cell surface receptors


Summary: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.

Top Publications

  1. Wong K, Valdez P, Tan C, Yeh S, Hongo J, Ouyang W. Phosphatidylserine receptor Tim-4 is essential for the maintenance of the homeostatic state of resident peritoneal macrophages. Proc Natl Acad Sci U S A. 2010;107:8712-7 pubmed publisher
    ..Resting rPMs produce higher TNF-alpha in culture. Their response to LPS, on the contrary, is dampened. Our data support an indispensible role of Tim-4 in maintaining the homeostasis of rPMs...
  2. Beerman I, Bhattacharya D, Zandi S, Sigvardsson M, Weissman I, Bryder D, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A. 2010;107:5465-70 pubmed publisher
    ..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging. ..
  3. Yetnikoff L, Eng C, Benning S, Flores C. Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. Eur J Neurosci. 2010;31:1292-302 pubmed publisher
    ..We propose VTA DCC receptor signaling as a novel mechanism in the series of glutamate-dependent cellular processes that lead to enduring plasticity by drugs of abuse. ..
  4. Morita Y, Ema H, Nakauchi H. Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med. 2010;207:1173-82 pubmed publisher
    ..These findings highlight the complexity and hierarchy of reconstitution capability, even among HSCs in the most primitive compartment. ..
  5. Baumann J, Park C, Mantis N. Recognition of secretory IgA by DC-SIGN: implications for immune surveillance in the intestine. Immunol Lett. 2010;131:59-66 pubmed publisher
    ..These data identify DC-SIGN as a putative receptor for SIgA, and reveal a mechanism by which DCs could collaborate with M cells in immune surveillance at mucosal surfaces. ..
  6. Mao H, Kano G, Hudson S, Brummet M, Zimmermann N, Zhu Z, et al. Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PLoS ONE. 2013;8:e68143 pubmed publisher
    Siglec-F and Siglec-8 are functional paralog proapoptotic cell surface receptors expressed on mouse and human eosinophils, respectively...
  7. Seki Y, Ichihara A, Mizuguchi Y, Sakoda M, Kurauchi Mito A, Narita T, et al. Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp. Front Biosci (Elite Ed). 2010;2:972-9 pubmed
    ..Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp. ..
  8. Mukherjee D, Devi K, Deka M, Malakar M, Kaur T, Barua D, et al. Association of toll-like receptor 2 ∆22 and risk for gastric cancer considering main effects and interactions with smoking: a matched case-control study from Mizoram, India. Tumour Biol. 2016;37:10821-6 pubmed publisher
    Toll-like receptors (TLRs) are evolutionary conserved cell surface receptors of the innate immune system. Smoking has significant immunological effects which are mediated via TLRs on various receptor-mediated innate response pathways...
  9. Nugent A, Proia R. The role of G protein-coupled receptors in lymphoid malignancies. Cell Signal. 2017;39:95-107 pubmed publisher
    ..G protein-coupled receptors (GPCRs) are an important class of cell surface receptors that represent an ideal target for lymphoma therapeutics...

More Information


  1. Cai H, Zhou X, Dougherty G, Reddy R, Haas G, Montrose D, et al. Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia. Psychoneuroendocrinology. 2018;90:43-51 pubmed publisher
    ..that rapidly alter neuronal excitability through interactions with ligand-gated ion channels and other cell surface receptors. They are originated from cholesterol and have important implications for schizophrenia (SZ) ..
  2. Zhou Y, Lu K, Pfefferle S, Bertram S, Glowacka I, Drosten C, et al. A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. J Virol. 2010;84:8753-64 pubmed publisher
    ..Thus, binding of MBL to SARS-S may interfere with other early pre- or postreceptor-binding events necessary for efficient viral entry...
  3. Budi E, Xu J, Derynck R. Regulation of TGF-β Receptors. Methods Mol Biol. 2016;1344:1-33 pubmed publisher
    In cells responding to extracellular polypeptide ligands, regulatory mechanisms at the level of cell surface receptors are increasingly seen to define the nature of the ligand-induced signaling responses...
