myod protein

Summary

Summary: A myogenic regulatory factor that controls myogenesis. Though it is not clear how its function differs from the other myogenic regulatory factors, MyoD appears to be related to fusion and terminal differentiation of the muscle cell.

Top Publications

  1. Yang J, Song Y, Seol J, Park J, Yang Y, Han J, et al. Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition. Proc Natl Acad Sci U S A. 2011;108:85-90 pubmed publisher
    ..Our results suggest distinct epigenetic management of the master regulator with RI pathway components for cellular differentiation. ..
  2. Kennedy K, Porter T, Mehta V, Ryan S, Price F, Peshdary V, et al. Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biol. 2009;7:67 pubmed publisher
    ..Finally, since RA enhances skeletal muscle progenitor formation, it will be a valuable tool for designing future stem cell therapies. ..
  3. Kanisicak O, Mendez J, Yamamoto S, Yamamoto M, Goldhamer D. Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD. Dev Biol. 2009;332:131-41 pubmed publisher
    ..The results suggest that satellite cells are derived from committed myogenic progenitors, irrespective of the anatomical location, embryological origin, or physiological properties of associated musculature. ..
  4. Waddell J, Zhang P, Wen Y, Gupta S, Yevtodiyenko A, Schmidt J, et al. Dlk1 is necessary for proper skeletal muscle development and regeneration. PLoS ONE. 2010;5:e15055 pubmed publisher
  5. Miyazaki M, Schroder E, Edelmann S, Hughes M, Kornacker K, Balke C, et al. Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat. PLoS ONE. 2011;6:e27168 pubmed publisher
  6. Taberlay P, Kelly T, Liu C, You J, De Carvalho D, Miranda T, et al. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell. 2011;147:1283-94 pubmed publisher
    ..Genome-wide, a high percentage of Polycomb targets are associated with putative enhancers in permissive states, suggesting that they may provide a widespread avenue for the initiation of cell-fate reprogramming. ..
  7. Hirai H, Katoku Kikyo N, Karian P, Firpo M, Kikyo N. Efficient iPS cell production with the MyoD transactivation domain in serum-free culture. PLoS ONE. 2012;7:e34149 pubmed publisher
    ..This study highlights the power of combining the transactivation domain of MyoD with a favorable culture environment. ..
  8. Hirai H, Verma M, Watanabe S, Tastad C, Asakura Y, Asakura A. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol. 2010;191:347-65 pubmed publisher
    ..Finally, MyoD, miR-1, and miR-206 are all down-regulated in quiescent satellite cells, which may be required for maintenance of muscle stem cells. ..
  9. Bichsel C, Neeld D, Hamazaki T, Chang L, Yang L, Terada N, et al. Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein. Cell Reprogram. 2013;15:117-25 pubmed publisher
    ..Here we demonstrate transient injection of MyoD protein by P. aeruginosa to be sufficient to induce myogenic conversion of mouse embryonic fibroblasts...
  10. Kojic S, Nestorovic A, Rakicevic L, Belgrano A, Stankovic M, Divac A, et al. A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys. 2010;502:60-7 pubmed publisher
    ..It is probable that Ankrd1/CARP has a role in the propagation of signals initiated by myogenic regulatory factors (MRFs) during myogenesis. ..

Detail Information

Publications69

  1. Yang J, Song Y, Seol J, Park J, Yang Y, Han J, et al. Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition. Proc Natl Acad Sci U S A. 2011;108:85-90 pubmed publisher
    ..Our results suggest distinct epigenetic management of the master regulator with RI pathway components for cellular differentiation. ..
  2. Kennedy K, Porter T, Mehta V, Ryan S, Price F, Peshdary V, et al. Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biol. 2009;7:67 pubmed publisher
    ..Finally, since RA enhances skeletal muscle progenitor formation, it will be a valuable tool for designing future stem cell therapies. ..
  3. Kanisicak O, Mendez J, Yamamoto S, Yamamoto M, Goldhamer D. Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD. Dev Biol. 2009;332:131-41 pubmed publisher
    ..The results suggest that satellite cells are derived from committed myogenic progenitors, irrespective of the anatomical location, embryological origin, or physiological properties of associated musculature. ..
