thrombomodulin

Summary

Summary: A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.

Top Publications

  1. Yamakawa K, Fujimi S, Mohri T, Matsuda H, Nakamori Y, Hirose T, et al. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study. Crit Care. 2011;15:R123 pubmed publisher
    ..Recombinant human soluble thrombomodulin (rhTM) binds to thrombin to inactivate coagulation, and the thrombin-rhTM complex activates protein C to ..
  2. Li Y, Chung H, Luo C, Chao T, Shyu K, Shi G, et al. Thrombomodulin is upregulated in cardiomyocytes during cardiac hypertrophy and prevents the progression of contractile dysfunction. J Card Fail. 2010;16:980-90 pubmed publisher
    Cardiac hypertrophy is a common response to pressure overload and leads to left ventricular (LV) dysfunction. Thrombomodulin (TM), an endothelial anticoagulant protein, was found to have direct effects on cellular proliferation and ..
  3. Mosnier L. Platelet factor 4 inhibits thrombomodulin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) by thrombin. J Biol Chem. 2011;286:502-10 pubmed publisher
    b>Thrombomodulin (TM) is a cofactor for thrombin-mediated activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI) and thereby helps coordinate coagulation, anticoagulation, fibrinolysis, and inflammation...
  4. Hiroi T, Deming C, Zhao H, Hansen B, Arkenbout E, Myers T, et al. Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors. Arterioscler Thromb Vasc Biol. 2009;29:1587-93 pubmed publisher
    Impairment of the thrombomodulin-protein C anticoagulant pathway has been implicated in pathological thrombosis associated with malignancy...
  5. Huang M, Wei P, Liu J, Liu D, Huey Chun H, An J, et al. Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression. Ann Surg Oncol. 2010;17:3379-85 pubmed publisher
    b>Thrombomodulin (TM) is a key molecule mediating circulation homeostasis through its binding to thrombin. The TM-thrombin complex can activate protein C and thrombin-activatable fibrinolysis inhibitor to form a tight clot...
  6. Andrulis M, Dietrich S, Longerich T, Koschny R, Burian M, Schmitt Gräf A, et al. Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease. Haematologica. 2012;97:1674-7 pubmed publisher
    ..Endothelial thrombomodulin was quantified along with histological markers of epithelial damage and cytotoxic T cells in colon biopsies ..
  7. Morser J. Thrombomodulin links coagulation to inflammation and immunity. Curr Drug Targets. 2012;13:421-31 pubmed
    b>Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external ..
  8. Geudens N, Van de Wouwer M, Vanaudenaerde B, Vos R, Van De Wauwer C, Verleden G, et al. The lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury. Eur Respir J. 2008;32:862-70 pubmed publisher
    ..Effective measures to prevent this complication are lacking. Thrombomodulin (TM) is an endothelial cell receptor and cofactor for thrombin-mediated generation of the anticoagulant and ..
  9. Tai C, Cheng C, Su H, Chen W, Wu C, Lin F, et al. Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkers. Tumour Biol. 2014;35:47-54 pubmed publisher
    b>Thrombomodulin (TM) has been shown to regulate many physiological and pathological processes, including inflammation, thrombosis, and tumor progression...

More Information

Publications62

  1. Wu C, Kim P, Manuel R, Seto M, Whitlow M, Nagashima M, et al. The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex. J Biol Chem. 2009;284:7059-67 pubmed publisher
    b>Thrombomodulin (TM) increases the catalytic efficiency of thrombin (IIa)-mediated activation of thrombin-activable fibrinolysis inhibitor (TAFI) 1250-fold...
  2. Chen L, Shyu H, Lin H, Lei H, Lin Y, Liu H, et al. Dengue virus induces thrombomodulin expression in human endothelial cells and monocytes in vitro. J Infect. 2009;58:368-74 pubmed publisher
    ..However, the mechanism to cause hemorrhage in DV infections remains poorly understood. Thrombomodulin (TM), expressed on the surface of endothelial cells and monocytes, is very important in regulation of ..
  3. Frontera V, Arcangeli M, Zimmerli C, Bardin F, Obrados E, Audebert S, et al. Cutting edge: JAM-C controls homeostatic chemokine secretion in lymph node fibroblastic reticular cells expressing thrombomodulin. J Immunol. 2011;187:603-7 pubmed publisher
    ..In this study, we show that thrombomodulin and platelet-derived growth factor receptor ? identify a population of fibroblastic reticular cells in which ..
