class f scavenger receptors
Summary: A group of structurally related scavenger receptors expressed predominately by ENDOTHELIAL CELLS. They-contain repeats of EPIDERMAL GROWTH FACTOR-like cysteine-rich motifs in their extracellular domains.
Beauvillain C, Meloni F, Sirard J, Blanchard S, Jarry U, Scotet M, et al
. The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells. J Hepatol. 2010;52:644-51 pubmed publisher
..This study highlights a central role for SRs in NS3 uptake and cross-presentation, and demonstrates a tightly orchestrated cooperation between signalling and endocytic innate receptors in NS3 recognition. ..
Murshid A, Gong J, Calderwood S. Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J Immunol. 2010;185:2903-17 pubmed publisher
..Extracellular Hsp90 can thus convey antigenic peptides through an efficient endocytosis pathway in APCs and facilitate cross presentation in a highly regulated manner. ..
Gong J, Zhu B, Murshid A, Adachi H, Song B, Lee A, et al
. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J Immunol. 2009;183:3092-8 pubmed publisher
..In addition, TLR-dependent, tumor cell killing was suppressed by SREC-1 knockdown in DC, suggesting a significant role for this receptor in HSP70.PC-F-mediated tumor immunity. ..
Apostolov E, Shah S, Ray D, Basnakian A. Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL. Arterioscler Thromb Vasc Biol. 2009;29:1622-30 pubmed publisher
..Our data suggest that cLDL uses a unique pattern of scavenger receptors. They show that LOX-1 receptor, and partially CD36, SREC-1, and SR-A1 receptors, are essential for the proatherogenic effects of cLDL on human endothelial cells. ..
Fischer N, Haug M, Kwok W, Kalbacher H, Wernet D, Dannecker G, et al
. Involvement of CD91 and scavenger receptors in Hsp70-facilitated activation of human antigen-specific CD4+ memory T cells. Eur J Immunol. 2010;40:986-97 pubmed publisher
Anastasio N, Ben Omran T, Teebi A, Ha K, Lalonde E, Ali R, et al
. Mutations in SCARF2 are responsible for Van Den Ende-Gupta syndrome. Am J Hum Genet. 2010;87:553-9 pubmed publisher
..However, the function of SCARF2 has not been characterized, and this study reports that phenotypic effects can be associated with defects in the scavenger receptor F family of genes...