tumor necrosis factor decoy receptors


Summary: A subclass of tumor necrosis family receptors that lack cell signaling domains. They bind to specific TNF RECEPTOR LIGANDS and are believed to play a modulating role in the TNF signaling pathway. Some of the decoy receptors are products of distinct genes, while others are products of ALTERNATIVE SPLICING of the MRNA for the active receptor.

Top Publications

  1. Wendling U, Walczak H, Dorr J, Jaboci C, Weller M, Krammer P, et al. Expression of TRAIL receptors in human autoreactive and foreign antigen-specific T cells. Cell Death Differ. 2000;7:637-44 pubmed
    ..Upon stimulation, levels of death-inducing TRAIL receptors decreased whereas TRAIL was up-regulated on the cell surface. In contrast to CD95, the role of TRAIL receptors in MS might not involve regulation of T cell vulnerability. ..
  2. Vallcaneras S, Ghersa F, Bastón J, Delsouc M, Meresman G, Casais M. TNFRp55 deficiency promotes the development of ectopic endometriotic-like lesions in mice. J Endocrinol. 2017;234:269-278 pubmed publisher
    ..This is evidence of the possible association of the deregulation of the TNFRp55 expression and the survival of the endometriotic tissue in ectopic sites. ..
  3. Nawashiro H, Martin D, Hallenbeck J. Inhibition of tumor necrosis factor and amelioration of brain infarction in mice. J Cereb Blood Flow Metab. 1997;17:229-32 pubmed
    ..001). The reduction in the volume of brain damage was 26% in animals that received 3 mg/kg of TNFbp topically. Further analysis of TNF-alpha inhibition following acute brain ischemia is indicated. ..
  4. Chen J, Zhang W, Chen K, Lin L, Dai H, Li K, et al. Urinary DcR2 is a novel biomarker for tubulointerstitial injury in patients with diabetic nephropathy. Am J Physiol Renal Physiol. 2017;313:F273-F281 pubmed publisher
    ..Our results indicate uDcR2 could potentially serve as a novel biomarker for TII and may reflect senescence of renal proximal tubular cells in DN pathogenesis. ..