  4. Waddell J, Zhang P, Wen Y, Gupta S, Yevtodiyenko A, Schmidt J, et al. Dlk1 is necessary for proper skeletal muscle development and regeneration. PLoS ONE. 2010;5:e15055 pubmed publisher
  5. Miyazaki M, Schroder E, Edelmann S, Hughes M, Kornacker K, Balke C, et al. Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat. PLoS ONE. 2011;6:e27168 pubmed publisher
  6. Taberlay P, Kelly T, Liu C, You J, De Carvalho D, Miranda T, et al. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell. 2011;147:1283-94 pubmed publisher
    ..Genome-wide, a high percentage of Polycomb targets are associated with putative enhancers in permissive states, suggesting that they may provide a widespread avenue for the initiation of cell-fate reprogramming. ..
  7. Hirai H, Katoku Kikyo N, Karian P, Firpo M, Kikyo N. Efficient iPS cell production with the MyoD transactivation domain in serum-free culture. PLoS ONE. 2012;7:e34149 pubmed publisher
    ..This study highlights the power of combining the transactivation domain of MyoD with a favorable culture environment. ..
  8. Hirai H, Verma M, Watanabe S, Tastad C, Asakura Y, Asakura A. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol. 2010;191:347-65 pubmed publisher
    ..Finally, MyoD, miR-1, and miR-206 are all down-regulated in quiescent satellite cells, which may be required for maintenance of muscle stem cells. ..
  9. Bichsel C, Neeld D, Hamazaki T, Chang L, Yang L, Terada N, et al. Direct reprogramming of fibroblasts to myocytes via bacterial injection of MyoD protein. Cell Reprogram. 2013;15:117-25 pubmed publisher
    ..Here we demonstrate transient injection of MyoD protein by P. aeruginosa to be sufficient to induce myogenic conversion of mouse embryonic fibroblasts...
  10. Kojic S, Nestorovic A, Rakicevic L, Belgrano A, Stankovic M, Divac A, et al. A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys. 2010;502:60-7 pubmed publisher
    ..It is probable that Ankrd1/CARP has a role in the propagation of signals initiated by myogenic regulatory factors (MRFs) during myogenesis. ..
  11. Watanabe S, Hirai H, Asakura Y, Tastad C, Verma M, Keller C, et al. MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells. Stem Cells. 2011;29:505-16 pubmed publisher
    ..This data suggests that the skeletal muscle system provides a well-defined differentiation model to further elaborate on the effects of iPSC reprogramming in somatic cells...
  12. Tao Y, Neppl R, Huang Z, Chen J, Tang R, Cao R, et al. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011;194:551-65 pubmed publisher
    ..Together, our experiments define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation. ..
  13. Hirai H, Tani T, Katoku Kikyo N, Kellner S, Karian P, Firpo M, et al. Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells. 2011;29:1349-61 pubmed publisher
    ..Our approach of fusing TADs to unrelated transcription factors has far-reaching implications as a powerful tool for transcriptional reprogramming beyond application to iPSC technology. ..
  14. Cao Y, Yao Z, Sarkar D, Lawrence M, Sanchez G, Parker M, et al. Genome-wide MyoD binding in skeletal muscle cells: a potential for broad cellular reprogramming. Dev Cell. 2010;18:662-74 pubmed publisher
    ..Therefore, in addition to regulating muscle gene expression, MyoD binds genome wide and has the ability to broadly alter the epigenome in myoblasts and myotubes. ..
  15. Gillespie M, Le Grand F, Scime A, Kuang S, von Maltzahn J, Seale V, et al. p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program. J Cell Biol. 2009;187:991-1005 pubmed publisher
    ..Together, these results establish a hitherto unappreciated and essential role for p38-gamma signaling in positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. ..
  16. Juan A, Kumar R, Marx J, Young R, Sartorelli V. Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells. Mol Cell. 2009;36:61-74 pubmed publisher
    ..Thus, miR-214 and Ezh2 establish a regulatory loop controlling PcG-dependent gene expression during differentiation. ..
