fish proteins


Summary: Proteins obtained from species of fish (FISHES).

Top Publications

  1. Proestou D, Flight P, Champlin D, Nacci D. Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic killifish (Fundulus heteroclitus). BMC Evol Biol. 2014;14:7 pubmed publisher
    ..Multiple tolerant and neighboring sensitive killifish populations were compared with the expectation that genetic loci associated with DLC tolerance would be revealed...
  2. Reitzel A, Karchner S, Franks D, Evans B, Nacci D, Champlin D, et al. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol. 2014;14:6 pubmed publisher
  3. Molés G, Gomez A, Carrillo M, Rocha A, Mylonas C, Zanuy S. Determination of Fsh quantity and bioactivity during sex differentiation and oogenesis in European sea bass. Biol Reprod. 2011;85:848-57 pubmed publisher
    ..Plasma Fsh bioactivity levels increased during vitellogenesis, suggesting that Fsh would be involved in the regulation of the midphases of oogenesis, whereas luteinizing hormone would be responsible for the final events...
  4. Nazeer R, Kumar N, Jai Ganesh R. In vitro and in vivo studies on the antioxidant activity of fish peptide isolated from the croaker (Otolithes ruber) muscle protein hydrolysate. Peptides. 2012;35:261-8 pubmed publisher
    ..6±7.25, 4.3±0.78 and 28.42±1.97) compared to the negative control (196.4±5.65, 1.3±0.45 and 15.1±0.35). Therefore, croaker muscle peptide can increase an endurance capacity and facilitate recovery from oxidative stress. ..
  5. Dort J, Sirois A, Leblanc N, Cote C, Jacques H. Beneficial effects of cod protein on skeletal muscle repair following injury. Appl Physiol Nutr Metab. 2012;37:489-98 pubmed publisher
    ..01) muscles. No effects were observed for peanut protein. These data indicate that cod protein is better for promoting growth and regeneration of skeletal muscle after trauma, partly because of the improved resolution of inflammation...
  6. Nagasawa K, Giannetto A, Fernandes J. Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod. PLoS ONE. 2012;7:e36908 pubmed publisher
  7. Harbeitner R, Hahn M, Timme Laragy A. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology. 2013;22:387-401 pubmed publisher
    ..This result suggests that adaptation to tolerate PCBs has altered the sensitivity of NBH fish to oxidative stress during embryonic development, demonstrating a cost of the PCB resistance adaptation. ..
  8. Forconi M, Canapa A, Barucca M, Biscotti M, Capriglione T, Buonocore F, et al. Characterization of sex determination and sex differentiation genes in Latimeria. PLoS ONE. 2013;8:e56006 pubmed publisher
    ..The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development. ..
  9. Svingerud T, Solstad T, Sun B, Nyrud M, Kileng y, Greiner Tollersrud L, et al. Atlantic salmon type I IFN subtypes show differences in antiviral activity and cell-dependent expression: evidence for high IFNb/IFNc-producing cells in fish lymphoid tissues. J Immunol. 2012;189:5912-23 pubmed publisher
    ..High IFN expression in response to TLR7 ligation is a feature shared by mammalian plasmacytoid dendritic cells...

More Information


  1. Cho J, Choi H, Lee D. Influence of the N- and C-terminal regions of antimicrobial peptide pleurocidin on antibacterial activity. J Microbiol Biotechnol. 2012;22:1367-74 pubmed
    ..Therefore, the present study suggests that hydrophobicity in the N- and C-terminal regions of pleurocidin plays a key role in its antibacterial activity. ..
  2. Darias M, Andree K, Boglino A, Fernández I, Estévez A, Gisbert E. Coordinated regulation of chromatophore differentiation and melanogenesis during the ontogeny of skin pigmentation of Solea senegalensis (Kaup, 1858). PLoS ONE. 2013;8:e63005 pubmed publisher
    ..In this study we present a first approximation towards explaining the genetic mechanisms for regulating pigmentation ontogeny in Senegalese sole, Solea senegalensis. ..
  3. Diepeveen E, Kim F, Salzburger W. Sequence analyses of the distal-less homeobox gene family in East African cichlid fishes reveal signatures of positive selection. BMC Evol Biol. 2013;13:153 pubmed publisher
    ..Here we study the dlx repertoire in 23 East African cichlid fishes to determine the rate of evolution and the signatures of selection pressure...
