toll like receptor 10


Summary: A pattern recognition receptor that is expressed in LUNG and in B-LYMPHOCYTES.

Top Publications

  1. Guo Y, Zhao G, Tanaka S, Yamaguchi T. Differential responses between monocytes and monocyte-derived macrophages for lipopolysaccharide stimulation of calves. Cell Mol Immunol. 2009;6:223-9 pubmed publisher
    ..Besides, no expression of TLR9 was found. As antigen presenting cells, monocytes and monocyte-derived macrophages respond differently to LPS, so they may have different functions in the innate immune system. ..
  2. Mailaparambil B, Krueger M, Heizmann U, Schlegel K, Heinze J, Heinzmann A. Genetic and epidemiological risk factors in the development of bronchopulmonary dysplasia. Dis Markers. 2010;29:1-9 pubmed publisher
    ..Genetic association was detected with single polymorphisms within Tumour necrosis factor alpha, Toll like receptor 10 and vascular endothelial growth factor...
  3. Galindo R, Mu oz P, de Miguel M, Marin C, Blasco J, Gortazar C, et al. Characterization of possible correlates of protective response against Brucella ovis infection in rams immunized with the B. melitensis Rev 1 vaccine. Vaccine. 2009;27:3039-44 pubmed publisher
    ..The TLR10, Bak and ANXI genes were expressed at higher levels in vaccinated and protected rams. These genes provide possible correlates of protective response to B. ovis infection in rams immunized with the B. melitensis Rev 1 vaccine...
  4. Law H, Cheung C, Sia S, Chan Y, Peiris J, Lau Y. Toll-like receptors, chemokine receptors and death receptor ligands responses in SARS coronavirus infected human monocyte derived dendritic cells. BMC Immunol. 2009;10:35 pubmed publisher
    ..We also compared adult and cord blood (CB) DCs to find a possible explanation for the age-dependent severity of SARS...
  5. Sumpter T, Lunz J, Demetris A, Thomson A. Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome. Transplantation. 2009;88:S40-4 pubmed publisher
    ..Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome. ..
  6. Biswas B, Narmadha G, Choudhary M, French F, Hall S, Yenugu S. Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation. Am J Reprod Immunol. 2009;62:243-52 pubmed publisher
    ..Tlrs seem to be expressed during male reproductive tract development and under conditions of androgen ablation, suggesting the preparedness of the male reproductive tract to detect an infection under all conditions of androgen status. ..
  7. Qian F, Zhang Q, Zhou L, Jin G, Bai J, Yin K. Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population. J Investig Allergol Clin Immunol. 2010;20:340-6 pubmed
    ..49; 95% CI, 0.26-0.95; P = .046). Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma. ..
  8. Heinzmann A, Mailaparambil B, Mingirulli N, Krueger M. Association of interleukin-13/-4 and toll-like receptor 10 with preterm births. Neonatology. 2009;96:175-81 pubmed publisher
    ..IL-13/IL-4 and TLR-10 might be involved in the genetics of PTB. The dissection of the genetic background may provide a deeper understanding of the pathophysiology of PTB and help to identify new drug targets for its prevention. ..
  9. Mahanonda R, Sa Ard Iam N, Eksomtramate M, Rerkyen P, Phairat B, Schaecher K, et al. Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J Periodontal Res. 2009;44:557-64 pubmed publisher
    ..Our results represent the first demonstration that CSE can modulate HGEC function by suppressing hBD-2 and enhancing IL-8 production, and this may be, in part, a possible mechanism which promotes periodontal disease. ..

More Information


  1. Guan Y, Ranoa D, Jiang S, Mutha S, Li X, Baudry J, et al. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. J Immunol. 2010;184:5094-103 pubmed publisher
    ..We conclude that human TLR10 cooperates with TLR2 in the sensing of microbes and fungi but possesses a signaling function distinct from that of other TLR2 subfamily members. ..