membrane proteins

Summary

Summary: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Top Publications

  1. Hopper J, Yu Y, Li D, Raymond A, Bostock M, Liko I, et al. Detergent-free mass spectrometry of membrane protein complexes. Nat Methods. 2013;10:1206-8 pubmed publisher
    ..We demonstrated that oligomeric complexes or proteins requiring defined lipid environments are stabilized to a greater extent in the absence of detergent. ..
  2. Gopinath T, Mote K, Veglia G. Sensitivity and resolution enhancement of oriented solid-state NMR: application to membrane proteins. Prog Nucl Magn Reson Spectrosc. 2013;75:50-68 pubmed publisher
    ..such as dipolar and chemical shift interactions, can be measured to determine structure and orientation of membrane proteins in lipid bilayers...
  3. Hermann C, Strittmatter L, Deane J, Boyle L. The binding of TAPBPR and Tapasin to MHC class I is mutually exclusive. J Immunol. 2013;191:5743-50 pubmed publisher
    ..In light of our findings, previous data determining the function of tapasin in the MHC class I Ag-processing and presentation pathway must be re-evaluated. ..
  4. Das N, Murray D, Cross T. Lipid bilayer preparations of membrane proteins for oriented and magic-angle spinning solid-state NMR samples. Nat Protoc. 2013;8:2256-70 pubmed publisher
    Solid-state NMR spectroscopy has been used successfully for characterizing the structure and dynamics of membrane proteins as well as their interactions with other proteins in lipid bilayers...
  5. Foster T, Geoghegan J, Ganesh V, Hook M. Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus. Nat Rev Microbiol. 2014;12:49-62 pubmed publisher
    ..Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections. ..
  6. Perreira J, Chin C, Feeley E, Brass A. IFITMs restrict the replication of multiple pathogenic viruses. J Mol Biol. 2013;425:4937-55 pubmed publisher
    ..This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis. ..
  7. Kurrle N, Ockenga W, Meister M, Völlner F, Kühne S, John B, et al. Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells. BMC Cancer. 2013;13:575 pubmed publisher
  8. Neuhaus A, Kooshapur H, Wolf J, Meyer N, Madl T, Saidowsky J, et al. A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes. J Biol Chem. 2014;289:437-48 pubmed publisher
    ..The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. ..
  9. Han X, Parkinson J. An unorthodox sensory adaptation site in the Escherichia coli serine chemoreceptor. J Bacteriol. 2014;196:641-9 pubmed publisher
    ..These findings are consistent with control of input-output signaling in Tsr through dynamic interplay of the structural stabilities of the HAMP and methylation bundles. ..

More Information

Publications72

  1. Ernst A, Brugger B. Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. 2014;1841:665-70 pubmed publisher
    ..This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. ..
  2. Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y, et al. Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population. Scand J Rheumatol. 2013;42:469-72 pubmed publisher
    ..The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population...
  3. Fenz S, Sachse R, Schmidt T, Kubick S. Cell-free synthesis of membrane proteins: tailored cell models out of microsomes. Biochim Biophys Acta. 2014;1838:1382-8 pubmed publisher
    ..It enables signal-induced translocation and posttranslational modification of de novo synthesized membrane proteins. Combining these microsomes with synthetic lipids within the electroswelling process allowed for the rapid ..
  4. Takahashi D, Kawamura Y, Uemura M. Changes of detergent-resistant plasma membrane proteins in oat and rye during cold acclimation: association with differential freezing tolerance. J Proteome Res. 2013;12:4998-5011 pubmed publisher
    ..This is the first report to describe compositional changes in the DRM during CA. The proteomic profiles obtained in the present study hint at many possible microdomain functions associated with CA and freezing tolerance. ..
  5. Bianchi E, Doe B, Goulding D, Wright G. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014;508:483-7 pubmed publisher
    ..Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives. ..
  6. Laganowsky A, Reading E, Allison T, Ulmschneider M, Degiacomi M, Baldwin A, et al. Membrane proteins bind lipids selectively to modulate their structure and function. Nature. 2014;510:172-175 pubmed publisher
    Previous studies have established that the folding, structure and function of membrane proteins are influenced by their lipid environments and that lipids can bind to specific sites, for example, in potassium channels...
