transcription factor brn 3a

Summary

Summary: A POU domain factor that activates GENETIC TRANSCRIPTION of GENES encoding NEUROFILAMENT PROTEINS; alpha internexin; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; and BCL-2 PROTO-ONCOGENE PROTEINS.

Top Publications

  1. Xu Y, Lopes C, Qian Y, Liu Y, Cheng L, Goulding M, et al. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons. J Neurosci. 2008;28:4037-46 pubmed publisher
    ..These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons. ..
  2. Lanier J, Dykes I, Nissen S, Eng S, Turner E. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Dev Dyn. 2009;238:3065-79 pubmed publisher
    ..These results underscore the importance of gene repression in regulating neuronal development, and the need for unbiased screens in the determination of developmental gene regulatory programs. ..
  3. Dunne J, Gascoyne D, Lister T, Brady H, Heidenreich O, Young B. AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia. Cancer Res. 2010;70:3985-95 pubmed publisher
    ..In summary, we identify POU4F1/BRN3A as a novel potential upregulated AML1/ETO target gene whose dramatically high expression may cooperate with AML1/ETO in t(8;21) cells. ..
  4. Badea T, Cahill H, Ecker J, Hattar S, Nathans J. Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells. Neuron. 2009;61:852-64 pubmed publisher
    ..These findings reveal distinct roles for Brn3a and Brn3b in programming RGC diversity, and they illustrate the broad utility of germline methods for genetically manipulating and visualizing individual identified mammalian neurons. ..
  5. Dykes I, Lanier J, Eng S, Turner E. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3 pubmed publisher
    ..Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. ..
  6. Ortín Martínez A, Jiménez López M, Nadal Nicolás F, Salinas Navarro M, Alarcón Martínez L, Sauve Y, et al. Automated quantification and topographical distribution of the whole population of S- and L-cones in adult albino and pigmented rats. Invest Ophthalmol Vis Sci. 2010;51:3171-83 pubmed publisher
    ..These data establish, for the first time, the total number and the topographical distribution of S- and L-cones in two rat strains and demonstrate the correlation of L-cones and RGC spatial distribution. ..
  7. Raymond I, Pool A, Vila A, Brecha N. A Thy1-CFP DBA/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells. Vis Neurosci. 2009;26:453-65 pubmed publisher
    ..This line will be of value for experimental studies investigating ganglion cells and their axons in vivo and in vitro during the progressive development of glaucoma. ..
  8. Esposito F, Tornincasa M, Chieffi P, De Martino I, Pierantoni G, Fusco A. High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. Cancer Res. 2010;70:5379-88 pubmed publisher
    ..Therefore, this study suggests a novel mechanism, based on Bcl-2 induction, by which HMGA1 overexpression contributes to the escape from apoptosis leading to neoplastic transformation. ..
  9. Lang B, Zhao L, Cai L, McKie L, Forrester J, McCaig C, et al. GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice. Neuropharmacology. 2010;58:215-25 pubmed publisher
    ..These data demonstrate that an appropriate level of PACAP signaling is required for normal retinogenesis and visual function. This finding may have implications in GABAergic neuron-related neurological conditions. ..

More Information

Publications26

  1. Fortier J, Payton J, Cahan P, Ley T, Walter M, Graubert T. POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature. Leukemia. 2010;24:950-7 pubmed publisher
    ..These genes provide novel candidates for understanding the biology and developing therapeutic approaches for t(8;21) AML. ..
  2. Berwick D, Diss J, Budhram Mahadeo V, Latchman D. A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction. J Biol Chem. 2010;285:15286-95 pubmed publisher
    ..7, leading to a synergistic increase in its expression. Thus, these data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins. ..
  3. Ndisang D, Khan A, Lorenzato F, Sindos M, Singer A, Latchman D. The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix. Oncogene. 2010;29:2701-11 pubmed publisher
  4. Moreno Bravo J, Perez Balaguer A, Martinez S, Puelles E. Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate. Dev Dyn. 2010;239:2094-101 pubmed publisher
    ..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei. ..
  5. Prakash N, Puelles E, Freude K, Trumbach D, Omodei D, Di Salvio M, et al. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development. 2009;136:2545-55 pubmed publisher
  6. Pan L, Yang Z, Feng L, Gan L. Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis. Development. 2005;132:703-12 pubmed
    ..These results indicate that Brn3 factors are functionally equal and that their unique roles in neurogenesis are determined by the distinctive Brn3 spatiotemporal expression patterns. ..
  7. Ichikawa H, Terayama R, Yamaai T, Jacobowitz D, Qiu F, Xiang M, et al. Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development. Cell Mol Neurobiol. 2009;29:691-8 pubmed publisher
    ..5 and E14.5. Caspase-3-dependent cell death of CB- and CR-ir neurons may be suppressed by the deficiency at E14.5. ..
  8. Nadal Nicolás F, Jiménez López M, Sobrado Calvo P, Nieto López L, Cánovas Martínez I, Salinas Navarro M, et al. Brn3a as a marker of retinal ganglion cells: qualitative and quantitative time course studies in naive and optic nerve-injured retinas. Invest Ophthalmol Vis Sci. 2009;50:3860-8 pubmed publisher
    ..Brn3a can be used as a reliable, efficient ex vivo marker to identify and quantify RGCs in control and optic nerve-injured retinas. ..
  9. Bedkowska G, Ławicki S, Szmitkowski M. [Molecular markers of carcinogenesis in the diagnostics of cervical cancer]. Postepy Hig Med Dosw (Online). 2009;63:99-105 pubmed
    ..In summary, it is evident that molecular makers of carcinogenesis are helpful in the diagnostics of cervical cancer, but further investigation and confirmation by a prospective study is necessary. ..
  10. Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiol Aging. 2009;30:2010-20 pubmed publisher
    ..Such an event is opposed by caloric restriction, a model of delayed aging, and favored by the p44 transgene in p44(+/+) animals, a model of accelerated aging. ..
  11. García Ayuso D, Salinas Navarro M, Agudo M, Cuenca N, Pinilla I, Vidal Sanz M, et al. Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina. Exp Eye Res. 2010;91:800-10 pubmed publisher
  12. Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, et al. The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nat Neurosci. 2010;13:1354-6 pubmed publisher
  13. Gascoyne D, Dunne J, Behjati S, Sebire N, Anderson J, Latchman D. EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A. Oncogene. 2010;29:3134-45 pubmed publisher
    ..These results extend the hypothesis that EWS/ETS proteins induce expression of neuronal markers such as BRN3A in EFT by showing that the function of those same markers may be restricted or controlled in an EWS/ETS-dependent manner. ..
  14. Quina L, Wang S, Ng L, Turner E. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009;29:14309-22 pubmed publisher
    ..Together, these findings begin to define a gene regulatory pathway for habenula development in mammals. ..
  15. Nelander J, Hebsgaard J, Parmar M. Organization of the human embryonic ventral mesencephalon. Gene Expr Patterns. 2009;9:555-61 pubmed publisher
    ..This data therefore suggest similar roles for these factors also in human VM development and dopamine neurogenesis. ..
  16. Harper M, Adamson L, Blits B, Bunge M, Grozdanic S, Sakaguchi D. Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res. 2009;89:538-48 pubmed publisher
    ..Additionally, our results demonstrate that genetically modified BDNF-producing MSCs can enhance survival of stressed RGC-5 cells and therefore, may be effective vehicles to deliver BDNF to retinal ganglion cells affected by disease. ..
  17. Ding Q, Chen H, Xie X, Libby R, Tian N, Gan L. BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons. J Neurosci. 2009;29:3992-4003 pubmed publisher
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival. ..