, Keunen J, Kilic E, et al. Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma. Ophthalmology. 2016;123:2265-7 pubmed publisher
  2. Boudousquié C, Bossi G, Hurst J, Rygiel K, Jakobsen B, Hassan N. Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells. Immunology. 2017;152:425-438 pubmed publisher
    ..These findings are of particular importance because IMCgp100 is currently undergoing clinical trials as a single agent or in combination with check point inhibitors for patients with malignant melanoma. ..
  3. Berard F, Blanco P, Davoust J, Neidhart Berard E, Nouri Shirazi M, Taquet N, et al. Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells. J Exp Med. 2000;192:1535-44 pubmed
    ..This demonstration of cross-priming against shared tumor antigens builds the basis for using allogeneic tumor cell lines to deliver tumor antigens to DCs for vaccination protocols. ..