pax5 transcription factor


Summary: A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.

Top Publications

  1. Hure M, Elco C, Ward D, Hutchinson L, Meng X, Dorfman D, et al. Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol. 2012;30:e49-53 pubmed publisher
  2. Ofverholm I, Tran A, Heyman M, Zachariadis V, Nordenskjold M, Nordgren A, et al. Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols. Leukemia. 2013;27:1936-9 pubmed publisher
  3. Wang H, Shabaik A. Metastatic Merkel cell carcinoma involving the bone marrow with chronic lymphocytic leukemia mimicking Richter transformation. Blood. 2013;122:2776 pubmed publisher
  4. Zhu J, Wang Y, Gong L, Huang G. Diagnosis of primary pulmonary T- cell/histiocyte-rich large B cell lymphoma with tissue eosinophilia via clinicopathological observation and molecular assay. Diagn Pathol. 2014;9:188 pubmed publisher
    ..The virtual slide(s) for this article can be found here: ..
  5. Hauer J, Martin Lorenzo A, Sanchez Garcia I. Infection causes childhood leukemia. Aging (Albany NY). 2015;7:607-8 pubmed
  6. Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
    ..Thus, B-lymphoid transcription factors function as metabolic gatekeepers by limiting the amount of cellular ATP to levels that are insufficient for malignant transformation. ..
  7. Rozenvald I, Richardson M, Brock L, Maiese R. Immunohistochemical Detection of Hairy Cell Leukemia in Paraffin Sections: The Role of Pax5 and CD103 Double Staining to Improve Specificity and Sensitivity. Arch Pathol Lab Med. 2017;141:837-840 pubmed publisher
    ..This dual-staining method is particularly helpful in cases with low-level involvement by HCL and can be used for determining minimal residual disease after treatment. ..
  8. Dong Y, Wu C, Zhao X, Zhang P, Zhang H, Zheng M, et al. Epigenetic modifications of the VH region after DJH recombination in Pro-B cells. Immunology. 2017;152:218-231 pubmed publisher
  9. Solanki A, Lau C, Saldana J, Ross S, Crompton T. The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh. J Exp Med. 2017;214:2041-2058 pubmed publisher

More Information


  1. Chan L, MUSCHEN M. B-cell identity as a metabolic barrier against malignant transformation. Exp Hematol. 2017;53:1-6 pubmed publisher