pax8 transcription factor


Summary: A paired box transcription factor that functions in the development of THYROCYTES and the control of thyroid-specific gene expression. Mutations in the PAX8 gene are associated with THYROID DYSGENESIS and THYROID NEOPLASMS.

Top Publications

  1. Antic T, Taxy J, Alikhan M, Segal J. Melanotic Translocation Renal Cell Carcinoma With a Novel ARID1B-TFE3 Gene Fusion. Am J Surg Pathol. 2017;41:1576-1580 pubmed publisher
  2. Song Y, Huang X, Shen G, Liu X, Zhang X. [Comparison of paired box genes 8 and 2 expression in epithelium tissues and the related tumors]. Zhonghua Zhong Liu Za Zhi. 2017;39:424-428 pubmed publisher
    ..6%(8/28)?9.1%(1/11)?17.6%(3/17)?pax8???????????????????????????????????pax2????????????(?p<0.05)? ??? pax2?pax8??????????????????????????pax8????????????pax2????????????????????????????????????. ..
  3. Szczepanek Parulska E, Zybek Kocik A, Wartofsky L, Ruchala M. Thyroid Hemiagenesis: Incidence, Clinical Significance, and Genetic Background. J Clin Endocrinol Metab. 2017;102:3124-3137 pubmed publisher
    ..Application of high-throughput technologies enabling a genome-wide search for novel factors involved in thyroid embryogenesis might be the next step to expand the knowledge on THA pathogenesis. ..
  4. Ghosh A, Syed S, Tanwar P. In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells. Development. 2017;144:3031-3041 pubmed publisher
    ..In summary, our results provide mechanistic insight into oviductal epithelial homoeostasis. ..
  5. Mao Y, Zeng L, Li Y, Liu Y, Wu J, Li L, et al. [Significance and expression of PAX8, PAX2, p53 and RAS in ovary and fallopian tubes to origin of ovarian high grade serous carcinoma]. Zhonghua Fu Chan Ke Za Zhi. 2017;52:687-696 pubmed publisher
    ..HGSC may be derived from fallopian tube, but further investigation would be necessary to confirm this. PAX8, PAX2, p53, RAS could be expected to be used as predictors of survival prognosis in patients with ovarian serous cancer...