myogenin

Summary

Summary: A myogenic regulatory factor that controls myogenesis. Myogenin is induced during differentiation of every skeletal muscle cell line that has been investigated, in contrast to the other myogenic regulatory factors that only appear in certain cell types.

Top Publications

  1. Faralli H, Martin E, Coré N, Liu Q, Filippi P, Dilworth F, et al. Teashirt-3, a novel regulator of muscle differentiation, associates with BRG1-associated factor 57 (BAF57) to inhibit myogenin gene expression. J Biol Chem. 2011;286:23498-510 pubmed publisher
    ..we showed that overexpression of Tshz3 impaired myogenic differentiation and promoted the down-regulation of myogenin (Myog) and up-regulation of paired-box factor 7 (Pax7)...
  2. Lee M, Jothi M, Gudkov A, Mal A. Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state. Cancer Res. 2011;71:3921-31 pubmed publisher
    ..Thus, targeting KMT1A may be a novel strategy for the treatment of this disease. ..
  3. Ohkawa Y, Marfella C, Imbalzano A. Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006;25:490-501 pubmed
    b>Myogenin is required not for the initiation of myogenesis but instead for skeletal muscle formation through poorly understood mechanisms...
  4. Martínez Moreno M, Martínez Ruiz A, Alvarez Barrientos A, Gavilanes F, Lamas S, Rodríguez Crespo I. Nitric oxide down-regulates caveolin-3 levels through the interaction with myogenin, its transcription factor. J Biol Chem. 2007;282:23044-54 pubmed
    ..in caveolin-3 levels are due to the alteration of the DNA binding activity of the muscular transcription factor myogenin. In the presence of *NO, the binding of transcription factors from cell nuclear extracts of muscular tissues to ..
  5. Kvorning T, Andersen M, Brixen K, Schjerling P, Suetta C, Madsen K. Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans. J Physiol. 2007;578:579-93 pubmed
    ..05). mRNA expression of IGF-IE(bc) and myogenin increased, while expression of myostatin decreased (P < 0...
  6. Flynn J, Meadows E, FIOROTTO M, Klein W. Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. PLoS ONE. 2010;5:e13535 pubmed publisher
    ..The myogenic transcription factor myogenin is required for skeletal muscle development during embryonic and fetal life, but myogenin's role in adult ..
  7. Yafe A, Shklover J, Weisman Shomer P, Bengal E, Fry M. Differential binding of quadruplex structures of muscle-specific genes regulatory sequences by MyoD, MRF4 and myogenin. Nucleic Acids Res. 2008;36:3916-25 pubmed publisher
    Four myogenic regulatory factors (MRFs); MyoD, Myf-5, MRF4 and Myogenin direct muscle tissue differentiation...
  8. Yajima H, Motohashi N, Ono Y, Sato S, Ikeda K, Masuda S, et al. Six family genes control the proliferation and differentiation of muscle satellite cells. Exp Cell Res. 2010;316:2932-44 pubmed publisher
    ..In addition, Six4 and Six5 repressed, while Six1 activated myogenin expression, suggesting that the differential regulation of myogenin expression is responsible for the ..
  9. Siu P, Donley D, Bryner R, Alway S. Myogenin and oxidative enzyme gene expression levels are elevated in rat soleus muscles after endurance training. J Appl Physiol (1985). 2004;97:277-85 pubmed
    ..whether endurance exercise training regulates increases in metabolic enzymes, which parallel modulations of myogenin and MyoD in skeletal muscle of rats...

More Information

Publications72

  1. Cao Y, Kumar R, Penn B, Berkes C, Kooperberg C, Boyer L, et al. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. EMBO J. 2006;25:502-11 pubmed
    ..Therefore, the role of Myog in mediating terminal differentiation is, in part, to enhance expression of a subset of genes previously initiated by Myod. ..
  2. Knapp J, Davie J, Myer A, Meadows E, Olson E, Klein W. Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size. Development. 2006;133:601-10 pubmed
    ..Here, we test this assumption by determining the role of the myogenic regulator myogenin in postnatal life...
  3. Seenundun S, Rampalli S, Liu Q, Aziz A, Palii C, Hong S, et al. UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis. EMBO J. 2010;29:1401-11 pubmed publisher
    ..Thus, removal of repressive H3K27me3 marks by UTX occurs through targeted recruitment followed by spreading across the gene. ..