  7. Esteves T, Durr A, Mundwiller E, Loureiro J, Boutry M, Gonzalez M, et al. Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia. Am J Hum Genet. 2014;94:268-77 pubmed publisher
    ..They have also important implications for genetic diagnosis and counseling in clinical practice because of the association of various modes of inheritance to this new clinico-genetic entity...
  8. Wenzel M, Chiriac A, Otto A, Zweytick D, May C, Schumacher C, et al. Small cationic antimicrobial peptides delocalize peripheral membrane proteins. Proc Natl Acad Sci U S A. 2014;111:E1409-18 pubmed publisher
    ..and Western blot analyses showed that integration of the peptide caused delocalization of peripheral membrane proteins essential for respiration and cell-wall biosynthesis, limiting cellular energy and undermining cell-wall ..
  9. Natale A, Duplantis J, Piasta K, Falke J. Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study. Biochemistry. 2013;52:7753-65 pubmed publisher
    ..In principle, this signal could spread out into the surrounding array via the kinase-adaptor ring, employing a series of alternating frozen-dynamic transitions that transmit low-energy attractant signals long distances...
  10. Wunderlich P, Glebov K, Kemmerling N, Tien N, Neumann H, Walter J. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and ?-secretase-dependent intramembranous cleavage. J Biol Chem. 2013;288:33027-36 pubmed publisher
    ..Together, these data demonstrate ?-secretase-mediated intramembranous proteolysis of TREM2 and functionally link two Alzheimer disease-associated proteins in one signaling pathway. ..
  11. Tung J, Li Y, Lin T, Hsiao C. Structure of the Sgt2 dimerization domain complexed with the Get5 UBL domain involved in the targeting of tail-anchored membrane proteins to the endoplasmic reticulum. Acta Crystallogr D Biol Crystallogr. 2013;69:2081-90 pubmed publisher
    ..This study provides detailed molecular insights into the specific binding of this GET-pathway complex...
  12. Agaisse H, Derre I. Expression of the effector protein IncD in Chlamydia trachomatis mediates recruitment of the lipid transfer protein CERT and the endoplasmic reticulum-resident protein VAPB to the inclusion membrane. Infect Immun. 2014;82:2037-47 pubmed publisher
    ..Altogether, the data presented here show that expression of the C. trachomatis effector protein IncD mediates the recruitment of the lipid transfer protein CERT and the ER-resident protein VAPB to the inclusion. ..
  13. S omi ska Wojew dzka M, Pawlik A, Soko owska I, Antoniewicz J, W grzyn G, Sandvig K. The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol. Biochem J. 2014;457:485-96 pubmed publisher
    ..Moreover, analysis of the involvement of EDEM1 and EDEM2 in ricin retrotranslocation to the cytosol may provide crucial information about general mechanisms of the recognition of ERAD substrates in the ER...
  14. Traub L, Bonifacino J. Cargo recognition in clathrin-mediated endocytosis. Cold Spring Harb Perspect Biol. 2013;5:a016790 pubmed publisher
    ..Related sorting events occur at other endosomal sorting stations. ..
  15. Zumbo A, Palucci I, Cascioferro A, Sali M, Ventura M, D Alfonso P, et al. Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis. Pathog Dis. 2013;69:232-9 pubmed publisher
    ..These results indicate that PE_PGRS33 is a protein with immunomodulatory activity and that protein stability and localization on the mycobacterial surface can affect these properties. ..
  16. Han S, Feng S, Xu L, Shi W, Wang X, Wang H, et al. Tim-3 on peripheral CD4? and CD8? T cells is involved in the development of glioma. DNA Cell Biol. 2014;33:245-50 pubmed publisher
    ..005) or Tim-3?CD8? T cells (p<0.001) in glioma patients. Our results suggested that Tim-3 may be involved in the development of glioma...
