Summary: A broadly expressed type D cyclin. Experiments using KNOCKOUT MICE suggest a role for cyclin D3 in LYMPHOCYTE development.
Møller M, Kania P, Ino Y, Gerdes A, Nielsen O, Louis D, et al
. Frequent disruption of the RB1 pathway in diffuse large B cell lymphoma: prognostic significance of E2F-1 and p16INK4A. Leukemia. 2000;14:898-904 pubmed
..lymphoma registry for alterations of the RB1 pathway at the genetic (RB1 and CDK4) and protein (pRb, cyclin D1, cyclin D3, CDK4, and E2F-1) level...
Schmitz R, Ceribelli M, Pittaluga S, Wright G, Staudt L. Oncogenic mechanisms in Burkitt lymphoma. Cold Spring Harb Perspect Med. 2014;4: pubmed publisher
..Additionally, CCND3 accumulates oncogenic mutations that stabilize cyclin D3 protein expression and drive proliferation...
Barr J, Goodfellow R, Colgan D, COLGAN J. Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division. J Immunol. 2017;198:3978-3988 pubmed publisher
..also failed to upregulate genes required for mitotic division, including those encoding the G1/S cyclin D3 and E2F transcription factors and their targets...
Wang H, Nicolay B, Chick J, Gao X, Geng Y, Ren H, et al
. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature. 2017;546:426-430 pubmed publisher
..Here, using human cancer cells and patient-derived xenografts in mice, we show that the cyclin D3-CDK6 kinase phosphorylates and inhibits the catalytic activity of two key enzymes in the glycolytic pathway, 6-..
Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, et al
. The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex. Nat Immunol. 2017;18:911-920 pubmed publisher
..Our results identify a key molecular mechanism by which the BTG2-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis. ..
Durham B, Getta B, Dietrich S, Taylor J, Won H, Bogenberger J, et al
. Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations. Blood. 2017;130:1644-1648 pubmed publisher
..These data provide further insight into the genetic bases of cHCL and vHCL and mechanisms of RAF inhibitor resistance encountered clinically. ..
Yang L, Wen Y, Lv G, Lin Y, Tang J, Lu J, et al
. ?-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation. Biochem Biophys Res Commun. 2017;494:325-331 pubmed publisher
..Recently, ? -LA has been reported to inhibit the growth of various cancer cells, but the precise signaling pathways that mediate the effects of ? -LA on non-small cell lung cancer (NSCLC) development remain unclear...