  4. Palacios D, Summerbell D, Rigby P, Boyes J. Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myogenin gene. Mol Cell Biol. 2010;30:3805-15 pubmed publisher
    ..Using the mouse Myogenin promoter as an example of the weak CpG island class of promoters, we find that it is initially methylated but ..
  5. Kim J, Choi B, Kim B, Park S, Hong K. Associations of the variation in the porcine myogenin gene with muscle fibre characteristics, lean meat production and meat quality traits. J Anim Breed Genet. 2009;126:134-41 pubmed publisher
    ..b>Myogenin belongs to the MyoD gene family, and is a candidate gene responsible for muscle fibre characteristics...
  6. Morgenstern D, Rees H, Sebire N, Shipley J, Anderson J. Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature. Pathol Oncol Res. 2008;14:233-8 pubmed publisher
    b>Myogenin immunostaining has been described as a useful marker of the alveolar subtype of rhabdomyosarcoma and as a tool for distinguishing it from the more common embryonal subtype...
  7. Galloway T, Bardal T, Kvam S, Dahle S, Nesse G, Randøl M, et al. Somite formation and expression of MyoD, myogenin and myosin in Atlantic halibut (Hippoglossus hippoglossus L.) embryos incubated at different temperatures: transient asymmetric expression of MyoD. J Exp Biol. 2006;209:2432-41 pubmed
    Genes encoding the myogenic regulating factors MyoD and myogenin and the structural muscle proteins myosin light chain 2 (MyLC2) and myosin heavy chain (MyHC) were isolated from juvenile Atlantic halibut (Hippoglossus hippoglossus L.)...
  8. Davie J, Cho J, Meadows E, Flynn J, Knapp J, Klein W. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol. 2007;311:650-64 pubmed
    The myogenic regulatory factors MyoD and myogenin are crucial for skeletal muscle development. Despite their importance, the mechanisms by which these factors selectively regulate different target genes are unclear...
  9. Deato M, Marr M, Sottero T, Inouye C, Hu P, Tjian R. MyoD targets TAF3/TRF3 to activate myogenin transcription. Mol Cell. 2008;32:96-105 pubmed publisher
    ..system to analyze the properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter...
  10. Ogawa M, Sakakibara Y, Kamemura K. Requirement of decreased O-GlcNAc glycosylation of Mef2D for its recruitment to the myogenin promoter. Biochem Biophys Res Commun. 2013;433:558-62 pubmed publisher
    Previously, we demonstrated that the expression of myogenin, a critical transcription factor for myogenesis, is negatively regulated by O-linked ?-N-acetylglucosamine (O-GlcNAc) glycosylation in mouse C2C12 cells...
  11. Abe S, Rhee S, Iwanuma O, Hiroki E, Yanagisawa N, Sakiyama K, et al. Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblasts. Anat Histol Embryol. 2009;38:305-10 pubmed publisher
    ..Myf-5 expressed only at early stage of the stretch group. Although mRNA and protein expressions of myogenin and MRF4 were detected both in the stretch and in the control group at 12 h after the stretching, their ..
  12. Wang X, Wu H, Zhang Z, Liu S, Yang J, Chen X, et al. Effects of interleukin-6, leukemia inhibitory factor, and ciliary neurotrophic factor on the proliferation and differentiation of adult human myoblasts. Cell Mol Neurobiol. 2008;28:113-24 pubmed publisher
    ..This study will provide the experimental and theoretic foundations for the basic and clinical researches about human myoblasts. ..
  13. Amthor H, Otto A, Macharia R, McKinnell I, Patel K. Myostatin imposes reversible quiescence on embryonic muscle precursors. Dev Dyn. 2006;235:672-80 pubmed
    ..We report that in contrast to the down-regulation in expression of Pax-3, Myf-5, MyoD, and Myogenin, expression of Pax-7 was maintained...
  14. Shiraishi S, Zhou C, Aoki T, Sato N, Chiba T, Tanaka K, et al. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. J Biol Chem. 2007;282:9017-28 pubmed
    ..b>Myogenin, a basic helix-loop-helix-type myogenic transcription factor, plays a critical role through transcriptional ..
