plectin

Summary

Summary: A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and ACTIN CYTOSKELETON and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.

Top Publications

  1. Herrmann H, Wiche G. Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. J Biol Chem. 1987;262:1320-5 pubmed
    Structural and functional characteristics of plectin from intermediate filament preparations of rat glioma C6 cells were compared to those of the intermediate filament-associated protein of Mr = 300,000 (IFAP-300K) of baby hamster kidney ..
  2. Skalli O, Jones J, Gagescu R, Goldman R. IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions. J Cell Biol. 1994;125:159-70 pubmed
    ..One possible exception is plectin, a protein that has been suggested to be very similar to IFAP 300...
  3. Lunter P, Wiche G. Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity. Biochem Biophys Res Commun. 2002;296:904-10 pubmed
    b>Plectin is a cyoskeletal linker protein that protects tissues against mechanical stress. We report here that the N-terminal domain of the nonreceptor tyrosine kinase Fer interacts with N-terminal sequences of plectin...
  4. Osmanagic Myers S, Wiche G. Plectin-RACK1 (receptor for activated C kinase 1) scaffolding: a novel mechanism to regulate protein kinase C activity. J Biol Chem. 2004;279:18701-10 pubmed
    ..of receptor for activated C kinase 1 (RACK1) to the cytoskeleton through the cytoskeletal linker protein plectin during the initial stages of cell adhesion...
  5. Schmidt T, Karsunky H, Frass B, Baum W, Denzel A, Moroy T. A novel protein (Fbf-1) that binds to CD95/APO-1/FAS and shows sequence similarity to trichohyalin and plectin. Biochim Biophys Acta. 2000;1493:249-54 pubmed
    ..In addition, it shows sequence similarity to trichohyalin and plectin pointing to a function as a structural protein.
  6. Selcen D, Juel V, Hobson Webb L, Smith E, Stickler D, Bite A, et al. Myasthenic syndrome caused by plectinopathy. Neurology. 2011;76:327-36 pubmed publisher
    b>Plectin crosslinks intermediate filaments to their targets in different tissues. Defects in plectin cause epidermolysis bullosa simplex (EBS), muscular dystrophy (MD), and sometimes pyloric atresia...
  7. Schroder R, Fürst D, Klasen C, Reimann J, Herrmann H, van der Ven P. Association of plectin with Z-discs is a prerequisite for the formation of the intermyofibrillar desmin cytoskeleton. Lab Invest. 2000;80:455-64 pubmed
    b>Plectin is a high-molecular mass protein (approximately 500 kd) that binds actin, intermediate filaments, and microtubules. Mutations of the plectin gene cause a generalized blistering skin disorder and muscular dystrophy...
  8. Walko G, Vukasinovic N, Gross K, Fischer I, Sibitz S, Fuchs P, et al. Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet. 2011;7:e1002396 pubmed publisher
    Autosomal recessive mutations in the cytolinker protein plectin account for the multisystem disorders epidermolysis bullosa simplex (EBS) associated with muscular dystrophy (EBS-MD), pyloric atresia (EBS-PA), and congenital myasthenia (..
  9. Pfendner E, Uitto J. Plectin gene mutations can cause epidermolysis bullosa with pyloric atresia. J Invest Dermatol. 2005;124:111-5 pubmed
    ..followed by heteroduplex scanning and/or direct nucleotide sequencing revealed homozygous mutations in the plectin gene (PLEC1), encoding another hemidesmosomal protein previously linked to EB with muscular dystrophy...

More Information

Publications62

  1. Ortega E, Buey R, Sonnenberg A, de Pereda J. The structure of the plakin domain of plectin reveals a non-canonical SH3 domain interacting with its fourth spectrin repeat. J Biol Chem. 2011;286:12429-38 pubmed publisher
    b>Plectin belongs to the plakin family of cytoskeletal crosslinkers, which is part of the spectrin superfamily...
  2. Castañón M, Walko G, Winter L, Wiche G. Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve. Histochem Cell Biol. 2013;140:33-53 pubmed publisher
    b>Plectin is a large, 500-kDa, intermediate filament (IF)-associated protein. It acts as a cytoskeletal crosslinker and signaling scaffold, affecting mechanical as well as dynamic properties of the cytoskeleton...
  3. Takawira D, Budinger G, Hopkinson S, Jones J. A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells. J Biol Chem. 2011;286:6301-10 pubmed publisher
    ..We tested the hypothesis that the cytoskeleton cross-linker plectin, known to bind both DG and AMPK in muscle cells, acts as a scaffold to regulate DG-mediated mechanical ..
