nf e2 transcription factor


Summary: A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.

Top Publications

  1. Buckley D, Klaassen C. Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fac. Drug Metab Dispos. 2009;37:847-56 pubmed publisher
    ..In conclusion, chemical activation of AhR, CAR, PXR, PPARalpha, and Nrf2 in mouse results in induction of distinct Ugt gene sets in liver and intestine, predominantly the Ugt1a isoforms. ..
  2. Shih P, Chan Y, Liao J, Wang M, Yen G. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. J Nutr Biochem. 2010;21:598-605 pubmed publisher
    ..Overall, supplementation of ME might be advantageous to the induction of an antioxidant defense system and for the improvement of memory deterioration in ageing animals. ..
  3. Mutschler M, Magin A, Buerge M, Roelz R, Schanne D, Will B, et al. NF-E2 overexpression delays erythroid maturation and increases erythrocyte production. Br J Haematol. 2009;146:203-17 pubmed publisher
    ..These data propose a role for NF-E2 in mediating the erythrocytosis of PV. ..
  4. Gurusamy N, Lekli I, Ahsan M, Ray D, Mukherjee S, Mascareno E, et al. Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors. FEBS Lett. 2010;584:187-93 pubmed publisher
    ..Our results suggest that drugs designed to down regulate CLP-1 could confer cardioprotection through the potentiation of redox cycling. ..
  5. Fu J, Woods C, Yehuda Shnaidman E, Zhang Q, Wong V, Collins S, et al. Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. Environ Health Perspect. 2010;118:864-70 pubmed publisher
    ..Our studies suggest that low levels of arsenic provoke a cellular adaptive oxidative stress response that increases antioxidant levels, dampens ROS signaling involved in GSIS, and thus disturbs beta-cell function. ..
  6. Ilieva E, Naudi A, Kichev A, Ferrer I, Pamplona R, Portero Otin M. Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease. Free Radic Biol Med. 2010;48:1302-10 pubmed publisher
    ..We suggest this was caused by complete and specific depletion of Grp78/BiP, contributing to the pathophysiology of this neurodegenerative disease. ..
  7. Ohashi K, Takizawa F, Tokumaru N, Nakayasu C, Toda H, Fischer U, et al. A molecule in teleost fish, related with human MHC-encoded G6F, has a cytoplasmic tail with ITAM and marks the surface of thrombocytes and in some fishes also of erythrocytes. Immunogenetics. 2010;62:543-59 pubmed publisher
    ..The ITAM-bearing of G6F-like suggests that the molecule plays an important role in cell activation, and G6F-like expression by erythrocytes suggests that these cells have functional overlap potential with thrombocytes...