  15. Riuzzi F, Sorci G, Sagheddu R, Donato R. HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription. J Cell Sci. 2012;125:1440-54 pubmed publisher
    ..We showed that myogenin repressed Pax7 transcription in differentiating myoblasts by binding to specific recognition sites in the Pax7 ..
  16. Castellani L, Salvati E, Alema S, Falcone G. Fine regulation of RhoA and Rock is required for skeletal muscle differentiation. J Biol Chem. 2006;281:15249-57 pubmed
    ..Finally, we have reported that Rock acts independently from RhoA in preventing myoblast exit from the cell cycle and commitment to differentiation and may receive signaling inputs from Raf-1 kinase. ..
  17. Lolis A, Londhe P, Beggs B, Byrum S, Tackett A, Davie J. Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes. J Biol Chem. 2013;288:7676-87 pubmed publisher
    ..The FACT complex is composed of two subunits: SSRP1 and SPT16. We have discovered that myogenin interacts with the FACT complex...
  18. Meadows E, Cho J, Flynn J, Klein W. Myogenin regulates a distinct genetic program in adult muscle stem cells. Dev Biol. 2008;322:406-14 pubmed publisher
    ..The purpose of this study was to determine the role that the myogenic basic helix-loop-helix regulatory factor myogenin has in postnatal muscle growth and adult muscle stem cell gene expression...
  19. Liu Q, Zha X, Faralli H, Yin H, Louis Jeune C, Perdiguero E, et al. Comparative expression profiling identifies differential roles for Myogenin and p38? MAPK signaling in myogenesis. J Mol Cell Biol. 2012;4:386-97 pubmed publisher
    ..is mediated by a complex gene expression program requiring both the muscle-specific transcription factor Myogenin (Myog) and p38? MAPK (p38?) signaling...
  20. Oikawa Y, Omori R, Nishii T, Ishida Y, Kawaichi M, Matsuda E. The methyl-CpG-binding protein CIBZ suppresses myogenic differentiation by directly inhibiting myogenin expression. Cell Res. 2011;21:1578-90 pubmed publisher
    ..of skeletal muscle are carried out mainly by satellite cells, which, upon stimulation, begin to express myogenin (Myog), the critical determinant of myogenic differentiation...
  21. Steffens A, Hong G, Bain L. Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogenin. Toxicol Appl Pharmacol. 2011;250:154-61 pubmed publisher
    ..arsenite, allowed to differentiate into myotubes, and expression of the muscle-specific transcription factor myogenin, along with the expression of tropomyosin, suppressor of cytokine signaling 3 (Socs3), prostaglandin I2 synthesis ..
  22. Fu J, Menzies K, Freeman R, Taubman M. EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability. J Biol Chem. 2007;282:12410-8 pubmed
    ..interference RNAs and EGLN3 antisense oligonucleotides blocked C2C12 differentiation and decreased levels of myogenin, a member of the MyoD family of myogenic regulatory factors, which plays a critical role in myogenic ..
  23. Parker M, Perry R, Fauteux M, Berkes C, Rudnicki M. MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation. Mol Cell Biol. 2006;26:5771-83 pubmed
    ..Upon induction of differentiation, a MyoD-HEB beta complex bound the E1 E-box of the myogenin promoter leading to transcriptional activation...
  24. Godbole P, Outram A, Wilcox D, Duffy P, Sebire N. Myogenin and desmin immunohistochemistry in the assessment of post-chemotherapy genitourinary embryonal rhabdomyosarcoma: prognostic and management implications. J Urol. 2006;176:1751-4 pubmed
    ..However, the recent use of immunohistochemical staining with desmin and myogenin in resected specimens and surveillance biopsies following adjuvant therapy may demonstrate scant positive ..
  25. Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, et al. Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007;302:602-16 pubmed
    ..between Six and Eya genes, but corresponding proteins activate key muscle determination genes (Myod, Myogenin and Mrf4)...
  26. Ohkawa Y, Yoshimura S, Higashi C, Marfella C, Dacwag C, Tachibana T, et al. Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis. J Biol Chem. 2007;282:6564-70 pubmed
    ..Brg1 ATPase are necessary to induce myogenesis in cell culture models and in developing embryonic tissue, whereas myogenin and Brg1 are critical for the expression of the late genes that induce terminal muscle differentiation...
