actomyosin

Summary

Summary: A protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.

Top Publications

  1. Padmanabhan A, Bakka K, Sevugan M, Naqvi N, D souza V, Tang X, et al. IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast. Curr Biol. 2011;21:467-72 pubmed publisher
    ..The fission yeast Schizosaccharomyces pombe, like animal cells, divides using an actomyosin ring and is an attractive model to study eukaryotic cytokinesis. In S...
  2. Meyer E, Ikmi A, Gibson M. Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia. Curr Biol. 2011;21:485-91 pubmed publisher
    ..considered a hallmark of pseudostratified vertebrate neuroepithelia, and prior investigations have proposed both actomyosin- and microtubule-dependent mechanisms for apical localization of the mitotic nucleus...
  3. He L, Wang X, Tang H, Montell D. Tissue elongation requires oscillating contractions of a basal actomyosin network. Nat Cell Biol. 2010;12:1133-42 pubmed publisher
    ..Inhibition of the actomyosin contractions or their coupling to extracellular matrix (ECM) blocked elongation of the whole tissue, whereas ..
  4. Huang B, Luo W, Sun L, Zhang Q, Jiang L, Chang J, et al. MiRNA-125a-3p is a negative regulator of the RhoA-actomyosin pathway in A549 cells. Int J Oncol. 2013;42:1734-42 pubmed publisher
    ..Here, we report the discovery of a new regulatory layer of the RhoA-actomyosin pathway through which miR-125a-3p controls tumor cell migration...
  5. Martinez Rico C, Pincet F, Thiery J, Dufour S. Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility. J Cell Sci. 2010;123:712-22 pubmed publisher
    ..of intercellular adhesion strength by integrin stimulation required activation of Src family kinases, ROCK and actomyosin contractility...
  6. Aratyn Schaus Y, Oakes P, Gardel M. Dynamic and structural signatures of lamellar actomyosin force generation. Mol Biol Cell. 2011;22:1330-9 pubmed publisher
    ..To elucidate these properties, we visualized the actomyosin dynamics and organization in U2OS cells over a broad range of forces...
  7. Ajduk A, Ilozue T, Windsor S, Yu Y, Seres K, Bomphrey R, et al. Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability. Nat Commun. 2011;2:417 pubmed publisher
    ..We find that these movements are caused by contractions of the actomyosin cytoskeleton triggered by Ca(2+) oscillations induced by fertilization...
  8. Verchot Lubicz J, Goldstein R. Cytoplasmic streaming enables the distribution of molecules and vesicles in large plant cells. Protoplasma. 2010;240:99-107 pubmed publisher
    ..Here, we synthesize recent insights into cytoplasmic streaming, molecular gradients, cytoskeletal and membrane dynamics, and expand current cellular models to identify important gaps in current research. ..
  9. Pohl C, Tiongson M, Moore J, Santella A, Bao Z. Actomyosin-based self-organization of cell internalization during C. elegans gastrulation. BMC Biol. 2012;10:94 pubmed publisher
    ..module can adapt to severe topological alterations, providing evidence of scalability and plasticity of actomyosin-based patterning...
  10. Govindan S, Sarkey J, Ji X, Sundaresan N, Gupta M, de Tombe P, et al. Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. J Muscle Res Cell Motil. 2012;33:17-30 pubmed publisher
    ..In addition, we discovered several acetylation sites within the 40 kDa fragment that could potentially affect actomyosin function...

Detail Information

Publications99

  1. Padmanabhan A, Bakka K, Sevugan M, Naqvi N, D souza V, Tang X, et al. IQGAP-related Rng2p organizes cortical nodes and ensures position of cell division in fission yeast. Curr Biol. 2011;21:467-72 pubmed publisher
    ..The fission yeast Schizosaccharomyces pombe, like animal cells, divides using an actomyosin ring and is an attractive model to study eukaryotic cytokinesis. In S...
  2. Meyer E, Ikmi A, Gibson M. Interkinetic nuclear migration is a broadly conserved feature of cell division in pseudostratified epithelia. Curr Biol. 2011;21:485-91 pubmed publisher
    ..considered a hallmark of pseudostratified vertebrate neuroepithelia, and prior investigations have proposed both actomyosin- and microtubule-dependent mechanisms for apical localization of the mitotic nucleus...
  3. He L, Wang X, Tang H, Montell D. Tissue elongation requires oscillating contractions of a basal actomyosin network. Nat Cell Biol. 2010;12:1133-42 pubmed publisher
    ..Inhibition of the actomyosin contractions or their coupling to extracellular matrix (ECM) blocked elongation of the whole tissue, whereas ..
