Summary: A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON.

Top Publications

  1. Delva E, Kowalczyk A. Regulation of cadherin trafficking. Traffic. 2009;10:259-67 pubmed publisher
    ..Particular emphasis is placed on the regulation of cadherin trafficking by catenins and the interplay between growth factor signaling pathways and cadherin endocytosis.
  2. Naydenov N, Brown B, Harris G, Dohn M, Morales V, Baranwal S, et al. A membrane fusion protein ?SNAP is a novel regulator of epithelial apical junctions. PLoS ONE. 2012;7:e34320 pubmed publisher
    ..These findings suggest novel roles for ?SNAP in promoting the formation of epithelial AJs and TJs by controlling Golgi-dependent expression and trafficking of junctional proteins. ..
  3. Zeng Y, Abdallah A, Lu J, Wang T, Chen Y, Terrian D, et al. delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles. Mol Cancer. 2009;8:19 pubmed publisher
    ..Taken together, our studies suggest that at least one consequence of an increased expression of delta-catenin in human prostate cancer is the alteration of cell cycle and survival gene profiles, thereby promoting tumor progression. ..
  4. Nelson W. Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem Soc Trans. 2008;36:149-55 pubmed publisher
    ..In the present article, in vitro protein assembly studies and live-cell studies of de novo cell-cell adhesion are discussed in the context of how the cadherin-catenin complex and the actin cytoskeleton regulate cell-cell adhesion. ..
  5. Pan S, Cheng L, White J, Lu W, Utleg A, Yan X, et al. Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers. OMICS. 2009;13:345-54 pubmed publisher
    ..Our results suggest that chemotherapy response may be determined by multiple and complex system properties involving extracellular-matrix, cell adhesion and junction proteins. ..
  6. Dabbs D, Kaplai M, Chivukula M, Kanbour A, Kanbour Shakir A, Carter G. The spectrum of morphomolecular abnormalities of the E-cadherin/catenin complex in pleomorphic lobular carcinoma of the breast. Appl Immunohistochem Mol Morphol. 2007;15:260-6 pubmed
    ..The E-cadherin protein internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the E-cadherin complex to the actin cytoskeleton of the cell...
  7. Liu Y, Xu H, Dai S, Wei Q, Yuan X, Wang E. Reduction of p120(ctn) isoforms 1 and 3 is significantly associated with metastatic progression of human lung cancer. APMIS. 2007;115:848-56 pubmed
    ..We conclude that reductions of isoforms 1 and 3 may play different roles in metastatic progression of human lung cancer. ..
  8. McCrea P, Gu D, Balda M. Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol. 2009;1:a002923 pubmed publisher
    ..This review assesses a variety of cell-cell junction-to-nuclear signaling pathways, and outlines interesting areas for further study...
  9. Stepniak E, Radice G, Vasioukhin V. Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol. 2009;1:a002949 pubmed publisher

More Information


  1. Petrova Y, Spano M, Gumbiner B. Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell. 2012;23:2092-108 pubmed publisher
  2. Lu Q, Zhang J, Allison R, Gay H, Yang W, Bhowmick N, et al. Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate. 2009;69:411-8 pubmed publisher
    ..0005). This study demonstrated, for the first time, the extracellular accumulation of delta-catenin in urine supporting its potential utility for non-invasive prostate cancer detection. ..
  3. Brown M, Burnett P, Denning M, Reynolds A. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res. 2009;315:39-49 pubmed publisher
    ..Using Va2 cells and PDGF stimulation, we show for the first time that PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions. ..
  4. Molina Ortiz I, Bartolomé R, Hernández Varas P, Colo G, Teixido J. Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA. J Biol Chem. 2009;284:15147-57 pubmed publisher
  5. Kim H, Han J, Park J, Oh M, James S, Chang S, et al. Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem. 2008;283:977-87 pubmed
    ..These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis. ..
  6. Taulet N, Comunale F, Favard C, Charrasse S, Bodin S, Gauthier Rouvière C. N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis. J Biol Chem. 2009;284:23137-45 pubmed publisher
    ..Thus, a functional N-cadherin-catenin complex occurs in cholesterol-rich membrane microdomains which allows the recruitment of RhoA and the regulation of its activity during myogenesis induction...