  4. Foisner R, Malecz N, Dressel N, Stadler C, Wiche G. M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase. Mol Biol Cell. 1996;7:273-88 pubmed
    b>Plectin, a widespread and abundant cytoskeletal cross-linking protein, serves as a target for protein kinases throughout the cell cycle, without any significant variation in overall phosphorylation level...
  5. Tang H, Chaffotte A, Thacher S. Structural analysis of the predicted coiled-coil rod domain of the cytoplasmic bullous pemphigoid antigen (BPAG1). Empirical localization of the N-terminal globular domain-rod boundary. J Biol Chem. 1996;271:9716-22 pubmed
    ..BPAG1 structural organization is similar to the intermediate filament-associated proteins desmoplakin I (DPI) and plectin. All three proteins have predicted dumbbell-like structure with central alpha-helical coiled-coil rod and regions ..
  6. Errante L, Wiche G, Shaw G. Distribution of plectin, an intermediate filament-associated protein, in the adult rat central nervous system. J Neurosci Res. 1994;37:515-28 pubmed
    b>Plectin is a high molecular weight protein originally identified and characterized as a major cytoskeletal component of the C6 rat glioma cell...
  7. Schroder R, Kunz W, Rouan F, Pfendner E, Tolksdorf K, Kappes Horn K, et al. Disorganization of the desmin cytoskeleton and mitochondrial dysfunction in plectin-related epidermolysis bullosa simplex with muscular dystrophy. J Neuropathol Exp Neurol. 2002;61:520-30 pubmed
    Mutations of the human plectin gene (Plec1) cause autosomal recessive epidermolysis bullosa simplex with muscular dystrophy (EBS-MD). Here, we report on molecular mechanisms leading to severe dystrophic muscle alterations in EBS-MD...
  8. Sawamura D, Goto M, Sakai K, Nakamura H, McMillan J, Akiyama M, et al. Possible involvement of exon 31 alternative splicing in phenotype and severity of epidermolysis bullosa caused by mutations in PLEC1. J Invest Dermatol. 2007;127:1537-40 pubmed
  9. Schroder R, Pacholsky D, Reimann J, Matten J, Wiche G, Furst D, et al. Primary longitudinal adhesion structures: plectin-containing precursors of costameres in differentiating human skeletal muscle cells. Histochem Cell Biol. 2002;118:301-10 pubmed
    b>Plectin is a high molecular mass protein (ca 530 kDa) that binds actin, intermediate filaments, and microtubules. Mutations of the human plectin gene cause epidermolysis bullosa simplex with muscular dystrophy...
  10. Koster J, Geerts D, Favre B, Borradori L, Sonnenberg A. Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci. 2003;116:387-99 pubmed
    ..The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only to BP230, but also to plectin. The interactions between these proteins are facilitated by the Y subdomain in the N-terminal plakin domain of ..
  11. Litjens S, Koster J, Kuikman I, van Wilpe S, de Pereda J, Sonnenberg A. Specificity of binding of the plectin actin-binding domain to beta4 integrin. Mol Biol Cell. 2003;14:4039-50 pubmed
    b>Plectin is a major component of the cytoskeleton and links the intermediate filament system to hemidesmosomes by binding to the integrin beta4 subunit...
  12. Pfendner E, Rouan F, Uitto J. Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations. Exp Dermatol. 2005;14:241-9 pubmed
    b>Plectin, a large multidomain adhesive protein with versatile binding functions, is expressed in a number of tissues and cell types...
  13. Ozawa T, Tsuruta D, Jones J, Ishii M, Ikeda K, Harada T, et al. Dynamic relationship of focal contacts and hemidesmosome protein complexes in live cells. J Invest Dermatol. 2010;130:1624-35 pubmed publisher
    ..In summary, we suggest that HPCs and FCs dynamics are tightly co-regulated in keratinocytes undergoing migration during wound healing...
  14. de Pereda J, Lillo M, Sonnenberg A. Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes. EMBO J. 2009;28:1180-90 pubmed publisher
    The interaction between the integrin alpha6beta4 and plectin is essential for the assembly and stability of hemidesmosomes, which are junctional adhesion complexes that anchor epithelial cells to the basement membrane...
  15. Bausch D, Mino Kenudson M, Fernandez del Castillo C, Warshaw A, Kelly K, Thayer S. Plectin-1 is a biomarker of malignant pancreatic intraductal papillary mucinous neoplasms. J Gastrointest Surg. 2009;13:1948-54; discussion 1954 pubmed publisher
    ..One such promising novel biomarker is Plectin-1 (Plec-1)...
