Genomes and Genes
fos related antigen 2
Summary: A basic-leucine zipper transcription factor that is closely related to C-FOS PROTEINS. It forms heterodimeric complexes with C-JUN PROTEINS to regulate GENE transcription.
- Beauvais G, Jayanthi S, McCoy M, Ladenheim B, Cadet J. Differential effects of methamphetamine and SCH23390 on the expression of members of IEG families of transcription factors in the rat striatum. Brain Res. 2010;1318:1-10 pubmed publisher..The SCH23390-mediated suppression of basal fra-1, egr-1, and egr-2 mRNA levels suggests that their basal expression in the striatum might be dependent on tonic stimulation of the DA D1 receptor. ..
- Li X, Wang Z, Yang L, Li Z, Ogata Y. Endothelin-1 regulates rat bone sialoprotein gene transcription. J Oral Sci. 2010;52:221-9 pubmed..These findings indicate that ET-1 increases BSP transcription via the CRE, FRE and HOX sites in the rat BSP gene promoter. ..
- Bolat I, Keklikoglu N. Immunoreactivity of ATF-2 and Fra-2 in human dental follicle. Folia Histochem Cytobiol. 2010;48:197-201 pubmed publisher..Besides, finding that ATF-2-IR and Fra-2-IR are different in CC although similar in EC shows that AP-1 members can be expressed at different ratios in same tissues. ..
- Bozec A, Bakiri L, Jimenez M, Schinke T, Amling M, Wagner E. Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production. J Cell Biol. 2010;190:1093-106 pubmed publisher..These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans. ..
- Yatkin E, Bernoulli J, Talvitie E, Santti R. Inflammation and epithelial alterations in rat prostate: impact of the androgen to oestrogen ratio. Int J Androl. 2009;32:399-410 pubmed publisher..The androgen-resistant endpoints of oestrogen action (body weight reduction and hyperplasia of seminal vesicle ducts) further indicate limitations in the possible preventive effects of androgen-replacement therapy. ..