  27. Tang H, Goldman D. Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Proc Natl Acad Sci U S A. 2006;103:16977-82 pubmed
    ..induction requires expression of the E-box binding, basic helix-loop-helix muscle-specific transcription factor, myogenin (Mgn). The mechanism by which muscle activity is coupled to gene expression is poorly defined...
  28. Nanni P, Nicoletti G, Palladini A, Astolfi A, Rinella P, Croci S, et al. Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4. Mol Cancer Ther. 2009;8:754-61 pubmed publisher
    ..Terminal myogenesis is controlled by cell-intrinsic myogenic transcription factors like myogenin and environmental mediators like interleukin 4 (IL-4)...
  29. De Luna N, Gallardo E, Soriano M, Dominguez Perles R, de la Torre C, Rojas García R, et al. Absence of dysferlin alters myogenin expression and delays human muscle differentiation "in vitro". J Biol Chem. 2006;281:17092-8 pubmed
    ..A luciferase reporter assay was performed to study myogenin activity in dysferlin-deficient cultures...
  30. Armand A, Bourajjaj M, Martínez Martínez S, el Azzouzi H, da Costa Martins P, Hatzis P, et al. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem. 2008;283:29004-10 pubmed publisher
    ..The myogenic basic helix-loop-helix transcription factors, MyoD, myogenin, Myf5, and MRF4 specify the myogenic lineage...
  31. Tse W, Town S, Murdoch G, Novak S, Dyck M, Putman C, et al. Uterine crowding in the sow affects litter sex ratio, placental development and embryonic myogenin expression in early gestation. Reprod Fertil Dev. 2008;20:497-504 pubmed
    ..gestation, and myogenic regulatory factor (MRF) transcript abundance was determined using real-time PCR for both myogenin (MYOG) and myoblast differentiation 1 (MYOD1)...
  32. Mukherjee A, Wilson E, Rotwein P. Insulin-like growth factor (IGF) binding protein-5 blocks skeletal muscle differentiation by inhibiting IGF actions. Mol Endocrinol. 2008;22:206-15 pubmed
  33. Tsuchiya K, Hosoi H, Misawa Furihata A, Houghton P, Sugimoto T. Insulin-like growth factor-I has different effects on myogenin induction and cell cycle progression in human alveolar and embryonal rhabdomyosarcoma cells. Int J Oncol. 2007;31:41-7 pubmed
    ..In this study, we found that IGF-I affected the induction of myogenin and cell cycle progression in alveolar RMS cells, but not in embryonal RMS cells...
  34. Hong G, Bain L. Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. Toxicol Appl Pharmacol. 2012;260:250-9 pubmed publisher
    ..that 20 nM sodium arsenite exposure to C2C12 mouse myocyte cells delayed myoblast differentiation due to reduced myogenin expression, the transcription factor that differentiates myoblasts into myotubes...
  35. Berghella L, De Angelis L, De Buysscher T, Mortazavi A, Biressi S, Forcales S, et al. A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle. Genes Dev. 2008;22:2125-38 pubmed publisher
    b>Myogenin is the dominant transcriptional regulator of embryonic and fetal muscle differentiation and during maturation is profoundly down-regulated...
  36. Pijet M, Pijet B, Litwiniuk A, Pajak B, Gajkowska B, Orzechowski A. Leptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways. Cytokine. 2013;61:445-54 pubmed publisher
    ..Summing up, partially opposite effects of insulin and leptin on skeletal muscle growth emphasize the importance of interplay between these cytokines. They determine how muscle mass is gained or lost. ..
  37. Sambasivan R, Cheedipudi S, Pasupuleti N, Saleh A, Pavlath G, Dhawan J. The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. J Cell Sci. 2009;122:3481-91 pubmed publisher
    ..We show that, similar to MyoD and p300, p8 and p68 are located at the myogenin promoter, and that knockdown of p8 compromises chromatin association of all four proteins...
  38. Steinbacher P, Haslett J, Obermayer A, Marschallinger J, Bauer H, Sänger A, et al. MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth. Dev Dyn. 2007;236:1106-14 pubmed
    ..Here, we use molecular techniques to provide a comprehensive characterization of MyoD and Myogenin expression during myogenic cell activation in embryos and larvae of brown trout, a fast-growing salmonid with ..
