steroidogenic factor 1


Summary: A transcription factor and member of the nuclear receptor family NR5 that is expressed throughout the adrenal and reproductive axes during development. It plays an important role in sexual differentiation, formation of primary steroidogenic tissues, and their functions in post-natal and adult life. It regulates the expression of key steroidogenic enzymes.

Top Publications

  1. Duan L, Fang F, Fu W, Fang Z, Wang H, Yu S, et al. Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report. BMC Endocr Disord. 2017;17:9 pubmed publisher
    ..This is the first report about a possible mechanism by which cancer stem cells induce adrenal corticomedullary tumours. ..
  2. Werner R, Mönig I, Lünstedt R, Wünsch L, Thorns C, Reiz B, et al. New NR5A1 mutations and phenotypic variations of gonadal dysgenesis. PLoS ONE. 2017;12:e0176720 pubmed publisher
    ..Exome sequencing of the sibling's family revealed TBX2 as a possible modifier of gonadal development in patients with NR5A1 mutations. ..
  3. Lu N, Li M, Lei H, Jiang X, Tu W, Lu Y, et al. Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells. J Steroid Biochem Mol Biol. 2017;172:89-97 pubmed publisher
    ..05), steroidogenic acute regulatory (StAR), steroidogenic factor 1 (SF1), P450scc in the mRNA and/or protein level (P<0...
  4. França M, Lerario A, Fragoso M, Lotfi C. New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells. Clinics (Sao Paulo). 2017;72:391-394 pubmed publisher
    Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis...
  5. Babinska A, Pęksa R, Wisniewski P, Swiatkowska Stodulska R, Sworczak K. Diagnostic and prognostic role of SF1, IGF2, Ki67, p53, adiponectin, and leptin receptors in human adrenal cortical tumors. J Surg Oncol. 2017;116:427-433 pubmed publisher
    ..Expression of the following proteins was examined: steroidogenic factor 1 (SF1), insulin growth factor 2 (IGF2), Ki67, p53, as well as adiponectin (Adipo R1, Adipo R2), and leptin (..
  6. Pedroso J, de Mendonca P, Fortes M, Tomaz I, Pecorali V, Auricino T, et al. SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance. J Endocrinol. 2017;235:207-222 pubmed publisher
    ..Therefore, cytokine signaling in SF1 cells exerts an important role to sustain training performance possibly by promoting the necessary metabolic adjustments during exercise. ..
  7. Wang W, Sun Y, Guo Y, Cai P, Li Y, Liu J, et al. Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern. Toxicol Lett. 2017;281:175-183 pubmed publisher
    ..In addition, DNA methylation might play a role in the downregulation of SF-1 gene expression induced by soy isoflavones...
  8. Liang D, Fan Z, Weng S, Jiao S, Wu Z, Zou Y, et al. Characterization and expression of StAR2a and StAR2b in the olive flounder Paralichthys olivaceus. Gene. 2017;626:1-8 pubmed publisher
    ..1-NR0b1 (P<0.05). Above study showed that expression of StAR2 was regulated by cAMP and the transcription factors, NR5a2 and NR0b1, indicating that StAR2 may have functions in flounder gonadal differentiation and maintenance. ..
  9. Xing Y, Morohashi K, Ingraham H, Hammer G. Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017;144:3798-3807 pubmed publisher
    The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1, Ad4bp) is crucial for formation, development and function of steroidogenic tissues...