  4. Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010;30:11157-66 pubmed publisher
    ..These results support the feasibility of BACE1 inhibition with a noncompetitive inhibitor as disease-modifying as well as symptomatic therapy for AD. ..
  5. Gay C, Zygmunt T, Torres Vazquez J. Diverse functions for the semaphorin receptor PlexinD1 in development and disease. Dev Biol. 2011;349:1-19 pubmed publisher
    Plexins are a family of single-pass transmembrane proteins that serve as cell surface receptors for Semaphorins during the embryonic development of animals...
  6. Choi S, Thomas T, Li M, Kotlyar A, Desai A, Baker J. Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate. Chem Commun (Camb). 2010;46:2632-4 pubmed publisher
    ..We report the synthesis and in vitro evaluation of folate receptor-targeted nanoconjugate that releases its therapeutic payload via a photochemical mechanism. ..
  7. Lalefar N, Witkowski A, Simonsen J, Ryan R. Wnt3a nanodisks promote ex vivo expansion of hematopoietic stem and progenitor cells. J Nanobiotechnology. 2016;14:66 pubmed publisher
    Wnt proteins modulate development, stem cell fate and cancer through interactions with cell surface receptors. Wnts are cysteine-rich, glycosylated, lipid modified, two domain proteins that are prone to aggregation...
  8. Roth G, Zimmermann M, Lubsczyk B, Pilz J, Faybik P, Hetz H, et al. Up-regulation of interleukin 33 and soluble ST2 serum levels in liver failure. J Surg Res. 2010;163:e79-83 pubmed publisher
    ..Especially, soluble ST2 maybe useful to discern acute from chronic hepatic failure or to monitor the course and the severity of the disease. ..
  9. Chavan T, Jang H, Khavrutskii L, Abraham S, Banerjee A, Freed B, et al. High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site. Biophys J. 2015;109:2602-2613 pubmed publisher
    Ras proteins are small GTPases that act as signal transducers between cell surface receptors and several intracellular signaling cascades...
  10. Han H, Mangala L, Lee J, Shahzad M, Kim H, Shen D, et al. Targeted gene silencing using RGD-labeled chitosan nanoparticles. Clin Cancer Res. 2010;16:3910-22 pubmed publisher
    ..This study shows that RGD-CH-NP is a novel and highly selective delivery system for siRNA with the potential for broad applications in human disease. ..
  11. Van Brocklyn J, Lee M, Menzeleev R, Olivera A, Edsall L, Cuvillier O, et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol. 1998;142:229-40 pubmed
    ..Thus, SPP is a prototype for a novel class of lipid mediators that act both extracellularly as ligands for cell surface receptors and intracellularly as second messengers.
  12. Derewenda Z. Application of protein engineering to enhance crystallizability and improve crystal properties. Acta Crystallogr D Biol Crystallogr. 2010;66:604-15 pubmed publisher
    ..This article presents an overview of protein-engineering methods designed to enhance crystallizability and discusses a number of examples of their successful application. ..
  13. Macchi E, Rudd T, Raman R, Sasisekharan R, Yates E, Naggi A, et al. Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. Biochemistry. 2016;55:6605-6616 pubmed
    ..Finally, interactions between LSTc and H7 were compared with those between LSTc and H1 of H1N1 (South Carolina 1918), contributing to our understanding of the recognition ability of HAs. ..
  14. Yassin L, Rojas M, Ramirez L, Garcia L, Vásquez G. Monocyte activation by apoptotic cells removal in systemic lupus erythematosus patients. Cell Immunol. 2010;266:52-60 pubmed publisher
    ..The decreased binding/phagocytosis of ACs observed in SLE patients, induces a distinct immune response compared with healthy controls. ..
  15. Ding L, Feng H, Macdonald R, Botzolakis E, Hu N, Gallagher M. GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors. J Biol Chem. 2010;285:26390-405 pubmed publisher
    ..These findings demonstrated that, in addition to causing a heterozygous loss of function of alpha1(AD) subunits, this epilepsy mutation also elicited a modest dominant negative effect that likely shapes the epilepsy phenotype. ..