  16. Foisner R, Feldman B, Sander L, Wiche G. Monoclonal antibody mapping of structural and functional plectin epitopes. J Cell Biol. 1991;112:397-405 pubmed
    To map structural and functional epitopes of the cytomatrix protein plectin, a set of mAbs was prepared by immunization of mice...
  17. Geerts D, Fontao L, Nievers M, Schaapveld R, Purkis P, Wheeler G, et al. Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol. 1999;147:417-34 pubmed
    ..We have investigated the recruitment of plectin into hemidesmosomes by the alpha6beta4 integrin and have shown that the cytoplasmic domain of the beta4 subunit ..
  18. Koster J, Kuikman I, Kreft M, Sonnenberg A. Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin. J Invest Dermatol. 2001;117:1405-11 pubmed
    ..Previous work has shown that the recruitment of plectin into hemidesmosomes is dependent on beta 4 and involves a region of the beta 4 cytoplasmic domain, which contains ..
  19. Sun D, Leung C, Liem R. Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins. J Cell Sci. 2001;114:161-172 pubmed
    ..b>Plectin and desmoplakin have GSR-containing domains at their C-termini and we further demonstrate that the GSR-containing ..
  20. Stegh A, Herrmann H, Lampel S, Weisenberger D, Andra K, Seper M, et al. Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis. Mol Cell Biol. 2000;20:5665-79 pubmed
    ..After induction of apoptosis through CD95 or tumor necrosis factor receptor I, active caspase 8 translocated to plectin, a major cross-linking protein of the three main cytoplasmic filament systems, whereas the caspase 8 prodomain ..
  21. Wiche G, Becker B, Luber K, Weitzer G, Castanon M, Hauptmann R, et al. Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil. J Cell Biol. 1991;114:83-99 pubmed
    We have determined the complete cDNA sequence of rat plectin from a number of well-characterized overlapping lambda gt11 clones...
  22. Andrä K, Kornacker I, Jörgl A, Zörer M, Spazierer D, Fuchs P, et al. Plectin-isoform-specific rescue of hemidesmosomal defects in plectin (-/-) keratinocytes. J Invest Dermatol. 2003;120:189-97 pubmed
    The various plectin isoforms are among the major crosslinking elements of the cytoskeleton. The importance of plectin in epithelia is convincingly supported by the severe skin blistering observed in plectin-deficient humans and mice...
  23. Kostan J, Gregor M, Walko G, Wiche G. Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin. J Biol Chem. 2009;284:18525-36 pubmed publisher
    ..Integrin alpha6beta4-plectin interaction plays a major role in the formation of hemidesmosomes, and thus the mechanisms regulating this ..
  24. Nikolic B, Mac Nulty E, Mir B, Wiche G. Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. J Cell Biol. 1996;134:1455-67 pubmed
    We have generated a series of plectin deletion and mutagenized cDNA constructs to dissect the functional sequences that mediate plectin's interaction with intermediate filament (IF) networks, and scored their ability to coalign or ..
  25. French K, Pollitt C. Equine laminitis: congenital, hemidesmosomal plectin deficiency in a Quarter Horse foal. Equine Vet J. 2004;36:299-303 pubmed
  26. Mellerio J, Smith F, McMillan J, McLean W, McGrath J, Morrison G, et al. Recessive epidermolysis bullosa simplex associated with plectin mutations: infantile respiratory complications in two unrelated cases. Br J Dermatol. 1997;137:898-906 pubmed
    b>Plectin is a 500 kDa protein involved in cytoskeleton-plasma membrane attachment with a wide tissue distribution including cutaneous and airway epithelia, muscle and neuronal tissue...
  27. Lie A, Schroder R, Blumcke I, Magin T, Wiestler O, Elger C. Plectin in the human central nervous system: predominant expression at pia/glia and endothelia/glia interfaces. Acta Neuropathol. 1998;96:215-21 pubmed
    b>Plectin is a high molecular weight protein that serves as a versatile cytoskeletal cross-linker molecule...
  28. Hijikata T, Nakamura A, Isokawa K, Imamura M, Yuasa K, Ishikawa R, et al. Plectin 1 links intermediate filaments to costameric sarcolemma through beta-synemin, alpha-dystrobrevin and actin. J Cell Sci. 2008;121:2062-74 pubmed publisher
    ..Although there is emerging evidence that plectin links IFs to costameres through dystrophin-glycoprotein complexes (DGC), the molecular organization from plectin ..
