signaling lymphocytic activation molecule family member 1
Summary: A 70-kDa SLAM family receptor that consists of an extracellular IMMUNOGLOBULIN-LIKE DOMAIN and an IMMUNOGLOBULIN C2-SET DOMAIN. It is expressed primarily by THYMOCYTES and activated T-LYMPHOCYTES, as well as by MACROPHAGES and DENDRITIC CELLS. It binds SLAMF1 receptors on other cells to mediate T-cell maturation and proliferation. It is also a receptor for the MEASLES VIRUS.
RACANIELLO V. Virology. An exit strategy for measles virus. Science. 2011;334:1650-1 pubmed publisher
Tornack J, Kawano Y, Garbi N, Hämmerling G, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017;47:1477-1487 pubmed publisher
..Thus, FACS-enrichment of Flt3/ Flt3L-eGFP-reporter negative, Lin- CD150+ CD48- EPCR+ CD41+ HSCs allows a further 5-fold enrichment of functional LT-HSCs. ..
Aversa G, Carballido J, Punnonen J, Chang C, Hauser T, Cocks B, et al
. SLAM and its role in T cell activation and Th cell responses. Immunol Cell Biol. 1997;75:202-5 pubmed
..SLAM was found to be a high-affinity self-ligand mediating molecular and cellular homophilic interactions. In this review we discuss SLAM as a receptor involved in T cell expansion and in directing immune responses to a Th0-Th1 pathway. ..
Bispo da Silva A, Cerqueira Coelho P, Alves Oliveira Amparo J, Alves de Almeida Carneiro M, Pereira Borges J, dos Santos Souza C, et al
. The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype. Chem Biol Interact. 2017;274:89-99 pubmed publisher
..These results point this flavonoid as a possible alternative in the treatment or prevention of neurodegenerative disorders. ..
Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman D, Clark E, et al
. The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling. PLoS ONE. 2017;12:e0185940 pubmed publisher