chondroitin sulfate proteoglycans


Summary: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.

Top Publications

  1. Iida J, Skubitz A, Furcht L, Wayner E, McCarthy J. Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin. J Cell Biol. 1992;118:431-44 pubmed
  2. Ong W, Levine J. A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus. Neuroscience. 1999;92:83-95 pubmed
  3. Yamada H, Fredette B, Shitara K, Hagihara K, Miura R, Ranscht B, et al. The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons. J Neurosci. 1997;17:7784-95 pubmed
    ..chondroitin sulfate proteoglycan that belongs to the aggrecan family and is one of the most abundant chondroitin sulfate proteoglycans in adult brain...
  4. Giangreco A, Goldie S, Failla V, Saintigny G, Watt F. Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP. J Invest Dermatol. 2010;130:604-8 pubmed publisher
  5. Chen Y, Zhao P, Borup R, Hoffman E. Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J Cell Biol. 2000;151:1321-36 pubmed
    ..Finally, our expression profiling results show that primary genetic defects can be identified by a reduction in the corresponding RNA. ..
  6. Bruckner G, Hausen D, Hartig W, Drlicek M, Arendt T, Brauer K. Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease. Neuroscience. 1999;92:791-805 pubmed
    ..It can be concluded that low susceptibility of neurons and cortical areas to neurofibrillary changes corresponds with high proportions of aggregating chondroitin sulphate proteoglycans in the neuronal microenvironment. ..
  7. Srisuthtayanont W, Pruksakorn D, Kongtawelert P, Pothacharoen P. Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes. BMC Complement Altern Med. 2017;17:286 pubmed publisher
    ..During that period, the expression of IL-1?, glycosaminoglycans (GAGs) content and Chondroitin sulfate proteoglycans (CSPGs) synthesis genes (ACAN, XT-1, XT-2, CHSY1 and ChPF) was measured...
  8. Wu Y, Siao C, Lu W, Sung T, Frohman M, Milev P, et al. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J Cell Biol. 2000;148:1295-304 pubmed
    ..These results demonstrate that tPA functions acutely, both through and independently of plasmin, to mediate mossy fiber reorganization. ..
  9. Narindrasorasak S, Lowery D, Gonzalez DeWhitt P, Poorman R, Greenberg B, Kisilevsky R. High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan. J Biol Chem. 1991;266:12878-83 pubmed
    ..Our results suggest that specific interactions between the AAP proteins and the extracellular matrix may be involved in the nucleation stages of Alzheimer's disease type amyloidogenesis. ..