  4. Huang B, Luo W, Sun L, Zhang Q, Jiang L, Chang J, et al. MiRNA-125a-3p is a negative regulator of the RhoA-actomyosin pathway in A549 cells. Int J Oncol. 2013;42:1734-42 pubmed publisher
    ..Here, we report the discovery of a new regulatory layer of the RhoA-actomyosin pathway through which miR-125a-3p controls tumor cell migration...
  5. Martinez Rico C, Pincet F, Thiery J, Dufour S. Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility. J Cell Sci. 2010;123:712-22 pubmed publisher
    ..of intercellular adhesion strength by integrin stimulation required activation of Src family kinases, ROCK and actomyosin contractility...
  6. Aratyn Schaus Y, Oakes P, Gardel M. Dynamic and structural signatures of lamellar actomyosin force generation. Mol Biol Cell. 2011;22:1330-9 pubmed publisher
    ..To elucidate these properties, we visualized the actomyosin dynamics and organization in U2OS cells over a broad range of forces...
  7. Ajduk A, Ilozue T, Windsor S, Yu Y, Seres K, Bomphrey R, et al. Rhythmic actomyosin-driven contractions induced by sperm entry predict mammalian embryo viability. Nat Commun. 2011;2:417 pubmed publisher
    ..We find that these movements are caused by contractions of the actomyosin cytoskeleton triggered by Ca(2+) oscillations induced by fertilization...
  8. Verchot Lubicz J, Goldstein R. Cytoplasmic streaming enables the distribution of molecules and vesicles in large plant cells. Protoplasma. 2010;240:99-107 pubmed publisher
    ..Here, we synthesize recent insights into cytoplasmic streaming, molecular gradients, cytoskeletal and membrane dynamics, and expand current cellular models to identify important gaps in current research. ..
  9. Pohl C, Tiongson M, Moore J, Santella A, Bao Z. Actomyosin-based self-organization of cell internalization during C. elegans gastrulation. BMC Biol. 2012;10:94 pubmed publisher
    ..module can adapt to severe topological alterations, providing evidence of scalability and plasticity of actomyosin-based patterning...
  10. Govindan S, Sarkey J, Ji X, Sundaresan N, Gupta M, de Tombe P, et al. Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. J Muscle Res Cell Motil. 2012;33:17-30 pubmed publisher
    ..In addition, we discovered several acetylation sites within the 40 kDa fragment that could potentially affect actomyosin function...
  11. Almonacid M, Celton Morizur S, Jakubowski J, Dingli F, Loew D, Mayeux A, et al. Temporal control of contractile ring assembly by Plo1 regulation of myosin II recruitment by Mid1/anillin. Curr Biol. 2011;21:473-9 pubmed publisher
    In eukaryotes, cytokinesis generally involves an actomyosin ring, the contraction of which promotes daughter cell segregation. Assembly of the contractile ring is tightly controlled in space and time...
  12. Calvert M, Wright G, Leong F, Chiam K, Chen Y, Jedd G, et al. Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction. J Cell Biol. 2011;195:799-813 pubmed publisher
    In eukaryotes, cytokinesis is accomplished by an actomyosin-based contractile ring...
  13. Gilden J, Peck S, Chen Y, Krummel M. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol. 2012;196:103-14 pubmed publisher
    ..This function of septins in assembling on an unstable cortex and retracting aberrantly protruding membranes explains the excessive blebbing and protrusion observed in septin-deficient T cells. ..
  14. Young B, Buser C, Drubin D. Isolation and partial purification of the Saccharomyces cerevisiae cytokinetic apparatus. Cytoskeleton (Hoboken). 2010;67:13-22 pubmed publisher
    ..The isolated apparatus contains all components of the actomyosin ring for which we tested-actin, myosin heavy and light chain, and IQGAP-as well as septins and the cytokinetic F-..
  15. Kaur S, Leszczynska K, Abraham S, Scarcia M, Hiltbrunner S, Marshall C, et al. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers. Arterioscler Thromb Vasc Biol. 2011;31:657-64 pubmed publisher
    ..in increased contraction of a collagen gel and increased phospho-myosin light chain, indicative of increased actomyosin contractility...
