minichromosome maintenance complex component 2
Summary: A minichromosome maintenance protein that is a key component of the six member MCM protein complex. It contains a NUCLEAR LOCALIZATION SIGNAL which may provide targeting of the protein complex and an extended N-terminus which is rich in SERINE residues.
Todorov I, Werness B, Wang H, Buddharaju L, Todorova P, Slocum H, et al
. HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues. Lab Invest. 1998;78:73-8 pubmed
Clement C, Almouzni G. MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork. Nat Struct Mol Biol. 2015;22:587-9 pubmed publisher
Yang Z, Jun H, Choi C, Yoo K, Cho C, Hussaini S, et al
. Age-related decline in BubR1 impairs adult hippocampal neurogenesis. Aging Cell. 2017;16:598-601 pubmed publisher
..Targeting BubR1 may represent a novel therapeutic strategy for age-related cognitive deficits. ..
Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson I, Kanemaki M. Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis. Genes Dev. 2017;31:816-829 pubmed publisher
..We propose that stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. ..
Izumi M, Mizuno T, Yanagi K, Sugimura K, Okumura K, Imamoto N, et al
. The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing. J Biol Chem. 2017;292:13008-13021 pubmed publisher
..These results suggest that human Mcm10 is bound to chromatin through the interaction with Mcm2-7 and is primarily involved in the initiation of DNA replication after loading of Cdc45 and Pol ?. ..
Salim D, Bradford W, Freeland A, Cady G, Wang J, Pruitt S, et al
. DNA replication stress restricts ribosomal DNA copy number. PLoS Genet. 2017;13:e1007006 pubmed publisher
..Taken together, these data begin to suggest the selective pressures that combine to yield a "normal" rDNA copy number. ..
Takeichi T, Sugiura K, Muro Y, Ogawa Y, Akiyama M. LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT. J Dermatol Sci. 2011;63:203-5 pubmed publisher
Wang H, Wang M, Yang N, Xu R. Structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2. Protein Cell. 2015;6:693-7 pubmed publisher