  16. Sasaki R, Miyashita T, Matsumoto N, Fujii K, Saito K, Ando T. Multiple keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome having distinct PTCH1 mutations: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e41-6 pubmed publisher
    ..The Ki-67 labeling index was significantly higher in the maxillary KCOT (17.7%) than in the mandibular KCOT (14.3%). These findings indicate distinct molecular mechanisms of tumorigenesis in these KCOTs...
  17. Yao G, Lam K, Perry K, Weisemann J, Rummel A, Jin R. Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel). 2017;9: pubmed publisher
    ..Taken together, these new findings advance our understanding of the structure and function of this newly identified toxin at the molecular level, and pave the way for the future development of more effective countermeasures. ..
  18. Connan C, Varela Chavez C, Mazuet C, Molgó J, Haustant G, Disson O, et al. Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall. Cell Microbiol. 2016;18:282-301 pubmed publisher
    ..loop that BoNT/B alone or the BoNT/B C-terminal domain of the heavy chain (HCcB), which interacts with cell surface receptors, translocates across the intestinal barrier...
  19. Marillier R, Brombacher T, Dewals B, Leeto M, Barkhuizen M, Govender D, et al. IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis. Am J Physiol Gastrointest Liver Physiol. 2010;298:G943-51 pubmed publisher
    ..mansoni eggs and to prevent premature mortality...
  20. Liu Q, Xu C, Wen C. Genetic and transformation studies reveal negative regulation of ERS1 ethylene receptor signaling in Arabidopsis. BMC Plant Biol. 2010;10:60 pubmed publisher
    ..Loss of ERS1 did not lead to an increase in total receptor gene expression, and functional compensation was not observed. The inhibitory effects of ERS1 on the ethylene signaling pathway imply negative receptor collaboration. ..
  21. Ontsouka E, Albrecht C, Bruckmaier R. Invited review: Growth-promoting effects of colostrum in calves based on interaction with intestinal cell surface receptors and receptor-like transporters. J Dairy Sci. 2016;99:4111-4123 pubmed publisher
    ..Therefore, the abundance and activity of cell surface receptors and receptor-like transporters binding colostral bioactive substances are a key aspect determining the ..
  22. Domínguez J, Christopeit T, Villaverde M, Gossas T, Otero J, Nystrom S, et al. Effect of the protonation state of the titratable residues on the inhibitor affinity to BACE-1. Biochemistry. 2010;49:7255-63 pubmed publisher
  23. Moreno J, Dejouvencel T, Labreuche J, Smadja D, Dussiot M, Martin Ventura J, et al. Peripheral artery disease is associated with a high CD163/TWEAK plasma ratio. Arterioscler Thromb Vasc Biol. 2010;30:1253-62 pubmed publisher
    ..Our results suggest that the sCD163/sTWEAK plasma ratio may be associated with atherothrombosis burden in PAD. We hypothesize that an imbalance between TWEAK and CD163 could reflect the progression of atherothrombosis. ..
  24. Chen Y, Ju L, Rushdi M, Ge C, Zhu C. Receptor-mediated cell mechanosensing. Mol Biol Cell. 2017;28:3134-3155 pubmed publisher
    ..Receptor-mediated cell mechanosensing is a multistep process that is initiated by binding of cell surface receptors to their ligands on the extracellular matrix or the surface of adjacent cells...
  25. Rousselle P, Letourneur F. Mysterious tasks of tyrosines in syndecan-1 cytoplasmic tail. ScientificWorldJournal. 2009;9:629-32 pubmed publisher
    ..cell-type-, and tissue-specific manner, and function either as coreceptors that cooperate with other cell surface receptors or as cell adhesion receptors that independently mediate cell signaling...
  26. Kläsener K, Yang J, Reth M. Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay. Methods Mol Biol. 2018;1707:171-181 pubmed publisher
    ..This chapter describes our methods to study the nano-scale organization of B cell surface receptors and co-receptors with Fab-PLA.
  27. Pal S, Lant B, Yu B, Tian R, Tong J, Krieger J, et al. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Curr Biol. 2017;27:868-876 pubmed publisher
    ..Taken together, our data establish CCM-3 as a novel regulator of rachis lumenization and polarity establishment during embryogenesis. ..