  16. Nkosi P, Targosz B, Labib K, Sanchez Diaz A. Hof1 and Rvs167 have redundant roles in actomyosin ring function during cytokinesis in budding yeast. PLoS ONE. 2013;8:e57846 pubmed publisher
    ..the budding yeast Saccharomyces cerevisiae, whereas the orthologous Cdc15 protein in fission yeast regulates the actomyosin ring by using its F-BAR domain to recruit actin nucleators to the cleavage site...
  17. Wiggan O, Shaw A, DeLuca J, Bamburg J. ADF/cofilin regulates actomyosin assembly through competitive inhibition of myosin II binding to F-actin. Dev Cell. 2012;22:530-43 pubmed publisher
    ..of actin depolymerizing factor (ADF)/cofilin proteins in human cells causes increased contractile cortical actomyosin assembly...
  18. Lee D, Harris T. An Arf-GEF regulates antagonism between endocytosis and the cytoskeleton for Drosophila blastoderm development. Curr Biol. 2013;23:2110-20 pubmed publisher
    ..Endocytosis also regulates the PM and can be promoted or inhibited by cytoskeletal networks. However, endocytic regulation of the general membrane cytoskeleton is undocumented...
  19. Mishra M, Huang Y, Srivastava P, Srinivasan R, Sevugan M, Shlomovitz R, et al. Cylindrical cellular geometry ensures fidelity of division site placement in fission yeast. J Cell Sci. 2012;125:3850-7 pubmed publisher
    Successful cytokinesis requires proper assembly of the contractile actomyosin ring, its stable positioning on the cell surface and proper constriction...
  20. Tebbs I, Pollard T. Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring. Mol Biol Cell. 2013;24:1904-17 pubmed publisher
    ..The Rng2p C-terminal domain is the only domain essential for viability. Our studies identified several distinct functions of Rng2 at multiple stages of cytokinesis...
  21. Levayer R, Lecuit T. Oscillation and polarity of E-cadherin asymmetries control actomyosin flow patterns during morphogenesis. Dev Cell. 2013;26:162-75 pubmed publisher
    b>Actomyosin flows are involved in a variety of cellular processes, including cytokinesis, cell migration, polarization, and morphogenesis. In epithelia, flow polarization orients cell deformations...
  22. Röper K. Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation. Dev Cell. 2012;23:939-53 pubmed publisher
    ..Crumbs, mediated by its large extracellular domain, determines the subcellular localization of a supracellular actomyosin cable in the cells at the placode border, with myosin II accumulating at edges where Crumbs is lowest...
  23. Abreu Blanco M, Verboon J, Parkhurst S. Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. J Cell Biol. 2011;193:455-64 pubmed publisher
    ..Specifically, plasma membrane mobilization and assembly of a contractile actomyosin ring are required for this process...
  24. Masuda S, Tomohiro T, Hatanaka Y. Rapidly photoactivatable ATP probes for specific labeling of tropomyosin within the actomyosin protein complex. Bioorg Med Chem Lett. 2011;21:2252-4 pubmed publisher
    ..These probes clearly labeled tropomyosin in the presence of other actomyosin components, that is, myosin, actin, and troponins...
  25. Mathur M, Chase P, Chalovich J. Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin. Biochem Biophys Res Commun. 2011;406:74-8 pubmed publisher
    We examined the cardiomyopathy-causing tropomyosin mutations E180G, D175N, and V95A to determine their effects on actomyosin regulation...
  26. Chancellor T, Lee J, Thodeti C, Lele T. Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation. Biophys J. 2010;99:115-23 pubmed publisher
    ..Together, these results are consistent with a model in which the nucleus balances a portion of the actomyosin tension in the cell...
  27. Borghi N, Sorokina M, Shcherbakova O, Weis W, PRUITT B, Nelson W, et al. E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad Sci U S A. 2012;109:12568-73 pubmed publisher
    ..We show that the actomyosin cytoskeleton exerts pN-tensile force on E-cadherin, and that this tension requires the catenin-binding domain of ..
  28. Mansson A. Actomyosin-ADP states, interhead cooperativity, and the force-velocity relation of skeletal muscle. Biophys J. 2010;98:1237-46 pubmed publisher
    ..Exploration of the parameter space of the model suggests that an actomyosin-ADP state (AM( *)ADP) that is separated from the actual ADP release step by a strain-dependent isomerization is ..
  29. Simões S, Mainieri A, Zallen J. Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension. J Cell Biol. 2014;204:575-89 pubmed publisher
    b>Actomyosin contraction generates mechanical forces that influence cell and tissue structure...
