Genomes and Genes
heparan sulfate proteoglycans
Summary: Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
- Murdoch A, Liu B, Schwarting R, Tuan R, Iozzo R. Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. J Histochem Cytochem. 1994;42:239-49 pubmed..The availability of MAb against precise regions of human perlecan will allow the investigation of this gene product in normal and diseased states. ..
- Swasdison S, Mayne R. Location of the integrin complex and extracellular matrix molecules at the chicken myotendinous junction. Cell Tissue Res. 1989;257:537-43 pubmed..This interaction does not appear to involve extensive binding to fibronectin or tenascin, but may involve laminin and heparan sulfate proteoglycan. ..
- Ji Z, Brecht W, Miranda R, Hussain M, Innerarity T, Mahley R. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J Biol Chem. 1993;268:10160-7 pubmed..e. binding and subsequent internalization by the receptor. ..
- Summerford C, Samulski R. Viral receptors and vector purification: new approaches for generating clinical-grade reagents. Nat Med. 1999;5:587-8 pubmed
- Sarrazin S, Lamanna W, Esko J. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011;3: pubmed publisherb>Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands...
- Wintle R, Kisilevsky R, Noonan D, Duncan A. In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG). Cytogenet Cell Genet. 1990;54:60-1 pubmed..1, by in situ hybridization. No secondary sites of hybridization were observed. ..
- Farhy Tselnicker I, van Casteren A, Lee A, Chang V, Aricescu A, Allen N. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron. 2017;96:428-445.e13 pubmed publisher..As mutations in glypicans are associated with neurological disorders, such as autism and schizophrenia, this signaling cascade offers new avenues to modulate synaptic function in disease. ..
- Snow A, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, et al. An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron. 1994;12:219-34 pubmed
- Sahni A, Patel J, Narra H, Schroeder C, Walker D, Sahni S. Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. PLoS ONE. 2017;12:e0183181 pubmed publisher..b>Heparan sulfate proteoglycans [HSPGs] facilitate the interactions between fibroblast growth factor(s) and their tyrosine kinase ..
- Kempf A, Boda E, Kwok J, Fritz R, Grande V, Kaelin A, et al. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017;43:24-34.e5 pubmed publisherb>Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes...
- Yayon A, Klagsbrun M, Esko J, Leder P, Ornitz D. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991;64:841-8 pubmed..Such an obligatory interaction of low and high affinity FGF receptors suggests a physiological role for heparin-like, low affinity receptors and constitutes a novel mechanism for the regulation of growth factor-receptor interactions. ..
- Kimura H, Tooyama I, McGeer P. Acidic FGF expression in the surroundings of senile plaques. Tohoku J Exp Med. 1994;174:279-93 pubmed..Possible significance of aFGF-positive astrocytes in the surroundings of the senile plaque will be discussed in relation to receptor mediated or non-mediated mechanisms. ..
- Kleinman H, McGarvey M, Hassell J, Star V, Cannon F, Laurie G, et al. Basement membrane complexes with biological activity. Biochemistry. 1986;25:312-8 pubmed..The reconstituted matrix was biologically active and stimulated the growth and differentiation of certain cells. ..
- Koopal C, Marais A, Westerink J, Visseren F. Autosomal dominant familial dysbetalipoproteinemia: A pathophysiological framework and practical approach to diagnosis and therapy. J Clin Lipidol. 2017;11:12-23.e1 pubmed publisher..To conclude, diagnosing ADFD is important to adequately treat patients and their family members. In patients presenting with mixed hyperlipidemia, (autosomal dominant) FD should be considered as part of the diagnostic work up. ..