cyclin dependent kinase inhibitor p19


Summary: An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN REPEATS. Aberrant expression of this protein has been associated with TESTICULAR CANCER.

Top Publications

  1. Zhang S, Tang Q, Xu F, Xue Y, Zhen Z, Deng Y, et al. RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. Mol Cancer Res. 2009;7:570-80 pubmed publisher
    ..Thus, RhoA may use two distinct effector pathways in regulating the G(1)-S progression of gastric cancer cells. ..
  2. Laine H, Sulg M, Kirjavainen A, Pirvola U. Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors. Dev Biol. 2010;337:134-46 pubmed publisher
    ..Thus, cyclin D1 critically contributes to the proliferative plasticity of supporting cells. These data suggest that targeted cyclin D1 induction in supporting cells might be an avenue for proliferative regeneration in the inner ear. ..
  3. Hagai T, Levy Y. Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding. Proc Natl Acad Sci U S A. 2010;107:2001-6 pubmed publisher
    ..Our study implies that, in addition to its known role as a recognition signal, the ubiquitin attachment may be directly involved in the cellular process it regulates by changing the biophysical properties of the substrate. ..
  4. Rao S, O Neil J, Liberator C, Hardwick J, Dai X, Zhang T, et al. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res. 2009;69:3060-8 pubmed publisher
  5. Zhang W, Zeng Z, Zhou Y, Xiong W, Fan S, Xiao L, et al. Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis. Acta Biochim Biophys Sin (Shanghai). 2009;41:414-28 pubmed
    ..These results suggested that cell cycle pathway was the most disregulated pathway in the EBV-associated NPC, and EBER-1 was closely associated with p16, CDK4, cyclin D1, and Rb.cyclin D1 could be the prognosis biomarker for NPC. ..
  6. Vincent B, Sunyach C, Orzechowski H, St George Hyslop P, Checler F. p53-Dependent transcriptional control of cellular prion by presenilins. J Neurosci. 2009;29:6752-60 pubmed publisher
    ..Furthermore, it adds support to previous reports linking secretase activities involved in betaAPP metabolism to the physiology of PrP(c). ..
  7. Rice K, Hormaeche I, Doulatov S, Flatow J, Grimwade D, Mills K, et al. Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Blood. 2009;114:5499-511 pubmed publisher
  8. Jankovic M, Robbiani D, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, et al. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci U S A. 2010;107:187-92 pubmed publisher
    ..We conclude that AID-induced double-strand breaks in non-Ig genes other than c-myc lead to their translocation, and that at least two nonoverlapping pathways protect against translocations in primary B cells. ..
  9. Malhas A, Saunders N, Vaux D. The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation. Cell Cycle. 2010;9:531-9 pubmed

More Information


  1. Yu J, Zhu B, Wickre M, Riedlinger G, Chen W, Hosui A, et al. The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. Hepatology. 2010;52:1808-18 pubmed publisher
    ..This study for the first time demonstrates that cytokines, through STAT5, induce the expression of a key cell cycle inhibitor. These experiments therefore shed mechanistic light on the context-specific role of STAT5 as tumor suppressor. ..