orphan nuclear receptors


Summary: A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.

Top Publications

  1. Finn A, Saeed O, Virmani R. Macrophage subsets in human atherosclerosis. Circ Res. 2012;110:e64; author reply e65-6 pubmed publisher
  2. Zhang Y, Wang L, Zhang J, Li Y, He Q, Li H, et al. Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats. Eur J Nutr. 2014;53:221-32 pubmed
    ..fragilis enriched vitamin K2-dependent osteocalcin mechanism in which AdipoR2, LXR-? and PPAR-? signaling were involved. ..
  3. McDonald G, Deepak S, Miguel L, Hall C, Isenberg D, Magee A, et al. Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. J Clin Invest. 2014;124:712-24 pubmed publisher
    ..Our data demonstrate that lipid metabolism defects contribute to SLE pathogenesis and suggest that targeting GSL biosynthesis restores T cell function in SLE. ..
  4. Kim G, Oh G, Yoon J, Lee G, Lee K, Kim S. Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor. J Clin Invest. 2015;125:183-93 pubmed publisher
    ..Moreover, targeting the interaction between TRAP80 and LXR should facilitate the development of potential LXR agonists that effectively prevent atherosclerosis. ..
  5. Malhotra S, Gupta S. Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation. Cell Mol Biol Lett. 2017;22:15 pubmed publisher
    ..These results suggest that the NR4A sub-family of nuclear orphan receptors has a role in trophoblastic cell differentiation. ..
  6. Choi Y, Song I, Jin Y, Jin H, Ji H, Jeong S, et al. Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis. Gene. 2017;632:7-15 pubmed publisher
    ..041). Some genetic changes in MSCs are involved in the pathophysiology of osteoporosis. The NR4A family might comprise common genes related to osteoporosis and obesity. ..
  7. Jeon J, Nam J, Kim H, Park Y, Bae S, Suh C. Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans. Arthritis Res Ther. 2014;16:R112 pubmed publisher
    ..NR1H3 genetic polymorphisms may be associated with disease susceptibility and clinical manifestations of SLE. Specifically, -1830 T?>?C polymorphism within NR1H3 promoter region may be involved in regulation of NR1H3 expression. ..
  8. Fond A, Lee C, Schulman I, Kiss R, Ravichandran K. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest. 2015;125:2748-58 pubmed publisher
    ..Collectively, these data identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes and with functional consequences in vivo. ..
  9. Sviridov D. Many ABCs make light work with cholesterol. Aging (Albany NY). 2013;5:637-8 pubmed

More Information


  1. Olivier M, BottG R, Frisdal E, Nowick M, Plengpanich W, Desmarchelier C, et al. ABCG1 is involved in vitamin E efflux. Biochim Biophys Acta. 2014;1841:1741-51 pubmed
    ..Overall, the present study reveals for the first time that ABCG1 is involved in cellular vitamin E efflux. ..
  2. Lee S, Tontonoz P. Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis. 2015;242:29-36 pubmed publisher
  3. Nanduri R, Bhutani I, Somavarapu A, Mahajan S, Parkesh R, Gupta P. ONRLDB--manually curated database of experimentally validated ligands for orphan nuclear receptors: insights into new drug discovery. Database (Oxford). 2015;2015: pubmed publisher
    b>Orphan nuclear receptors are potential therapeutic targets...
  4. Fulton J, Mazumder B, Whitchurch J, Monteiro C, Collins H, Chan C, et al. Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death Dis. 2017;8:e2677 pubmed publisher
  5. Polyzos S, Kountouras J, Mantzoros C. Sulfated oxysterols as candidates for the treatment of nonalcoholic fatty liver disease. Metabolism. 2012;61:755-8 pubmed publisher