  17. Delgado Olguin P, Brand Arzamendi K, Scott I, Jungblut B, Stainier D, Bruneau B, et al. CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors. J Biol Chem. 2011;286:12483-94 pubmed publisher
    ..We conclude that CTCF modulates MRF functional interactions in the orchestration of myogenesis. ..
  18. Aziz A, Liu Q, Dilworth F. Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle. Epigenetics. 2010;5:691-5 pubmed publisher
    ..Thus Mef2d, Six4, and p38? MAPK function coordinately as regulators of a master regulator to mediate expression of MyoD target genes. ..
  19. Choi J, Jang H, Kim H, Kim S, Cho E, Youn H. Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem Biophys Res Commun. 2010;401:327-32 pubmed publisher
    ..Altogether, the present study suggests a de-repression model and expands the understanding on the dynamic regulation of chromatin during myogenesis...
  20. Troy A, Cadwallader A, Fedorov Y, Tyner K, Tanaka K, Olwin B. Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38?/? MAPK. Cell Stem Cell. 2012;11:541-53 pubmed publisher
    ..Thus, satellite cells employ a mechanism to generate distinct daughter cells, coupling the Par complex and p38?/? MAPK signaling to link the response to muscle injury with satellite cell self-renewal. ..
  21. Zhang L, WANG X, Wang H, Du J, Mitch W. Satellite cell dysfunction and impaired IGF-1 signaling cause CKD-induced muscle atrophy. J Am Soc Nephrol. 2010;21:419-27 pubmed publisher
    ..These signaling pathways may hold potential therapeutic targets to reduce CKD-related muscle wasting. ..
  22. Zhang X, Patel S, McCarthy J, Rabchevsky A, Goldhamer D, Esser K. A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle. Nucleic Acids Res. 2012;40:3419-30 pubmed publisher
  23. Buas M, Kabak S, Kadesch T. The Notch effector Hey1 associates with myogenic target genes to repress myogenesis. J Biol Chem. 2010;285:1249-58 pubmed publisher
    ..Expression of Hey1 in C2C12 myoblasts correlates with reduced recruitment of MyoD to these promoters, arguing that Hey1 inhibits myogenesis by associating with and repressing expression of key myogenic targets. ..
  24. Osborn D, Li K, Hinits Y, Hughes S. Cdkn1c drives muscle differentiation through a positive feedback loop with Myod. Dev Biol. 2011;350:464-75 pubmed publisher
    ..Hh is known to enhance MRF expression. Here we show that Hh is also essential at a second step that increases Myod protein activity, permitting it to promote Myogenin expression...
  25. L honoré A, Ouimette J, Lavertu Jolin M, Drouin J. Pitx2 defines alternate pathways acting through MyoD during limb and somitic myogenesis. Development. 2010;137:3847-56 pubmed publisher
    ..Muscle-specific wiring of regulatory networks composed of similar transcription factors thus underlies development of distinct skeletal muscles. ..
  26. Soleimani V, Yin H, Jahani Asl A, Ming H, Kockx C, van Ijcken W, et al. Snail regulates MyoD binding-site occupancy to direct enhancer switching and differentiation-specific transcription in myogenesis. Mol Cell. 2012;47:457-68 pubmed publisher
    ..Together, these results reveal a regulatory paradigm that directs distinct gene expression programs in progenitors versus terminally differentiated cells. ..
  27. Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin M, Johnson R, et al. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012;139:1910-20 pubmed publisher
    ..This MyoD repression is predominant in ventral limb regions and is likely to contribute to the differential increase of the global mass of ventral muscles versus dorsal muscles. ..
  28. Dilworth F, Blais A. Epigenetic regulation of satellite cell activation during muscle regeneration. Stem Cell Res Ther. 2011;2:18 pubmed publisher
  29. Ling B, Bharathy N, Chung T, Kok W, Li S, Tan Y, et al. Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2012;109:841-6 pubmed publisher
    ..These findings provide evidence of an unanticipated role for methyltransferases in cellular differentiation states by direct posttranslational modification of a transcription factor. ..
  30. Mokalled M, Johnson A, Creemers E, Olson E. MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Genes Dev. 2012;26:190-202 pubmed publisher
    ..Our results provide new insights into the genetic circuitry of muscle regeneration and identify MASTR as a central regulator of this process. ..