  30. Stachowiak M, McCall P, Thoresen T, Balcioglu H, Kasiewicz L, Gardel M, et al. Self-organization of myosin II in reconstituted actomyosin bundles. Biophys J. 2012;103:1265-74 pubmed publisher
    Cells assemble a variety of bundled actomyosin structures in the cytoskeleton for activities such as cell-shape regulation, force production, and cytokinesis...
  31. Verma P, Ostermeyer Fay A, Brown D. Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1. Mol Biol Cell. 2010;21:2226-40 pubmed publisher
    ..b>Actomyosin-induced tension destabilized both long and short tubules; they often snapped and resolved to small vesicles...
  32. Calvo F, Ege N, Grande García A, Hooper S, Jenkins R, Chaudhry S, et al. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol. 2013;15:637-46 pubmed publisher
    ..Remodelling of the ECM and promotion of cancer cell invasion requires the actomyosin cytoskeleton...
  33. Ochala J, Gokhin D, Iwamoto H, Fowler V. Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers. FASEB J. 2014;28:408-15 pubmed publisher
    ..tropomyosin movement over actin subunits during thin-filament activation, thus reducing both the fraction of actomyosin crossbridges in the strongly bound state (-29%) and fiber force-generating capacity (-31%)...
  34. Melendez J, Stengel K, Zhou X, Chauhan B, Debidda M, ANDREASSEN P, et al. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem. 2011;286:15132-7 pubmed publisher
    RhoA, the founding member of mammalian Rho GTPase family, is thought to be essential for actomyosin regulation. To date, the physiologic function of RhoA in mammalian cell regulation has yet to be determined genetically...
  35. Hidalgo Carcedo C, Hooper S, Chaudhry S, Williamson P, Harrington K, Leitinger B, et al. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol. 2011;13:49-58 pubmed publisher
    ..Here we show that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell-cell contact...
  36. Chua J, Rikhy R, Lippincott Schwartz J. Dynamin 2 orchestrates the global actomyosin cytoskeleton for epithelial maintenance and apical constriction. Proc Natl Acad Sci U S A. 2009;106:20770-5 pubmed publisher
    ..This is due to Dyn2's interactions with deacetylated cortactin and downstream effectors, which cause enhanced actomyosin contraction. Neither inhibitors of endocytosis nor GTP-shifted Dyn2 mutants induce apical constriction...
  37. Prochniewicz E, Pierre A, McCullough B, Chin H, Cao W, Saunders L, et al. Actin filament dynamics in the actomyosin VI complex is regulated allosterically by calcium-calmodulin light chain. J Mol Biol. 2011;413:584-92 pubmed publisher
    ..Such modulation of filament dynamics may contribute to the Ca(2)(+)- and CaM-dependent regulation of myosin VI motility and ATP utilization. ..
  38. Wloka C, Bi E. Mechanisms of cytokinesis in budding yeast. Cytoskeleton (Hoboken). 2012;69:710-26 pubmed publisher
    ..Cytokinesis in budding yeast is driven by two interdependent cellular events: actomyosin ring (AMR) constriction and the formation of a chitinous cell wall structure called the primary septum (PS), the ..
  39. Gauthier N, Fardin M, Roca Cusachs P, Sheetz M. Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading. Proc Natl Acad Sci U S A. 2011;108:14467-72 pubmed publisher
    Cell migration and spreading involve the coordination of membrane trafficking, actomyosin contraction, and modifications to plasma membrane tension and area. The biochemical or biophysical basis for this coordination is however unknown...
  40. Mseka T, Coughlin M, Cramer L. Graded actin filament polarity is the organization of oriented actomyosin II filament bundles required for fibroblast polarization. Cell Motil Cytoskeleton. 2009;66:743-53 pubmed publisher
    b>Actomyosin II filament assemblies in cells are required for shaping the cell body and forming the cell rear during morphological polarization and triggering of migration...
  41. Previs M, Beck Previs S, Gulick J, Robbins J, Warshaw D. Molecular mechanics of cardiac myosin-binding protein C in native thick filaments. Science. 2012;337:1215-8 pubmed publisher
    The heart's pumping capacity results from highly regulated interactions of actomyosin molecular motors...
  42. Sawyer J, Harris N, Slep K, Gaul U, Peifer M. The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. J Cell Biol. 2009;186:57-73 pubmed publisher
    ..Apical constriction of mesodermal cells initiates but is not completed. The actomyosin cytoskeleton disconnects from AJs, uncoupling actomyosin constriction and cell shape change...
