retinoic acid receptor alpha


Summary: A nuclear receptor protein which belongs to a family of transcription regulators of ligand-responsive regulatory proteins which include steroid hormone receptors. In addition to a C-terminal ligand-binding domain, these nuclear receptors contain a highly-conserved N-terminal zinc-finger domain that mediates binding ligand-responsive elements.

Top Publications

  1. Palmeira dos Santos C, Pereira G, Barbosa C, Jurkiewicz A, Smaili S, Bincoletto C. Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine?induced death of leukaemia cells. J Cancer Res Clin Oncol. 2014;140:909-20 pubmed
  2. Zhu H, Qin Y, Huang X. Resistance to arsenic therapy in acute promyelocytic leukemia. N Engl J Med. 2014;370:1864-6 pubmed publisher
  3. Niu H, Chacko J, Hadwiger G, Welch J. Absence of natural intracellular retinoids in mouse bone marrow cells and implications for PML-RARA transformation. Blood Cancer J. 2015;5:e284 pubmed publisher
  4. Ichikawa S, Ichikawa S, Ishikawa I, Takahashi T, Fujiwara T, Harigae H. Successful treatment of acute promyelocytic leukemia with a t(X;17)(p11.4;q21) and BCOR-RARA fusion gene. Cancer Genet. 2015;208:162-3 pubmed publisher
  5. Rashidi A, Fisher S. FISH-negative, cytogenetically cryptic acute promyelocytic leukemia. Blood Cancer J. 2015;5:e320 pubmed publisher
  6. Miro Estruch I, Melchers D, Houtman R, De Haan L, Groten J, Louisse J, et al. Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action. Biochim Biophys Acta Proteins Proteom. 2017;1865:1195-1206 pubmed publisher
    b>Retinoic Acid Receptor alpha (RAR?/NR1B1), Retinoic Acid Receptor beta (RAR?/NR1B2) and Retinoic Acid Receptor gamma (RAR?/NR1B3) are transcription factors regulating gene expression in response to retinoids...
  7. Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol. 1999;56:1329-39 pubmed
    ..Our results provide evidence for the existence of a potent enhancer module, 8 kb distal to the transcription start point, which mediates the transcriptional induction of CYP3A4 by activators of hPXR. ..
  8. Bosch A, Bertran S, Lu Y, Garcia A, Jones A, Dawson M, et al. Reversal by RAR? agonist Am580 of c-Myc-induced imbalance in RAR?/RAR? expression during MMTV-Myc tumorigenesis. Breast Cancer Res. 2012;14:R121 pubmed publisher
  9. Zhang L, Wang J, Liu L, Zheng C, Wang Y. Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells. Molecules. 2017;22: pubmed publisher
    ..Together, the conjugate P-A was a promising candidate for the potential treatment of human gastric cancer. ..

More Information


  1. Melnick A, Licht J. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood. 1999;93:3167-215 pubmed
  2. Strehl S, Konig M, Boztug H, Cooper B, Suzukawa K, Zhang S, et al. All-trans retinoic acid and arsenic trioxide resistance of acute promyelocytic leukemia with the variant STAT5B-RARA fusion gene. Leukemia. 2013;27:1606-10 pubmed publisher
  3. Janesick A, Tang W, Nguyen T, Blumberg B. RAR?2 is required for vertebrate somitogenesis. Development. 2017;144:1997-2008 pubmed publisher
    ..These results demonstrate for the first time an early and essential role for RAR?2 in vertebrate somitogenesis. ..
  4. Andriamoratsiresy D, Piskunov A, Lutzing R, Rochette Egly C. PFN2a, a new partner of RAR? in the cytoplasm. Biochem Biophys Res Commun. 2018;495:846-853 pubmed publisher
    ..Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RAR?. ..