  31. Della Gaspera B, Armand A, Sequeira I, Chesneau A, Mazabraud A, Lecolle S, et al. Myogenic waves and myogenic programs during Xenopus embryonic myogenesis. Dev Dyn. 2012;241:995-1007 pubmed publisher
    ..However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5-dependent and -independent lineages. ..
  32. Sambasivan R, Gayraud Morel B, Dumas G, Cimper C, Paisant S, Kelly R, et al. Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell. 2009;16:810-21 pubmed publisher
    ..These findings identify novel genetic networks that may provide insights into myopathies which often affect only subsets of muscles...
  33. Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, et al. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012;198:815-32 pubmed publisher
    ..We conclude that Six1 homeoproteins act as a rheostat system to ensure proper regeneration of the tissue and replenishment of the stem cell pool during the events that follow skeletal muscle trauma. ..
  34. Blum R, Vethantham V, Bowman C, Rudnicki M, Dynlacht B. Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1. Genes Dev. 2012;26:2763-79 pubmed publisher
    ..Our studies identified a role for MyoD1 in condition-specific enhancer assembly through recruitment of transcription factors and histone-modifying enzymes that shape muscle differentiation. ..
  35. Kim C, Kim K, Yoo Y. Melatonin-induced autophagy is associated with degradation of MyoD protein in C2C12 myoblast cells. J Pineal Res. 2012;53:289-97 pubmed publisher
    ..However, the lysosomal pathway of MyoD protein degradation remains unknown...
  36. Liu R, Ginn S, Lek M, North K, Alexander I, Little D, et al. Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a. BMC Musculoskelet Disord. 2009;10:51 pubmed publisher
    ..These data demonstrate the osteogenic sensitivity of muscle progenitors and provide a mechanistic insight into the variable response of different cell lineages to BMP-2. ..
  37. Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, et al. Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J. 2012;31:2994-3007 pubmed publisher
    ..The data indicate that MyoD determines cell fate and facilitates differentiation-dependent gene expression through Chd2-dependent deposition of H3.3 at myogenic loci prior to differentiation. ..
  38. Fong A, Yao Z, Zhong J, Cao Y, Ruzzo W, Gentleman R, et al. Genetic and epigenetic determinants of neurogenesis and myogenesis. Dev Cell. 2012;22:721-35 pubmed publisher
    ..These findings demonstrate that the differentiation program is genetically determined by E box sequence, whereas cell lineage epigenetically determines the availability of E boxes for each differentiation program. ..
  39. Stuelsatz P, Pouzoulet F, Lamarre Y, Dargelos E, Poussard S, Leibovitch S, et al. Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts. J Biol Chem. 2010;285:12670-83 pubmed publisher
    ..Our results identify calpain 3 as a potential new player in the muscular regeneration process by promoting renewal of the satellite cell compartment. ..
  40. Grefte S, Kuijpers M, Kuijpers Jagtman A, Torensma R, Von den Hoff J. Myogenic capacity of muscle progenitor cells from head and limb muscles. Eur J Oral Sci. 2012;120:38-45 pubmed publisher
    ..Therefore, in vivo myogenic differences between those muscles might rely on the local microenvironment. Thus, regenerative strategies for limb muscles might also be used for head muscles. ..
  41. Freer Prokop M, O Flaherty J, Ross J, Weyman C. Non-canonical role for the TRAIL receptor DR5/FADD/caspase pathway in the regulation of MyoD expression and skeletal myoblast differentiation. Differentiation. 2009;78:205-12 pubmed publisher
    ..Thus, our data suggests a non-canonical role for the TRAIL receptor/FADD pathway in the regulation of MyoD expression and skeletal myoblast differentiation. ..
  42. Gianakopoulos P, Mehta V, Voronova A, Cao Y, Yao Z, Coutu J, et al. MyoD directly up-regulates premyogenic mesoderm factors during induction of skeletal myogenesis in stem cells. J Biol Chem. 2011;286:2517-25 pubmed publisher
    ..Taken together, MyoD directs stem cells into the skeletal muscle lineage by binding and activating the expression of premyogenic mesoderm genes, prior to activating myoblast genes. ..
