Genomes and Genes
Summary: A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON.
- Lu Q, Zhang J, Allison R, Gay H, Yang W, Bhowmick N, et al. Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate. 2009;69:411-8 pubmed publisher..0005). This study demonstrated, for the first time, the extracellular accumulation of delta-catenin in urine supporting its potential utility for non-invasive prostate cancer detection. ..
- Brown M, Burnett P, Denning M, Reynolds A. PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway. Exp Cell Res. 2009;315:39-49 pubmed publisher..Using Va2 cells and PDGF stimulation, we show for the first time that PDGFR-mediated phosphorylation at this site is dependent on PKCalpha, a conventional PKC isoform implicated previously in disruption of adherens junctions. ..
- Kim H, Han J, Park J, Oh M, James S, Chang S, et al. Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem. 2008;283:977-87 pubmed..These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis. ..
- Taulet N, Comunale F, Favard C, Charrasse S, Bodin S, Gauthier Rouvière C. N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis. J Biol Chem. 2009;284:23137-45 pubmed publisher..Thus, a functional N-cadherin-catenin complex occurs in cholesterol-rich membrane microdomains which allows the recruitment of RhoA and the regulation of its activity during myogenesis induction...
- van Oort I, Tomita K, Van Bokhoven A, Bussemakers M, Kiemeney L, Karthaus H, et al. The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. Prostate. 2007;67:1432-8 pubmed..Among these markers, alpha-catenin seems the best prognostic marker for prostate cancer specific survival. Larger studies are needed to confirm this result. ..
- Macpherson I, Hooper S, Serrels A, McGarry L, Ozanne B, Harrington K, et al. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene. 2007;26:5214-28 pubmed..Furthermore, membranous p120 is maintained in invasive squamous cell carcinomas in tumours suggesting that p120 may be important for the collective invasion of tumours cells in vivo. ..
- Zhang J, O Donnell J, Holian O, Vincent P, Kim K, Lum H. P120 catenin represses transcriptional activity through Kaiso in endothelial cells. Microvasc Res. 2010;80:233-9 pubmed publisher..Overall, the findings provide evidence that in endothelial cells, p120ctn has a transcription repression function through regulation of Kaiso, possibly as a cofactor with the transcription factor. ..
- Kurley S, Bierie B, Carnahan R, Lobdell N, Davis M, Hofmann I, et al. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development. 2012;139:1754-64 pubmed publisher..Our findings reveal an essential role for p120 in mammary morphogenesis. ..
- Lee S, Peng I, Ng Y, Yanagisawa M, Bamji S, Elia L, et al. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. J Cell Biol. 2008;183:893-908 pubmed publisher..Our results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function. ..
- Perrin Tricaud C, Rutishauser U, Tricaud N. P120 catenin is required for thickening of Schwann cell myelin. Mol Cell Neurosci. 2007;35:120-9 pubmed..These data show that p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath. ..
- Arikkath J, Reichardt L. Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity. Trends Neurosci. 2008;31:487-94 pubmed publisher..These exciting discoveries provide insights into novel functional roles of the complex beyond regulating cell adhesion. ..
- Kiss A, Troyanovsky R, Troyanovsky S. p120-catenin is a key component of the cadherin-gamma-secretase supercomplex. Mol Biol Cell. 2008;19:4042-50 pubmed publisher..The cell-cell contact location of this supercomplex makes it an important candidate for conducting different signals that rely on gamma-secretase proteolytic activity. ..
- Herron C, Lowery A, Hollister P, Reynolds A, Vincent P. p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding. Am J Physiol Heart Circ Physiol. 2011;300:H36-48 pubmed publisher..These results demonstrate that p120 is required for maintaining VE-cadherin expression and TEER independently of its NH(2) terminus and its role in regulating Rho. ..
- Smalley Freed W, Efimov A, Burnett P, Short S, Davis M, Gumucio D, et al. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 2010;120:1824-35 pubmed publisher..Thus, we conclude that p120 has an essential role in barrier function and epithelial homeostasis and survival in the intestine. ..
- Reynolds A. p120-catenin: Past and present. Biochim Biophys Acta. 2007;1773:2-7 pubmed..The anecdotal parts have no particular purpose, but are mostly unpublished and perhaps of interest to some. ..