  43. Kaya M, Higuchi H. Nonlinear elasticity and an 8-nm working stroke of single myosin molecules in myofilaments. Science. 2010;329:686-9 pubmed publisher
    ..Taking account of the nonlinear nature of myosin elasticity is essential to relate myosin's internal structural changes to physiological force generation and filament sliding. ..
  44. Monier B, Pélissier Monier A, Brand A, Sanson B. An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos. Nat Cell Biol. 2010;12:60-9 pubmed publisher
    ..Here we demonstrate, in early Drosophila melanogaster embryos, that actomyosin-based barriers stop cells from invading neighbouring compartments...
  45. David D, Tishkina A, Harris T. The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila. Development. 2010;137:1645-55 pubmed publisher
    ..This cell constriction typically requires actomyosin contractility...
  46. Yonemura S. Cadherin-actin interactions at adherens junctions. Curr Opin Cell Biol. 2011;23:515-22 pubmed publisher
    ..Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ..
  47. Dasanayake N, Michalski P, Carlsson A. General mechanism of actomyosin contractility. Phys Rev Lett. 2011;107:118101 pubmed
    ..The stresses are overwhelmingly contractile because minifilament equilibrium positions having contractile stress have lower energy than those for expansive stress. Force chains lead to unexpectedly large stresses. ..
  48. Jendretzki A, Ciklic I, Rodicio R, Schmitz H, Heinisch J. Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck. Mol Genet Genomics. 2009;282:437-51 pubmed publisher
    Cytokinesis in yeast can be achieved by plasma membrane ingression, which is dependent on actomyosin ring constriction...
  49. Kippert A, Fitzner D, Helenius J, Simons M. Actomyosin contractility controls cell surface area of oligodendrocytes. BMC Cell Biol. 2009;10:71 pubmed publisher
    ..How is this expansion controlled? Here we show that cell surface area depends on actomyosin contractility and is regulated by physical properties of the supporting matrix...
  50. Chang L, Chen P, Lien M, Ho Y, Lin C, Pan Y, et al. Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting. Development. 2011;138:3803-12 pubmed publisher
    ..of this process and find that cell sorting occurs when differential expression of Ed triggers the assembly of actomyosin cable...
  51. Zhang D, Vjestica A, Oliferenko S. The cortical ER network limits the permissive zone for actomyosin ring assembly. Curr Biol. 2010;20:1029-34 pubmed publisher
    ..This triggers delocalized assembly of actomyosin cables and compromises their compaction into a single medially positioned ring...
  52. Guillot C, Lecuit T. Adhesion disengagement uncouples intrinsic and extrinsic forces to drive cytokinesis in epithelial tissues. Dev Cell. 2013;24:227-41 pubmed publisher
    Cytokinesis entails cell invagination by a contractile actomyosin ring...
  53. Mayer M, Depken M, Bois J, Jülicher F, Grill S. Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows. Nature. 2010;467:617-21 pubmed publisher
    ..In Caenorhabditis elegans zygotes, anteroposterior polarization is facilitated by a large-scale flow of the actomyosin cortex, which directs the asymmetry of the first mitotic division...
  54. Kaur H, Kumar S, Kukkar D, Kaur I, Singh K, Bharadwaj L. Transportation of drug-(polystyrene bead) conjugate by actomyosin motor system. J Biomed Nanotechnol. 2010;6:279-86 pubmed
    ..64 microm/s). This further ascertains the microcomposites formation. The present study provides an insight into the actin-myosin based molecular motor systems for an efficient tool for drug transportation. ..
  55. Borau C, Kim T, Bidone T, García Aznar J, Kamm R. Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks. PLoS ONE. 2012;7:e49174 pubmed publisher
    ..This implies an important role of actomyosin contractility in the cell mechano-sensing...
  56. Tak cs B, O Neall Hennessey E, Het nyi C, Kardos J, Szent Gy rgyi A, Kov cs M. Myosin cleft closure determines the energetics of the actomyosin interaction. FASEB J. 2011;25:111-21 pubmed publisher
    ..To clarify the role of the closure of myosin's actin-binding cleft in the actomyosin interaction, we performed rapid kinetic, spectroscopic, and calorimetric experiments and atomic-level energetic ..
  57. Abreu Blanco M, Verboon J, Liu R, Watts J, Parkhurst S. Drosophila embryos close epithelial wounds using a combination of cellular protrusions and an actomyosin purse string. J Cell Sci. 2012;125:5984-97 pubmed publisher
    ..Our results show that embryonic epithelial wound repair is mediated by two simultaneously acting mechanisms: crawling driven by cellular protrusions and actomyosin ring contraction along the leading edge of the wound.
