nogo receptors


Summary: GPI-linked proteins consisting of eight elongated leucine-rich repeats at their N-temini that are connected to the GPI by a "stalk" region rich in prolines, serines and threonines. They bind to NOGO PROTEIN; however, some Nogo receptors also bind MYELIN ASSOCIATED GLYCOPROTEIN and other cell surface glycoproteins. Interactions between nogo receptors and their ligands modulate nerve growth and NEURONAL PLASTICITY.

Top Publications

  1. Zhao Y, Sivaji S, Chiang M, Ali H, Zukowski M, Ali S, et al. Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels. Neuron. 2017;96:355-372.e6 pubmed publisher
    ..These studies highlight deficits in new synapse assembly as a potential initiator of cognitive pathology in AD, and pinpoint calcium dysregulation mediated by NgRs and T-type channels as key components. VIDEO ABSTRACT. ..
  2. Wang G, Liu S, Wang L, Meng L, Cui C, Zhang H, et al. Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells. Int J Biol Sci. 2017;13:135-144 pubmed publisher
    ..In conclusion, Lcn2 significantly promoted human PASMC ER stress and proliferation by augmenting intracellular iron. The up-regulation of Lcn2 probably involved in the pathogenesis and progression of PH. ..
  3. Fang L, Wang Y, Zheng Q, Yang T, Zhao P, Zhao H, et al. Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2017;17:346 pubmed publisher
    ..BSYSC could attenuate axonal injury and promote repair of axonal damage in EAE mice in part through the down-regulation of NogoA/NgR and RhoA/ROCK signaling pathways. ..