  4. Regneri J, Schartl M. Expression regulation triggers oncogenicity of xmrk alleles in the Xiphophorus melanoma system. Comp Biochem Physiol C Toxicol Pharmacol. 2012;155:71-80 pubmed publisher
  5. WENGER M, Sattler U, Goldschmidt Clermont E, Segner H. 17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection. Fish Shellfish Immunol. 2011;31:90-7 pubmed publisher
    ..In conclusion, the results from this study suggest that estrogens are able to modulate immune parameters of trout with functional consequences on their ability to cope with pathogens. ..
  6. Ruangsri J, Salger S, Caipang C, Kiron V, Fernandes J. Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.). Fish Shellfish Immunol. 2012;32:396-406 pubmed publisher
    ..Moreover, the two pis paralogues have undergone structural diversification and it is likely that they play multifunctional roles in Atlantic cod...
  7. Debiais Thibaud M, Oulion S, Bourrat F, Laurenti P, Casane D, Borday Birraux V. The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula. BMC Evol Biol. 2011;11:307 pubmed publisher
    ..Here we examine Dlx gene expression in oral teeth and dermal denticles in order to test the hypothesis of serial homology between these odontodes...
  8. Srivastava S, Ratha B. Unusual hepatic mitochondrial arginase in an Indian air-breathing teleost, Heteropneustes fossilis: purification and characterization. Comp Biochem Physiol B Biochem Mol Biol. 2013;164:133-41 pubmed publisher
    ..fossilis hepatic ARG II showed cross reactivity with a 96 kDa band on native PAGE and a 48 kDa band on SDS-PAGE. The molecular, immunological and kinetic properties suggest uniqueness of the hepatic mitochondrial ARG II in H. fossilis...
  9. Langevin C, Aleksejeva E, Passoni G, Palha N, Levraud J, Boudinot P. The antiviral innate immune response in fish: evolution and conservation of the IFN system. J Mol Biol. 2013;425:4904-20 pubmed publisher
    ..In this review, by comparing the IFN system between teleosts and mammals, we will focus on its evolution in vertebrates. ..
  10. Zheng W, Sun L. Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 2011;30:638-45 pubmed publisher
    ..These results indicate that for qRT-PCR analysis of gene expression in Japanese flounder as a function of bacterial infection, the choice of reference genes should be made according to tissue type...
  11. Li R, Dooley H, Wang T, Secombes C, Bird S. Characterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): cartilaginous fish BAFF has a unique extra exon that may impact receptor binding. Dev Comp Immunol. 2012;36:707-17 pubmed publisher
    ..The dogfish BAFF is highly expressed in immune tissues, such as spleen, and is up-regulated by PWM in peripheral blood leucocytes, suggesting a potentially important role in the immune system...
  12. Polakof S, Skiba Cassy S, Kaushik S, Seiliez I, Soengas J, Panserat S. Glucose and lipid metabolism in the pancreas of rainbow trout is regulated at the molecular level by nutritional status and carbohydrate intake. J Comp Physiol B. 2012;182:507-16 pubmed publisher
  13. Chang M, Collet B, Nie P, Lester K, Campbell S, Secombes C, et al. Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss). J Virol. 2011;85:8403-12 pubmed publisher
    ..Interestingly, MDA5 expression was not affected by overexpressed LGP2 in transfected cells and vice versa, suggesting that they likely act in parallel as positive regulators for IFN production...
  14. Infante C, Ponce M, Manchado M. Duplication of calsequestrin genes in teleosts: molecular characterization in the Senegalese sole (Solea senegalensis). Comp Biochem Physiol B Biochem Mol Biol. 2011;158:304-14 pubmed publisher
    ..Comprehensively, these results demonstrate the existence of four calsequestrin genes in teleosts differentially regulated by THs. ..
  15. Mieiro C, Bervoets L, Joosen S, Blust R, Duarte A, Pereira M, et al. Metallothioneins failed to reflect mercury external levels of exposure and bioaccumulation in marine fish--considerations on tissue and species specific responses. Chemosphere. 2011;85:114-21 pubmed publisher
    ..Overall, the applicability of MT content in fish tissues as biomarker of exposure to mercury was uncertain, reporting limitations in reflecting the metal exposure levels and the subsequent accumulation extent. ..
  16. Ings J, Servos M, Vijayan M. Hepatic transcriptomics and protein expression in rainbow trout exposed to municipal wastewater effluent. Environ Sci Technol. 2011;45:2368-76 pubmed publisher
    ..The disruption in multiple stress-related pathways suggests that tertiary-treated MWWEs exposure may reduce fish performance to subsequent stressors...
  17. Olsvik P, Waagbø R, Pedersen S, Meier S. Transcriptional effects of dietary exposure of oil-contaminated Calanus finmarchicus in Atlantic herring (Clupea harengus). J Toxicol Environ Health A. 2011;74:508-28 pubmed publisher
    ..In conclusion, this study suggests that 2 mo of oil exposure affected genes encoding proteins involved in temperature homeostasis and possible membrane stability in addition to immune-responsive proteins in Atlantic herring. ..