  4. Yamakawa K, Ogura H, Fujimi S, Morikawa M, Ogawa Y, Mohri T, et al. Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. Intensive Care Med. 2013;39:644-52 pubmed publisher
    Evidence of efficacy and safety of, and especially mortality related to, recombinant human thrombomodulin (rhTM) treatment for sepsis-induced disseminated intravascular coagulation (DIC) is limited...
  5. Cui W, Wilson J, Wen J, Angsana J, Qu Z, Haller C, et al. Thrombomodulin improves early outcomes after intraportal islet transplantation. Am J Transplant. 2009;9:1308-16 pubmed publisher
    ..In the presence of thrombin, thrombomodulin generates activated protein C (APC), which limits procoagulant and proinflammatory responses...
  6. Sierko E, Wojtukiewicz M, Zawadzki R, Zimnoch L, Kisiel W. Expression of protein C (PC), protein S (PS) and thrombomodulin (TM) in human colorectal cancer. Thromb Res. 2010;125:e71-5 pubmed publisher
    ..important inhibitory mechanism is provided by the protein C (PC) system consisting of PC, protein S (PS) and thrombomodulin (TM)...
  7. Ito T, Maruyama I. Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation. J Thromb Haemost. 2011;9 Suppl 1:168-73 pubmed publisher
    b>Thrombomodulin (TM) is an endothelial anticoagulant cofactor that promotes thrombin-mediated activation of protein C...
  8. Hagiwara S, Iwasaka H, Matsumoto S, Hasegawa A, Yasuda N, Noguchi T. In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models. Shock. 2010;33:282-8 pubmed publisher
    ..We investigated whether the use of recombinant thrombomodulin (rTM), which has activity comparable with antithrombin, tissue factor pathway inhibitor, and activated protein ..
  9. Lin P, Shen H, Chen C, Wu S, Kao H, Huang J, et al. The inhibition in tumor necrosis factor-alpha-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-kappaB and reactive oxygen species. J Thromb Thrombolysis. 2010;29:52-9 pubmed publisher
    ..b>Thrombomodulin (TM) plays protective roles against thrombosis...
  10. Kuo C, Chen P, Chang B, Sung M, Shi C, Lee J, et al. The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen. Blood. 2012;119:1302-13 pubmed publisher
    ..Recently, we demonstrated that LeY is a specific ligand of the recombinant lectin-like domain of thrombomodulin (TM)...
  11. Ding B, Hong N, Christofidou Solomidou M, Gottstein C, Albelda S, Cines D, et al. Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med. 2009;180:247-56 pubmed publisher
    Endothelial thrombomodulin (TM) regulates thrombosis and inflammation. Diverse forms of pulmonary and vascular injury are accompanied by down-regulation of TM, which aggravates tissue injury...
  12. Liu P, Tsai J, Chiu C, Hwang J, Chou S, Wang C, et al. Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer. Mol Carcinog. 2010;49:874-81 pubmed publisher
    b>Thrombomodulin (TM) plays a role in coagulation, inflammation, and cell adhesion...
  13. Huang H, Chang T, Chang Y, Wen H. UVB irradiation regulates ERK1/2- and p53-dependent thrombomodulin expression in human keratinocytes. PLoS ONE. 2013;8:e67632 pubmed publisher
    b>Thrombomodulin (TM) is highly expressed in endothelial cells and acts as a natural anticoagulation factor to maintain circulation homeostasis...
  14. Leung L, Myles T, Nishimura T, Song J, Robinson W. Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Mol Immunol. 2008;45:4080-3 pubmed publisher
    ..fibrinolysis inhibitor or TAFI) is a plasma procarboxypeptidase that is activated by the thrombin-thrombomodulin complex on the vascular endothelial surface...
  15. Crikis S, Zhang X, Dezfouli S, Dwyer K, Murray Segal L, Salvaris E, et al. Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice. Am J Transplant. 2010;10:242-50 pubmed publisher
    b>Thrombomodulin (TBM) is an important vascular anticoagulant that has species specific effects...
  16. Miwa Y, Yamamoto K, Onishi A, Iwamoto M, Yazaki S, Haneda M, et al. Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation. Xenotransplantation. 2010;17:26-37 pubmed publisher
    ..Molecular incompatibilities in the coagulation systems between pigs and humans, such as the thrombomodulin (TM)-protein C system or direct prothrombinase activity, have been suggested as possible causes...
  17. Wu Z, Liu M, Liang M, Fu J. Sirt1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure. Blood. 2012;119:2422-9 pubmed publisher
    ..b>Thrombomodulin (TM), a central player of the anticoagulant protein C system, is regulated by Kruppel-like factor 2 (KLF2) at ..
