hepatitis a virus cellular receptor 1


Summary: An Ig domain-containing membrane receptor for HEPATITIS A VIRUS; EBOLA VIRUS; MARBURG VIRUS; and DENGUE VIRUS. It may also function to modulate ASTHMA and HYPERSENSITIVITY.

Top Publications

  1. Seo M, Park M, Choi S, Jeon J, Noh H, Kim J, et al. Effect of treatment on urinary kidney injury molecule-1 in IgA nephropathy. BMC Nephrol. 2013;14:139 pubmed publisher
    ..These results suggest a potential role for urinary KIM-1 as a biomarker for predicting treatment response in IgAN, however, further study is needed to verify this. ..
  2. Benli E, Ayyildiz S, Cirrik S, Noyan T, Ayyildiz A, Cirakoglu A. Early term effect of ureterorenoscopy (URS) on the Kidney: research measuring NGAL, KIM-1, FABP and CYS C levels in urine. Int Braz J Urol. 2017;43:887-895 pubmed publisher
    ..These changes reached statistical significance for NGAL, but did not reach significance for the other parameters. In conclusion, the URS procedure significantly affects the kidney; however, this effect disappears over time. ..
  3. McIlroy D, Wagener G, Lee H. Biomarkers of acute kidney injury: an evolving domain. Anesthesiology. 2010;112:998-1004 pubmed publisher
  4. Chen H, Wang L, Wang W, Cheng C, Zhang Y, Zhou Y, et al. ELABELA and an ELABELA Fragment Protect against AKI. J Am Soc Nephrol. 2017;28:2694-2707 pubmed publisher
    ..Together, our results suggest that ELA32 and ELA11 may be therapeutic candidates for treating AKI. ..
  5. Oh S, Park G, Lee S, Seo C, Shin H, Oh D. Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposur. BMC Complement Altern Med. 2017;17:544 pubmed publisher
    ..Furthermore, an in vivo proof-of-concept study is needed. ..
  6. Ostermann M, Philips B, Forni L. Clinical review: Biomarkers of acute kidney injury: where are we now?. Crit Care. 2012;16:233 pubmed publisher
    ..We outline the major studies described to date as well as discuss potential reasons for the discrepancies observed and suggest that evolution of the field may result in success with ultimately an improvement in patient outcomes. ..
  7. Duan S, Liu G, Yu Z, Pan P. Urinary KIM-1, IL-18 and Cys-c as early predictive biomarkers in gadolinium-based contrast-induced nephropathy in the elderly patients. Clin Nephrol. 2013;80:349-54 pubmed publisher
    ..Urinary KIM-1, IL-18 and Cys-C could be early predictive biomarkers of Gd-CIN in the elderly patients, which showed a good performance in early diagnosis of Gd-CIN as compared with serum creatinine. ..
  8. Chung B, Kim B, Doh K, Cho M, Kim K, Yang C. Protective effect of 1?,25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells. PLoS ONE. 2017;12:e0172536 pubmed publisher
    ..All participants provided written informed consent in accordance with the Declaration of Helsinki. This study was approved by the Institutional Review Board of Seoul St. Mary's Hospital (KC13TNMI0701). ..
  9. Sun I, Shin S, Cho A, Yoon H, Chang M, Lee K. Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus. PLoS ONE. 2017;12:e0175890 pubmed publisher
    ..By multivariate logistic regression, serum NGAL and the presence of chronic kidney disease were significant predictors of AKI. Serum NGAL might be an additive predictor for scrub typhus-associated AKI. ..

More Information


  1. Coca S, Nadkarni G, Huang Y, Moledina D, Rao V, Zhang J, et al. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. J Am Soc Nephrol. 2017;28:2786-2793 pubmed publisher
    ..Moreover, addition of these biomarkers to clinical prognostic models significantly improved discrimination for the renal outcome. ..
  2. Miao J, Friedman E, Wu A, Todd J, Estis J, Xu X, et al. Clinical utility of single molecule counting technology for quantification of KIM-1 in patients with heart failure and chronic kidney disease. Clin Biochem. 2017;50:889-895 pubmed publisher
    ..0001). Plasma KIM-1 is quantifiable in healthy volunteers, elevated in CKD and CHF patients, and correlates with eGFR. Additional investigation is needed to determine if KIM-1 provides prognostic value for CKD and CHF patient outcomes. ..
  3. Lobato G, Lobato M, Thomé F, Veronese F. Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl-?-D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes. Braz J Med Biol Res. 2017;50:e6106 pubmed publisher
    ..039). In conclusion, urinary NGAL was associated with adverse renal outcomes and increased risk of death in this cohort. If baseline urinary KIM-1 and NGAL predict progression to worse stages of CKD is something yet to be explored. ..
  4. Gu X, He H, Lin L, Luo G, Wen Y, Xiang D, et al. Tim-1+ B cells suppress T cell interferon-gamma production and promote Foxp3 expression, but have impaired regulatory function in coronary artery disease. APMIS. 2017;125:872-879 pubmed publisher
    ..Together, these results demonstrated that CAD patients presented an inflammatory disorder in regulatory B cells, which could be used as a therapeutic target. ..
  5. Boddu R, Fan C, Rangarajan S, Sunil B, Bolisetty S, Curtis L. Unique sex- and age-dependent effects in protective pathways in acute kidney injury. Am J Physiol Renal Physiol. 2017;313:F740-F755 pubmed publisher
    ..These distinctions may offer novel targets to exploit therapeutically in both females and males in the treatment of AKI. ..
  6. Wei J, Song J, Jiang S, Zhang G, Wheeler D, Zhang J, et al. Role of intratubular pressure during the ischemic phase in acute kidney injury. Am J Physiol Renal Physiol. 2017;312:F1158-F1165 pubmed publisher
    ..In summary, we found that higher Pt during the ischemic phase promoted the development of AKI, while lower Pt protected from kidney injury. Pt may be a potential target for treatment of AKI. ..
  7. Liu J, Li G, Li L, Liu Z, Zhou Q, Wang G, et al. Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population. BMC Nephrol. 2017;18:67 pubmed publisher
    ..Collectively, these findings suggest that SP-D may be useful as a biomarker of AKI susceptibility and prognosis. ..
  8. Park M, Shlipak M, Vittinghoff E, Katz R, Siscovick D, Sarnak M, et al. Associations of kidney injury markers with subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Clin Nephrol. 2015;84:358-63 pubmed publisher
  9. Haase M, Haase Fielitz A. Can novel biomarkers complement best possible clinical assessment for early acute kidney injury diagnosis?. J Am Coll Cardiol. 2011;58:2310-2 pubmed publisher
  10. Mohamed F, Buckley N, Pickering J, Wunnapuk K, Dissanayake S, Chathuranga U, et al. Nephrotoxicity-induced proteinuria increases biomarker diagnostic thresholds in acute kidney injury. BMC Nephrol. 2017;18:122 pubmed publisher
    ..AKI biomarker cutoffs for diagnosis, outcome prediction and AKI stratification increased in the presence of albuminuria. This may lead to over-diagnosis of AKI in conditions independently associated with proteinuria. ..