lymphotoxin beta receptor


Summary: A member of the tumor necrosis factor receptor superfamily. It has specificity for LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. The receptor plays a role in regulating lymphoid ORGANOGENESIS and the differentiation of certain subsets of NATURAL KILLER T-CELLS. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Top Publications

  1. Fava R, Browning J, Gatumu M, Skarstein K, Bolstad A. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. Adv Exp Med Biol. 2011;691:383-90 pubmed publisher
  2. Hu X, Zimmerman M, Bardhan K, Yang D, Waller J, Liles G, et al. Lymphotoxin ? receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-?B activation. Carcinogenesis. 2013;34:1105-14 pubmed publisher
  3. Onder L, Mörbe U, Pikor N, Novković M, Cheng H, Hehlgans T, et al. Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. Immunity. 2017;47:80-92.e4 pubmed publisher
    ..Finally, the finding that pharmacologically enforced interaction between LTi cells and LECs promotes ectopic LN formation underscores the central LTo function of LECs. ..
  4. Kim J, Kim E, Kim H, Kurie J, Ahn Y. MKK4 activates non-canonical NF?B signaling by promoting NF?B2-p100 processing. Biochem Biophys Res Commun. 2017;491:337-342 pubmed publisher
    ..These results suggest that the MKK4/JNK-dependent pathway regulates NF?B2 processing/activation and, through this mechanism, MKK4 and NF?B2 control cellular growth and senescence. ..