p45 subunit nf e2 transcription factor


Summary: A tissue-specific subunit of NF-E2 transcription factor that interacts with small MAF PROTEINS to regulate gene expression. P45 NF-E2 protein is expressed primarily in MEGAKARYOCYTES; ERYTHROID CELLS; and MAST CELLS.

Top Publications

  1. Reems J, Wang W, Tsubata K, Abdurrahman N, Sundell B, Tijssen M, et al. Dynamin 3 participates in the growth and development of megakaryocytes. Exp Hematol. 2008;36:1714-27 pubmed publisher
  2. Cavin C, Delatour T, Marin Kuan M, Fenaille F, Holzhäuser D, Guignard G, et al. Ochratoxin A-mediated DNA and protein damage: roles of nitrosative and oxidative stresses. Toxicol Sci. 2009;110:84-94 pubmed publisher
    ..The exact role of nitrosative stress still remains to be established. ..
  3. Ronkainen H, Vaarala M, Kauppila S, Soini Y, Paavonen T, Rask J, et al. Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncol Rep. 2009;21:1519-23 pubmed
    ..Nfr2 staining was not a prognostic factor in renal cancer-specific survival. In RCC, Keap1 is associated with a more advanced disease, a higher grade and a poorer prognosis. ..
  4. Motohashi H, Kimura M, Fujita R, Inoue A, Pan X, Takayama M, et al. NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. Blood. 2010;115:677-86 pubmed publisher
    ..Increased ROS enhanced platelet gene expression. These results suggest that p45 dominates over Nrf2 to enhance megakaryocytic maturation by promoting ROS accumulation. ..
  5. Lee T, Shyu Y, Hsu P, Chang C, Wen S, Hsiao W, et al. JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells. Proc Natl Acad Sci U S A. 2010;107:52-7 pubmed publisher
  6. Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, et al. Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis. Mol Cell Biol. 2010;30:2668-80 pubmed publisher
    ..This study thus provides a unique in vivo validation of the hierarchical relationship between GATA1 and p45 in megakaryocytes. ..
  7. Pozner R, Ure A, Jaquenod de Giusti C, D Atri L, Italiano J, Torres O, et al. Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling. PLoS Pathog. 2010;6:e1000847 pubmed publisher
    ..Our study introduces a potential mechanism for thrombocytopenia in VHF and other diseases associated with increased bone marrow type I IFN levels...
  8. Demers C, Chaturvedi C, Ranish J, Juban G, Lai P, Morle F, et al. Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus. Mol Cell. 2007;27:573-84 pubmed
  9. Fu Y, Yu J, Ding X, Han J. Effects of acupuncture on expressions of the transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mice. J Tradit Chin Med. 2009;29:54-9 pubmed

More Information


  1. Mahajan M, Karmakar S, Newburger P, Krause D, Weissman S. Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture. Exp Hematol. 2009;37:1143-1156.e3 pubmed publisher
  2. Steiner L, Maksimova Y, Schulz V, Wong C, Raha D, Mahajan M, et al. Chromatin architecture and transcription factor binding regulate expression of erythrocyte membrane protein genes. Mol Cell Biol. 2009;29:5399-412 pubmed publisher
  3. Harikumar K, Kuttan G, Kuttan R. Inhibition of viral carcinogenesis by Phyllanthus amarus. Integr Cancer Ther. 2009;8:254-60 pubmed publisher
    ..P.amarus is known to inhibit chemically induced neoplasm in different rodent models.The current results indicate that P.amarus has the ability to suppress virally induced cancers as well...
  4. Chaturvedi C, Hosey A, Palii C, Perez Iratxeta C, Nakatani Y, Ranish J, et al. Dual role for the methyltransferase G9a in the maintenance of beta-globin gene transcription in adult erythroid cells. Proc Natl Acad Sci U S A. 2009;106:18303-8 pubmed publisher
    ..Collectively, these results reveal a dual role for G9a in maintaining proper expression (both repression and activation) of the beta-globin genes in differentiating adult erythroid cells...
  5. Zhou Z, Li X, Deng C, Ney P, Huang S, BUNGERT J. USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. J Biol Chem. 2010;285:15894-905 pubmed publisher
    ..The data provide mechanistic insight into how ubiquitous and tissue-restricted transcription factors cooperate to regulate the recruitment and activity of transcription complexes in a tissue-specific chromatin domain. ..
  6. Wang W, Schwemmers S, Hexner E, Pahl H. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood. 2010;116:254-66 pubmed publisher
    ..Our data identify NF-E2 as a novel AML1 target gene and delineate a role for aberrant AML1 expression in mediating elevated NF-E2 expression in MPN patients...