  39. Macpherson P, Wang X, Goldman D. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. J Cell Biochem. 2011;112:2149-59 pubmed publisher
    ..Muscle denervation stimulates muscle atrophy and Myogenin (Myog) is a muscle-specific transcription factor that is highly induced following muscle denervation...
  40. De Marco M, Turco M, Rosati A. BAG3 protein is induced during cardiomyoblast differentiation and modulates myogenin expression. Cell Cycle. 2011;10:850-2 pubmed
  41. Alapat D, Chaudhry T, Ardakany Taghavi R, Kohtz D. Fiber-types of sarcomeric proteins expressed in cultured myogenic cells are modulated by the dose of myogenin activity. Cell Signal. 2009;21:128-35 pubmed publisher
    ..of fast or slow skeletal muscle fiber types can be determined by the activity and dose of at least one MRF, myogenin. The dose of myogenin is modulated by two parameters: the phosphorylation state of the transcriptional activation ..
  42. Li D, Niu Z, Yu W, Qian Y, Wang Q, Li Q, et al. SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. Nucleic Acids Res. 2009;37:7059-71 pubmed publisher
    ..and characterized the human SMYD1 promoter, which contains highly conserved serum response factor (SRF) and myogenin binding sites...
  43. Olguin H, Yang Z, Tapscott S, Olwin B. Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination. J Cell Biol. 2007;177:769-79 pubmed
    ..Previously, we showed that Pax7 overexpression in adult primary myoblasts down-regulates MyoD and prevents myogenin induction, inhibiting myogenesis...
  44. Ramamoorthy S, Donohue M, Buck M. Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. Am J Physiol Endocrinol Metab. 2009;297:E392-401 pubmed publisher
    ..model of muscle wasting, TNF-alpha induces oxidative stress and nitric oxide synthase-2 (NOS2) and decreases myogenin, Jun-D, and creatinine kinase muscle isoform (CKM) expression...
  45. Qin R, Mao T, Gu X, Hu K, Liu Y, Chen J, et al. Regulation of skeletal muscle differentiation in fibroblasts by exogenous MyoD gene in vitro and in vivo. Mol Cell Biochem. 2007;302:233-9 pubmed
    ..RT-PCR and immunohistochemistry confirmed the increased expression of characteristic downstream molecule myogenin and mysion heavy chains during myogenic differentiation...
  46. Gong C, Kim Y, Woeller C, Tang Y, Maquat L. SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev. 2009;23:54-66 pubmed publisher
    ..balance between SMD and the two types of NMD in view of data indicating that PAX3 mRNA is an SMD target whose decay promotes myogenesis whereas myogenin mRNA is a classical NMD target encoding a protein required for myogenesis.
  47. Tokugawa S, Sakuma K, Fujiwara H, Hirata M, Oda R, Morisaki S, et al. The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the rat. Neuropathology. 2009;29:211-8 pubmed publisher
    ..postsurgery, PKCtheta immunoreactivity was observed in half the differentiating satellite cells labeling with myogenin. After 4 and 6 days, the localization of PKCtheta coincided with those of Pax7 and TGF-beta...
  48. Li Z, Yang J, Gao X, Lu J, Zhang Y, Wang K, et al. Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells. J Biol Chem. 2007;282:18872-8 pubmed
    b>Myogenin and its upstream regulator MyoD are known to be required for myogenic cell differentiation...
  49. Gao X, Pan W, Dai H, Zhang Y, Wu N, Shen Y. CARM1 activates myogenin gene via PCAF in the early differentiation of TPA-induced rhabdomyosarcoma-derived cells. J Cell Biochem. 2010;110:162-70 pubmed publisher
    ..Here, we show that CARM1 can be recruited to the promoter of myogenin gene to enhance its transcriptional activation via PCAF at the early stage of TPA-induced RD cell differentiation...
  50. Konig S, Béguet A, Bader C, Bernheim L. The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca2+ signals to human myoblast differentiation and fusion. Development. 2006;133:3107-14 pubmed
    ..induces an increase in expression/activity of two key transcription factors of the differentiation process, myogenin and MEF2. Blocking hyperpolarization inhibits myoblast differentiation...
  51. Luo S, Zhang C, Zhang B, Kim C, Qiu Y, Du Q, et al. Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2. EMBO J. 2009;28:2568-82 pubmed publisher
    ..chromatin remodelling by its interaction with MBD2 (methyl CpG-binding protein 2), underlying FAK regulation of myogenin expression and muscle differentiation...