  58. Versaevel M, Grevesse T, Gabriele S. Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun. 2012;3:671 pubmed publisher
    ..and deformation of the nucleus are regulated by lateral compressive forces driven by tension in central actomyosin fibres...
  59. Munoz J, Cortés J, Sipiczki M, Ramos M, Clemente Ramos J, Moreno M, et al. Extracellular cell wall ?(1,3)glucan is required to couple septation to actomyosin ring contraction. J Cell Biol. 2013;203:265-82 pubmed publisher
    ..We show that Bgs4-derived ?(1,3)glucan is required for correct and stable actomyosin ring positioning in the cell middle, before the start of septum formation and anchorage to the cell wall...
  60. Andreeva A, Lee J, Lohia M, Wu X, Macara I, Lu X. PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity. Dev Cell. 2014;29:20-33 pubmed publisher
    b>Actomyosin contractility plays a key role in tissue morphogenesis...
  61. Bolinger C, Zasadil L, Rizaldy R, Hildebrand J. Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction. Dev Dyn. 2010;239:2078-93 pubmed publisher
    ..based on their subcellular distribution and the subsequent assembly of spatially and organizationally distinct actomyosin networks that are dependent on the ability to engage Rho-kinase and the activity of myosin II...
  62. Sanz Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, et al. ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma. Cancer Cell. 2011;20:229-45 pubmed publisher
    ..We show that cytokine signaling through the receptor subunit GP130-IL6ST and the kinase JAK1 generates actomyosin contractility through Rho-kinase dependent signaling...
  63. Dugina V, Zwaenepoel I, Gabbiani G, Clement S, Chaponnier C. Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci. 2009;122:2980-8 pubmed publisher
    ..Our results reveal new aspects of beta- and gamma-actin organization that support their functional diversity. ..
  64. Okeyo K, Adachi T, Sunaga J, Hojo M. Actomyosin contractility spatiotemporally regulates actin network dynamics in migrating cells. J Biomech. 2009;42:2540-8 pubmed publisher
    ..network dynamics has been the focus of many studies, it is not yet clear how mechanical forces generated by actomyosin contractility spatiotemporally regulate this fundamental aspect of cell migration...
  65. Fernandez Gonzalez R, Simões S, Röper J, Eaton S, Zallen J. Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell. 2009;17:736-43 pubmed publisher
    Axis elongation in Drosophila occurs through polarized cell rearrangements driven by actomyosin contractility...
  66. Weith A, Sadayappan S, Gulick J, Previs M, VanBuren P, Robbins J, et al. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. J Mol Cell Cardiol. 2012;52:219-27 pubmed publisher
    ..Phosphorylation of 4 serines within the motif decreases the fragments' actin-binding capacity and actomyosin inhibition...
  67. Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald N, et al. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012;125:5860-72 pubmed publisher
    ..to the Phactr1 C-terminal region, and Phactr1 C-terminal RPEL mutants that cannot bind G-actin induce aberrant actomyosin structures dependent on their nuclear accumulation and on PP1 binding...
  68. Zhou J, Kim H, Wang J, Davidson L. Macroscopic stiffening of embryonic tissues via microtubules, RhoGEF and the assembly of contractile bundles of actomyosin. Development. 2010;137:2785-94 pubmed publisher
    ..attribute tissue stiffening to Xlfc, a previously identified RhoGEF, which binds microtubules and regulates the actomyosin cytoskeleton...
  69. Sawyer J, Choi W, Jung K, He L, Harris N, Peifer M. A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. 2011;22:2491-508 pubmed publisher
    ..Germband cells have an apical actomyosin network undergoing cyclical contractions...
  70. Pattabiraman P, Rao P. Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 2010;298:C749-63 pubmed publisher
    ..Rho GTPase-mediated resistance to aqueous humor drainage, we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix (ECM) synthesis in human trabecular meshwork (TM) cells ..
  71. Tamada M, Farrell D, Zallen J. Abl regulates planar polarized junctional dynamics through ?-catenin tyrosine phosphorylation. Dev Cell. 2012;22:309-19 pubmed publisher
    ..These results demonstrate that the asymmetrically localized Abl tyrosine kinase directs planar polarized junctional remodeling during Drosophila axis elongation through the tyrosine phosphorylation of ?-catenin...