  43. Micheli L, Leonardi L, Conti F, Maresca G, Colazingari S, Mattei E, et al. PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB. J Biol Chem. 2011;286:5691-707 pubmed publisher
    ..As a whole, these results indicate that PC4 plays a role in muscle differentiation by controlling the MyoD pathway through multiple mechanisms, and as such, it positively regulates regenerative myogenesis. ..
  44. Pijet M, Pijet B, Litwiniuk A, Pajak B, Gajkowska B, Orzechowski A. Leptin impairs myogenesis in C2C12 cells through JAK/STAT and MEK signaling pathways. Cytokine. 2013;61:445-54 pubmed publisher
    ..Summing up, partially opposite effects of insulin and leptin on skeletal muscle growth emphasize the importance of interplay between these cytokines. They determine how muscle mass is gained or lost. ..
  45. Hirai H, Tani T, Kikyo N. Structure and functions of powerful transactivators: VP16, MyoD and FoxA. Int J Dev Biol. 2010;54:1589-96 pubmed publisher
  46. Starkey J, Yamamoto M, Yamamoto S, Goldhamer D. Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem. 2011;59:33-46 pubmed publisher
    ..The authors conclude that skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt an adipogenic fate. ..
  47. Abe S, Rhee S, Iwanuma O, Hiroki E, Yanagisawa N, Sakiyama K, et al. Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblasts. Anat Histol Embryol. 2009;38:305-10 pubmed publisher
    ..Our results suggest that the MRFs are up-regulated upon mechanical stimulus and each member plays a different major role for either proliferation or differentiation of the myoblasts. ..
  48. Harford T, Shaltouki A, Weyman C. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis. 2010;15:71-82 pubmed publisher
    ..Finally, MyoD mediated regulation of the apoptotic response to these various stimuli, in both myoblasts and fibroblasts, correlates with the level of induction of the pro-apoptotic Bcl2 family member PUMA. ..
  49. Miyake T, Alli N, McDermott J. Nuclear function of Smad7 promotes myogenesis. Mol Cell Biol. 2010;30:722-35 pubmed publisher
    ..Thus, Smad7 has a nuclear coactivator function that is independent of TGF-beta signaling and necessary to promote myogenic differentiation. ..
  50. Williams A, Valdez G, Moresi V, Qi X, McAnally J, Elliott J, et al. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science. 2009;326:1549-54 pubmed publisher
    ..Thus, miR-206 slows ALS progression by sensing motor neuron injury and promoting the compensatory regeneration of neuromuscular synapses. ..
  51. Mitchell K, Pannérec A, Cadot B, Parlakian A, Besson V, Gomes E, et al. Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development. Nat Cell Biol. 2010;12:257-66 pubmed publisher
    ..Taken together, our findings uncover a new and anatomically identifiable population of muscle progenitors and define a key role for Pax7 in a non-satellite cell population during postnatal muscle growth. ..
  52. Philipot O, Joliot V, Ait Mohamed O, Pellentz C, Robin P, Fritsch L, et al. The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. PLoS ONE. 2010;5:e9425 pubmed publisher
    ..Taken together, our data show a new role for Runx1/CBFbeta in the control of the proliferation/differentiation in skeletal myoblasts. ..
  53. Andrews J, Zhang X, McCarthy J, McDearmon E, Hornberger T, Russell B, et al. CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A. 2010;107:19090-5 pubmed publisher
    ..The identification of MyoD as a clock-controlled gene provides a mechanism by which the circadian clock may generate a muscle-specific circadian transcriptome in an adaptive role for the daily maintenance of adult skeletal muscle...
  54. Mal A. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. EMBO J. 2006;25:3323-34 pubmed
    ..These findings suggest that Suv39h1 presence in association with MyoD on the promoter of muscle genes silences gene transcription, providing a necessary checkpoint between proliferation and differentiation. ..
