hmgb3 protein


Summary: An HMG-box domain (HMG-BOX DOMAINS) found highly expressed in embryonic tissue and in placenta.

Top Publications

  1. Nemeth M, Curtis D, Kirby M, Garrett Beal L, Seidel N, Cline A, et al. Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood. 2003;102:1298-306 pubmed
    ..We conclude that down-regulation of Hmgb3 protein levels is an important step for myeloid and B-cell differentiation.
  2. Maciotta S, Meregalli M, Cassinelli L, Parolini D, Farini A, Fraro G, et al. Hmgb3 is regulated by microRNA-206 during muscle regeneration. PLoS ONE. 2012;7:e43464 pubmed publisher
    ..These findings suggest that myomiR-206 may be a potential therapeutic target in muscle diseases. ..
  3. Sandoval Hernández A, Hernández H, Restrepo A, Muñoz J, Bayon G, Fernández A, et al. Liver X Receptor Agonist Modifies the DNA Methylation Profile of Synapse and Neurogenesis-Related Genes in the Triple Transgenic Mouse Model of Alzheimer's Disease. J Mol Neurosci. 2016;58:243-53 pubmed publisher
    ..Our results suggest a new potential mechanism to explain the beneficial effect of GW3965. ..
  4. Gong Y, Cao Y, Song L, Zhou J, Wang C, Wu B. HMGB3 characterization in gastric cancer. Genet Mol Res. 2013;12:6032-9 pubmed publisher
    ..This information helps to provide insight into the molecular mechanisms of HMGB3 in human gastric cancer. ..
  5. Nemeth M, Kirby M, Bodine D. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci U S A. 2006;103:13783-8 pubmed
    ..From these data, we propose a model in which Hmgb3 is required for the proper balance between HSC self-renewal and differentiation. ..
  6. Xu J, Tian H, Liu X, Wang W, Liang A. Localization and functional analysis of HmgB3p, a novel protein containing high-mobility-group-box domain from Tetrahymena thermophila. Gene. 2013;526:87-95 pubmed publisher
    ..It may bind to micronucleus-specific DNA sequences or structures and is likely to have some function specific to micronuclei of T. thermophila. ..
  7. Terada K, Furukawa T. Sumoylation controls retinal progenitor proliferation by repressing cell cycle exit in Xenopus laevis. Dev Biol. 2010;347:180-94 pubmed publisher
    ..Furthermore, progenitor proliferation is regulated, at least in part, by sumoylation of transcription factor Sp1. These results suggest a significant role of sumoylation for cell cycle regulation in retinal progenitors. ..
  8. Cao J, Li S, Zhang H, Shi D. High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development. Mech Dev. 2012;129:263-74 pubmed publisher
    ..Therefore, our results suggest that hmgb genes may function to fine-tune the specification and/or dorsoventral patterning of mesoderm during zebrafish and Xenopus development. ..
  9. Zhang Z, Chang Y, Zhang J, Lu Y, Zheng L, Hu Y, et al. HMGB3 promotes growth and migration in colorectal cancer by regulating WNT/?-catenin pathway. PLoS ONE. 2017;12:e0179741 pubmed publisher
    ..These results may be the reason for HMGB3 oncogene role in CRC. In summary, our data indicated that HMGB3 may serve as an oncoprotein and could be used as a potential prognostic marker in CRC. ..