  72. Nightingale T, White I, Doyle E, Turmaine M, Harrison Lavoie K, Webb K, et al. Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosis. J Cell Biol. 2011;194:613-29 pubmed publisher
    ..However, once fused, a dynamic ring of actin filaments and myosin II forms around the granule, and actomyosin II contractility squeezes VWF content out into the extracellular environment...
  73. Pizarro G, Ogut O. Impact of actin glutathionylation on the actomyosin-S1 ATPase. Biochemistry. 2009;48:7533-8 pubmed publisher
    ..Substituting glutathionylated F-actin for unmodified F-actin reduced the maximum actomyosin-S1 ATPase, and this was accompanied by an increase in the activation energy of the steady state ATPase...
  74. Ojkic N, Wu J, Vavylonis D. Model of myosin node aggregation into a contractile ring: the effect of local alignment. J Phys Condens Matter. 2011;23:374103 pubmed publisher
    b>Actomyosin bundles frequently form through aggregation of membrane-bound myosin clusters. One such example is the formation of the contractile ring in fission yeast from a broad band of cortical nodes...
  75. Wu Y, Zhou P, Lan G, Gao D, Li Q, Wei D, et al. MPF governs the assembly and contraction of actomyosin rings by activating RhoA and MAPK during chemical-induced cytokinesis of goat oocytes. PLoS ONE. 2010;5:e12706 pubmed publisher
    ..The results suggested that microtubule inhibitors activated MPF, which induced actomyosin assembly (formation of ooplasmic protrusion) by activating RhoA and thus MAPK...
  76. Simone R, Dinardo S. Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. Development. 2010;137:1385-94 pubmed publisher
    ..Indeed, depletion of Myosin II or dlg disrupts these processes. These results show that tight spatial regulation of actomyosin contractility is required to produce this high-energy arrangement of cells.
  77. Wu J, Ye Y, Wang N, Pollard T, Pringle J. Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast. Genetics. 2010;186:897-915 pubmed publisher
    ..One mutation affects Cdc4, a myosin light chain that is an essential component of the cytokinetic actomyosin ring. Five others cause frequent cell lysis during cell separation and map to two loci...
  78. Albet Torres N, Bloemink M, Barman T, Candau R, Frölander K, Geeves M, et al. Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. J Biol Chem. 2009;284:22926-37 pubmed publisher
    ..myosin subfragment 1, showed that the effects on sliding speed were not because of a reduced rate of ATP-induced actomyosin dissociation because the rate of this process was increased by amrinone...
  79. Ramachandran C, Patil R, Combrink K, Sharif N, Srinivas S. Rho-Rho kinase pathway in the actomyosin contraction and cell-matrix adhesion in immortalized human trabecular meshwork cells. Mol Vis. 2011;17:1877-90 pubmed
    The outflow facility for aqueous humor across the trabecular meshwork (TM) is enhanced by agents that oppose the actomyosin contraction of its resident cells...
  80. Thoresen T, Lenz M, Gardel M. Reconstitution of contractile actomyosin bundles. Biophys J. 2011;100:2698-705 pubmed publisher
    Contractile actomyosin bundles are critical for numerous aspects of muscle and nonmuscle cell physiology...
  81. Tsujioka M, Yumura S, Inouye K, Patel H, Ueda M, Yonemura S. Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis. Proc Natl Acad Sci U S A. 2012;109:12992-7 pubmed publisher
    ..adhesion molecule that binds to talin A, reverted this phenotype, suggesting a requirement of the link between actomyosin and SibA by talin A for rear retraction...
  82. Proctor S, Minc N, Boudaoud A, Chang F. Contributions of turgor pressure, the contractile ring, and septum assembly to forces in cytokinesis in fission yeast. Curr Biol. 2012;22:1601-8 pubmed publisher
    A paradigm of cytokinesis in animal cells is that the actomyosin contractile ring provides the primary force to divide the cell...
  83. Hawkins R, Poincloux R, Benichou O, Piel M, Chavrier P, Voituriez R. Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environments. Biophys J. 2011;101:1041-5 pubmed publisher
    We present a model of cell motility generated by actomyosin contraction of the cell cortex...
  84. Köhler S, Schmoller K, Crevenna A, Bausch A. Regulating contractility of the actomyosin cytoskeleton by pH. Cell Rep. 2012;2:433-9 pubmed publisher
    ..Small variations in pH provide a mechanism of controlling the contractility of cytoskeletal structures, which can be expected to have broad implications in our understanding of cytoskeletal regulation. ..
