large maf transcription factors


Summary: A family of high molecular weight Maf transcription factors that contain distinct activation domains.

Top Publications

  1. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner Weir S, et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006;293:526-39 pubmed
    ..Thus, this redundancy in the function and expression of the large-Maf factors may explain the normal islet morphology observed in the MafA knockout mice at birth. ..
  2. Harmon J, Bogdani M, Parazzoli S, Mak S, Oseid E, Berghmans M, et al. beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology. 2009;150:4855-62 pubmed publisher
    ..These studies demonstrate that enhancement of intrinsic antioxidant defenses of the beta-cell protects it against deterioration during hyperglycemia...
  3. Kaneto H, Matsuoka T, Kawashima S, Yamamoto K, Kato K, Miyatsuka T, et al. Role of MafA in pancreatic beta-cells. Adv Drug Deliv Rev. 2009;61:489-96 pubmed publisher
    ..These results suggest that MafA plays a crucial role in pancreatic beta-cells and could be a novel therapeutic target for diabetes. ..
  4. Takeuchi T, Kudo T, Ogata K, Hamada M, Nakamura M, Kito K, et al. Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes Cells. 2009;14:941-7 pubmed publisher
    ..These results indicate that c-Maf alone is essential for lens development, and that MafA/L-Maf and MafB are dispensable in mice. ..
  5. Tsuchiya M, Maeda A, Suzuki A, Yasuda K, Yoshida T, Nitta K, et al. Suppression of MafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells. Int J Mol Med. 2009;23:725-32 pubmed
    ..Expression of the genes encoding the adipocytokines, adiponectin and adipsin was also suppressed. The results suggested a possible role of the transcriptional factor MafA in regulation of adipocyte function and differentiation. ..
  6. Du A, Hunter C, Murray J, Noble D, Cai C, Evans S, et al. Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009;58:2059-69 pubmed publisher
    ..These results demonstrate the requirement for Isl-1 in the maturation, proliferation, and survival of the second wave of hormone-producing islet cells. ..
  7. Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, et al. MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes. 2010;59:2530-9 pubmed publisher
    ..Our results provide insight into the sequential manner by which MafA and MafB regulate islet ?-cell formation and maturation. ..
  8. Saito K, Inagaki S, Mituyama T, Kawamura Y, Ono Y, Sakota E, et al. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila. Nature. 2009;461:1296-9 pubmed publisher
    ..Thus, in gonadal somatic cells, tj gives rise simultaneously to two different molecules: the TJ protein, which activates Piwi expression, and piRNAs, which define the Piwi targets for silencing. ..
  9. Kondo T, El Khattabi I, Nishimura W, Laybutt D, Geraldes P, Shah S, et al. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009;23:1281-90 pubmed publisher
    ..Therefore, preventing p38 MAPK-mediated degradation of MafA represents a novel approach to improve beta-cell function. ..

More Information


  1. Lazo de la Vega Monroy M, Fernandez Mejia C. [Transcription factors in the adult beta cell]. Rev Invest Clin. 2009;61:428-46 pubmed
    ..The study of transcription factors is crucial for understanding the normal function of the beta cell, essential knowledge in developing new strategies for fighting diabetes. ..
  2. Nishimura W, Bonner Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009;333:108-20 pubmed publisher
    ..These findings imply that MafA should be used to enhance maturation, rather than specification, of beta-cells from stem/progenitor cells. ..
  3. Noso S, Kataoka K, Kawabata Y, Babaya N, Hiromine Y, Yamaji K, et al. Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes. Diabetes. 2010;59:2579-87 pubmed publisher
    ..These data indicate that functional polymorphisms of MafA are associated with reduced expression of insulin in the thymus and susceptibility to type 1 diabetes in the NOD mouse as well as human type 1 diabetes. ..
  4. Raum J, Hunter C, Artner I, Henderson E, Guo M, Elghazi L, et al. Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol. 2010;30:4234-44 pubmed publisher
    ..These data highlight the nature of the cis- and trans-acting factors controlling the beta-cell-specific expression of MafA. ..
  5. Matsuoka T, Kaneto H, Miyatsuka T, Yamamoto T, Yamamoto K, Kato K, et al. Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes. Diabetes. 2010;59:1709-20 pubmed publisher
    ..It is likely that the augmented expression of c-Jun in diabetic islets decreases MafA expression and thereby reduces insulin biosynthesis, which is often observed in type 2 diabetes. ..
  6. Lecoin L, Rocques N, El Yakoubi W, Ben Achour S, Larcher M, Pouponnot C, et al. MafA transcription factor identifies the early ret-expressing sensory neurons. Dev Neurobiol. 2010;70:485-97 pubmed publisher
    ..This marker will allow further functional characterization of these neurons. ..
  7. Guo S, Vanderford N, Stein R. Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding. J Biol Chem. 2010;285:12655-61 pubmed publisher
    ..These results demonstrate a novel relationship between the phosphoamino acid-rich transactivation and b-Zip domains in controlling MafA DNA-binding activity. ..
  8. Shimohata H, Yoh K, Fujita A, Morito N, Ojima M, Tanaka H, et al. MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy. Biochem Biophys Res Commun. 2009;389:235-40 pubmed publisher
    ..MafA(-/-)MafK(+) mice might be a useful model for the analysis of human diabetic nephropathy. ..
  9. Kaneto H, Matsuoka T, Katakami N, Matsuhisa M. Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells. Curr Med Chem. 2009;16:3144-51 pubmed
    ..The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-beta-cells and thereby is a useful tool to efficiently induce insulin-producing surrogate beta-cells. ..
  10. Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, et al. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009;64:857-70 pubmed publisher
    ..Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs. ..
  11. Robine N, Lau N, Balla S, Jin Z, Okamura K, Kuramochi Miyagawa S, et al. A broadly conserved pathway generates 3'UTR-directed primary piRNAs. Curr Biol. 2009;19:2066-76 pubmed publisher
    ..These findings strongly increase the breadth of Argonaute-mediated small RNA systems in metazoans. ..
  12. Otting N, Doxiadis G, Bontrop R. Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis). Immunogenetics. 2009;61:745-53 pubmed publisher
    ..Furthermore, the discovery of 53 unreported Mafa-B sequences expands the lexicon of alleles significantly, and may help in understanding the complex organisation of the macaque B region. ..
  13. Wilson L, Wong S, Yu N, Geras Raaka E, Raaka B, Gershengorn M. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells. 2009;27:2703-11 pubmed publisher
    ..We conclude that the INS gene in hIPCs is modified epigenetically ("silenced") so that it is resistant to activation by transcription factors. ..