Summary: A family of GTP-binding proteins that were initially identified in YEASTS where they were shown to initiate the process of septation and bud formation. Septins form into hetero-oligomeric complexes that are comprised of several distinct septin subunits. These complexes can act as cytoskeletal elements that play important roles in CYTOKINESIS, cytoskeletal reorganization, BIOLOGICAL TRANSPORT, and membrane dynamics.

Top Publications

  1. Connolly D, Hoang H, Adler E, Tazearslan C, Simmons N, Bernard V, et al. Septin 9 amplification and isoform-specific expression in peritumoral and tumor breast tissue. Biol Chem. 2014;395:157-67 pubmed publisher
    b>Septins are a large family of GTP-binding proteins abnormally expressed in many solid tumors...
  2. Pinto A, Pereira H, Zeraik A, Ciol H, Ferreira F, Brandao Neto J, et al. Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii. J Biol Chem. 2017;292:10899-10911 pubmed publisher
    b>Septins are filament-forming GTP-binding proteins involved in many essential cellular events related to cytoskeletal dynamics and maintenance...
  3. Zhang N, Zhang Y, Zhao S, Sun Y. Septin4 as a novel binding partner of PARP1 contributes to oxidative stress induced human umbilical vein endothelial cells injure. Biochem Biophys Res Commun. 2018;496:621-627 pubmed publisher
    ..In conclusions, our founding indicates that Septin4 is a novel essential factor involved in oxidative stress induced vascular endothelial cell injury by interacting with apoptosis-related protein PARP1. ..
  4. Lindsey J. Antibodies to the Epstein-Barr virus proteins BFRF3 and BRRF2 cross-react with human proteins. J Neuroimmunol. 2017;310:131-134 pubmed publisher
    ..Using Western blots and ELISA, we demonstrated that MS patients were more likely to have high levels of antibodies to one or another of these self antigens. ..
  5. Mazon Moya M, Willis A, Torraca V, Boucontet L, Shenoy A, Colucci Guyon E, et al. Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLoS Pathog. 2017;13:e1006467 pubmed publisher
    ..b>Septins, highly conserved cytoskeletal proteins, have emerged as key players in innate immunity to bacterial infection, ..
  6. Lu H, Galeano M, Ott E, Kaeslin G, Kausalya P, Kramer C, et al. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Nat Genet. 2017;49:1025-1034 pubmed publisher
    ..Together, these data provide what is, to our knowledge, the first conclusive evidence that ARPKD is not a homogeneous disorder and further establish DZIP1L as a second gene involved in ARPKD pathogenesis. ..
  7. Beise N, Trimble W. Septins at a glance. J Cell Sci. 2011;124:4141-6 pubmed publisher
  8. Patasi C, Godočíková J, Michlíková S, Nie Y, Káčeriková R, Kválová K, et al. The role of Bni5 in the regulation of septin higher-order structure formation. Biol Chem. 2015;396:1325-37 pubmed publisher
    b>Septins are a family of conserved cytoskeletal proteins playing an essential role in cytokinesis and in many other cellular processes in fungi and animals...
  9. Bai X, Bowen J, Knox T, Zhou K, Pendziwiat M, Kuhlenbäumer G, et al. Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules. J Cell Biol. 2013;203:895-905 pubmed
    ..Thus, the SEPT9 repeat motifs bind and bundle MTs, and thereby promote asymmetric neurite growth. These results provide the first insight into the mechanism of septin interaction with MTs and the molecular and cellular basis of HNA. ..

More Information


  1. Cabezas Cruz A, Alberdi P, Valdes J, Villar M, De La Fuente J. Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum. Front Biosci (Landmark Ed). 2017;22:1830-1844 pubmed
    ..scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor ..
  2. Toriyama M, Toriyama M, Wallingford J, Finnell R. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J. 2017;31:3622-3635 pubmed publisher
    ..Toriyama, M., Toriyama, M., Wallingford, J. B., Finnell, R. H. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
  3. Schrock A, Leisse A, de Vos L, Gevensleben H, Dröge F, Franzen A, et al. Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study. Clin Chem. 2017;63:1288-1296 pubmed publisher
    ..The early detection of a recurrent/metastatic disease or a second malignancy could lead to an earlier consecutive treatment, thereby improving patients' outcomes. ..
  4. Rex D, Boland C, Dominitz J, Giardiello F, Johnson D, Kaltenbach T, et al. Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2017;153:307-323 pubmed publisher
    ..Persons with a single first-degree relative diagnosed at ≥60 years with CRC or an advanced adenoma can be offered average-risk screening options beginning at age 40 years. ..
  5. Zent E, Wittinghofer A. Human septin isoforms and the GDP-GTP cycle. Biol Chem. 2014;395:169-80 pubmed publisher
    b>Septins form oligomeric complexes consisting of septins from different subgroups, which form filaments that are involved in a number of biological processes...
  6. Boubakar L, Falk J, Ducuing H, Thoinet K, Reynaud F, Derrington E, et al. Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance. Neuron. 2017;95:834-851.e5 pubmed publisher
    ..Monitoring the dynamics of Septins, which play key roles in yeast polarity, indicates that Septin 7 tags process sites for re-initiation of process ..
  7. Dolat L, Hu Q, Spiliotis E. Septin functions in organ system physiology and pathology. Biol Chem. 2014;395:123-41 pubmed publisher
    Human septins comprise a family of 13 genes that encode for >30 protein isoforms with ubiquitous and tissue-specific expressions...
  8. Fliegauf M, Kahle A, Haffner K, Zieger B. Distinct localization of septin proteins to ciliary sub-compartments in airway epithelial cells. Biol Chem. 2014;395:151-6 pubmed
    ..In addition to cytoplasmic localization we found that septins are either enriched at the apical cell cortex including the ciliary bases (septin-2, -4, -6, and -7), or show ..
  9. Mahmud M, Oda M, Usui D, Inoshima Y, Ishiguro N, Kamatari Y. A multispecific monoclonal antibody G2 recognizes at least three completely different epitope sequences with high affinity. Protein Sci. 2017;26:2162-2169 pubmed publisher