  18. Takizawa F, Koppang E, Ohtani M, Nakanishi T, Hashimoto K, Fischer U, et al. Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments. Mol Immunol. 2011;48:1360-8 pubmed publisher
    ..Expression patterns of IL-4/13A and interferon gamma (IFN-?) in isolated trout gill cells and pronephrocytes were consistent with Th2 identity of IL-4/13A...
  19. Myosho T, Otake H, Masuyama H, Matsuda M, Kuroki Y, Fujiyama A, et al. Tracing the emergence of a novel sex-determining gene in medaka, Oryzias luzonensis. Genetics. 2012;191:163-70 pubmed publisher
    ..Gsdf is downstream of Dmy in the sex-determining cascade of O. latipes, suggesting that emergence of the Dmy-independent Gsdf allele led to the appearance of this novel sex-determining gene in O. luzonensis...
  20. Lu X, Chen J, Huang Z, Shi Y, Lv J. Identification and characterization of a novel cathelicidin from ayu, Plecoglossus altivelis. Fish Shellfish Immunol. 2011;31:52-7 pubmed publisher
    ..Thus, aCATH may play an important role in the innate immunity of ayu, and this work enriches our knowledge in fish antimicrobial peptides...
  21. Cánepa M, Zhu Y, Fossati M, Stiller J, Vissio P. Cloning, phylogenetic analysis and expression of somatolactin and its receptor in Cichlasoma dimerus: their role in long-term background color acclimation. Gen Comp Endocrinol. 2012;176:52-61 pubmed publisher
    ..e., melanophores, in long-term black background exposure in C. dimerus. ..
  22. Rajan B, Fernandes J, Caipang C, Kiron V, Rombout J, Brinchmann M. Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua) revealing immune competent molecules. Fish Shellfish Immunol. 2011;31:224-31 pubmed publisher
    ..Five of the aforementioned proteins were cloned and their tissue distribution was analysed by RT-PCR...
  23. Chen G, Feng L, Kuang S, Liu Y, Jiang J, Hu K, et al. Effect of dietary arginine on growth, intestinal enzyme activities and gene expression in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian). Br J Nutr. 2012;108:195-207 pubmed publisher
    ..0 g/kg diet. These results indicate that arginine improved fish growth, digestive and absorptive ability and regulated the expression of TOR and 4E-BP genes...
  24. Zou J, Secombes C. Teleost fish interferons and their role in immunity. Dev Comp Immunol. 2011;35:1376-87 pubmed publisher
  25. Quinn N, McGowan C, Cooper G, Koop B, Davidson W. Ribosomal genes and heat shock proteins as putative markers for chronic, sublethal heat stress in Arctic charr: applications for aquaculture and wild fish. Physiol Genomics. 2011;43:1056-64 pubmed publisher
    ..We suggest that these are candidate gene targets for the future development of genetic markers for broodstock development or for monitoring temperature stress and recovery in wild or cultured conditions. ..
  26. Seiliez I, Panserat S, Lansard M, Polakof S, Plagnes Juan E, Surget A, et al. Dietary carbohydrate-to-protein ratio affects TOR signaling and metabolism-related gene expression in the liver and muscle of rainbow trout after a single meal. Am J Physiol Regul Integr Comp Physiol. 2011;300:R733-43 pubmed publisher
    ..In conclusion, this study demonstrated that macro-nutrient composition of the diet strongly affected the insulin/amino acids signaling pathway and expression pattern of genes related to metabolism. ..
  27. Larsen H, Austb L, K nig M, S rum H, Rimstad E, Koppang E. Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK-1) is influenced by temperature, but not by virus infection or bacterin stimulation. Dev Comp Immunol. 2013;41:50-8 pubmed publisher
    ..Our findings revealed no connections between the pigmentary and immune systems, but demonstrated a hereto undiscovered temperature-effect on the tyrosinase gene family...
  28. Dos Anjos N, Schulze T, Brack W, Val A, Schirmer K, Scholz S. Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems. Aquat Toxicol. 2011;103:46-52 pubmed publisher
    ..The data demonstrate the high sensitivity of cyp1a as indicator of oil exposure; further studies should be considered to test its usefulness at known contaminated sites and to evaluate influential factors by, e.g. mesocosm experiments...
  29. Pilon G, Ruzzin J, Rioux L, Lavigne C, White P, Frøyland L, et al. Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. Metabolism. 2011;60:1122-30 pubmed publisher
    ..Rats were fed a high-fat, high-sucrose diet containing protein from casein or fish proteins from bonito, herring, mackerel, or salmon...