  18. Li Y, Kuo C, Shi G, Wu H. The role of thrombomodulin lectin-like domain in inflammation. J Biomed Sci. 2012;19:34 pubmed publisher
    b>Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity...
  19. Ogawa Y, Yamakawa K, Ogura H, Kiguchi T, Mohri T, Nakamori Y, et al. Recombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis. J Trauma Acute Care Surg. 2012;72:1150-7 pubmed publisher
    ..The purpose of this study was to examine the efficacy of recombinant human soluble thrombomodulin (rhTM), a novel anticoagulant agent, for treating patients with sepsis-induced disseminated intravascular ..
  20. Weiler H. Regulation of inflammation by the protein C system. Crit Care Med. 2010;38:S18-25 pubmed publisher
    ..b>Thrombomodulin controls the complement arm of the innate immune system in a thrombin-dependent manner through activation of ..
  21. Inomata M, Ishihara Y, Matsuyama T, Imamura T, Maruyama I, Noguchi T, et al. Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis. J Periodontol. 2009;80:1511-7 pubmed publisher
    The endothelial cell surface glycoprotein thrombomodulin (TM) inhibits vascular coagulation and inflammation via regulation of thrombin-mediated activation of protein C...
  22. Pawlak K, Domaniewski T, Mysliwiec M, Pawlak D. Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease. Thromb Res. 2009;124:452-7 pubmed publisher
    ..of SOX: Cu/Zn superoxide dismutase (Cu/Zn SOD), malondialdehyde (MDA); and endothelial dysfunction markers: thrombomodulin (TM) and von Willebrand factor (vWF) levels in 148 ESRD patients and healthy controls...
  23. Matsuyama T, Tokuda M, Izumi Y. Significance of thrombomodulin release from gingival epithelial cells in periodontitis patients. J Periodontal Res. 2008;43:379-85 pubmed
    b>Thrombomodulin, a cell transmembrane glycoprotein, binds to thrombin and converts it from a procoagulant protease to an anticoagulant enzyme that activates protein C. Thrombomodulin is very important in regulating the function of thrombin...
  24. Lobato R, White W, Mathew J, Newman M, Smith P, McCants C, et al. Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses. Circulation. 2011;124:S143-8 pubmed publisher
    ..comparisons and clinical predictors of mortality, the homozygote minor allele of a common variant in the thrombomodulin (THBD) gene (rs1042579) was independently associated with significantly increased risk of all-cause mortality (..
  25. Yao G, Liu Z, Zhang X, Zheng C, Chen H, Zeng C, et al. Circulating thrombomodulin and vascular cell adhesion molecule-1 and renal vascular lesion in patients with lupus nephritis. Lupus. 2008;17:720-6 pubmed publisher
    ..Soluble E-selectin, thrombomodulin (TM) and vascular cell adhesion molecule-1 (VCAM-1) were measured by ELISA...
  26. Vincent J, Ramesh M, Ernest D, Larosa S, Pachl J, Aikawa N, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013;41:2069-79 pubmed publisher
    To determine the safety and efficacy of recombinant thrombomodulin (ART-123) in patients with suspected sepsis-associated disseminated intravascular coagulation.
  27. Wei H, Li Y, Shi G, Liu S, Chang P, Kuo C, et al. Thrombomodulin domains attenuate atherosclerosis by inhibiting thrombin-induced endothelial cell activation. Cardiovasc Res. 2011;92:317-27 pubmed publisher
    ..b>Thrombomodulin (TM) inhibits thrombin effects by binding thrombin through its domains 2 and 3 (TMD23)...
  28. Stroncek J, Xue Y, Haque N, Lawson J, Reichert W. In vitro functional testing of endothelial progenitor cells that overexpress thrombomodulin. Tissue Eng Part A. 2011;17:2091-100 pubmed publisher
    ..the augmentation of endothelial progenitor cell (EPC) thromboresistance by using gene therapy to overexpress thrombomodulin (TM), an endothelial cell membrane glycoprotein that has potent anti-coagulant properties...
  29. Ma C, Shi G, Shi C, Kao Y, Lin S, Wu H. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012;188:6328-37 pubmed publisher
    ..We previously demonstrated that LPS binds to monocytic membrane-bound thrombomodulin (TM), but the role of monocytic TM in LPS-induced inflammation remains unknown...