More Information


  1. Swasdison S, Mayne R. Location of the integrin complex and extracellular matrix molecules at the chicken myotendinous junction. Cell Tissue Res. 1989;257:537-43 pubmed
    ..This interaction does not appear to involve extensive binding to fibronectin or tenascin, but may involve laminin and heparan sulfate proteoglycan. ..
  2. Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, et al. Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med. 2017;214:1431-1452 pubmed publisher
    ..Thus, low levels of cohesin expression in the developing brain lead to changes in gene expression that in turn lead to a specific and abnormal neuronal and behavioral phenotype. ..
  3. Ritter S, Collins J, Krastins B, Sarracino D, Lopez M, Losina E, et al. Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther. 2014;16:456 pubmed publisher
    ..079. Our results suggest that when combined, levels of peptides representative of clusterin and lubricin in plasma are as predictive of OA progression as age. Replication of these findings in other prospective OA cohorts is planned. ..
  4. Chung K, Taylor J, Shum D, Chan S. Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos. Development. 2000;127:2673-83 pubmed
    ..After continuous enzymatic digestion of the chondroitin sulfate proteoglycans with chondroitinase ABC, which removes the glycosaminoglycan chains, navigation of retinal axons was ..
  5. Koppe G, Bruckner G, Brauer K, Hartig W, Bigl V. Developmental patterns of proteoglycan-containing extracellular matrix in perineuronal nets and neuropil of the postnatal rat brain. Cell Tissue Res. 1997;288:33-41 pubmed
    ..The results provide further evidence that the accumulation of certain CSPGs in the extracellular space is spatiotemporally related to distinct patterns of neuronal activity at the regional and cellular level. ..
  6. Dold L, Luda C, Schwarze Zander C, Boesecke C, Hansel C, Nischalke H, et al. Genetic polymorphisms associated with fatty liver disease and fibrosis in HIV positive patients receiving combined antiretroviral therapy (cART). PLoS ONE. 2017;12:e0178685 pubmed publisher
    ..Nevertheless, SNPs may modify metabolic complications once metabolic abnormalities have developed. Hence, subsequent analysis of a larger cohort is needed. ..
  7. Calabro A, Hascall V, Caterson B. Monoclonal antibodies directed against epitopes within the core protein structure of the large aggregating proteoglycan (aggrecan) from the swarm rat chondrosarcoma. Arch Biochem Biophys. 1992;298:349-60 pubmed
    ..These antibodies have been proven to be useful for identifying aggrecan-like molecules in several connective tissues other than cartilage. ..
  8. Jaworski D, Kelly G, Hockfield S. Intracranial injury acutely induces the expression of the secreted isoform of the CNS-specific hyaluronan-binding protein BEHAB/brevican. Exp Neurol. 1999;157:327-37 pubmed
    ..Glial process extension, a central element in the glial response to injury, may require the reexpression of both cytoskeletal and matrix elements that are normally expressed during the glial motility seen in the immature brain. ..
  9. Thon N, Haas C, Rauch U, Merten T, Fassler R, Frotscher M, et al. The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Eur J Neurosci. 2000;12:2547-58 pubmed
    ..They suggest a role of brevican in reactive gliosis and are compatible with the hypothesis that brevican is involved in the synaptic reorganization of denervated brain areas. ..
  10. Gupta Bansal R, Frederickson R, Brunden K. Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation. J Biol Chem. 1995;270:18666-71 pubmed
    ..A beta interaction. The ability of proteoglycans to bind fibrillar A beta and inhibit its proteolytic degradation suggests a possible mechanism of senile plaque accumulation and persistence in Alzheimer's disease. ..
  11. Nielsen J, Kulahin N, Walmod P. Extracellular protein interactions mediated by the neural cell adhesion molecule, NCAM: heterophilic interactions between NCAM and cell adhesion molecules, extracellular matrix proteins, and viruses. Adv Exp Med Biol. 2010;663:23-53 pubmed publisher
  12. Busslinger G, Stocsits R, van der Lelij P, Axelsson E, Tedeschi A, Galjart N, et al. Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl. Nature. 2017;544:503-507 pubmed publisher
  13. Gupta P, Zhang Z, Sugiman Marangos S, Tam J, Raman S, Julien J, et al. Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants. J Biol Chem. 2017;292:17290-17301 pubmed publisher
    ..In addition to establishing the binding region for CSPG4, this work ascribes for the first time a role in TcdB CROPs in receptor binding and further clarifies the relative roles of host receptors in TcdB pathogenesis. ..
  14. Yamane Y, Yaoita H, Couchman J. Basement membrane proteoglycans are of epithelial origin in rodent skin. J Invest Dermatol. 1996;106:531-7 pubmed
  15. Yayon A, Klagsbrun M, Esko J, Leder P, Ornitz D. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991;64:841-8 pubmed
    ..Such an obligatory interaction of low and high affinity FGF receptors suggests a physiological role for heparin-like, low affinity receptors and constitutes a novel mechanism for the regulation of growth factor-receptor interactions. ..
  16. Tsidulko A, Kazanskaya G, Kostromskaya D, Aidagulova S, Kiselev R, Volkov A, et al. Prognostic relevance of NG2/CSPG4, CD44 and Ki-67 in patients with glioblastoma. Tumour Biol. 2017;39:1010428317724282 pubmed publisher
  17. Yuan B, Pehlivan D, Karaca E, Patel N, Charng W, Gambin T, et al. Global transcriptional disturbances underlie Cornelia de Lange syndrome and related phenotypes. J Clin Invest. 2015;125:636-51 pubmed publisher
    ..Together, our data, along with recent transcriptome studies, suggest that CdLS and related phenotypes may be "transcriptomopathies" rather than cohesinopathies. ..
  18. Kleinman H, McGarvey M, Hassell J, Star V, Cannon F, Laurie G, et al. Basement membrane complexes with biological activity. Biochemistry. 1986;25:312-8 pubmed
    ..The reconstituted matrix was biologically active and stimulated the growth and differentiation of certain cells. ..
  19. Ohta K, Tannahill D, Yoshida K, Johnson A, Cook G, Keynes R. Embryonic lens repels retinal ganglion cell axons. Dev Biol. 1999;211:124-32 pubmed
    ..Our experiments have excluded two candidate repellents for RGC axons (collapsin-1/sema III and chondroitin sulfate proteoglycans). These results implicate the lens in the earliest stages of RGC axon guidance...
  20. Scranton T, Iwata M, Carlson S. The SV2 protein of synaptic vesicles is a keratan sulfate proteoglycan. J Neurochem. 1993;61:29-44 pubmed
  21. Wintle R, Kisilevsky R, Noonan D, Duncan A. In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG). Cytogenet Cell Genet. 1990;54:60-1 pubmed
    ..1, by in situ hybridization. No secondary sites of hybridization were observed. ..