Summary: Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.

Top Publications

  1. Pappas L, Xu X, Abramson D, Jhanwar S. Genomic instability and proliferation/survival pathways in RB1-deficient malignancies. Adv Biol Regul. 2017;64:20-32 pubmed publisher
    ..TR?1, TR?2 and Rb-KD all led to the downstream PTTG1 accumulation, apparently through an activation of E2F1 resulting in extensive genomic instability as seen in other Rb-deficient tumors. ..
  2. Read M, Fong J, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson R, et al. Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene. 2017;36:5296-5308 pubmed publisher
    ..Together our findings indicate that PBF and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome. ..
  3. Gurvits N, Löyttyniemi E, Nykanen M, Kuopio T, Kronqvist P, Talvinen K. Separase is a marker for prognosis and mitotic activity in breast cancer. Br J Cancer. 2017;117:1383-1391 pubmed publisher
    ..The complex inhibitory interactions involving securin and cyclin B1 were investigated in double- and triple-IFs and revealed patient subgroups with aberrant regulation ..