  7. van Oort I, Tomita K, Van Bokhoven A, Bussemakers M, Kiemeney L, Karthaus H, et al. The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. Prostate. 2007;67:1432-8 pubmed
    ..Among these markers, alpha-catenin seems the best prognostic marker for prostate cancer specific survival. Larger studies are needed to confirm this result. ..
  8. Macpherson I, Hooper S, Serrels A, McGarry L, Ozanne B, Harrington K, et al. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene. 2007;26:5214-28 pubmed
    ..Furthermore, membranous p120 is maintained in invasive squamous cell carcinomas in tumours suggesting that p120 may be important for the collective invasion of tumours cells in vivo. ..
  9. Zhang J, O Donnell J, Holian O, Vincent P, Kim K, Lum H. P120 catenin represses transcriptional activity through Kaiso in endothelial cells. Microvasc Res. 2010;80:233-9 pubmed publisher
    ..Overall, the findings provide evidence that in endothelial cells, p120ctn has a transcription repression function through regulation of Kaiso, possibly as a cofactor with the transcription factor. ..
  10. Kurley S, Bierie B, Carnahan R, Lobdell N, Davis M, Hofmann I, et al. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development. 2012;139:1754-64 pubmed publisher
    ..Our findings reveal an essential role for p120 in mammary morphogenesis. ..
  11. Lee S, Peng I, Ng Y, Yanagisawa M, Bamji S, Elia L, et al. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. J Cell Biol. 2008;183:893-908 pubmed publisher
    ..Our results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function. ..
  12. Perrin Tricaud C, Rutishauser U, Tricaud N. P120 catenin is required for thickening of Schwann cell myelin. Mol Cell Neurosci. 2007;35:120-9 pubmed
    ..These data show that p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath. ..
  13. Abu Elneel K, Ochiishi T, Medina M, Remedi M, Gastaldi L, Caceres A, et al. A delta-catenin signaling pathway leading to dendritic protrusions. J Biol Chem. 2008;283:32781-91 pubmed publisher
  14. Arikkath J, Reichardt L. Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci. 2008;31:487-94 pubmed publisher
    ..These exciting discoveries provide insights into novel functional roles of the complex beyond regulating cell adhesion. ..
  15. Kiss A, Troyanovsky R, Troyanovsky S. p120-catenin is a key component of the cadherin-gamma-secretase supercomplex. Mol Biol Cell. 2008;19:4042-50 pubmed publisher
    ..The cell-cell contact location of this supercomplex makes it an important candidate for conducting different signals that rely on gamma-secretase proteolytic activity. ..
  16. Kim K, Oh M, Ki H, Wang T, Bareiss S, Fini M, et al. Identification of E2F1 as a positive transcriptional regulator for delta-catenin. Biochem Biophys Res Commun. 2008;369:414-20 pubmed publisher
  17. Herron C, Lowery A, Hollister P, Reynolds A, Vincent P. p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding. Am J Physiol Heart Circ Physiol. 2011;300:H36-48 pubmed publisher
    ..These results demonstrate that p120 is required for maintaining VE-cadherin expression and TEER independently of its NH(2) terminus and its role in regulating Rho. ..
  18. Smalley Freed W, Efimov A, Burnett P, Short S, Davis M, Gumucio D, et al. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 2010;120:1824-35 pubmed publisher
    ..Thus, we conclude that p120 has an essential role in barrier function and epithelial homeostasis and survival in the intestine. ..
  19. Reynolds A. p120-catenin: Past and present. Biochim Biophys Acta. 2007;1773:2-7 pubmed
    ..The anecdotal parts have no particular purpose, but are mostly unpublished and perhaps of interest to some. ..
  20. Filiz A, Senol Z, Sucullu I, Kurt Y, Demirbas S, Akin M. The survival effect of E-cadherin and catenins in colorectal carcinomas. Colorectal Dis. 2010;12:1223-30 pubmed publisher
    ..04, P?=?0.03, respectively). The decreased membranous expression of E-cadherin and ?-catenin and increased cytoplasmic expression of ?-catenin might be used as a prognostic marker to monitor patients with colorectal cancer. ..