More Information


  1. Li M, Cai Y, Zhao H, Xu Z, Sun Q, Luo M, et al. Overexpression of HMGB3 protein promotes cell proliferation, migration and is associated with poor prognosis in urinary bladder cancer patients. Tumour Biol. 2015;36:4785-92 pubmed publisher
    ..In sum, our data suggests HMGB3 may serve as an important oncoprotein and indicate that overexpression of HMGB3 in UBC could be used as a potential prognostic marker. ..
  2. Chen X, Zhao G, Wang F, Gao F, Luo H, Wang Y, et al. Upregulation of miR-513b inhibits cell proliferation, migration, and promotes apoptosis by targeting high mobility group-box 3 protein in gastric cancer. Tumour Biol. 2014;35:11081-9 pubmed publisher
    ..01). Furthermore, western blotting revealed that HMGB3 protein was overexpressed in tumor samples relative to matched, non-malignant adjacent tissues...
  3. Elgamal O, Park J, Gusev Y, Azevedo Pouly A, Jiang J, Roopra A, et al. Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation. PLoS ONE. 2013;8:e76402 pubmed publisher
    ..In conclusion, regulation of HMGB3 by miR-205 reduced both proliferation and invasion of breast cancer cells. Our findings suggest that modulating miR-205 and/or targeting HMGB3 are potential therapies for advanced breast cancer. ..
  4. Tsuzuki S, Seto M. TEL (ETV6)-AML1 (RUNX1) initiates self-renewing fetal pro-B cells in association with a transcriptional program shared with embryonic stem cells in mice. Stem Cells. 2013;31:236-47 pubmed publisher
  5. Somervaille T, Matheny C, Spencer G, Iwasaki M, Rinn J, Witten D, et al. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell. 2009;4:129-40 pubmed publisher
  6. Hayes D, Secrist H, Bangur C, Wang T, Zhang X, Harlan D, et al. Multigene real-time PCR detection of circulating tumor cells in peripheral blood of lung cancer patients. Anticancer Res. 2006;26:1567-75 pubmed
    ..These data indicate the diagnostic and prognostic utility of a multigene real-time RT-PCR assay to detect tumor cells in the peripheral blood of lung cancer patients. ..
  7. Hauke S, Leopold S, Schlueter C, Flohr A, Murua Escobar H, Rogalla P, et al. Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene. Biochim Biophys Acta. 2005;1729:24-31 pubmed
    ..It is hypothesized that HMGA2-dependent tumorigenesis is caused by a disturbed equilibrium in the co-expression of the HMGA2 splice variants leading to aberrant cell proliferation and/or malignant transformation of cells. ..
  8. Zhu S, Deng S, Ma Q, Zhang T, Jia C, Zhuo D, et al. MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2. Circ Res. 2013;112:152-64 pubmed publisher
    ..miR-10A* and miR-21 regulate EPC senescence via suppressing Hmga2 expression and modulation of microRNAs may represent a potential therapeutic intervention in improving EPC-mediated angiogenesis and vascular repair. ..
  9. Li L, Huang J, Ju Z, Li Q, Wang C, Qi C, et al. Multiple promoters and targeted microRNAs direct the expressions of HMGB3 gene transcripts in dairy cattle. Anim Genet. 2013;44:241-50 pubmed publisher
    ..05). The findings suggest that HMGB3 expression is under complex transcriptional and post-transcriptional control by alternate promoter usage, alternative splicing mechanism and microRNAs in dairy cattle...
  10. Tang H, Luo X, Xu G, Wang Y, Feng Z, Xu H, et al. High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma. World J Gastroenterol. 2012;18:7319-26 pubmed publisher
    ..Among 92 patients with gastric adenocarcinomas surgically removed in this study, high HMGB3 protein expression was detected in the gastric adenocarcinoma tissues vs peritumoral tissues (P < 0.001)...
  11. Song N, Liu B, Wu J, Zhang R, Duan L, He W, et al. Prognostic value of HMGB3 expression in patients with non-small cell lung cancer. Tumour Biol. 2013;34:2599-603 pubmed publisher
    ..In sum, our data suggest that HMGB3 plays an important role in NSCLC progression, and that overexpression of HMGB3 in tumor tissues could be used as a potential prognostic marker for patients with NSCLC. ..
  12. Yang C, Chen L, Su J, Feng X, Rao Y. Two novel homologs of high mobility group box 3 gene in grass carp (Ctenopharyngodon idella): potential roles in innate immune responses. Fish Shellfish Immunol. 2013;35:1501-10 pubmed publisher
    ..Taken together, current study provides the first evidence that HMGB3 participates in broad antiviral and antibacterial immune responses in teleosts. ..
  13. Nemeth M, Cline A, Anderson S, Garrett Beal L, Bodine D. Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors. Blood. 2005;105:627-34 pubmed
    ..This defect is compensated for by the ability of Hmgb3(-/Y) progenitors to expand rapidly and differentiate into normal numbers of hematopoietic cells. ..
  14. Stemmer C, Leeming D, Franssen L, Grimm R, Grasser K. Phosphorylation of maize and Arabidopsis HMGB proteins by protein kinase CK2alpha. Biochemistry. 2003;42:3503-8 pubmed
  15. Hu L, Yang X, Yuan D, Zeng F, Zhang X. GhHmgB3 deficiency deregulates proliferation and differentiation of cells during somatic embryogenesis in cotton. Plant Biotechnol J. 2011;9:1038-48 pubmed publisher
    ..These results in response to the down-regulation of GhHmgB3 revealed series of ?-catenin-related mechanisms might be responsible for the deregulation of proliferation and differentiation of cells in cotton SE. ..
  16. Kiilerich B, Stemmer C, Merkle T, Launholt D, Gorr G, Grasser K. Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens. Gene. 2008;407:86-97 pubmed publisher
    ..In summary, our data show that functional HMGB-type proteins occur in Physcomitrella and most likely in other lower plant species...
  17. Terada K, Kitayama A, Kanamoto T, Ueno N, Furukawa T. Nucleosome regulator Xhmgb3 is required for cell proliferation of the eye and brain as a downstream target of Xenopus rax/Rx1. Dev Biol. 2006;291:398-412 pubmed
    ..Our findings reveal a novel aspect of progenitor cell proliferation during embryonic central nervous system (CNS) development. ..