  28. Baxter R. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol Endocrinol Metab. 2000;278:E967-76 pubmed
    ..The regulation of cell sensitivity to inhibitory IGFBP signaling may play a role in the growth control of malignant cells...
  29. Ng S, Lee L, Chow B. Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians. Ann N Y Acad Sci. 2010;1200:15-32 pubmed publisher
    ..This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species. ..
  30. Cruz A, Fraga A, Fountain J, Rangel Moreno J, Torrado E, Saraiva M, et al. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010;207:1609-16 pubmed publisher
    ..This finding that repeated exposure to mycobacterial antigen promotes enhanced IL-17-dependent pathological consequences has important implications for the design of effective vaccines against Mtb...
  31. Lin D, Chun T, Kang L. Adipose extracellular matrix remodelling in obesity and insulin resistance. Biochem Pharmacol. 2016;119:8-16 pubmed publisher
    ..attention has been paid to the role played by the interaction between peri-adipocyte ECM and their cognate cell surface receptors. This review will address what is currently known about the roles played by adipose ECM, their modifiers, ..
  32. Stöckmann H, Todorovic V, Richardson P, Marin V, Scott V, Gerstein C, et al. Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors. J Am Chem Soc. 2017;139:16822-16829 pubmed publisher
    ..Given that all cell-surface receptors are glycosylated, we expect that GlycoFRET can be generalized with applications in chemical biology and biotechnology, such as target engagement, receptor pharmacology, and high-throughput screening...
  33. Cohen T, Schwarz T, Vigant F, Gardner T, Hernandez R, Lee B, et al. The Microtubule Inhibitor Podofilox Inhibits an Early Entry Step of Human Cytomegalovirus. Viruses. 2016;8: pubmed
    ..is a ubiquitous ?-herpesvirus that infects many different cell types through an initial binding to cell surface receptors followed by a fusion event at the cell membrane or endocytic vesicle...
  34. Hislop A, Palendira U, Leese A, Arkwright P, Rohrlich P, Tangye S, et al. Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets. Blood. 2010;116:3249-57 pubmed publisher
  35. Chen X, Chern M, Canlas P, Ruan D, Jiang C, Ronald P. An ATPase promotes autophosphorylation of the pattern recognition receptor XA21 and inhibits XA21-mediated immunity. Proc Natl Acad Sci U S A. 2010;107:8029-34 pubmed publisher
    ..XA21 is degraded in the presence of the pathogen-associated molecular pattern Ax21 when XB24 is overexpressed. These results demonstrate a function for this large class of broadly conserved ATPases in PRR-mediated immunity. ..
  36. Huang Y, Hsu S. TRAIL-functionalized gold nanoparticles selectively trigger apoptosis in polarized macrophages. Nanotheranostics. 2017;1:326-337 pubmed publisher
    ..Nanoparticles coated with multiple ligands can act as multivalent ligands that may actively crosslink cell surface receptors to affect downstream signals...
  37. Rahimi P, Vahabpour R, Motevalli F, Shayestehpour M, Amiran M, Yazdani S, et al. Truncated JFH1 E2 protein: Is It Reliable to Be Used in Diagnostic ELISA Test and as a Protein-Based Vaccine Candidate?. Protein Pept Lett. 2017;: pubmed publisher
    HCV E2 glycoprotein which mediates attachment to target cells via cell surface receptors is one of the most attractive proteins for designing an effective vaccine...
  38. Murakami S, Ohki Hamazaki H, Watanabe K, Ikenaka K, Ono K. Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain. J Comp Neurol. 2010;518:2019-34 pubmed publisher
  39. Stella N. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia. 2010;58:1017-30 pubmed publisher
  40. Mamalis N, Grossniklaus H, Waring G, Werner L, Brubaker J, Davis D, et al. Ablation of lens epithelial cells with a laser photolysis system: histopathology, ultrastructure, and immunochemistry. J Cataract Refract Surg. 2010;36:1003-10 pubmed publisher
    ..Along with the cells, laminin, fibronectin, and cell debris remained in the untreated areas but were removed by the treatment. This treatment may be useful in preventing posterior capsule opacification. ..
