Genomes and Genes
ga binding protein transcription factor
Summary: A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.
- Leuenberger N, Pradervand S, Wahli W. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest. 2009;119:3138-48 pubmed publisher..Physiologically, this repression conferred on female mice protection against estrogen-induced intrahepatic cholestasis, the most common hepatic disease during pregnancy, suggesting a therapeutic target for prevention of this disease. ..
- Pandit A, Vadnal J, Houston S, Freeman E, McDonough J. Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis. J Neurol Sci. 2009;279:14-20 pubmed publisher..We conclude that in MS cortex a chronic increase in oxidative stress leads to aberrant regulation of transcription of genes involved in energy metabolism. ..
- Tran Q, Xu L, Phan V, Goodwin S, Rahman M, Jin V, et al. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009;30:480-6 pubmed publisher..Together, these findings provide new insight into the actions of clinically relevant and lead dithiolethione analogues. ..
- Wallerman O, Motallebipour M, Enroth S, Patra K, Bysani M, Komorowski J, et al. Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37:7498-508 pubmed publisher..An interaction between HNF4a and GABP was seen at TSS, with one-third of the HNF4a positive promoters being bound also by GABP, and this interaction was verified by co-immunoprecipitations. ..
- Bruni F, Polosa P, Gadaleta M, Cantatore P, Roberti M. Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. J Biol Chem. 2010;285:3939-48 pubmed publisher..Finally, we developed a more stringent consensus with respect to the general consensus of NRF-2/GA-binding protein when searching for NRF-2 binding sites in the promoter of mitochondrial proteins. ..
- Lai C, Zhang Y, Rogers S, Mager D. Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 2009;37:3032-43 pubmed publisher..These findings demonstrate that a retroelement insertion has led to gene-regulatory change and functional diversification of rodent NKG2D. ..
- Yu S, Zhao D, Jothi R, Xue H. Critical requirement of GABPalpha for normal T cell development. J Biol Chem. 2010;285:10179-88 pubmed publisher..Our observations collectively indicate that in addition to regulating IL-7Ralpha expression, GABP is critically required for TCR rearrangements and hence normal T cell development. ..
- Uchiumi F, Enokida K, Shiraishi T, Masumi A, Tanuma S. Characterization of the promoter region of the human IGHMBP2 (Smubp-2) gene and its response to TPA in HL-60 cells. Gene. 2010;463:8-17 pubmed publisher..1 modulates TPA-induced IGHMBP2 promoter activity. Taken together, these observations suggest that the duplicated GGAA motifs are essential for the IGHMBP2 promoter activity and its positive response to TPA in HL-60 cells. ..
- Wilms H, Sievers J, Rickert U, Rostami Yazdi M, Mrowietz U, Lucius R. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. J Neuroinflammation. 2010;7:30 pubmed publisher..Collectively, these results suggest that the neuroprotective effects of DMF may be in part functionally attributable to the compound's ability to inhibit expression of multiple neuroinflammatory mediators in brain of MS patients. ..
- Shimokawa T, Nunomura S, Enomoto Y, Ra C. Amino acid residues in the beta3 strand and subsequent loop of the conserved ETS domain that mediate basic leucine zipper (bZIP) recruitment and potentially distinguish functional attributes of Ets proteins. Biochem J. 2010;430:129-39 pubmed publisher..The identified amino acid residues could confer the specificity of the action on the Ets proteins in diverse biological processes through mediating the recruitment of its partner factor. ..