lim domain proteins


Summary: A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.

Top Publications

  1. Shalaby S, Hayashi Y, Nonaka I, Noguchi S, Nishino I. Novel FHL1 mutations in fatal and benign reducing body myopathy. Neurology. 2009;72:375-6 pubmed publisher
  2. Kawashima H, Obayashi A, Kawamura M, Masaki S, Tamada S, Iguchi T, et al. Galectin 9 and PINCH, novel immunotherapy targets of renal cell carcinoma: a rationale to find potential tumour antigens and the resulting cytotoxic T lymphocytes induced by the derived peptides. BJU Int. 2014;113:320-32 pubmed
    ..The clonal expansion of the CTLs was shown by the clonality of T-cell receptor V? repertoires. A novel approach based on clinical observations yielded promising tumour antigens as immunotherapy targets of RCC. ..
  3. Rashid M, Belmont J, Carpenter D, Turner C, Olson E. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002-4014 pubmed publisher
  4. Yang T, Kersigo J, Wu S, Fritzsch B, Bassuk A. Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. PLoS ONE. 2017;12:e0183773 pubmed publisher
    ..Our findings argue against the role of Prickle1 in regulating hair cell polarity in the cochlea. Instead, Prickle1 regulates the polarity-related growth of distal and central processes of apical SGNs. ..
  5. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher
    ..Altogether, our data suggest that FHL1 is a novel regulator of calcium homeostasis and implicate it as the causative gene for X-linked recessive hypoparathyroidism. ..
  6. Ruggieri V, Agriesti F, Tataranni T, Perris R, Mangieri D. Paving the path for invasion: The polyedric role of LASP1 in cancer. Tumour Biol. 2017;39:1010428317705757 pubmed publisher
    ..This may be decisive not only to optimize existing pharmacological regimes but also to delineate novel, more efficacious therapeutic and/or preventive approaches. ..
  7. Bertrand A, BONNEMANN C, Bonne G. 199th ENMC international workshop: FHL1 related myopathies, June 7-9, 2013, Naarden, The Netherlands. Neuromuscul Disord. 2014;24:453-62 pubmed publisher
  8. Cabantous S, Doumbo O, Poudiougou B, Louis L, Barry A, Oumar A, et al. Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders. J Infect Dis. 2017;216:771-775 pubmed publisher
    ..39) in children with cerebral malaria, compared with those with uncomplicated malaria. These findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria and neurodegenerative disorders. ..
  9. Matrone G, Meng S, Gu Q, Lv J, Fang L, Chen K, et al. Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration. Arterioscler Thromb Vasc Biol. 2017;37:1860-1868 pubmed publisher
    ..i>Lmo2 KD reduced Lmo2-Sphk1 gene interaction, impaired intersegmental vessels formation, and reduced cell migration. We identified for the first time Sphk1 as downstream effector of Lmo2. ..

More Information


  1. Vanoni M. Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. Arch Biochem Biophys. 2017;632:118-141 pubmed publisher
  2. Jia L, Gui B, Zheng D, Decker K, Tinay I, Tan M, et al. Androgen receptor-regulated miRNA-193a-3p targets AJUBA to promote prostate cancer cell migration. Prostate. 2017;77:1000-1011 pubmed publisher
    ..Conclusions Our results suggest a novel AR/miR-193a-3p/AJUBA pathway implicated in PCa progression. MiR-193a-3p is a potential therapeutic target for metastatic PCa. ..
  3. Van Moerbeke M, Kasim A, Talloen W, Reumers J, Göhlmann H, Shkedy Z. A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays. BMC Bioinformatics. 2017;18:273 pubmed publisher
    ..The REIDS model provides a work flow for the identification of alternative splicing events relying on the established linear mixed model. The model can be applied to different types of arrays. ..
  4. Krivega I, Dean A. LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Res. 2017;45:8255-8268 pubmed publisher
    ..Thus, lineage specific factors largely mediate enhancer-promoter looping in erythroid cells independent of mediator and cohesin. ..
  5. Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid C, et al. GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 2017;627:491-499 pubmed publisher
  6. Zeller T, Schurmann C, Schramm K, Muller C, Kwon S, Wild P, et al. Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. Hypertension. 2017;70:743-750 pubmed publisher
    ..Translational approaches further established evidence for the potential use of CRIP1 as emerging disease-related biomarker. ..
  7. Castro Sánchez S, Álvarez Satta M, Tohamy M, Beltran S, Derdak S, Valverde D. Whole exome sequencing as a diagnostic tool for patients with ciliopathy-like phenotypes. PLoS ONE. 2017;12:e0183081 pubmed publisher
  8. Wang X, Chemmama I, Yu C, Huszagh A, Xu Y, Viner R, et al. The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress. J Biol Chem. 2017;292:16310-16320 pubmed publisher
  9. Lee B, Stallcup M. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes. J Biol Chem. 2017;292:9320-9334 pubmed publisher
    ..Thus, Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor. ..
  10. Rashid M, Runci A, Russo M, Tafani M. Muscle Lim Protein (MLP)/CSRP3 at the crossroad between mechanotransduction and autophagy. Cell Death Dis. 2015;6:e1940 pubmed publisher
  11. Sala S, Catillon M, Hadzic E, Schaffner Reckinger E, Van Troys M, Ampe C. The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions. PLoS ONE. 2017;12:e0177879 pubmed publisher
  12. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma Y, et al. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017;67:322-333.e6 pubmed publisher
  13. Kihara T, Sugimoto Y, Shinohara S, Takaoka S, Miyake J. Cysteine-rich protein 2 accelerates actin filament cluster formation. PLoS ONE. 2017;12:e0183085 pubmed publisher
    ..This F-actin clustering activity of CRP2 was cooperative with ?-actinin. Thus, binding of CRP2 to F-actin accelerates actin polymerization and F-actin cluster formation. ..
  14. Zhu S, Zhang X, Weichert Leahey N, Dong Z, Zhang C, Lopez G, et al. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017;32:310-323.e5 pubmed publisher
    ..Our results provide in vivo validation of LMO1 as an important oncogene that promotes neuroblastoma initiation, progression, and widespread metastatic dissemination. ..
  15. Schaarschmidt H, Ellinghaus D, Rodriguez E, Kretschmer A, Baurecht H, Lipinski S, et al. A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis. J Allergy Clin Immunol. 2015;136:802-6 pubmed publisher
  16. Stanulovic V, Cauchy P, Assi S, Hoogenkamp M. LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage. Nucleic Acids Res. 2017;45:9874-9888 pubmed publisher
    ..Comparison of Lmo2-/- with Tal1-/- Flk-1+ cells further showed that TAL1 was required to initiate or sustain Lmo2 expression...