  30. Zhang Y, Gui J. Molecular regulation of interferon antiviral response in fish. Dev Comp Immunol. 2012;38:193-202 pubmed publisher
    ..We highlight the roles of IRF3 and IRF7 in activation of fish IFN response. In addition, the unique mechanisms underlying IRF3/7-dependent fish IFN response and auto-regulation of fish IFN gene expression are discussed. ..
  31. Quinn N, McGowan C, Cooper G, Koop B, Davidson W. Identification of genes associated with heat tolerance in Arctic charr exposed to acute thermal stress. Physiol Genomics. 2011;43:685-96 pubmed publisher
    ..Our results highlight the importance of using more than one approach to identify candidate genes, particularly when examining a complicated trait such as UTT in a highly complex genome for which there is no reference genome. ..
  32. de Bruijn I, Belmonte R, Anderson V, Saraiva M, Wang T, van West P, et al. Immune gene expression in trout cell lines infected with the fish pathogenic oomycete Saprolegnia parasitica. Dev Comp Immunol. 2012;38:44-54 pubmed publisher
    ..parasitica. These results demonstrate that particular immune genes are up-regulated in response to S. parasitica infection and that AMPs may play a crucial role in the first line of defence against oomycetes in fish...
  33. Xu T, Sun Y, Shi G, Wang R. Miiuy croaker hepcidin gene and comparative analyses reveal evidence for positive selection. PLoS ONE. 2012;7:e35449 pubmed publisher
  34. Ngo D, Ryu B, Vo T, Himaya S, Wijesekara I, Kim S. Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin. Int J Biol Macromol. 2011;49:1110-6 pubmed publisher
    ..The present study demonstrated that the peptides derived from Pacific cod (G. macrocephalus) skin gelatin could be used in the food industry as functional ingredients with potent antioxidative and antihypertensive benefits. ..
  35. Najafian L, Babji A. A review of fish-derived antioxidant and antimicrobial peptides: their production, assessment, and applications. Peptides. 2012;33:178-85 pubmed publisher
    ..In addition, we discuss the extraction of fish proteins, enzymatic production, and the techniques used to isolate and characterize these compounds...
  36. O Quin K, Smith D, Naseer Z, Schulte J, Engel S, Loh Y, et al. Divergence in cis-regulatory sequences surrounding the opsin gene arrays of African cichlid fishes. BMC Evol Biol. 2011;11:120 pubmed publisher
  37. Cao M, Duan J, Cheng N, Zhong X, Wang Z, Hu W, et al. Sexually dimorphic and ontogenetic expression of dmrt1, cyp19a1a and cyp19a1b in Gobiocypris rarus. Comp Biochem Physiol A Mol Integr Physiol. 2012;162:303-9 pubmed publisher
    ..cyp19a1b is expressed coordinately with cyp19a1a until 15 days after hatching. These results show that dmrt1 and cyp19a1a play important roles in sex determination and sex differentiation in G. rarus. ..
  38. Lokesh J, Fernandes J, Korsnes K, Bergh O, Brinchmann M, Kiron V. Transcriptional regulation of cytokines in the intestine of Atlantic cod fed yeast derived mannan oligosaccharide or ?-glucan and challenged with Vibrio anguillarum. Fish Shellfish Immunol. 2012;33:626-31 pubmed publisher
    ..The differential responses of cytokines in the intestine of fish upon exposure to V. anguillarum suggest that both mannan oligosaccharides and ?-glucans impact the ability of Atlantic cod to respond to the pathogen...
  39. Wang W, Zhang M, Sun L. Ferritin M of Cynoglossus semilaevis: an iron-binding protein and a broad-spectrum antimicrobial that depends on the integrity of the ferroxidase center and nucleation center for biological activity. Fish Shellfish Immunol. 2011;31:269-74 pubmed publisher
    ..These results also indicate the importance of the conserved iron uptake and mineralization sites to the function of CsFerM...
  40. Chen M, Huang X, Yuen D, Cheng C. A study on the functional interaction between the GH/PRL family of polypeptides with their receptors in zebrafish: Evidence against GHR1 being the receptor for somatolactin. Mol Cell Endocrinol. 2011;337:114-21 pubmed publisher
    ..The zebrafish SLs, found to be biologically active in another assay, were found to be ineffective in interacting with the zebrafish GHRs and PRLRs. Our data argue against the hypothesis that GHR1 is the SL receptor. ..
