lim kinases


Summary: Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation of a threonine residue within the activation loop by intracellular signaling kinases such as P21-ACTIVATED KINASES and by RHO KINASE.

Top Publications

  1. Arber S, Barbayannis F, Hanser H, Schneider C, Stanyon C, Bernard O, et al. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature. 1998;393:805-9 pubmed
    ..By modulating the stability of actin cytoskeletal structures, this pathway should play a central role in regulating cell motility and morphogenesis. ..
  2. Iwatake M, Nishishita K, Okamoto K, Tsukuba T. The Rho-specific guanine nucleotide exchange factor Plekhg5 modulates cell polarity, adhesion, migration, and podosome organization in macrophages and osteoclasts. Exp Cell Res. 2017;359:415-430 pubmed publisher
    ..Thus, Plekhg5 affects cell polarity, migration, adhesion, degradation, and podosome organization in macrophages and osteoclasts. ..
  3. Simhadri P, Malwade R, Vanka R, Nakka V, Kuppusamy G, Babu P. Dysregulation of LIMK-1/cofilin-1 pathway: A possible basis for alteration of neuronal morphology in experimental cerebral malaria. Ann Neurol. 2017;82:429-443 pubmed publisher
    ..Therefore, this study could help to establish newer therapeutic strategies addressing long-term cognitive impairment after CM. Ann Neurol 2017;82:429-443. ..
  4. Kim H, Choi H, Park J, Kim M, Lee H, Petersen R, et al. Regulation of RhoA activity by the cellular prion protein. Cell Death Dis. 2017;8:e2668 pubmed publisher
  5. Shahi P, Wang C, Chou J, Hagerling C, Gonzalez Velozo H, Ruderisch A, et al. GATA3 targets semaphorin 3B in mammary epithelial cells to suppress breast cancer progression and metastasis. Oncogene. 2017;36:5567-5575 pubmed publisher
    ..Moreover, SEMA3B interferes with activation of LIM kinases (LIMK1 and LIMK2) to abrogate breast cancer progression...
  6. Sun J, Gao X, Meng D, Xu Y, Wang X, Gu X, et al. Antagomirs Targeting MicroRNA-134 Increase Limk1 Levels After Experimental Seizures in Vitro and in Vivo. Cell Physiol Biochem. 2017;43:636-643 pubmed publisher
    ..Blockage of miR-134 upregulates limk1 expression and downregulated cofilin expression in hippocampus of the SE rats. This mechanism may contribute to the neuroprotective effects of Ant-134. ..
  7. Shi C, Ren L, Sun C, Yu L, Bian X, Zhou X, et al. miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients. Br J Cancer. 2017;117:1036-1047 pubmed publisher
    ..miR-29a/b/c are important tumour suppressors and novel prognostic biomarkers of gliomas, and miR-29a/b/c and CDC42 are potential therapeutic candidates for malignant gliomas. ..
  8. Liao Q, Li R, Zhou R, Pan Z, Xu L, Ding Y, et al. LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression. Br J Cancer. 2017;117:563-571 pubmed publisher
    ..Our findings provide new insights into the metastasis of CRC and advocate for the development of clinical intervention strategies against advanced CRC. ..
  9. Nguyen B, Yoshimura K, Kumazawa S, Tawata S, Maruta H. Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro. Drug Discov Ther. 2017;11:110-114 pubmed publisher
    ..To the best of our knowledge, FRA is the first marine compound that selectively inhibits PAK1. Likewise, these nymphaeols are the first propolis ingredients that selectively inhibit PAK1. ..

More Information


  1. Yi F, Guo J, Dabbagh D, Spear M, He S, Kehn Hall K, et al. Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol. 2017;91: pubmed publisher
  2. Kaminskaya A, Nikitina E, Medvedeva A, Gerasimenko M, Chernikova D, Savateeva Popova E. [Influence of limk1 Gene Polymorphism on Learning Acquisition and Memory Formation with pCREB Distribution and Aggregate Formation in Neuromuscular Junctions in Drosophila melanogaster]. Genetika. 2015;51:685-93 pubmed
    ..Moreover, only agn(ts3) demonstrates amyloid-like aggregate formation in NMJ. This suggests that this impedes pCREb transport and thereby impairs the formation of short- and long-term memory. ..
  3. Xu L, Guo Q, Chang G, Qiu L, Liu X, Bi Y, et al. Discovery of microRNAs during early spermatogenesis in chicken. PLoS ONE. 2017;12:e0177098 pubmed publisher
  4. Dimri M, Bilogan C, Pierce L, Naegele G, Vasanji A, Gibson I, et al. Three-dimensional structural analysis reveals a Cdk5-mediated kinase cascade regulating hepatic biliary network branching in zebrafish. Development. 2017;144:2595-2605 pubmed publisher
    ..A small-molecule compound that interferes with the downstream kinase cascade rescued the mutant phenotype. These results provide new insights into branching morphogenesis of the intrahepatic biliary network. ..
  5. Sparrow A, Sweetman D, Welham S. LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development. Life Sci. 2017;186:17-24 pubmed publisher
    ..Pharmacological blockade of LIM-kinase function in the early developing kidney results in failure of renal development. This is likely due to prevention of dividing cells from completion of mitosis with their resultant loss. ..
  6. Wang W, Townes Anderson E. LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After Injury. Invest Ophthalmol Vis Sci. 2015;56:7847-58 pubmed publisher
    ..Thus structural remodeling, in the form of either axonal retraction or neuritic growth, requires LIMK activity. LIM kinase inhibition may have therapeutic potential for reducing pathologic rod terminal plasticity after retinal injury. ..
  7. Crompton M, Purnell T, Tyrer H, Parker A, Ball G, Hardisty Hughes R, et al. A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways. PLoS Genet. 2017;13:e1006969 pubmed publisher
    ..Our analysis implicates PAK1 and RAC1, and downstream signalling in LIMK1 and NF-κB pathways in the development of chronic OM. ..
  8. Zebda N, Bernard O, Bailly M, Welti S, Lawrence D, Condeelis J. Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension. J Cell Biol. 2000;151:1119-28 pubmed
    ..These results indicate a direct role for ADF/cofilin in the generation of the barbed ends that are required for lamellipod extension in response to EGF stimulation. ..
  9. Mervis C, Robinson B, Pani J. Visuospatial construction. Am J Hum Genet. 1999;65:1222-9 pubmed