  85. Samuel M, Lopez J, McGhee E, Croft D, Strachan D, Timpson P, et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and ?-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 2011;19:776-91 pubmed publisher
    ..Mechanosensation of tissue stiffness activates the Rho/ROCK pathway to increase actomyosin-mediated cellular tension to re-establish force equilibrium...
  86. Li M, Nilsen A, Shi Y, Fusser M, Ding Y, Fu Y, et al. ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nat Commun. 2013;4:1832 pubmed publisher
    Regulation of actomyosin dynamics by post-transcriptional modifications in cytoplasmic actin is still poorly understood...
  87. Sumida G, Stamer W. Sphingosine-1-phosphate enhancement of cortical actomyosin organization in cultured human Schlemm's canal endothelial cell monolayers. Invest Ophthalmol Vis Sci. 2010;51:6633-8 pubmed publisher
    ..cells, the authors hypothesized that Schlemm's canal (SC) cells in culture respond to S1P by increasing actomyosin organization at the cell cortex...
  88. Huang J, Huang Y, Yu H, Subramanian D, Padmanabhan A, Thadani R, et al. Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast. J Cell Biol. 2012;199:831-47 pubmed publisher
    In many eukaryotes, cytokinesis requires the assembly and constriction of an actomyosin-based contractile ring...
  89. Filas B, Oltean A, Majidi S, Bayly P, Beebe D, Taber L. Regional differences in actomyosin contraction shape the primary vesicles in the embryonic chicken brain. Phys Biol. 2012;9:066007 pubmed publisher
    ..Here, we show that regional variations in actomyosin-based contractility play a major role in vesicle formation in the embryonic chicken brain...
  90. Vlachos S, Harden N. Genetic evidence for antagonism between Pak protein kinase and Rho1 small GTPase signaling in regulation of the actin cytoskeleton during Drosophila oogenesis. Genetics. 2011;187:501-12 pubmed publisher
    ..Reduction of any component of the Rho1-activated actomyosin contractility pathway suppresses pak oogenesis defects, suggesting that Pak counteracts Rho1 signaling...
  91. Dorn J, Zhang L, Paradis V, Edoh Bedi D, Jusu S, Maddox P, et al. Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans. Curr Biol. 2010;20:2046-51 pubmed publisher
    ..We propose that cytoskeletal bundling by anillin promotes formation of the midbody tube, which ensures the fidelity of PBE. ..
  92. Godsel L, Dubash A, Bass Zubek A, Amargo E, Klessner J, Hobbs R, et al. Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell. 2010;21:2844-59 pubmed publisher
    ..Together with our previous findings, these data suggest that PKP2 may functionally link RhoA- and PKC-dependent pathways to drive actin reorganization and regulate DP-IF interactions required for normal desmosome assembly...
  93. Bergert M, Chandradoss S, Desai R, Paluch E. Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A. 2012;109:14434-9 pubmed publisher
    ..We demonstrate that shifting the balance between actin protrusivity and actomyosin contractility leads to immediate transitions between blebs and lamellipodia in migrating cells...
  94. Laporte D, Ojkic N, Vavylonis D, Wu J. ?-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly. Mol Biol Cell. 2012;23:3094-110 pubmed publisher
    The actomyosin contractile ring assembles through the condensation of a broad band of nodes that forms at the cell equator in fission yeast cytokinesis. The condensation process depends on actin filaments that interconnect nodes...
  95. Inutsuka A, Goda M, Fujiyoshi Y. Calyculin A-induced neurite retraction is critically dependent on actomyosin activation but not on polymerization state of microtubules. Biochem Biophys Res Commun. 2009;390:1160-6 pubmed publisher
    ..Based on all these findings, we propose that CL-A generates strong contractile forces by actomyosin to induce rapid neurite retraction independently from MT depolymerization.
  96. Redemann S, Pecreaux J, Goehring N, Khairy K, Stelzer E, Hyman A, et al. Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos. PLoS ONE. 2010;5:e12301 pubmed publisher
    ..Thus, the invaginations serve as a tool to localize the sites of force generation at the cortex and allow us to estimate a lower limit on the number of cortical force generators within the cell. ..
  97. Gorfinkiel N, Blanchard G. Dynamics of actomyosin contractile activity during epithelial morphogenesis. Curr Opin Cell Biol. 2011;23:531-9 pubmed publisher
    ..cell behaviour is not continuous but proceeds in pulses driven by the contractile activity of dynamic cortical actomyosin networks...
  98. Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, et al. Forces driving epithelial spreading in zebrafish gastrulation. Science. 2012;338:257-60 pubmed publisher
    Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction...