catecholamine receptors


Summary: Cell surface proteins that bind catecholamines with high affinity and trigger intracellular changes which influence the behavior of cells. The catecholamine messengers epinephrine, norepinephrine, and dopamine are synthesized from tyrosine by a common biosynthetic pathway.

Top Publications

  1. Kulinskii V, Kolesnichenko L. [Catecholamines: biochemistry, pharmacology, physiology, clinical aspects]. Vopr Med Khim. 2002;48:45-67 pubmed
    ..CA participate in pathogenesis of many illnesses and in the defence mechanisms of a body. CA and related substances are effective and widely used drugs. ..
  2. Kolusheva S, Molt O, Herm M, Schrader T, Jelinek R. Selective detection of catecholamines by synthetic receptors embedded in chromatic polydiacetylene vesicles. J Am Chem Soc. 2005;127:10000-1 pubmed
    ..The chromatic assembly provides a generic route for high sensitivity detection of ligand-receptor interactions. ..
  3. Akashi Y, Anker S. Takotsubo cardiomyopathy. Int J Cardiol. 2006;112:114-5 pubmed
    ..This disease is a new entity of acute reversible heart failure. Abnormal catecholamine dynamics due to stress may be the primary cause of this condition. ..
  4. Inoue H, Kawachi S, Yasuda K. [Biogenic amines (catecholamines, catecholamine receptors and others)]. Nihon Rinsho. 2002;60 Suppl 7:273-9 pubmed
  5. Dudkowska M, Manteuffel Cymborowska M, Chmurzynska W, Grzelakowska Sztabert B. Catecholamines participate in the induction of ornithine decarboxylase gene expression in normal and hyperplastic mouse kidney. Biochim Biophys Acta. 1999;1454:71-9 pubmed
    ..Use of selective agonists of catecholamine receptors demonstrated the importance of dopamine D2 receptors, and to a lower extent beta adrenoreceptors, in the ..
  6. Takeuchi S, Okamura T, Shonai K, Imamura S. Distribution of catecholaminergic receptors in the rat's pancreas islet. Nihon Ika Daigaku Zasshi. 1990;57:119-26 pubmed
    ..It was concluded that the sympathetic alpha receptor and DA1 was distributed on the B-cells, the sympathetic beta 2 receptors on the D-cell and the DA2 on the varicosity of the sympathetic beta 2 neuron. ..
  7. Lübbecke F, Steudle V, Schütterle G, Wizemann V. Catecholaminergic and muscarinergic receptors in chronic experimental uremia. Clin Physiol Biochem. 1989;7:149-60 pubmed
  8. Moore T, Schettler S, Killiany R, Herndon J, Luebke J, Moss M, et al. Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behav Brain Res. 2005;160:208-21 pubmed
    ..Further analysis revealed a significant relationship between monoamine receptor binding and cognitive performance on three tasks: delayed non-matching to sample, delayed recognition span test and the conceptual set-shifting task. ..
  9. Huss M, Chen W, Ludolph A. Guanfacine Extended Release: A New Pharmacological Treatment Option in Europe. Clin Drug Investig. 2016;36:1-25 pubmed publisher
    ..We review recent advances in understanding of the pathophysiology of ADHD with a focus on the roles of catecholamine receptors in context of the α2A-adrenergic receptor agonist guanfacine extended release (GXR), a new non-..

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  1. Rey E, Hernández Díaz F, Abreu P, Alonso R, Tabares L. Dopamine induces intracellular Ca2+ signals mediated by alpha1B-adrenoceptors in rat pineal cells. Eur J Pharmacol. 2001;430:9-17 pubmed
    ..These results suggest that dopamine induced Ca2+ signals are mainly due to the activation of one subtype of alpha-adrenoceptor, the alpha1B. ..
  2. Grass K, Prast H, Philippu A. Influence of catecholamine receptor agonists and antagonists on the ultradian rhythm of the EEG in the posterior hypothalamus. Naunyn Schmiedebergs Arch Pharmacol. 1998;357:169-75 pubmed
    ..Together with previous observations, the results indicate that the ultradian EEG rhythm is susceptible to modulatory mechanisms mediated by catecholaminergic neurons. ..
  3. Correll C, Malhotra A. Pharmacogenetics of antipsychotic-induced weight gain. Psychopharmacology (Berl). 2004;174:477-89 pubmed
    ..To enhance power, future studies should pay close attention to population selection and avoidance/control of confounds, particularly past treatment exposure. ..
  4. Choi H, Jang Y, Kim H, Hwang O. Tetrahydrobiopterin is released from and causes preferential death of catecholaminergic cells by oxidative stress. Mol Pharmacol. 2000;58:633-40 pubmed
    ..This BH4-induced cytotoxicity may represent a mechanism by which selective degeneration of dopaminergic terminals and neurons occur. ..
  5. Modi P, Kashyap A, Nair V, Ross G, Fu M, Savelli J, et al. Modulation of brain catecholamine absorbing proteins by dopaminergic agents. Eur J Pharmacol. 1996;299:213-20 pubmed
    ..These results clearly demonstrate the pharmacological modulation of CATNAPs by dopaminergic agents and suggest their possible role in the cytoprotection against damage caused by free radicals generated by oxidative stress. ..
  6. Russo S, Daniels A, Viveros O, Reinhard J. Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurotoxicol Teratol. 1994;16:277-81 pubmed
    ..The data suggest that mice may be more sensitive to the toxicant because less striatal MPP+ appears to be stored in the reserpine-sensitive storage vesicle. ..
  7. Hotta H, Uchida S. Aging of the autonomic nervous system and possible improvements in autonomic activity using somatic afferent stimulation. Geriatr Gerontol Int. 2010;10 Suppl 1:S127-36 pubmed publisher
    ..g. stroking skin or acupuncture) to increase sympathetic, parasympathetic and central cholinergic activity. ..
  8. Andersson K, Arner P. Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors. Int J Obes Relat Metab Disord. 2001;25:1225-32 pubmed
  9. Paetsch P, Greenshaw A. 2-Phenylethylamine-induced changes in catecholamine receptor density: implications for antidepressant drug action. Neurochem Res. 1993;18:1015-22 pubmed
    ..On the basis of these observations, the effects of long term increases in brain PEA on catecholamine receptors have been assessed...
  10. Strange P. The energetics of ligand binding at catecholamine receptors. Trends Pharmacol Sci. 1996;17:238-44 pubmed
    ..Here Philip Strange considers these events for catecholamine receptors, concentrating mostly on dopamine receptors; where necessary the discussion is widened to include other ..
  11. Iyer V, Hajjar R, Armoundas A. Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2007;100:e22-31 pubmed
    ..In conclusion, these minimal order models of mutant CSQN2 and RyR2 provide plausible mechanisms by which defects in RyR2 gating may lead to the cellular triggers for arrhythmia, with implications for the development of targeted therapy. ..
  12. McAllister T, Flashman L, McDonald B, Saykin A. Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. J Neurotrauma. 2006;23:1450-67 pubmed
    ..We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI. ..
  13. Ueno S. [The role of the sympatho-adrenomedullary system and adrenergic receptors in the pathogenesis of orthostatic hypotension in diabetes mellitus]. Nihon Naibunpi Gakkai Zasshi. 1988;64:1293-312 pubmed
    To clarify the role of the sympatho-adrenomedullary and renin-angiotensin-aldosterone systems, and catecholamine receptors, in the pathogenesis of orthostatic hypotension in diabetes mellitus (DM), urinary excretion of catecholamines, ..
  14. Hauser J, Czarny M. [The study of candidate genes in psychiatric disease. II. Affective disorders]. Psychiatr Pol. 1999;33:553-63 pubmed
    ..In many medical centers it was found that in affective disorders the polymorphism of gene's receptor D4, GABA and serotonin transporter could be of etiological importance. ..
  15. Christopoulos S, Bourdeau I, Lacroix A. Aberrant expression of hormone receptors in adrenal Cushing's syndrome. Pituitary. 2004;7:225-35 pubmed
  16. Lentes K, Mathieu E, Bischoff R, Rasmussen U, Pavirani A. Hydrophobic cluster analysis of G protein-coupled receptors: a powerful tool to derive structural and functional information from 2D-representation of protein sequences. J Recept Res. 1993;13:179-94 pubmed
    ..We have applied HCA to the analysis of different families of G-protein coupled receptors, such as catecholamine receptors as well as peptide hormone receptors...
  17. Foley T, Greenwood B, Day H, Koch L, Britton S, Fleshner M. Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue. Behav Brain Res. 2006;174:132-42 pubmed
    ..These data suggest that central serotonergic and dopaminergic systems may be involved in the mechanisms by which HCR have delayed onset of exercise-induced fatigue compared to LCR. ..
  18. Kumar J, Rajkumar R, Farooq U, Lee L, Tan F, Dawe G. Evidence of D2 receptor expression in the nucleus incertus of the rat. Physiol Behav. 2015;151:525-34 pubmed publisher
    ..This is the first evidence of expression of a catecholamine receptor, D2-like immunoreactivity, in the NI. ..
  19. Guo S, Wilson S, Cooke S, Chitnis A, Driever W, Rosenthal A. Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons. Dev Biol. 1999;208:473-87 pubmed
    ..They further reveal an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes. ..
  20. Barnea E, Perlman R, Fakih H, Bick T, Kol S, Hochberg Z. The role of catecholamines in estradiol and progesterone secretion by cultured explants and cells of human term placentae. Acta Endocrinol (Copenh). 1989;121:767-72 pubmed
    ..The marked response of the explant system as compared with the marginal response of the cell culture system indicates that cell to cell contact/communication is required for full expression of catecholamine effect. ..
  21. Insel P, Kirstein S. Naturally occurring variants in catecholamine receptor genes. Auton Autacoid Pharmacol. 2003;23:228-30 pubmed
  22. Badia A, Moron A, Cuffi L, Vila E. Effects of ergotamine on cardiovascular catecholamine receptors in the pithed rat. Gen Pharmacol. 1988;19:475-81 pubmed
  23. Faull K, Bowersox S, Zeller DeAmicis L, Maddaluno J, Ciaranello R, Dement W. Influence of freezer storage time on cerebral biogenic amine and metabolite concentrations and receptor ligand binding characteristics. Brain Res. 1988;450:225-30 pubmed
    ..These findings have significance for the measurement of dopamine and norepinephrine concentrations in autopsied brains kept frozen in storage. ..
  24. Hano T. [Molecular biology in regulation of kidney functions: Catecholamine/acetylcholine]. Nihon Rinsho. 2006;64 Suppl 2:252-6 pubmed
  25. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, et al. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 1998;101:527-35 pubmed
  26. Yasuoka A, Abe K, Saigo K, Arai S, Emori Y. Molecular cloning of a fish gene encoding a novel seven-transmembrane receptor related distantly to catecholamine, histamine, and serotonin receptors. Biochim Biophys Acta. 1995;1235:467-9 pubmed
  27. Kato N. [Involvement of catecholamine receptors in the pathogenesis of hypertension and hypertensive target-organ damage]. Nihon Rinsho. 2004;62 Suppl 3:156-9 pubmed
  28. Osier N, Dixon C. Catecholaminergic based therapies for functional recovery after TBI. Brain Res. 2016;1640:15-35 pubmed publisher
    ..findings, challenges translating therapies to clinical practice, the complexity or lack of specificity of catecholamine receptors, as well as potentially counfounding effects of personal and genetic factors...
  29. Lowery C, Elliott C, Cooper A, Hadden C, Sonon R, Azadi P, et al. Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Pharmacological blockade of 5-HT or catecholamine receptors counteracted the 5-HT/catecholamine-mediated aggregation and altered the level and composition of glycan ..
  30. Rodrigues A, da Silva G, Mateussi A, Fernandes E, Miguel O, Yunes R, et al. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci. 2002;70:1347-58 pubmed
    ..verticillatus elicited a significant antidepressant-like effect, when assessed in the TST and FST in mice. Its action seems to involve an interaction with adrenergic, dopaminergic, glutamatergic and serotonergic systems. ..
  31. Lambe E, Krimer L, Goldman Rakic P. Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkey. J Neurosci. 2000;20:8780-7 pubmed
    ..By contrast, 5-HT innervation of both types of neurons remains relatively constant over the age range studied. ..
  32. Imai Y, Rodan S, Rodan G. Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells. Endocrinology. 1988;122:456-63 pubmed
    ..reduction in the hormone-responsive adenylate cyclase activity was associated with lower levels of beta-catecholamine receptors, without a change in apparent receptor affinity and with lower levels of the GTP-binding proteins Gs and ..
  33. Spencer T, Biederman J, Wilens T. Pharmacotherapy of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am. 2000;9:77-97 pubmed
    ..As with other areas of medicine, it is sometimes necessary to use multiple agents to treat comorbidity or to achieve an effective response. ..
  34. Brickman T, Suhadolc R, Armstrong S. Interspecies variations in Bordetella catecholamine receptor gene regulation and function. Infect Immun. 2015;83:4639-52 pubmed publisher
    ..pertussis. Additional evidence of the in vivo importance of the B. pertussis receptors was obtained from serologic studies demonstrating pertussis patient serum reactivity with the B. pertussis BfrD and BfrE proteins. ..
  35. Vincent J, Cardinaud B, Vernier P. [Evolution of monoamine receptors and the origin of motivational and emotional systems in vertebrates]. Bull Acad Natl Med. 1998;182:1505-14; discussion 1515-6 pubmed
    ..These data suggest that a D1/beta receptor gene duplication was required to elaborate novel catecholamine psychomotor adaptive responses and that a noradrenergic system specifically emerged at the origin of vertebrate evolution. ..
  36. Vetulani J, Marona Lewicka D, Michaluk J, Popik P. Stability and variability of locomotor responses of laboratory rodents. III. Effect of environmental factors and lack of catecholamine receptor correlates. Pol J Pharmacol Pharm. 1988;40:273-80 pubmed
    ..No correlation between the native locomotor activity and cortical and striatal binding sites for [3H]prazosin and [3H]spiroperidol was found. ..
  37. Nishino S, Reid M, Dement W, Mignot E. Neuropharmacology and neurochemistry of canine narcolepsy. Sleep. 1994;17:S84-92 pubmed
  38. Crayton J, Joshi I, Gulati A, Arora R, Wolf W. Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex. Brain Res. 1996;728:260-2 pubmed
    ..No significant differences were found in other measures. It is possible that corticosteroids exert some of their behavioral effects via regulation of 5-HT1A sites in frontal cortex. ..
  39. Gwosdow A, O Connell N, Spencer J, Kumar M, Agarwal R, Bode H, et al. Interleukin-1-induced corticosterone release occurs by an adrenergic mechanism from rat adrenal gland. Am J Physiol. 1992;263:E461-6 pubmed
    ..Both IL-1 alpha and IL-1 beta significantly increased (P less than 0.05) epinephrine levels after a 24-h incubation period compared with media-treated controls.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  40. Irannejad R, KOTOWSKI S, von Zastrow M. Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol. 2014;535:403-18 pubmed publisher
    ..Studies of adenylyl cyclase regulation by catecholamine receptors have led to a remarkably detailed understanding of the basic biochemistry of G protein-linked signal ..
  41. Salvadore G, Quiroz J, Machado Vieira R, Henter I, Manji H, Zarate C. The neurobiology of the switch process in bipolar disorder: a review. J Clin Psychiatry. 2010;71:1488-501 pubmed publisher
    ..There is a clear need to improve our understanding of the neurobiology of the switch process; research in this field would benefit from the systematic and integrated assessment of variables associated with switching. ..