  30. Iba T, Nakarai E, Takayama T, Nakajima K, Sasaoka T, Ohno Y. Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model. Crit Care. 2009;13:R203 pubmed publisher
    Recombinant human soluble thrombomodulin (rhsTM) is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant administration of rhsTM and antithrombin (AT)...
  31. Levi M, van der Poll T. Thrombomodulin in sepsis. Minerva Anestesiol. 2013;79:294-8 pubmed
    b>Thrombomodulin has a pivotal role in the protein C system that is important in the pathogenesis of sepsis...
  32. Strijbos M, Rao C, Schmitz P, Kraan J, Lamers C, Sleijfer S, et al. Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial damage. Thromb Haemost. 2008;100:642-7 pubmed
    ..Plasma concentrations of E-selectin, endoglin, and thrombomodulin were assessed by ELISA in plasma obtained from 40 healthy donors and 40 patients...
  33. Joner M, Nakazawa G, Finn A, Quee S, Coleman L, Acampado E, et al. Endothelial cell recovery between comparator polymer-based drug-eluting stents. J Am Coll Cardiol. 2008;52:333-42 pubmed publisher
    ..Dual fluorescent immunolabeling was performed for platelet-endothelial cell adhesion molecule (PECAM)-1 and thrombomodulin (TM), factors involved in cell-to-cell contact and thrombogenicity, respectively...
  34. Kitazono M, Yokota H, Satoh H, Onda H, Matsumoto G, Fuse A, et al. Measurement of inflammatory cytokines and thrombomodulin in chronic subdural hematoma. Neurol Med Chir (Tokyo). 2012;52:810-5 pubmed
    ..removed during the procedure were examined, and the hematoma serum levels of cytokines measured such as thrombomodulin (TM), interleukin-6 (IL-6), tumor necrosis factor-? (TNF?), and interleukin-10 (IL-10)...
  35. Kao Y, Wu L, Shi C, Chu C, Huang C, Kuo C, et al. Downregulation of thrombomodulin, a novel target of Snail, induces tumorigenesis through epithelial-mesenchymal transition. Mol Cell Biol. 2010;30:4767-85 pubmed publisher
    The expression of thrombomodulin (TM), a calcium-dependent adhesion molecule, is frequently downregulated in various cancer types. However, the mechanism responsible for the low expression level of TM in tumorigenesis is unknown...
  36. Stortoni P, Cecati M, Giannubilo S, Sartini D, Turi A, Emanuelli M, et al. Placental thrombomodulin expression in recurrent miscarriage. Reprod Biol Endocrinol. 2010;8:1 pubmed publisher
    Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds ..
  37. Ito T, Kawahara K, Okamoto K, Yamada S, Yasuda M, Imaizumi H, et al. Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes. Arterioscler Thromb Vasc Biol. 2008;28:1825-30 pubmed publisher
    ..We previously reported that thrombomodulin (TM), an endothelial thrombin-binding protein, bound to HMGB1, thereby protecting mice from lethal endotoxemia...
  38. Conway E. Thrombomodulin and its role in inflammation. Semin Immunopathol. 2012;34:107-25 pubmed publisher
    The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data were collected from published research...
  39. Hatzipantelis E, Athanassiou Metaxa M, Gombakis N, Tzimouli V, Taparkou A, Sidi Fragandrea V, et al. Thrombomodulin and von Willebrand factor: relation to endothelial dysfunction and disease outcome in children with acute lymphoblastic leukemia. Acta Haematol. 2011;125:130-5 pubmed publisher
    ..In children with ALL, there was a significant increase in thrombomodulin (TM) and von Willebrand factor (vWF) levels during the acute phase of the disease and during treatment...
  40. Haghazali M, Molaei M, Mashayekhi R, Zojaji H, Pourhoseingholi M, Shooshtarizadeh T, et al. Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori. Indian J Pathol Microbiol. 2011;54:103-6 pubmed publisher
    ..The aim of this present study was to evaluate proinflammatory cytokines including interleukin 1, 6, 8, 10, and thrombomodulin in H. pylori-infected patients with PUD and gastric cancer...
  41. Horowitz N, Blevins E, Miller W, Perry A, Talmage K, Mullins E, et al. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 2011;118:2889-95 pubmed publisher
    b>Thrombomodulin (TM) is a predominantly endothelial transmembrane glycoprotein that modulates hemostatic function through a domain that controls thrombin-mediated proteolysis and an N-terminal lectin-like domain that controls inflammatory ..