- Filiz A, Senol Z, Sucullu I, Kurt Y, Demirbas S, Akin M. The survival effect of E-cadherin and catenins in colorectal carcinomas. Colorectal Dis. 2010;12:1223-30 pubmed publisher..04, P?=?0.03, respectively). The decreased membranous expression of E-cadherin and ?-catenin and increased cytoplasmic expression of ?-catenin might be used as a prognostic marker to monitor patients with colorectal cancer. ..
- Li D, Zhou J, Wang L, Shin M, Su P, Lei X, et al. Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions. J Cell Biol. 2010;191:631-44 pubmed publisher..Our findings also contribute to the understanding of microenvironmental regulation of hESC identity and somatic reprogramming. ..
- Godsel L, Dubash A, Bass Zubek A, Amargo E, Klessner J, Hobbs R, et al. Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell. 2010;21:2844-59 pubmed publisher..Together with our previous findings, these data suggest that PKP2 may functionally link RhoA- and PKC-dependent pathways to drive actin reorganization and regulate DP-IF interactions required for normal desmosome assembly...
- Brigidi G, Bamji S. Cadherin-catenin adhesion complexes at the synapse. Curr Opin Neurobiol. 2011;21:208-14 pubmed publisher..Moreover, we will discuss molecular mechanisms underlying cadherin turnover and the subsequent impact on synaptic connections. ..
- Kronstein R, Seebach J, Grossklaus S, Minten C, Engelhardt B, Drab M, et al. Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res. 2012;93:130-40 pubmed publisher..Our results highlight the pivotal role of caveolin-1 in VE-cadherin-mediated cell adhesion via catenins and, in turn, in barrier function regulation.
- Curtis M, Johnson K, Wheelock M. E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments. Cell Commun Adhes. 2008;15:365-78 pubmed publisher..The authors have previously reported that catenins coimmunoprecipate with pro-N-cadherin, and that the N-cadherin/catenin complex forms in the Golgi/endoplasmic ..
- Wang T, Chen Y, Hong H, Zeng Y, Zhang J, Lu J, et al. Increased nucleotide polymorphic changes in the 5'-untranslated region of delta-catenin (CTNND2) gene in prostate cancer. Oncogene. 2009;28:555-64 pubmed publisher..This is the first report of delta-catenin gene mutation in cancer and supports the notion that multiple mechanisms contribute to its increased expression in carcinogenesis. ..
- Meng W, Mushika Y, Ichii T, Takeichi M. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Cell. 2008;135:948-59 pubmed publisher..We propose that the PLEKHA7/Nezha/MT complex regulates the ZA integrity by recruiting KIFC3 to this junctional site. ..
- Liu W, Nelson C, Pirone D, Chen C. E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol. 2006;173:431-41 pubmed..Together, these findings demonstrate a stimulatory role for E-cadherin in proliferative regulation, and identify a simple mechanism by which cell-cell contact may trigger or inhibit epithelial cell proliferation in different settings. ..
- McCrea P, Park J. Developmental functions of the P120-catenin sub-family. Biochim Biophys Acta. 2007;1773:17-33 pubmed..directed towards p120-catenin, which in conjunction with the p120-catenin sub-family members ARVCF- and delta-catenins, are the subjects of this review...
- Fukumoto Y, Shintani Y, Reynolds A, Johnson K, Wheelock M. The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane. Exp Cell Res. 2008;314:52-67 pubmed..These data suggest that serine/threonine phosphorylation of p120 influences the dynamics of E-cadherin in junctions. ..
- Sallee J, Wittchen E, Burridge K. Regulation of cell adhesion by protein-tyrosine phosphatases: II. Cell-cell adhesion. J Biol Chem. 2006;281:16189-92 pubmed..This review will discuss the role of protein-tyrosine phosphatases in cell-cell interactions, with an emphasis on cadherin-mediated adhesions. ..
- Daniel J. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Biochim Biophys Acta. 2007;1773:59-68 pubmed..Hence it remains to be determined whether the sole role of nuclear p120(ctn) is regulation of Kaiso or whether p120(ctn) binds and regulates other transcription factors or nuclear proteins. ..