  41. Forster E, Bock H, Herz J, Chai X, Frotscher M, Zhao S. Emerging topics in Reelin function. Eur J Neurosci. 2010;31:1511-8 pubmed publisher
    ..The present review has been inspired by a session entitled 'Functions of Reelin in the developing and adult hippocampus', held at the Spring Hippocampal Research Conference in Verona/Italy, June 2009. ..
  42. Liu S, Gasperini R, Foa L, Small D. Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2. J Alzheimers Dis. 2010;21:655-66 pubmed publisher
    ..This decrease in AMPARs may contribute to the decline in cognitive function seen in AD. ..
  43. Muik A, Reul J, Friedel T, Muth A, Hartmann K, Schneider I, et al. Covalent coupling of high-affinity ligands to the surface of viral vector particles by protein trans-splicing mediates cell type-specific gene transfer. Biomaterials. 2017;144:84-94 pubmed publisher
    ..fragments (scFvs) or designed ankyrin repeat proteins (DARPins), exhibiting high-affinity binding to cell surface receptors selectively expressed on the surface of target cells, were coupled to AAV particles harboring mutations in ..
  44. Walker J, McLeod K, Kim S, Conway S, Hamilton D. Periostin as a multifunctional modulator of the wound healing response. Cell Tissue Res. 2016;365:453-65 pubmed publisher
    ..Matricellular proteins (MPs) are a group of diverse non-structural ECM components that bind cell surface receptors mediating interactions between the cell and its microenviroment, effectively regulating adhesion, ..
  45. Ban E, Lye M, Chong P, Yap Y, Lim S, Abdul Rahman H. Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia. PLoS ONE. 2017;12:e0187200 pubmed publisher
    ..Integrins are members of a family of cell surface receptors that mediate the cell-cell and extracellular matrix (ECM) interactions...
  46. Martin H, Comeskey D, Simpson R, Laing W, McGhie T. Quantification of folate in fruits and vegetables: A fluorescence-based homogeneous assay. Anal Biochem. 2010;402:137-45 pubmed publisher
    ..These data are similar to published values. However, the assay will not detect 5-formyltetrahydrofolate which is a significant constituent of the total folate in lettuce, spinach, carrot, and peppers. ..
  47. Nakase I, Ueno N, Katayama M, Noguchi K, Takatani Nakase T, Kobayashi N, et al. Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes. Chem Commun (Camb). 2016;53:317-320 pubmed publisher
    We demonstrate a novel system for inducing clustering of cell surface receptors via recognition peptide segments displayed on exosomes, leading to receptor activation...
  48. Daley S, Teh C, Hu D, Strasser A, Gray D. Cell death and thymic tolerance. Immunol Rev. 2017;277:9-20 pubmed publisher
    ..Numerous cytokine and cell surface receptors direct thymocyte differentiation but the primary determinant of cell fate is the engagement of the T-cell ..
  49. Yu J, Sun M, Chen Z, Lu J, Liu Y, Zhou L, et al. Magnesium modulates amyloid-beta protein precursor trafficking and processing. J Alzheimers Dis. 2010;20:1091-106 pubmed publisher
    ..Our findings suggest that supplementation of magnesium has a therapeutic potential for preventing AD. ..
  50. Hind S, Strickler S, Boyle P, Dunham D, Bao Z, O Doherty I, et al. Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system. Nat Plants. 2016;2:16128 pubmed publisher
    ..detect the presence of potential pathogens through the perception of conserved microbial patterns by cell surface receptors. Certain solanaceous plants, including tomato, potato and pepper, detect flgII-28, a region of bacterial ..
  51. Murray M, Peters N, Reeves M. Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection. Pathogens. 2018;7: pubmed publisher
    ..very early stages of infection the virus relies on the outcome of interactions between virion components, cell surface receptors and host signalling pathways to promote an environment that supports infection...
  52. Freeman G, Casasnovas J, Umetsu D, DeKruyff R. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev. 2010;235:172-89 pubmed publisher
  53. Wright A, Fox A, Johnson K, Zinn K. Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands. PLoS ONE. 2010;5:e12288 pubmed publisher
    ..In the future, these deficiency kits will allow Drosophila researchers to rapidly and efficiently execute genome-wide anatomical screens that require examination of individual embryos at high magnification. ..