  42. Yazaki S, Iwamoto M, Onishi A, Miwa Y, Hashimoto M, Oishi T, et al. Production of cloned pigs expressing human thrombomodulin in endothelial cells. Xenotransplantation. 2012;19:82-91 pubmed publisher
    ..Our attention has been directed toward human thrombomodulin (hTM), because it is expected to exhibit the following beneficial effects on coagulation control and ..
  43. Rong Y, Zhang M, Zhang L, Wang X, Shen Y. JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter. FEBS Lett. 2010;584:852-8 pubmed publisher
    b>Thrombomodulin (TM) is an important vascular protective molecule that has anticoagulant, anti-inflammatory and anti-apoptotic properties. TM is downregulated in many thrombotic and vascular diseases...
  44. Lu Z, He X, Hong G, He F, Liang H, Qiu Q, et al. [Expression of thrombomodulin, endothelial protein C receptor in lung tissue of acute paraquat poisoned rats and intervention of sodium dimercaptopropane sulfonate]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009;27:453-6 pubmed
    To observe the expression and effect of thrombomodulin (TM) mRNA and endothelial protein C receptor (EPCR) mRNA in lung tissue of acute paraquat poisoned rats, and intervention of sodium dimercaptopropane sulfonate (Na-DMPS)...
  45. Lin F, Tsai Y, Lee C, Lin C, Lin Y, Li C, et al. TNF-?-decreased thrombomodulin expression in monocytes is inhibited by propofol through regulation of tristetraprolin and human antigen R activities. Shock. 2011;36:279-88 pubmed publisher
    b>Thrombomodulin (TM) is expressed on the surface of monocytes and is a key regulator of actual immune capacity. Propofol is an anesthetic agent that exerts anti-inflammatory effects...
  46. Geiger H, Pawar S, Kerschen E, Nattamai K, Hernandez I, Liang H, et al. Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med. 2012;18:1123-9 pubmed publisher
    ..Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-..
  47. Shah S, Ashavaid T, Mankeshwar R, Ponde C, Rajani R. Role of thrombomodulin gene in Indian population with coronary artery disease. Biomarkers. 2012;17:610-7 pubmed publisher
    b>Thrombomodulin (TM), a natural anticoagulant have been implicated in the pathogenesis of coronary artery disease (CAD) thus emphasizing its potential role as a biomarker...
  48. Erem C, Ucuncu O, Yilmaz M, Kocak M, Nuhoglu I, Ersoz H. Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism. Endocrine. 2009;35:75-80 pubmed publisher
    ..Factors V(FV), VII (FVII), VIII (FVIII) activities, von Willebrand factor (vWF), protein C, protein S, thrombomodulin (TM), TFPI, and TAFI were measured...
  49. Dharmasaroja P, Dharmasaroja P, Sobhon P. Increased plasma soluble thrombomodulin levels in cardioembolic stroke. Clin Appl Thromb Hemost. 2012;18:289-93 pubmed publisher
    Soluble thrombomodulin (sTM) has been proposed as a potential marker of ischemic stroke. Results from previous studies remain controversial among different populations...
  50. Keven K, Elmaci S, Sengul S, Akar N, Egin Y, Genc V, et al. Soluble endothelial cell protein C receptor and thrombomodulin levels after renal transplantation. Int Urol Nephrol. 2010;42:1093-8 pubmed publisher
    Both thrombomodulin (TM) and endothelial protein C receptor (EPCR) are candidate biomarkers of endothelial damage and have a role of anti-thrombotic defense mechanism in vascular structure...
  51. Tripodi A, Primignani M, Chantarangkul V, Dell Era A, Clerici M, de Franchis R, et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology. 2009;137:2105-11 pubmed publisher
    ..controls) for levels of pro- and anti-coagulants and for thrombin generation in the presence or absence of thrombomodulin (the main physiologic activator of the protein C anticoagulant pathway)...
  52. Lin S, Hsieh F, Chen Y, Lin C, Kuan I, Wang S, et al. Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNFalpha-treated human aortic endothelial cells. Histol Histopathol. 2009;24:1147-59 pubmed publisher
    Expression of functionally active thrombomodulin (TM) on endothelial cells is critical for vascular thromboresistance...
  53. Varol F, Ozgen L, Sayin N, Demir M. Correlation between maternal plasma thrombomodulin and infant birth weight in hypertensive disorders of pregnancy. Clin Appl Thromb Hemost. 2009;15:166-70 pubmed publisher
    To evaluate the association between maternal plasma thrombomodulin levels and infant birth weights in pregnancy-induced hypertension. Plasma thrombomodulin levels were measured in 80 pregnant women living in the Trakya region of Turkey...