  21. Li D, Zhou J, Wang L, Shin M, Su P, Lei X, et al. Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions. J Cell Biol. 2010;191:631-44 pubmed publisher
    ..Our findings also contribute to the understanding of microenvironmental regulation of hESC identity and somatic reprogramming. ..
  22. Hong J, Park J, Cho K, Gu D, Ji H, Artandi S, et al. Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci. 2010;123:4351-65 pubmed publisher
  23. Godsel L, Dubash A, Bass Zubek A, Amargo E, Klessner J, Hobbs R, et al. Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell. 2010;21:2844-59 pubmed publisher
    ..Together with our previous findings, these data suggest that PKP2 may functionally link RhoA- and PKC-dependent pathways to drive actin reorganization and regulate DP-IF interactions required for normal desmosome assembly...
  24. Brigidi G, Bamji S. Cadherin-catenin adhesion complexes at the synapse. Curr Opin Neurobiol. 2011;21:208-14 pubmed publisher
    ..Moreover, we will discuss molecular mechanisms underlying cadherin turnover and the subsequent impact on synaptic connections. ..
  25. Kronstein R, Seebach J, Grossklaus S, Minten C, Engelhardt B, Drab M, et al. Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res. 2012;93:130-40 pubmed publisher
    ..Our results highlight the pivotal role of caveolin-1 in VE-cadherin-mediated cell adhesion via catenins and, in turn, in barrier function regulation.
  26. Curtis M, Johnson K, Wheelock M. E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments. Cell Commun Adhes. 2008;15:365-78 pubmed publisher
    ..The authors have previously reported that catenins coimmunoprecipate with pro-N-cadherin, and that the N-cadherin/catenin complex forms in the Golgi/endoplasmic ..
  27. Wang T, Chen Y, Hong H, Zeng Y, Zhang J, Lu J, et al. Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. Oncogene. 2009;28:555-64 pubmed publisher
    ..This is the first report of delta-catenin gene mutation in cancer and supports the notion that multiple mechanisms contribute to its increased expression in carcinogenesis. ..
  28. Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008;135:948-59 pubmed publisher
    ..We propose that the PLEKHA7/Nezha/MT complex regulates the ZA integrity by recruiting KIFC3 to this junctional site. ..
  29. Liu W, Nelson C, Pirone D, Chen C. E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol. 2006;173:431-41 pubmed
    ..Together, these findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings. ..
  30. McCrea P, Park J. Developmental functions of the P120-catenin sub-family. Biochim Biophys Acta. 2007;1773:17-33 pubmed
    ..directed towards p120-catenin, which in conjunction with the p120-catenin sub-family members ARVCF- and delta-catenins, are the subjects of this review...
  31. Fukumoto Y, Shintani Y, Reynolds A, Johnson K, Wheelock M. The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res. 2008;314:52-67 pubmed
    ..These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions. ..
  32. Sallee J, Wittchen E, Burridge K. Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion. J Biol Chem. 2006;281:16189-92 pubmed
    ..This review will discuss the role of protein-tyrosine phosphatases in cell-cell interactions, with an emphasis on cadherin-mediated adhesions. ..
  33. Daniel J. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Biochim Biophys Acta. 2007;1773:59-68 pubmed
    ..Hence it remains to be determined whether the sole role of nuclear p120(ctn) is regulation of Kaiso or whether p120(ctn) binds and regulates other transcription factors or nuclear proteins. ..
  34. Perez Moreno M, Fuchs E. Catenins: keeping cells from getting their signals crossed. Dev Cell. 2006;11:601-12 pubmed
    ..In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin...
  35. Esposito N, Chivukula M, Dabbs D. The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 2007;20:130-8 pubmed
    ..with antibodies against estrogen receptor, progesterone receptor, HER2/neu, 34betaE12, E-cadherin, and the catenins. Twenty-five percent of patients with tubulolobular carcinoma presented with greater than stage I disease, ..
