disks large homolog 4 protein


Summary: A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

Top Publications

  1. Seo B, Lee J, Kim H, Kang M. Neuronal calcium channel α1 subunit interacts with AMPA receptor, increasing its cell surface localisation. Biochem Biophys Res Commun. 2018;498:402-408 pubmed publisher
    ..The α1 subunit increased the cell-surface localisation of the AMPA-R, which could be a post-synaptic function of the Cav2. ..

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