  55. Deato M, Marr M, Sottero T, Inouye C, Hu P, Tjian R. MyoD targets TAF3/TRF3 to activate myogenin transcription. Mol Cell. 2008;32:96-105 pubmed publisher
  56. Schabort E, van der Merwe M, Loos B, Moore F, Niesler C. TGF-beta's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner. Exp Cell Res. 2009;315:373-84 pubmed publisher
    ..These results demonstrate that TGF-beta promotes proliferation and delays differentiation of C2C12 myoblasts in an isoform-independent manner. ..
  57. Di Padova M, Caretti G, Zhao P, Hoffman E, Sartorelli V. MyoD acetylation influences temporal patterns of skeletal muscle gene expression. J Biol Chem. 2007;282:37650-9 pubmed
    ..Our results reveal that MyoD acetylation influences transcription of selected genes expressed at defined stages of the muscle program by regulating chromatin access of MyoD, histone acetylation, and RNA polymerase II recruitment. ..
  58. Cooper S, Kizana E, Yates J, Lo H, Yang N, Wu Z, et al. Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis. Neuromuscul Disord. 2007;17:276-84 pubmed
  59. Macqueen D, Johnston I. A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization. FEBS Lett. 2006;580:4996-5002 pubmed publisher
    ..Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature...
  60. Hjiantoniou E, Anayasa M, Nicolaou P, Bantounas I, Saito M, Iseki S, et al. Twist induces reversal of myotube formation. Differentiation. 2008;76:182-92 pubmed
    ..The exploitation of Twist-mediated reversal of differentiation and the study of its specific mechanism would be important in order to study mammalian cellular de-differentiation and determine its potential in muscle regeneration. ..
  61. Armand A, Bourajjaj M, Martínez Martínez S, el Azzouzi H, da Costa Martins P, Hatzis P, et al. Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem. 2008;283:29004-10 pubmed publisher
    ..Thus, the combined findings provide a novel transcriptional paradigm for the first steps of myogenesis, where a calcineurin/NFATc3 pathway regulates myogenin induction in cooperation with MyoD during myogenesis. ..
  62. Grifone R, Demignon J, Giordani J, Niro C, Souil E, Bertin F, et al. Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Dev Biol. 2007;302:602-16 pubmed
    ..These results establish a new hierarchy of genes controlling early steps of hypaxial myogenic commitment in the mouse embryo. ..
  63. Krajnak K, Waugh S, Miller R, Baker B, Geronilla K, Alway S, et al. Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats. Muscle Nerve. 2006;34:720-30 pubmed
    ..Based on these findings we conclude that reducing satellite-cell apoptosis in aged animals may improve muscle recovery after injury. ..
  64. Parker M, Perry R, Fauteux M, Berkes C, Rudnicki M. MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation. Mol Cell Biol. 2006;26:5771-83 pubmed
    ..Therefore, HEB alpha and HEB beta play novel and central roles in orchestrating the regulation of myogenic factor activity through myogenic differentiation. ..
  65. Pawlikowski B, Lee L, Zuo J, Kramer R. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009;238:138-49 pubmed publisher
    ..This study extends our understanding of the role of Pax7 in regulating human satellite stem cell differentiation and self-renewal. ..
  66. Ohkawa Y, Yoshimura S, Higashi C, Marfella C, Dacwag C, Tachibana T, et al. Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis. J Biol Chem. 2007;282:6564-70 pubmed
    ..These findings strongly suggest that the skeletal muscle phenotype is maintained by myogenin and the continuous activity of Brg1-based SWI/SNF chromatin-remodeling enzymes. ..
  67. Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, et al. Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements. Int J Mol Med. 2007;19:925-32 pubmed
    ..These findings indicate that Dec2 employs multiple mechanisms, including DNA-binding and protein-protein interactions, to achieve E-box-dependent transcriptional repressions. ..
  68. Sun L, Ma K, Wang H, Xiao F, Gao Y, Zhang W, et al. JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J Cell Biol. 2007;179:129-38 pubmed
    ..Thus, JAK1-STAT1-STAT3 constitutes a signaling pathway that promotes myoblast proliferation and prevents premature myoblast differentiation. ..
  69. Gonçalves M, Swildens J, Holkers M, Narain A, van Nierop G, van de Watering M, et al. Genetic complementation of human muscle cells via directed stem cell fusion. Mol Ther. 2008;16:741-8 pubmed publisher