  36. McCrea P, Gu D. The catenin family at a glance. J Cell Sci. 2010;123:637-42 pubmed publisher
  37. Ichii T, Takeichi M. p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. Genes Cells. 2007;12:827-39 pubmed
    ..These results suggest that p120 has the ability to regulate MT dynamics and that this activity, in turn, affects cell motility independently of the cadherin adhesion system. ..
  38. Arikkath J, Peng I, Ng Y, Israely I, Liu X, Ullian E, et al. Delta-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development. J Neurosci. 2009;29:5435-42 pubmed publisher
  39. Shapiro L, Weis W. Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol. 2009;1:a003053 pubmed publisher
    ..Rather than stably bridging beta-catenin to actin, it appears that alpha-catenin actively regulates the actin cytoskeleton at cadherin-based cell-cell contacts. ..
  40. Matter C, Pribadi M, Liu X, Trachtenberg J. Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo. Neuron. 2009;64:320-7 pubmed publisher
    ..Our results indicate that delta-catenin regulates the maintenance of dendrites and dendritic spines in mature cortex but does not appear to be necessary for the initial establishment of these structures during development. ..
  41. Barami K, Lewis Tuffin L, Anastasiadis P. The role of cadherins and catenins in gliomagenesis. Neurosurg Focus. 2006;21:E13 pubmed
    ..They reorganize the actin cytoskeleton via interaction with the catenins. Modulation of the cadherin/catenin system plays a role in cell motility...
  42. Hartsock A, Nelson W. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660-9 pubmed
  43. Abe K, Takeichi M. EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A. 2008;105:13-9 pubmed
  44. Jiang G, Wang Y, Dai S, Liu Y, Stoecker M, Wang E, et al. P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via ?-catenin and Kaiso respectively. PLoS ONE. 2012;7:e30303 pubmed publisher
  45. Boguslavsky S, Grosheva I, Landau E, Shtutman M, Cohen M, Arnold K, et al. p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A. 2007;104:10882-7 pubmed
    ..Cortactin and p120 are shown to directly interact with each other via the cortactin N-terminal region. We propose that the mechanism underlying p120 functions at the leading edge involves its cooperation with cortactin. ..
  46. Keil R, Wolf A, Huttelmaier S, Hatzfeld M. Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle. 2007;6:122-7 pubmed
    ..In the cytoplasm, the p120 catenins appear responsible for the spatio-temporal control of small Rho-GTPases in various cellular contexts...
  47. Wildenberg G, Dohn M, Carnahan R, Davis M, Lobdell N, Settleman J, et al. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell. 2006;127:1027-39 pubmed
    ..We propose that Rac activation links diverse signaling systems to AJ assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho. ..
  48. Harris T, Tepass U. Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol. 2010;11:502-14 pubmed publisher
    ..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis. ..
  49. Niessen C, Gottardi C. Molecular components of the adherens junction. Biochim Biophys Acta. 2008;1778:562-71 pubmed publisher
    ..The molecular machineries that organize these adhesion receptor complexes into higher order junction structures, and the functional consequences of this junctional organization will be discussed. ..
  50. Perez Moreno M, Davis M, Wong E, Pasolli H, Reynolds A, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell. 2006;124:631-44 pubmed
    ..drugs, we show that these features are not attributable to reductions in junctional cadherins and catenins, but rather NFkB activation...
  51. Anastasiadis P. p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta. 2007;1773:34-46 pubmed
    ..quiescent phenotype of epithelial cells. Here, we review the new evidence on the relationship of p120 to Rho GTPases, and discuss potential roles for the p120-Rho connection in normal and malignant cells. ..
  52. Wang E, Liu Y, Xu H, Dai S, Liu N, Xie C, et al. Abnormal expression and clinicopathologic significance of p120-catenin in lung cancer. Histol Histopathol. 2006;21:841-7 pubmed publisher
    ..Reduced expression or even the absence of p120ctn isoform 1 and 3 in tumor cell membranes may be responsible for the abnormal expression of p120ctn that has been found in lung cancer. ..