heparan sulfate proteoglycans


Summary: Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)

Top Publications

  1. Narindrasorasak S, Lowery D, Gonzalez DeWhitt P, Poorman R, Greenberg B, Kisilevsky R. High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan. J Biol Chem. 1991;266:12878-83 pubmed
    ..Our results suggest that specific interactions between the AAP proteins and the extracellular matrix may be involved in the nucleation stages of Alzheimer's disease type amyloidogenesis. ..
  2. Murakami S, Takenaka Uema A, Kobayashi T, Kato K, Shimojima M, Palmarini M, et al. Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses. J Virol. 2017;91: pubmed publisher
    ..Moreover, we found that heparin is a strong inhibitor of AKAV and SBV infections. Revealing the molecular mechanisms of virus-host interactions is critical in order to understand virus biology and develop novel live attenuated vaccines. ..
  3. van Putten J, Paul S. Binding of syndecan-like cell surface proteoglycan receptors is required for Neisseria gonorrhoeae entry into human mucosal cells. EMBO J. 1995;14:2144-54 pubmed
    ..Here we report that cell surface heparan sulfate proteoglycans may play a role in the establishment of an infection, by functioning as receptors for the invasion-..
  4. Yamane Y, Yaoita H, Couchman J. Basement membrane proteoglycans are of epithelial origin in rodent skin. J Invest Dermatol. 1996;106:531-7 pubmed
    ..membrane proteoglycans in mammalian skin comprise at least one chondroitin sulfate proteoglycan and heparan sulfate proteoglycans, including perlecan...
  5. Basit S, Albalawi A, Alharby E, Khoshhal K. Exome sequencing identified rare variants in genes HSPG2 and ATP2B4 in a family segregating developmental dysplasia of the hip. BMC Med Genet. 2017;18:34 pubmed publisher
    ..This study provides the first evidence of digenic inheritance of DDH in a family and extends the spectrum of genetic heterogeneity in this human disorder. ..
  6. Higgins C, Richardson G, Ferdinando D, Westgate G, Jahoda C. Modelling the hair follicle dermal papilla using spheroid cell cultures. Exp Dermatol. 2010;19:546-8 pubmed publisher
    ..This method of DP cell culture may provide us with a tool to elucidate our understanding of signalling within the DP as it relates to induction, maintenance or even inhibition of hair growth. ..
  7. Nielsen J, Kulahin N, Walmod P. Extracellular protein interactions mediated by the neural cell adhesion molecule, NCAM: heterophilic interactions between NCAM and cell adhesion molecules, extracellular matrix proteins, and viruses. Adv Exp Med Biol. 2010;663:23-53 pubmed publisher
  8. Bansal R, Pfeiffer S. Regulation of oligodendrocyte differentiation by fibroblast growth factors. Adv Exp Med Biol. 1997;429:69-77 pubmed
  9. Gupta Bansal R, Frederickson R, Brunden K. Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation. J Biol Chem. 1995;270:18666-71 pubmed
    ..A beta interaction. The ability of proteoglycans to bind fibrillar A beta and inhibit its proteolytic degradation suggests a possible mechanism of senile plaque accumulation and persistence in Alzheimer's disease. ..

More Information


  1. Murdoch A, Liu B, Schwarting R, Tuan R, Iozzo R. Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. J Histochem Cytochem. 1994;42:239-49 pubmed
    ..The availability of MAb against precise regions of human perlecan will allow the investigation of this gene product in normal and diseased states. ..
  2. Swasdison S, Mayne R. Location of the integrin complex and extracellular matrix molecules at the chicken myotendinous junction. Cell Tissue Res. 1989;257:537-43 pubmed
    ..This interaction does not appear to involve extensive binding to fibronectin or tenascin, but may involve laminin and heparan sulfate proteoglycan. ..
  3. Ji Z, Brecht W, Miranda R, Hussain M, Innerarity T, Mahley R. Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells. J Biol Chem. 1993;268:10160-7 pubmed
    ..e. binding and subsequent internalization by the receptor. ..
  4. Summerford C, Samulski R. Viral receptors and vector purification: new approaches for generating clinical-grade reagents. Nat Med. 1999;5:587-8 pubmed
  5. Sarrazin S, Lamanna W, Esko J. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011;3: pubmed publisher
    b>Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands...
  6. Wintle R, Kisilevsky R, Noonan D, Duncan A. In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG). Cytogenet Cell Genet. 1990;54:60-1 pubmed
    ..1, by in situ hybridization. No secondary sites of hybridization were observed. ..
  7. Farhy Tselnicker I, van Casteren A, Lee A, Chang V, Aricescu A, Allen N. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron. 2017;96:428-445.e13 pubmed publisher
    ..As mutations in glypicans are associated with neurological disorders, such as autism and schizophrenia, this signaling cascade offers new avenues to modulate synaptic function in disease. ..
  8. Snow A, Sekiguchi R, Nochlin D, Fraser P, Kimata K, Mizutani A, et al. An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron. 1994;12:219-34 pubmed
  9. Sahni A, Patel J, Narra H, Schroeder C, Walker D, Sahni S. Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. PLoS ONE. 2017;12:e0183181 pubmed publisher
    ..b>Heparan sulfate proteoglycans [HSPGs] facilitate the interactions between fibroblast growth factor(s) and their tyrosine kinase ..
  10. Kempf A, Boda E, Kwok J, Fritz R, Grande V, Kaelin A, et al. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017;43:24-34.e5 pubmed publisher
    b>Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes...
  11. Yayon A, Klagsbrun M, Esko J, Leder P, Ornitz D. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991;64:841-8 pubmed
    ..Such an obligatory interaction of low and high affinity FGF receptors suggests a physiological role for heparin-like, low affinity receptors and constitutes a novel mechanism for the regulation of growth factor-receptor interactions. ..
  12. Kimura H, Tooyama I, McGeer P. Acidic FGF expression in the surroundings of senile plaques. Tohoku J Exp Med. 1994;174:279-93 pubmed
    ..Possible significance of aFGF-positive astrocytes in the surroundings of the senile plaque will be discussed in relation to receptor mediated or non-mediated mechanisms. ..
  13. Kleinman H, McGarvey M, Hassell J, Star V, Cannon F, Laurie G, et al. Basement membrane complexes with biological activity. Biochemistry. 1986;25:312-8 pubmed
    ..The reconstituted matrix was biologically active and stimulated the growth and differentiation of certain cells. ..
  14. Koopal C, Marais A, Westerink J, Visseren F. Autosomal dominant familial dysbetalipoproteinemia: A pathophysiological framework and practical approach to diagnosis and therapy. J Clin Lipidol. 2017;11:12-23.e1 pubmed publisher
    ..To conclude, diagnosing ADFD is important to adequately treat patients and their family members. In patients presenting with mixed hyperlipidemia, (autosomal dominant) FD should be considered as part of the diagnostic work up. ..