fos related antigen 2


Summary: A basic-leucine zipper transcription factor that is closely related to C-FOS PROTEINS. It forms heterodimeric complexes with C-JUN PROTEINS to regulate GENE transcription.

Top Publications

  1. Palkovits M, Gallatz K, Boor P, Sebekova K, Klassen A, Bahner U, et al. Neuronal activation in the CNS during different forms of acute renal failure in rats. Neuroscience. 2009;159:862-82 pubmed publisher
    ..Data presented here indicate that a wide variety of neurons in several regulatory mechanisms is affected by ARF-induced peripheral and central alterations. ..
  2. Mathas S, Kreher S, Meaburn K, Johrens K, Lamprecht B, Assaf C, et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:5831-6 pubmed publisher
    ..Also, our data demonstrate that deregulation of breakpoint-proximal genes has a key role in ALCL. ..
  3. Hu D, Mackenzie P. Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells. Mol Pharmacol. 2009;76:425-39 pubmed publisher
    ..Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. ..
  4. Hein S, Mahner S, Kanowski C, Löning T, Janicke F, Milde Langosch K. Expression of Jun and Fos proteins in ovarian tumors of different malignant potential and in ovarian cancer cell lines. Oncol Rep. 2009;22:177-83 pubmed
    ..No correlation with the proliferative and invasive potential of ovarian cancer cell lines could be found. ..
  5. Kim M, Shim K, Kim S. Inhibitory effect of cantharidin on osteoclast differentiation and bone resorption. Arch Pharm Res. 2010;33:457-62 pubmed publisher
  6. Trojanowska M. Cellular and molecular aspects of vascular dysfunction in systemic sclerosis. Nat Rev Rheumatol. 2010;6:453-60 pubmed publisher
    ..An improved knowledge of the molecular and cellular pathways that contribute to SSc vasculopathy could help in the design of effective therapies in the future. ..
  7. Lawson V, Maurice D, Silk J, Cerundolo V, Weston K. Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2. J Immunol. 2009;183:2575-84 pubmed publisher
    ..Taken together, these data define Fra-2 as necessary for regulation of normal iNKT cell development and function, and they demonstrate the central role played by the AP-1 family in this lineage. ..
  8. Maurer B, Busch N, Jungel A, Pileckyte M, Gay R, Michel B, et al. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. Circulation. 2009;120:2367-76 pubmed publisher
    ..Fra-2 transgenic mice are a promising preclinical model to study the mechanisms and therapeutic approaches of the peripheral vasculopathy in systemic sclerosis. ..
  9. Reich N, Maurer B, Akhmetshina A, Venalis P, Dees C, Zerr P, et al. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. Arthritis Rheum. 2010;62:280-90 pubmed publisher
    ..Since transgenic overexpression of Fra-2 causes not only fibrosis but also vascular disease, Fra-2 might be an interesting novel candidate for molecular-targeted therapies for SSc. ..

More Information


  1. Beauvais G, Jayanthi S, McCoy M, Ladenheim B, Cadet J. Differential effects of methamphetamine and SCH23390 on the expression of members of IEG families of transcription factors in the rat striatum. Brain Res. 2010;1318:1-10 pubmed publisher
    ..The SCH23390-mediated suppression of basal fra-1, egr-1, and egr-2 mRNA levels suggests that their basal expression in the striatum might be dependent on tonic stimulation of the DA D1 receptor. ..
  2. Schröder C, Schumacher U, Muller V, Wirtz R, Streichert T, Richter U, et al. The transcription factor Fra-2 promotes mammary tumour progression by changing the adhesive properties of breast cancer cells. Eur J Cancer. 2010;46:1650-60 pubmed publisher
  3. Roy S, Khanna S, Azad A, Schnitt R, He G, Weigert C, et al. Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. Cardiovasc Res. 2010;87:647-55 pubmed publisher
  4. Li X, Wang Z, Yang L, Li Z, Ogata Y. Endothelin-1 regulates rat bone sialoprotein gene transcription. J Oral Sci. 2010;52:221-9 pubmed
    ..These findings indicate that ET-1 increases BSP transcription via the CRE, FRE and HOX sites in the rat BSP gene promoter. ..
  5. Bolat I, Keklikoglu N. Immunoreactivity of ATF-2 and Fra-2 in human dental follicle. Folia Histochem Cytobiol. 2010;48:197-201 pubmed publisher
    ..Besides, finding that ATF-2-IR and Fra-2-IR are different in CC although similar in EC shows that AP-1 members can be expressed at different ratios in same tissues. ..
  6. Bozec A, Bakiri L, Jimenez M, Schinke T, Amling M, Wagner E. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. J Cell Biol. 2010;190:1093-106 pubmed publisher
    ..These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans. ..
  7. Yatkin E, Bernoulli J, Talvitie E, Santti R. Inflammation and epithelial alterations in rat prostate: impact of the androgen to oestrogen ratio. Int J Androl. 2009;32:399-410 pubmed publisher
    ..The androgen-resistant endpoints of oestrogen action (body weight reduction and hyperplasia of seminal vesicle ducts) further indicate limitations in the possible preventive effects of androgen-replacement therapy. ..