signaling lymphocytic activation molecule family


Summary: Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.

Top Publications

  1. Radomir L, Cohen S, Kramer M, Bakos E, Lewinsky H, Barak A, et al. T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. J Immunol. 2017;199:2745-2757 pubmed publisher
    ..Thus, naive T cells regulate B cell survival in a SLAMF6- and SAP-dependent manner. ..
  2. Suzuki Y. Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation. Microbiol Immunol. 2017;61:185-189 pubmed publisher
    ..These results suggest that the receptor functionality may be predicted from the docking scores of virion surface proteins and cellular receptor molecules. ..
  3. Chen J, Zhong M, Guo H, Davidson D, Mishel S, Lu Y, et al. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature. 2017;544:493-497 pubmed publisher
    ..They also reveal a novel SAP adaptor-independent function for a SLAM receptor. Lastly, they suggest that patients with tumours expressing SLAMF7 are more likely to respond to SIRP?-CD47 blockade therapy. ..
  4. Karampetsou M, Comte D, Kis Toth K, Kyttaris V, Tsokos G. Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus. PLoS ONE. 2017;12:e0186073 pubmed publisher
    ..lupus erythematosus (SLE) identified the 1q23 region on human chromosome 1, containing the Signaling Lymphocytic Activation Molecule Family (SLAMF) cluster of genes, as a lupus susceptibility locus...
  5. Woo J, Vierboom M, Kwon H, Chao D, Ye S, Li J, et al. PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis. Arthritis Res Ther. 2013;15:R207 pubmed
    ..The activity of PDL241 in both in vitro and in vivo models highlights the potential of CD319 as a therapeutic target in RA. ..
  6. Doherty T, Scott D, Walford H, Khorram N, Lund S, Baum R, et al. Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84. J Allergy Clin Immunol. 2014;133:1203-5 pubmed publisher
  7. Chen C, Mittal R, Klingensmith N, Burd E, Terhorst C, Martin G, et al. Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis. J Immunol. 2017;199:1961-1966 pubmed publisher
    ..Our results illuminate a novel role for 2B4 coinhibitory signaling on CD4+ T cells in mediating immune dysregulation. ..
  8. Meazza R, Falco M, Marcenaro S, Loiacono F, Canevali P, Bellora F, et al. Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients. Eur J Immunol. 2017;47:1051-1061 pubmed publisher
    ..Killing of autologous mature DC by self-iNKR defective XLP1 NK cells may impair adaptive responses, further exacerbating the patients' immune defect. ..