ga binding protein transcription factor


Summary: A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.

Top Publications

  1. Chandele A, Joshi N, Zhu J, Paul W, Leonard W, Kaech S. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol. 2008;180:5309-19 pubmed
  2. Lucas M, Crider K, Powell D, Kapoor Vazirani P, Vertino P. Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha. J Biol Chem. 2009;284:14698-709 pubmed publisher
    ..These data indicate that the intronic HS2 element acts in cis to maintain transcriptional competency at the TMS1 locus and that this activity is mediated by the ets transcription factor, GABPalpha. ..
  3. George L, Lokhandwala M, Asghar M. Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. Am J Physiol Renal Physiol. 2009;297:F1174-80 pubmed publisher
    ..Both Nrf-2 and NF-kappaB seem to play key role in this phenomenon. ..
  4. Thompson K, Rosenzweig B, Zhang J, Knapton A, Honchel R, Lipshultz S, et al. Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats. Cancer Chemother Pharmacol. 2010;66:303-14 pubmed publisher
    ..To identify potential additional cardioprotective treatment strategies, we investigated early doxorubicin-induced changes in cardiac gene expression...
  5. Mangiullo R, Gnoni A, Damiano F, Siculella L, Zanotti F, Papa S, et al. 3,5-diiodo-L-thyronine upregulates rat-liver mitochondrial F(o)F(1)-ATP synthase by GA-binding protein/nuclear respiratory factor-2. Biochim Biophys Acta. 2010;1797:233-40 pubmed publisher
    ..These findings provide new insights into the T2 role on bioenergetic mechanisms. ..
  6. Jiao S, Bailey C, Zhang S, Ladunga I. Probabilistic peak calling and controlling false discovery rate estimations in transcription factor binding site mapping from ChIP-seq. Methods Mol Biol. 2010;674:161-77 pubmed publisher
    ..s Quantitative Enrichment of Sequence Tags (QuEST) software tool. We demonstrate the prediction of the human growth-associated binding protein (GABPalpha) based on ChIP-seq observations. ..
  7. Venditti P, Chiellini G, Di Stefano L, Napolitano G, Zucchi R, Columbano A, et al. The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine. J Endocrinol. 2010;205:279-89 pubmed publisher
  8. Eynon N, Alves A, Sagiv M, Yamin C, Sagiv M, Meckel Y. Interaction between SNPs in the NRF2 gene and elite endurance performance. Physiol Genomics. 2010;41:78-81 pubmed publisher
  9. Hollenhorst P, Chandler K, Poulsen R, Johnson W, Speck N, Graves B. DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet. 2009;5:e1000778 pubmed publisher
    ..These findings demonstrate that diversity of DNA binding motifs may enable variable transcription factor function at different genomic sites. ..

More Information


  1. Kerr J, Gough J, Richards S, Main J, Enlander D, McCreary M, et al. Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with chronic fatigue syndrome/myalgic encephalomyelitis. J Gen Virol. 2010;91:893-7 pubmed publisher
  2. Leuenberger N, Pradervand S, Wahli W. Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest. 2009;119:3138-48 pubmed publisher
    ..Physiologically, this repression conferred on female mice protection against estrogen-induced intrahepatic cholestasis, the most common hepatic disease during pregnancy, suggesting a therapeutic target for prevention of this disease. ..
  3. Boros J, Donaldson I, O Donnell A, Odrowaz Z, Zeef L, Lupien M, et al. Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009;19:1963-73 pubmed publisher
  4. Pandit A, Vadnal J, Houston S, Freeman E, McDonough J. Impaired regulation of electron transport chain subunit genes by nuclear respiratory factor 2 in multiple sclerosis. J Neurol Sci. 2009;279:14-20 pubmed publisher
    ..We conclude that in MS cortex a chronic increase in oxidative stress leads to aberrant regulation of transcription of genes involved in energy metabolism. ..
  5. Tran Q, Xu L, Phan V, Goodwin S, Rahman M, Jin V, et al. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009;30:480-6 pubmed publisher
    ..Together, these findings provide new insight into the actions of clinically relevant and lead dithiolethione analogues. ..
  6. Wallerman O, Motallebipour M, Enroth S, Patra K, Bysani M, Komorowski J, et al. Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37:7498-508 pubmed publisher
    ..An interaction between HNF4a and GABP was seen at TSS, with one-third of the HNF4a positive promoters being bound also by GABP, and this interaction was verified by co-immunoprecipitations. ..
  7. Bruni F, Polosa P, Gadaleta M, Cantatore P, Roberti M. Nuclear respiratory factor 2 induces the expression of many but not all human proteins acting in mitochondrial DNA transcription and replication. J Biol Chem. 2010;285:3939-48 pubmed publisher
    ..Finally, we developed a more stringent consensus with respect to the general consensus of NRF-2/GA-binding protein when searching for NRF-2 binding sites in the promoter of mitochondrial proteins. ..
  8. Lai C, Zhang Y, Rogers S, Mager D. Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion. Nucleic Acids Res. 2009;37:3032-43 pubmed publisher
    ..These findings demonstrate that a retroelement insertion has led to gene-regulatory change and functional diversification of rodent NKG2D. ..
  9. Yu S, Zhao D, Jothi R, Xue H. Critical requirement of GABPalpha for normal T cell development. J Biol Chem. 2010;285:10179-88 pubmed publisher
    ..Our observations collectively indicate that in addition to regulating IL-7Ralpha expression, GABP is critically required for TCR rearrangements and hence normal T cell development. ..
  10. Uchiumi F, Enokida K, Shiraishi T, Masumi A, Tanuma S. Characterization of the promoter region of the human IGHMBP2 (Smubp-2) gene and its response to TPA in HL-60 cells. Gene. 2010;463:8-17 pubmed publisher
    ..1 modulates TPA-induced IGHMBP2 promoter activity. Taken together, these observations suggest that the duplicated GGAA motifs are essential for the IGHMBP2 promoter activity and its positive response to TPA in HL-60 cells. ..
  11. Wilms H, Sievers J, Rickert U, Rostami Yazdi M, Mrowietz U, Lucius R. Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. J Neuroinflammation. 2010;7:30 pubmed publisher
    ..Collectively, these results suggest that the neuroprotective effects of DMF may be in part functionally attributable to the compound's ability to inhibit expression of multiple neuroinflammatory mediators in brain of MS patients. ..
  12. Shimokawa T, Nunomura S, Enomoto Y, Ra C. Amino acid residues in the beta3 strand and subsequent loop of the conserved ETS domain that mediate basic leucine zipper (bZIP) recruitment and potentially distinguish functional attributes of Ets proteins. Biochem J. 2010;430:129-39 pubmed publisher
    ..The identified amino acid residues could confer the specificity of the action on the Ets proteins in diverse biological processes through mediating the recruitment of its partner factor. ..