  42. Freestone P, Haigh R, Lyte M. Blockade of catecholamine-induced growth by adrenergic and dopaminergic receptor antagonists in Escherichia coli O157:H7, Salmonella enterica and Yersinia enterocolitica. BMC Microbiol. 2007;7:8 pubmed
  43. Knoll J, Yoneda F, Knoll B, Ohde H, Miklya I. (-)1-(Benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. Br J Pharmacol. 1999;128:1723-32 pubmed
    ..1 microg kg(-1) s.c. In the shuttle box, (-)BPAP in rats was about 130 times more potent than (-)deprenyl in antagonizing tetrabenazine induced inhibition of performance. ..
  44. Maslova L, Shishkina G, Dygalo N, Naumenko E. [The role of glucocorticoids at the corticosterone level after stress in the early ontogeny of gray rats]. Ross Fiziol Zh Im I M Sechenova. 1997;83:74-9 pubmed
    ..The modification of adrenocortical function with the stress in early postnatal life seems to be connected with changes in hypothalamic catecholamine synthesis and can be prevented with exogenous glycocorticoids. ..
  45. Silveira D, Schachter S, Schomer D, Holmes G. Flurothyl-induced seizures in rats activate Fos in brainstem catecholaminergic neurons. Epilepsy Res. 2000;39:1-12 pubmed
    ..Further studies are necessary to determine whether activation of brainstem catecholaminergic neurons contribute to the autonomic manifestations that frequently accompany epileptic seizures. ..
  46. Sakata H. [A clinical evaluation of fetal wellbeing--based on fetal behavior with emphasis on conditions contributing to the dissociation of behavior]. Nihon Sanka Fujinka Gakkai Zasshi. 1991;43:853-63 pubmed
    ..In conclusion, if fetal behavior is to be used as a method for evaluating wellbeing, it is necessary to also assess the convergence or association of the various behavioral parameters in order for it to be utilized as a clinical tool. ..
  47. Kimura H, Yamada K, Nagashima M, Furukawa T. Involvement of catecholamine receptor activities in modulating the incidence of yawning in rats. Pharmacol Biochem Behav. 1996;53:1017-21 pubmed
    ..The results suggest that catecholamine receptor activities seem to play different roles in inhibitory modulation of the occurrence of yawning caused by dopaminergic and cholinergic stimulation. ..
  48. Lomax A, Sharkey K, Furness J. The participation of the sympathetic innervation of the gastrointestinal tract in disease states. Neurogastroenterol Motil. 2010;22:7-18 pubmed publisher
    ..Finally, we focus on inflammation, diabetes and postoperative ileus as conditions in which there is sympathetic involvement in compromised gut function. ..
  49. Pombal M, Lopez J, de Arriba M, Megias M, González A. Distribution of neuropeptide FF-like immunoreactive structures in the lamprey central nervous system and its relation to catecholaminergic neuronal structures. Peptides. 2006;27:1054-72 pubmed
    ..The presence of NPFF-ir fibers in the lamprey neurohypophysis suggests that the involvement of NPFF-like substances in the hypothalamo-hypophyseal system had emerged early during evolution. ..
  50. Knoll J. (-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain. Pharmacol Toxicol. 1998;82:57-66 pubmed
  51. Green B, Brown D. Interactions Between Bacteria and the Gut Mucosa: Do Enteric Neurotransmitters Acting on the Mucosal Epithelium Influence Intestinal Colonization or Infection?. Adv Exp Med Biol. 2016;874:121-41 pubmed publisher
    ..coli. These neurotransmitter actions are mediated by well-defined catecholamine receptors situated on the basolateral membranes of epithelial cells rather than through direct interactions with ..
  52. Stevens Felten S, Bellinger D. Noradrenergic and peptidergic innervation of lymphoid organs. Chem Immunol. 1997;69:99-131 pubmed
  53. Mansart A, Bollaert P, Seguin C, Levy B, Longrois D, Mallie J. Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. Shock. 2003;19:38-44 pubmed