transmembrane activator and caml interactor protein


Summary: A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.

Top Publications

  1. Ware C. APRIL and BAFF connect autoimmunity and cancer. J Exp Med. 2000;192:F35-8 pubmed
  2. Kryštůfková O, Barbasso Helmers S, Venalis P, Malmström V, Lindroos E, Vencovský J, et al. Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. Arthritis Res Ther. 2014;16:454 pubmed publisher
    ..BAFF production could be influenced by type-I IFN produced by pDCs. Thus, B-cell-related molecular pathways may participate in the pathogenesis of myositis in this subset of patients. ..
  3. Haselmayer P, Vigolo M, Nys J, Schneider P, Hess H. A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells. Eur J Immunol. 2017;47:1075-1085 pubmed publisher
    ..Targeting plasma cells with TACI-Fc might be beneficial to prevent autoantibody-mediated damages in SLE. ..