natural cytotoxicity triggering receptor 1


Summary: A 46-kD stimulatory receptor found on resting and activated NATURAL KILLER CELLS. It has specificity for VIRAL HEMAGGLUTININS that are expressed on infected cells.

Top Publications

  1. Michel L, Jean Louis F, Bégué E, Bensussan A, Bagot M. Use of PLS3, Twist, CD158k/KIR3DL2, and NKp46 gene expression combination for reliable Sézary syndrome diagnosis. Blood. 2013;121:1477-8 pubmed publisher
  2. Ganesan S, Luu T, Chambers B, Meinke S, Brodin P, Vivier E, et al. The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education. Scand J Immunol. 2017;86:135-142 pubmed publisher
    ..We conclude that signalling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse. ..
  3. Bar On Y, Charpak Amikam Y, Glasner A, Isaacson B, Duev Cohen A, Tsukerman P, et al. NKp46 Recognizes the Sigma1 Protein of Reovirus: Implications for Reovirus-Based Cancer Therapy. J Virol. 2017;91: pubmed publisher
  4. Ortonne N, le Gouvello S, Tabák R, Marie Cardine A, Setiao J, Berrehar F, et al. CD158k/KIR3DL2 and NKp46 are frequently expressed in transformed mycosis fungoides. Exp Dermatol. 2012;21:461-3 pubmed publisher
    ..Among NCR, NKp46 was expressed in all investigated cases. The role of KIR3DL2 and NKp46 in tMF oncogenesis remains to be studied. ..
  5. Cimini E, Viola D, Cabeza Cabrerizo M, Romanelli A, Tumino N, Sacchi A, et al. Different features of V?2 T and NK cells in fatal and non-fatal human Ebola infections. PLoS Negl Trop Dis. 2017;11:e0005645 pubmed publisher
    ..Further studies are required to characterize the protective effector functions of V?2 and NK cells. ..
  6. Miletić A, Lenartic M, Popovic B, Brizic I, Trsan T, Miklic K, et al. NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation. Eur J Immunol. 2017;47:1443-1456 pubmed publisher
    ..As a consequence, NCR1gfp/gfp mice produced lower amounts of MCMV-specific antibodies upon infection, which correlated with lower number of virus-specific antibody secreting cells in analyzed lymph nodes. ..
  7. Kwong B, Rua R, Gao Y, Flickinger J, Wang Y, Kruhlak M, et al. T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation. Nat Immunol. 2017;18:1117-1127 pubmed publisher
    ..Our findings uncover a detrimental role of T-bet-dependent NKp46+ ILCs in the development of CNS autoimmune disease. ..