  41. O Quin K, Smith A, Sharma A, Carleton K. New evidence for the role of heterochrony in the repeated evolution of cichlid opsin expression. Evol Dev. 2011;13:193-203 pubmed publisher
  42. Bak S, Iida M, Hirano M, Iwata H, Kim E. Potencies of red seabream AHR1- and AHR2-mediated transactivation by dioxins: implication of both AHRs in dioxin toxicity. Environ Sci Technol. 2013;47:2877-85 pubmed publisher
    ..In silico docking simulations supported that both rsAHRs have potentials to bind to these congeners. These results suggest that dioxin toxicities may be mediated by both rsAHRs in red seabreams. ..
  43. Bridle A, Nosworthy E, Polinski M, Nowak B. Evidence of an antimicrobial-immunomodulatory role of Atlantic salmon cathelicidins during infection with Yersinia ruckeri. PLoS ONE. 2011;6:e23417 pubmed publisher
    ..ruckeri . We propose that Atlantic salmon cathelicidins participate in the interplay between the innate and adaptive immune systems via the release of cytokines enabling a more effective response to invading pathogens...
  44. Li Y, Hu Y, Sun J, Sun L. CsCXCe1: A novel Cynoglossus semilaevis CXC chemokine that functions as a chemoattractant and an immunomodulator for peripheral blood leukocytes. Dev Comp Immunol. 2012;37:55-64 pubmed publisher
    ..Taken together, these results indicate that CsCXCe1 is likely a new type of CXC chemokine that exerts chemotactic and immunostimulatory effects on PBL...
  45. Li Y, Zhou J, Huang K, Sun Y, Zeng X. Purification of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide with an antihypertensive effect from loach (Misgurnus anguillicaudatus). J Agric Food Chem. 2012;60:1320-5 pubmed publisher
    ..An antihypertensive effect in spontaneously hypertensive rats revealed that oral administration of LPH-IV could decrease systolic blood pressure significantly. ..
  46. Nakao M, Tsujikura M, Ichiki S, Vo T, Somamoto T. The complement system in teleost fish: progress of post-homolog-hunting researches. Dev Comp Immunol. 2011;35:1296-308 pubmed publisher
    ..Importance of the protein level characterization of the complement components is also emphasized, especially for understanding of the isotypic diversity of the components, a unique feature of teleost complement system. ..
  47. Hosomi R, Fukunaga K, Arai H, Kanda S, Nishiyama T, Yoshida M. Fish protein decreases serum cholesterol in rats by inhibition of cholesterol and bile acid absorption. J Food Sci. 2011;76:H116-21 pubmed publisher
  48. Whittington A, Moerland T. Resurrecting prehistoric parvalbumins to explore the evolution of thermal compensation in extant Antarctic fish parvalbumins. J Exp Biol. 2012;215:3281-92 pubmed publisher
    ..The overall results suggest that the current thermal phenotype of Antarctic PVs can be recapitulated by just two amino acid substitutions. ..
  49. Johnsen H, Tveiten H, Torgersen J, Andersen Ø. Divergent and sex-dimorphic expression of the paralogs of the Sox9-Amh-Cyp19a1 regulatory cascade in developing and adult atlantic cod (Gadus morhua L.). Mol Reprod Dev. 2013;80:358-70 pubmed publisher
    ..These divergent and sex-dimorphic expression patterns of the cod sox9 and cyp19a1 paralogs demonstrate the complexity of the genetic network regulating sexual development in fish...
  50. Kim S, Ngo D, Vo T. Marine fish-derived bioactive peptides as potential antihypertensive agents. Adv Food Nutr Res. 2012;65:249-60 pubmed publisher
    ..This contribution presents an overview of the ACE inhibitory peptides derived from marine fishes and discusses their future prospects to be used as potential drug candidates for preventing and treating high blood pressure. ..
  51. McCarthy I, Fuiman L. Post-prandial changes in protein synthesis in red drum (Sciaenops ocellatus) larvae. J Exp Biol. 2011;214:1821-8 pubmed publisher
  52. Choi H, Lee D. Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity. Biochim Biophys Acta. 2012;1820:1831-8 pubmed publisher
    ..However, the synergistic activity and mechanism(s) of pleurocidin in combination with conventional antibiotics, and the antibiofilm effect of the peptide are poorly understood...
  53. Shi J, Zhang Y, Liu T, Sun F, Gui J. Subcellular localization and functional characterization of a fish IRF9 from crucian carp Carassius auratus. Fish Shellfish Immunol. 2012;33:258-66 pubmed publisher
    ..Taken together, these data suggest that crucian carp IFN induces the expression of ISGs and also of itself possibly by the JAK-STAT signaling pathway that is conserved from fish to mammals. ..