  29. Konieczny P, Fuchs P, Reipert S, Kunz W, Zeöld A, Fischer I, et al. Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms. J Cell Biol. 2008;181:667-81 pubmed publisher
    Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy...
  30. Spurny R, Abdoulrahman K, Janda L, Rünzler D, Köhler G, Castañón M, et al. Oxidation and nitrosylation of cysteines proximal to the intermediate filament (IF)-binding site of plectin: effects on structure and vimentin binding and involvement in IF collapse. J Biol Chem. 2007;282:8175-87 pubmed
    As an intermediate filament (IF)-based cytolinker protein, plectin plays a key role in the maintenance of cellular cytoarchitecture and serves at the same time as a scaffolding platform for signaling cascades...
  31. Tian R, Gregor M, Wiche G, Goldman J. Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease. Am J Pathol. 2006;168:888-97 pubmed
    ..Here, we describe the expression of the cytoskeletal linker protein plectin in the AxD brain...
  32. Fujiwara S, Kohno K, Iwamatsu A, Naito I, Shinkai H. Identification of a 450-kDa human epidermal autoantigen as a new member of the plectin family. J Invest Dermatol. 1996;106:1125-30 pubmed
    ..cDNAs were isolated, and their deduced amino acid sequences indicated that the encoded proteins belonged to the plectin family...
  33. Nakamura H, Sawamura D, Goto M, Nakamura H, McMillan J, Park S, et al. Epidermolysis bullosa simplex associated with pyloric atresia is a novel clinical subtype caused by mutations in the plectin gene (PLEC1). J Mol Diagn. 2005;7:28-35 pubmed
    ..Mutations in the plectin gene (PLEC1) cause EBS associated with muscular dystrophy, whereas JEB associated with pyloric atresia (PA) ..
  34. Rezniczek G, Janda L, Wiche G. Plectin. Methods Cell Biol. 2004;78:721-55 pubmed
  35. Reipert S, Steinböck F, Fischer I, Bittner R, Zeöld A, Wiche G. Association of mitochondria with plectin and desmin intermediate filaments in striated muscle. Exp Cell Res. 1999;252:479-91 pubmed
    b>Plectin (M(r) > 500,000) is a versatile and widely expressed cytolinker protein. In striated muscle it is predominantly found at the Z-disc level where it colocalizes with the intermediate filament protein desmin...
  36. Okuda T, Matsuda S, Nakatsugawa S, Ichigotani Y, Iwahashi N, Takahashi M, et al. Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin. Biochem Biophys Res Commun. 1999;264:568-74 pubmed
    ..This novel gene, named as macrophin (microfilament and actin filament cross-linker protein related to plectin and dystrophin, Accession No...
  37. Hijikata T, Murakami T, Ishikawa H, Yorifuji H. Plectin tethers desmin intermediate filaments onto subsarcolemmal dense plaques containing dystrophin and vinculin. Histochem Cell Biol. 2003;119:109-23 pubmed
    b>Plectin is a versatile cytoskeletal linker protein that preferentially localizes at interfaces between intermediate filaments and the plasma membrane in muscle, epithelial cells, and other tissues...
  38. Ketema M, Kreft M, Secades P, Janssen H, Sonnenberg A. Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis. Mol Biol Cell. 2013;24:2454-66 pubmed publisher
    Nesprin-3 is a nuclear envelope protein that connects the nucleus to intermediate filaments by interacting with plectin. To investigate the role of nesprin-3 in the perinuclear localization of plectin, we generated nesprin-3-knockout ..
  39. Yu P, Babicky M, Jaquish D, French R, Marayuma K, Mose E, et al. The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. Int J Cancer. 2012;131:1744-54 pubmed publisher
    ..These studies revealed plectin, a large protein of the spectrin superfamily, to be a novel RON interactant...
  40. Favre B, Schneider Y, Lingasamy P, Bouameur J, Begre N, Gontier Y, et al. Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin. Eur J Cell Biol. 2011;90:390-400 pubmed publisher
    b>Plectin is a versatile cytolinker protein critically involved in the organization of the cytoskeletal filamentous system...
  41. Katada K, Tomonaga T, Satoh M, Matsushita K, Tonoike Y, Kodera Y, et al. Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma. J Proteomics. 2012;75:1803-15 pubmed publisher
    ..Western blotting and immunohistochemical analysis confirmed that the expression of plectin was significantly increased in most cancer tissues as compared with non-cancer tissues...
  42. Pawar H, Kashyap M, Sahasrabuddhe N, Renuse S, Harsha H, Kumar P, et al. Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery. Cancer Biol Ther. 2011;12:510-22 pubmed publisher
    ..These novel biomarker candidates included prosaposin (PSAP), plectin 1 (PLEC1) and protein disulfide isomerase A 4 (PDIA4) that were further validated to be overexpressed by ..