  17. Ercoli G, Tani C, Pezzicoli A, Vacca I, Martinelli M, Pecetta S, et al. LytM proteins play a crucial role in cell separation, outer membrane composition, and pathogenesis in nontypeable Haemophilus influenzae. MBio. 2015;6:e02575 pubmed publisher
    ..proteins, including the chaperones HtrA, SurA, and Skp, and an accumulation of β-barrel-containing outer membrane proteins comprising the autotransporters Hap, IgA serine protease, and HMW2A, as observed by proteomic analysis...
  18. Zowalaty A, Ye X. Seipin deficiency leads to defective parturition in mice. Biol Reprod. 2017;97:378-386 pubmed publisher
    ..This study demonstrates an association of seipin with myometrium and parturition. ..
  19. Jiang D, Zhang J, Cheng L, Zhang G, Li Y, Li Z, et al. Hantavirus Gc induces long-term immune protection via LAMP-targeting DNA vaccine strategy. Antiviral Res. 2018;150:174-182 pubmed publisher
    ..Importantly, the pan-epitope reaction to Gc indicated that Gc should be with potential for use in further hantavirus DNA vaccine investigations. ..
  20. Bhatia H, Pattnaik B, Datta M. Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo. Int J Obes (Lond). 2016;40:861-9 pubmed publisher
    ..Transcript levels of lipid droplet membrane proteins, apolipoproteins and β-oxidation genes were quantified by quantitative reverse transcription-PCR...
  21. Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, et al. Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes. Biochem J. 2009;424:399-410 pubmed publisher
    ..Superose 6 gel-filtration chromatography of solubilized membrane proteins from adipocytes stimulated with insulin or CL demonstrated the reversible assembly of distinct ..
  22. Huang X, Lüthi M, Ontsouka E, Kallol S, Baumann M, Surbek D, et al. Establishment of a confluent monolayer model with human primary trophoblast cells: novel insights into placental glucose transport. Mol Hum Reprod. 2016;22:442-56 pubmed publisher
    ..positivity for the cell-cell adhesion molecule E-cadherin, the tight junction protein 1 (ZO-1) and the membrane proteins ATP-binding cassette transporter A1 (ABCA1) and glucose transporter 1 (GLUT1)...
  23. Muller S, Radic M. Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms. Clin Rev Allergy Immunol. 2015;49:232-9 pubmed publisher
    ..Juxtaposition of citrullinated histones with infectious pathogens and complement and immune complexes may compromise tolerance of nuclear autoantigens and promote autoimmunity. ..
  24. Ji D, Zhang Y, Yao S, Zhai X, Zhang L, Zhang Y, et al. Cav-1 deficiency promotes liver fibrosis in carbon tetrachloride (CCl4)-induced mice by regulation of oxidative stress and inflammation responses. Biomed Pharmacother. 2018;102:26-33 pubmed publisher
    ..In conclusion, our results indicated that Cav-1 played an important role in CCl4-induced hepatic injury, which may be used as potential therapeutic target for hepatic fibrosis treatment. ..
  25. Tranchant C, Anheim M. Movement disorders in mitochondrial diseases. Rev Neurol (Paris). 2016;172:524-529 pubmed publisher
    ..In other cases, muscle biopsies followed by metabolic and genetic studies may be useful for arriving at a diagnosis. ..
  26. Maccarrone M, Totaro A, Leuti A, Giacovazzo G, Scipioni L, Mango D, et al. Early alteration of distribution and activity of hippocampal type-1 cannabinoid receptor in Alzheimer's disease-like mice overexpressing the human mutant amyloid precursor protein. Pharmacol Res. 2018;130:366-373 pubmed publisher
    ..Recent studies reported that APP interacts with other membrane proteins, including G protein coupled receptors, affecting their biological functions...
  27. Ramos Treviño J, Bassol Mayagoitia S, Ruiz Flores P, Espino Silva P, Saucedo Cardenas O, Villa Cedillo S, et al. In Vitro Evaluation of Damage by Heavy Metals in Tight and Gap Junctions of Sertoli Cells. DNA Cell Biol. 2017;36:829-836 pubmed publisher
  28. Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V. Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I. Biochim Biophys Acta Bioenerg. 2017;1858:175-181 pubmed publisher
    ..We conclude that NUYM has an important stabilizing function for the electron input module of complex I and is essential for proper complex I function. ..
  29. Dzierlenga A, Clarke J, Cherrington N. Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes. Drug Metab Dispos. 2016;44:1799-1807 pubmed
    ..the activation status of various mediators implicated in the active membrane retrieval or insertion of membrane proteins to identify which processes may be important in rodent methionine and choline deficient diet-induced NASH...
  30. Zhang J. Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein. Biochem J. 2000;348 Pt 3:597-606 pubmed
    ..These findings suggest that TM2 in a polytopic membrane protein with an extracellular N-terminus may play a critical role in controlling correct membrane translocation and folding of the protein in general...
  31. Shao S, Rodrigo Brenni M, Kivlen M, Hegde R. Mechanistic basis for a molecular triage reaction. Science. 2017;355:298-302 pubmed publisher
    ..We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined...
  32. Rämö O, Kumar D, Gucciardo E, Joensuu M, Saarekas M, Vihinen H, et al. NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology. Sci Rep. 2016;6:35969 pubmed publisher
  33. Zhu L, Weierstall U, Cherezov V, Liu W. Serial Femtosecond Crystallography of Membrane Proteins. Adv Exp Med Biol. 2016;922:151-160 pubmed publisher
    b>Membrane proteins, including G protein-coupled receptors (GPCRs), constitute the most important drug targets...
  34. Salsano S, Quiñonero A, Pérez S, Garrido Gómez T, Simón C, Dominguez F. Dynamic expression of PGRMC1 and SERBP1 in human endometrium: an implication in the human decidualization process. Fertil Steril. 2017;108:832-842.e1 pubmed publisher
    ..The human decidualization process could be altered by the overexpression or mislocalization of PGRMC1 in ESC. ..
  35. Bi Z, Merl Pham J, Uehlein N, Zimmer I, Mühlhans S, Aichler M, et al. RNAi-mediated downregulation of poplar plasma membrane intrinsic proteins (PIPs) changes plasma membrane proteome composition and affects leaf physiology. J Proteomics. 2015;128:321-32 pubmed publisher
    ..Based on these results, we conclude that PIP proteins not only play essential roles in whole leaf water and CO2 flux but have important roles in the regulation of stomatal movement. ..
  36. Nichols B, Holthuis J, Pelham H. The Sec1p homologue Vps45p binds to the syntaxin Tlg2p. Eur J Cell Biol. 1998;77:263-8 pubmed
    SNAREs are compartmentally specific membrane proteins required for intracellular membrane fusion...
  37. Margolles A, Flórez A, Moreno J, van Sinderen D, de los Reyes Gavilan C. Two membrane proteins from Bifidobacterium breve UCC2003 constitute an ABC-type multidrug transporter. Microbiology. 2006;152:3497-505 pubmed
    ..This is mediated by, among others, multidrug resistance (MDR) transporters, membrane proteins which extrude noxious compounds with very different chemical structures and cellular targets...
  38. Harb F, Prunetti L, Giudici Orticoni M, Guiral M, Tinland B. Insertion and self-diffusion of a monotopic protein, the Aquifex aeolicus sulfide quinone reductase, in supported lipid bilayers. Eur Phys J E Soft Matter. 2015;38:110 pubmed publisher
    Monotopic proteins constitute a class of membrane proteins that bind tightly to cell membranes, but do not span them...
  39. Dhara M, Mohrmann R, Bruns D. v-SNARE function in chromaffin cells. Pflugers Arch. 2018;470:169-180 pubmed publisher
    ..Specifically, we will focus on the role of vesicle associated membrane proteins, also referred to as vesicular SNAREs, in fusion and rapid cargo discharge...
  40. Moses M, Hedegård P, Hatzakis N. Quantification of Functional Dynamics of Membrane Proteins Reconstituted in Nanodiscs Membranes by Single Turnover Functional Readout. Methods Enzymol. 2016;581:227-256 pubmed publisher
    ..Studying the function of membrane proteins at the single-molecule level remains a formidable challenge, and to date there is limited number of ..
  41. Sénicourt L, Iatmanen Harbi S, Hattab C, Ostuni M, Giraud M, Lacapere J. Recombinant Overexpression of Mammalian TSPO Isoforms 1 and 2. Methods Mol Biol. 2017;1635:1-25 pubmed publisher
    ..Cell-free expression was the best system to overexpress pure TSPO2. ..
  42. Feng J, Lin P, Guo S, Jia Y, Wang Y, Zadlock F, et al. Identification and characterization of a novel conserved 46 kD maltoporin of Aeromonas hydrophila as a versatile vaccine candidate in European eel (Anguilla anguilla). Fish Shellfish Immunol. 2017;64:93-103 pubmed publisher
    ..hydrophila-mediated diseases. The outer membrane proteins (OMPs) are highly immunogenic and capable of eliciting protective immune responses...
  43. Post D, Slütter B, Schilling B, Chande A, Rasmussen J, Jones B, et al. Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates. MBio. 2017;8: pubmed publisher
    ..Spectral counting of mass spectrometric data showed enrichment for membrane proteins in both strains...
  44. Wang H, Li Q, Fang Y, Yu S, Tang B, Na L, et al. Biochemical and functional characterization of the periplasmic domain of the outer membrane protein A from enterohemorrhagic Escherichia coli. Microbiol Res. 2016;182:109-15 pubmed publisher
    ..In addition, OmpAper contributes to the adhesion of bacteria to HeLa cells in vitro and ex vivo. These results provide an additional understanding of the role of OmpA in EHEC physiology and pathogenesis. ..
  45. Pourhajibagher M, Bahador A. Outer membrane protein 100 of Aggregatibacter actinomycetemcomitans act as a biopharmaceutical target for photodynamic therapy: An in silico analysis. Photodiagnosis Photodyn Ther. 2016;16:154-160 pubmed publisher
    ..According to the results, anionic indocyanine green tends to interact with Omp100 during PDT as a major target. ..
  46. Fu W, Wang L, Kim S, Li J, Dynlacht B. Role for the IFT-A Complex in Selective Transport to the Primary Cilium. Cell Rep. 2016;17:1505-1517 pubmed publisher
    ..Furthermore, we show that Wdr35 is essential for entry of many membrane proteins into the cilium through robust interactions with cargoes and other IFT-A subunits, but the actin network ..
  47. Duran Fernández Feijoo C, Carrasco Carrasco C, Villalmazo Francisco N, Cebrià Romero J, Fernández Lorenzo J, Jimenez Chillaron J, et al. Influence of catch up growth on spatial learning and memory in a mouse model of intrauterine growth restriction. PLoS ONE. 2017;12:e0177468 pubmed publisher
    ..CUG after a period of prenatal malnutrition seems to improve learning skills. The functional alterations observed might be related to lower PSD95 activity and a possible dysfunction in the hormone regulation of synaptic plasticity. ..
  48. Shimada H, Nakamura Y, Nakanishi T, Tamai I. OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion. Biochem Pharmacol. 2015;98:629-38 pubmed publisher
    ..Thus, OATP2A1 contributes to PGE2 secretion by macrophages via exocytosis induced by Ca(2+) influx, independently of PGE2 synthesis and metabolism. ..
  49. Chen Q, Denard B, Lee C, Han S, Ye J, Ye J. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Mol Cell. 2016;63:567-578 pubmed publisher
    ..In the presence of ceramide, translocation of TM4SF20 is TRAM2-independent. We designate this mechanism-causing regulated inversion of the membrane topology as "regulated alternative translocation." ..
  50. Liu Y, Cong X, Liu W, Laganowsky A. Characterization of Membrane Protein-Lipid Interactions by Mass Spectrometry Ion Mobility Mass Spectrometry. J Am Soc Mass Spectrom. 2017;28:579-586 pubmed publisher
    Lipids in the biological membrane can modulate the structure and function of integral and peripheral membrane proteins. Distinguishing individual lipids that bind selectively to membrane protein complexes from an ensemble of lipid-bound ..
  51. Oliveira F, Coelho I, Lopes M, Taranto A, Junior M, Santos L, et al. The Use of Reverse Vaccinology and Molecular Modeling Associated with Cell Proliferation Stimulation Approach to Select Promiscuous Epitopes from Schistosoma mansoni. Appl Biochem Biotechnol. 2016;179:1023-40 pubmed publisher
    ..In this work, computational analyses of Schistosoma mansoni membrane proteins were performed to predict epitopes with high affinity for different human leukocyte antigen (HLA)-DRB1...
  52. Paul A, Danley M, Saha B, Tawfik O, Paul S. PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65. Sci Rep. 2015;5:12520 pubmed publisher
    ..Kinase C zeta (PKCζ) forms Partitioning-defective (PAR) polarity complex for apico-basal distribution of membrane proteins essential to maintain normal cellular junctional complexes and tissue homeostasis...
  53. Chikindas M, Emond E, Haandrikman A, Kok J, Leenhouts K, Pandian S, et al. Heterologous Processing and Export of the Bacteriocins Pediocin PA-1 and Lactococcin A in Lactococcus Lactis: A Study with Leader Exchange. Probiotics Antimicrob Proteins. 2010;2:66-76 pubmed publisher
    ..These results show the potential of the lactococcin LcnC/LcnD machinery as a maturation system for peptides carrying double-glycine-type amino-terminal leaders. ..
  54. Holzinger A, Kammerer S, Berger J, Roscher A. cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter. Biochem Biophys Res Commun. 1997;239:261-4 pubmed
    ..The ALD protein (ALDP) and the ALDR gene product are peroxisomal membrane proteins belonging to the superfamily of transporters containing an ATP-binding cassette (ABC-transporters)...
  55. Thota L, Ponnusamy T, Philip S, Lu X, Mundkur L. Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apobtm2Sgy/Ldlrtm1Her/J mice. Sci Rep. 2017;7:3997 pubmed publisher
  56. Shin S, Ault J, Stone H. Flow-Driven Rapid Vesicle Fusion via Vortex Trapping. Langmuir. 2015;31:7178-82 pubmed publisher
    Fusion between suspended lipid vesicles is difficult to achieve without membrane proteins or ions because the vesicles have extremely low equilibrium membrane tension and high poration energy...
  57. Kathawala R, Gupta P, Ashby C, Chen Z. The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade. Drug Resist Updat. 2015;18:1-17 pubmed publisher
    ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy derived from ATP hydrolysis essentially to translocate, ..
  58. Klink B, Zent E, Juneja P, Kuhlee A, Raunser S, Wittinghofer A. A recombinant BBSome core complex and how it interacts with ciliary cargo. elife. 2017;6: pubmed publisher
    ..on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins. The transport of these proteins involves the BBSome, an eight-membered protein complex that is recruited to ..
  59. Bass R, Miller A, Gloor S, Falke J. The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis. Methods Enzymol. 2007;423:3-24 pubmed
    ..It is particularly difficult to analyze the interaction surfaces of membrane proteins on a structural level, both because membrane proteins are less accessible to high-resolution structural ..
  60. Han W, Liu J. Epigenetic silencing of the Wnt antagonist APCDD1 by promoter DNA hyper-methylation contributes to osteosarcoma cell invasion and metastasis. Biochem Biophys Res Commun. 2017;491:91-97 pubmed publisher
    ..Thus, we have provided the first evidence that APCDD1 expression is epigenetically silenced in OS, which may facilitate invasion and metastasis of OS cells. ..
  61. Lüders K, Patzig J, Simons M, Nave K, Werner H. Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. Glia. 2017;65:1762-1776 pubmed publisher
    ..We conclude that PLP-dependent loss of oligodendroglial support is the primary cause of axonal degeneration in SPG2. ..
  62. Meabon J, de Laat R, Ieguchi K, Serbzhinsky D, Hudson M, Huber B, et al. Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling. Mol Cell Neurosci. 2016;70:1-10 pubmed publisher
    ..The three Trk paralogs are members of the LIG superfamily of membrane proteins, which share extracellular domains consisting of leucine-rich repeat and C2 Ig domains...
  63. Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, et al. Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer. Int J Oncol. 2016;49:111-22 pubmed publisher
    ..Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR?320a-mediated pathways may provide important insights into the potential mechanisms of PCa metastasis. ..