  52. Benhaddou A, Keime C, Ye T, Morlon A, Michel I, Jost B, et al. Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation. Cell Death Differ. 2012;19:220-31 pubmed publisher
    ..We show that TEAD factors directly induce Myogenin, CDKN1A and Caveolin 3 expression to promote myoblast differentiation...
  53. Fu X, Zhao J, Zhu M, Foretz M, Viollet B, Dodson M, et al. AMP-activated protein kinase ?1 but not ?2 catalytic subunit potentiates myogenin expression and myogenesis. Mol Cell Biol. 2013;33:4517-25 pubmed publisher
    ..mice and AMPK conditional KO mice, and knockout of the ?1 but not the ?2 subunit resulted in downregulation of myogenin and reduced myogenesis...
  54. Rao P, Kumar R, Farkhondeh M, Baskerville S, Lodish H. Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A. 2006;103:8721-6 pubmed
    ..By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression...
  55. Zhang L, Wang C. Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain. Oncogene. 2007;26:1595-605 pubmed
    ..Here, we identify myogenin gene as a direct target of PD-dependent PAX3-FKHR activation pathway in vitro and in vivo...
  56. Mastroyiannopoulos N, Nicolaou P, Anayasa M, Uney J, Phylactou L. Down-regulation of myogenin can reverse terminal muscle cell differentiation. PLoS ONE. 2012;7:e29896 pubmed publisher
    ..Myogenic Regulatory Factors (MRFs), MyoD, myogenin, Myf5 and Myf6 are basic-helix-loop-helix (bHLH) transcription factors essential towards the regulation of ..
  57. Krskova L, Augustinakova A, Drahokoupilova E, Sumerauer D, Mudry P, Kodet R. Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression. Neoplasma. 2011;58:415-23 pubmed
    ..A molecular study of Igf2, MyoD1 and Myogenin was performed to determine the expression profiles and to assess the possible utility of these genes as potential ..
  58. Tang H, MacPherson P, Marvin M, Meadows E, Klein W, Yang X, et al. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Mol Biol Cell. 2009;20:1120-31 pubmed publisher
    ..Recently, it was reported that histone deacetylase 4 (HDAC4) can mediate denervation-induced myogenin and nicotinic acetylcholine receptor gene expression...
  59. Jogo M, Shiraishi S, Tamura T. Identification of MAFbx as a myogenin-engaged F-box protein in SCF ubiquitin ligase. FEBS Lett. 2009;583:2715-9 pubmed publisher
    Myogenesis is conducted by transcription factors including MyoD and myogenin. Myogenin is known to be polyubiquitinated by SCF (Skp1/Cullin 1/F-box protein) followed by proteasomal degradation, though the participating F-box protein is ..
  60. Moresi V, Williams A, Meadows E, Flynn J, Potthoff M, McAnally J, et al. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell. 2010;143:35-45 pubmed publisher
    ..We show that myogenin, an essential regulator of muscle development, controls neurogenic atrophy...
  61. Lindström M, Pedrosa Domellöf F, Thornell L. Satellite cell heterogeneity with respect to expression of MyoD, myogenin, Dlk1 and c-Met in human skeletal muscle: application to a cohort of power lifters and sedentary men. Histochem Cell Biol. 2010;134:371-85 pubmed publisher
    ..Our study unequivocally shows that staining for MyoD and myogenin are present in nuclei of SCs and of myoblasts and myotubes in areas of muscle fibre regeneration...
  62. Buas M, Kabak S, Kadesch T. The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem. 2010;285:1249-58 pubmed publisher
    ..Our results indicate instead that Hey1 is recruited to the promoter regions of myogenin and Mef2C, two genes whose induction is critical for myogenesis...
  63. Weise C, Dai F, Prols F, Ketelsen U, Dohrmann U, Kirsch M, et al. Myogenin (Myf4) upregulation in trans-differentiating fibroblasts from a congenital myopathy with arrest of myogenesis and defects of myotube formation. Anat Embryol (Berl). 2006;211:639-48 pubmed
    ..The abnormal upregulation of Myf4 and p21 in the patient who suffered from a severe congenital myopathy suggests that the regulation of Myf4 and p21 gene expression during myogenesis might be of interest for further studies. ..