- Perez Moreno M, Fuchs E. Catenins: keeping cells from getting their signals crossed. Dev Cell. 2006;11:601-12 pubmed..In recent years, conventional views have similarly been shaken about the other two major AJ catenins, alpha-catenin and p120-catenin...
- Esposito N, Chivukula M, Dabbs D. The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. Mod Pathol. 2007;20:130-8 pubmed..with antibodies against estrogen receptor, progesterone receptor, HER2/neu, 34betaE12, E-cadherin, and the catenins. Twenty-five percent of patients with tubulolobular carcinoma presented with greater than stage I disease, ..
- Ichii T, Takeichi M. p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. Genes Cells. 2007;12:827-39 pubmed..These results suggest that p120 has the ability to regulate MT dynamics and that this activity, in turn, affects cell motility independently of the cadherin adhesion system. ..
- Shapiro L, Weis W. Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol. 2009;1:a003053 pubmed publisher..Rather than stably bridging beta-catenin to actin, it appears that alpha-catenin actively regulates the actin cytoskeleton at cadherin-based cell-cell contacts. ..
- Matter C, Pribadi M, Liu X, Trachtenberg J. Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo. Neuron. 2009;64:320-7 pubmed publisher..Our results indicate that delta-catenin regulates the maintenance of dendrites and dendritic spines in mature cortex but does not appear to be necessary for the initial establishment of these structures during development. ..
- Barami K, Lewis Tuffin L, Anastasiadis P. The role of cadherins and catenins in gliomagenesis. Neurosurg Focus. 2006;21:E13 pubmed..They reorganize the actin cytoskeleton via interaction with the catenins. Modulation of the cadherin/catenin system plays a role in cell motility...
- Hartsock A, Nelson W. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660-9 pubmed
- Abe K, Takeichi M. EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. Proc Natl Acad Sci U S A. 2008;105:13-9 pubmed
- Boguslavsky S, Grosheva I, Landau E, Shtutman M, Cohen M, Arnold K, et al. p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A. 2007;104:10882-7 pubmed..Cortactin and p120 are shown to directly interact with each other via the cortactin N-terminal region. We propose that the mechanism underlying p120 functions at the leading edge involves its cooperation with cortactin. ..
- Keil R, Wolf A, Huttelmaier S, Hatzfeld M. Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle. 2007;6:122-7 pubmed..In the cytoplasm, the p120 catenins appear responsible for the spatio-temporal control of small Rho-GTPases in various cellular contexts...
- Wildenberg G, Dohn M, Carnahan R, Davis M, Lobdell N, Settleman J, et al. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell. 2006;127:1027-39 pubmed..We propose that Rac activation links diverse signaling systems to AJ assembly by controlling transient p190RhoGAP interactions with p120 and localized inhibition of Rho. ..
- Harris T, Tepass U. Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol. 2010;11:502-14 pubmed publisher..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis. ..
- Niessen C, Gottardi C. Molecular components of the adherens junction. Biochim Biophys Acta. 2008;1778:562-71 pubmed publisher..The molecular machineries that organize these adhesion receptor complexes into higher order junction structures, and the functional consequences of this junctional organization will be discussed. ..
- Perez Moreno M, Davis M, Wong E, Pasolli H, Reynolds A, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell. 2006;124:631-44 pubmed..drugs, we show that these features are not attributable to reductions in junctional cadherins and catenins, but rather NFkB activation...
- Anastasiadis P. p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta. 2007;1773:34-46 pubmed..quiescent phenotype of epithelial cells. Here, we review the new evidence on the relationship of p120 to Rho GTPases, and discuss potential roles for the p120-Rho connection in normal and malignant cells. ..
- Wang E, Liu Y, Xu H, Dai S, Liu N, Xie C, et al. Abnormal expression and clinicopathologic significance of p120-catenin in lung cancer. Histol Histopathol. 2006;21:841-7 pubmed publisher..Reduced expression or even the absence of p120ctn isoform 1 and 3 in tumor cell membranes may be responsible for the abnormal expression of p120ctn that has been found in lung cancer. ..