  43. Gundesli H, Talim B, Korkusuz P, Balci Hayta B, Cirak S, Akarsu N, et al. Mutation in exon 1f of PLEC, leading to disruption of plectin isoform 1f, causes autosomal-recessive limb-girdle muscular dystrophy. Am J Hum Genet. 2010;87:834-41 pubmed publisher
    ..1_9del mutation containing an initiation codon in exon 1f, which is an isoform-specific sequence of plectin isoform 1f...
  44. Sonnenberg A, Rojas A, de Pereda J. The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain. J Mol Biol. 2007;368:1379-91 pubmed
    b>Plectin is a large and versatile cytoskeletal linker and member of the plakin protein family. Plakins share a conserved region called the plakin domain located near their N terminus...
  45. Brown M, Hallam J, Liu Y, Yamada K, Shaw S. Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin. J Immunol. 2001;167:641-5 pubmed
    ..We demonstrate that human peripheral blood T lymphocytes express plectin, an IF-binding, cytoskeletal cross-linking protein...
  46. Steinböck F, Nikolic B, Coulombe P, Fuchs E, Traub P, Wiche G. Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain. J Cell Sci. 2000;113 ( Pt 3):483-91 pubmed
    b>Plectin, the largest and most versatile member of the cytolinker/plakin family of proteins characterized to date, has a tripartite structure comprising a central 200 nm-long (&agr;)-helical rod domain flanked by large globular ..
  47. Hijikata T, Murakami T, Imamura M, Fujimaki N, Ishikawa H. Plectin is a linker of intermediate filaments to Z-discs in skeletal muscle fibers. J Cell Sci. 1999;112 ( Pt 6):867-76 pubmed
    b>Plectin is a versatile linker protein which is associated with various types of cytoskeletal components and/or filaments including intermediate filaments, and its deficiency causes the disruption of myofibrils, or muscular dystrophy...
  48. Pulkkinen L, Smith F, Shimizu H, Murata S, Yaoita H, Hachisuka H, et al. Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy. Hum Mol Genet. 1996;5:1539-46 pubmed
    ..that tissue separation occurs intracellularly at the level of the hemidesmosomal inner plaque, which contains plectin, a high molecular weight cytoskeletal associated protein, also expressed in the sarcolemma of the muscle...
  49. McLean W, Pulkkinen L, Smith F, Rugg E, Lane E, Bullrich F, et al. Loss of plectin causes epidermolysis bullosa with muscular dystrophy: cDNA cloning and genomic organization. Genes Dev. 1996;10:1724-35 pubmed
    b>Plectin is a widely expressed high molecular weight protein that is involved in cytoskeleton-membrane attachment in epithelial cells, muscle, and other tissues...
  50. Ketema M, Wilhelmsen K, Kuikman I, Janssen H, Hodzic D, Sonnenberg A. Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin. J Cell Sci. 2007;120:3384-94 pubmed
    ..and into the endoplasmic reticulum (ER), where it becomes colocalized with the cytoskeletal crosslinker protein plectin. Both nesprin-3alpha and plectin can form dimers, and dimerization of plectin is required for its interaction ..
  51. Ackerl R, Walko G, Fuchs P, Fischer I, Schmuth M, Wiche G. Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects. J Cell Sci. 2007;120:2435-43 pubmed
    b>Plectin, a widespread intermediate filament-based cytolinker protein capable of interacting with a variety of cytoskeletal structures and plasma membrane-bound junctional complexes, serves essential functions in maintenance of cell and ..
  52. Joubeh S, Mori O, Owaribe K, Hashimoto T. Immunofluorescence analysis of the basement membrane zone components in human anagen hair follicles. Exp Dermatol. 2003;12:365-70 pubmed
    ..present study, immunofluorescence was used to determine the expression of various BMZ components, particularly plectin, BP230, BP180, alpha6beta4 integrin, laminin 5 and type VII collagen, in anagen hair follicles from human scalp...
  53. Clubb B, Chou Y, Herrmann H, Svitkina T, Borisy G, Goldman R. The 300-kDa intermediate filament-associated protein (IFAP300) is a hamster plectin ortholog. Biochem Biophys Res Commun. 2000;273:183-7 pubmed publisher
    b>Plectin is a high-molecular-weight cytoskeleton-associated protein that was initially identified in intermediate filament (IF)-enriched fractions of rat C6 glioma cells...