cyclin dependent kinase inhibitor p15

Summary

Summary: An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.

Top Publications

  1. Folkersen L, Kyriakou T, Goel A, Peden J, Malarstig A, Paulsson Berne G, et al. Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants. PLoS ONE. 2009;4:e7677 pubmed publisher
  2. Jarinova O, Stewart A, Roberts R, Wells G, Lau P, Naing T, et al. Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol. 2009;29:1671-7 pubmed publisher
    ..9p21.3 may promote atherosclerosis by regulating expression of ANRIL, which in turn is associated with altered expression of genes controlling cellular proliferation pathways. ..
  3. Wrensch M, Jenkins R, Chang J, Yeh R, Xiao Y, Decker P, et al. Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet. 2009;41:905-8 pubmed publisher
    ..85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases. ..
  4. Schlegel N, Eichhoff O, Hemmi S, Werner S, Dummer R, Hoek K. Id2 suppression of p15 counters TGF-beta-mediated growth inhibition of melanoma cells. Pigment Cell Melanoma Res. 2009;22:445-53 pubmed publisher
    ..We conclude that transition to increased aggressiveness in melanoma cells requires Id2 upregulation to suppress TGF-beta induction of p15(Ink4b) and thus help to circumvent TGF-beta-mediated inhibition of proliferation. ..
  5. Camacho C, Mukherjee B, McEllin B, Ding L, Hu B, Habib A, et al. Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks. Carcinogenesis. 2010;31:1889-96 pubmed publisher
    ..Indeed, we find that reexpression of p15 in tumor-derived cells significantly attenuates the tumorigenic potential of these cells, indicating that p15 loss may be a critical event in tumorigenesis triggered by complex DSBs. ..
  6. Braggio E, Maiolino A, Gouveia M, Magalhães R, Souto Filho J, Garnica M, et al. Methylation status of nine tumor suppressor genes in multiple myeloma. Int J Hematol. 2010;91:87-96 pubmed publisher
    ..Our data suggest that DAPK and RAR beta hypermethylation are adverse prognostic factors in MM. The relevance of these findings as poor prognosis indicators requires confirmation in a larger sample with longer follow-ups. ..
  7. Hu C, Chang T, Cheng C, Liu C, Wu J, Li M, et al. Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. FEBS J. 2010;277:1202-18 pubmed publisher
    ..In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2. ..
  8. Szymczak S, Igl B, Ziegler A. Detecting SNP-expression associations: a comparison of mutual information and median test with standard statistical approaches. Stat Med. 2009;28:3581-96 pubmed publisher
    ..Only the alternative approaches were able to identify three genes (ADM, FCGR3B and ADORA1) as promising candidates to clarify the molecular mechanism of the genetic association. ..
  9. Wen J, Rönn T, Olsson A, Yang Z, Lu B, Du Y, et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS ONE. 2010;5:e9153 pubmed publisher

More Information

Publications62

  1. Yap K, Li S, Muñoz Cabello A, Raguz S, Zeng L, Mujtaba S, et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010;38:662-74 pubmed publisher
    ..Our study suggests a mechanism by which noncoding RNA participates directly in epigenetic transcriptional repression. ..
  2. Kim R, Lieberman M, Lee R, Shin K, Mehrazarin S, Oh J, et al. Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling. Exp Cell Res. 2010;316:2600-8 pubmed publisher
    ..Taken together, these data suggest that Bmi-1 suppresses senescence of cells by inhibiting the TGF-beta signaling pathway in NHOK. ..
  3. Loftus S, Antonellis A, Matera I, Renaud G, Baxter L, Reid D, et al. Gpnmb is a melanoblast-expressed, MITF-dependent gene. Pigment Cell Melanoma Res. 2009;22:99-110 pubmed publisher
    ..Future analysis of the Gpnmb locus will provide insight into the transcriptional regulation of melanocytes, and Gpnmb expression can be used as a marker for analyzing melanocyte development and disease progression. ..
  4. Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, et al. Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab Invest. 2010;90:360-73 pubmed publisher
    ..These results not only show two distinct molecular pathways for iron-induced peritoneal mesothelioma, but also support the hypothesis that oxidative stress by iron overload is a major cause of CDKN2A/2B homozygous deletion. ..
  5. Lakshmikuttyamma A, Scott S, DeCoteau J, Geyer C. Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition. Oncogene. 2010;29:576-88 pubmed publisher
    ..The results from this study highlight the potential of H3K9 methyltransferases as therapeutic targets for reactivating expression of hypermethylated genes. ..
  6. Laharanne E, Chevret E, Idrissi Y, Gentil C, Longy M, Ferrer J, et al. CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma. Mod Pathol. 2010;23:547-58 pubmed publisher
  7. Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, et al. Exercise effects on methylation of ASC gene. Int J Sports Med. 2010;31:671-5 pubmed publisher
    ..In summary, chronic moderate exercise appears to attenuate the age-dependent decrease in ASC methylation, implying suppression of excess pro-inflammatory cytokines through reduction of ASC expression. ..
  8. Chinnasri P, Pairojkul C, Jearanaikoon P, Sripa B, Bhudhisawasdi V, Tantimavanich S, et al. Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma. Hum Pathol. 2009;40:817-26 pubmed publisher
  9. Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 2010;464:409-12 pubmed publisher
  10. Yang X, Zhang Q, Chen M, Li Q, Yang Z, Li L, et al. MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans. Clin Biochem. 2009;42:1071-5 pubmed publisher
    ..71 in male subjects. The risk of rs7027989 and rs1063192 remained significant after adjusting for covariates. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese. ..
  11. Choi S, Kim T, Singh S. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009;26:2280-8 pubmed publisher
    ..Rh2-mediated cell cycle arrest in human breast cancer cells is caused by p15(Ink4B) and p27(Kip1)-dependent inhibition of kinase activities of G(1)-S specific Cdks/cyclin complexes. ..
  12. Wahlstrand B, Orho Melander M, Delling L, Kjeldsen S, Narkiewicz K, Almgren P, et al. The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension. J Hypertens. 2009;27:769-73 pubmed publisher
  13. Wang X, Li W, Zheng J, Chen Q, Zou H, Ma L, et al. Tumor suppressor gene alterations of spontaneously malignant transformed cells from human embryonic muscle in vitro. Oncol Rep. 2010;24:555-61 pubmed
    ..In conclusion, our research shows that the inactivation of tumor suppressor genes may play an important role in the process of malignant transformation of embryonic muscle cells in vitro. ..
  14. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS ONE. 2009;4:e7643 pubmed publisher
    ..0006). The current study confirmed the association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 diabetes. These type 2 diabetes risk loci contributed to the disease additively. ..
  15. Conway C, Beswick S, Elliott F, Chang Y, Randerson Moor J, Harland M, et al. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. Genes Chromosomes Cancer. 2010;49:425-38 pubmed publisher
    ..There was no association between reduced gene dosage at 9p21.3 and subtype or site of tumor. This study presents supportive evidence that CDKN2B, P14ARF, and CDKN2A may all play a tumor suppressor role in melanoma progression. ..
  16. Jiang S, Ma X, Huang Y, Xu Y, Zheng R. [Phenylhexyl isothiocyanate induces gene p15 demethylation by down-regulating DNA methyltransferases in Molt-4 cells]. Yao Xue Xue Bao. 2009;44:350-4 pubmed
  17. Novara F, Beri S, Bernardo M, Bellazzi R, Malovini A, Ciccone R, et al. Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood. Hum Genet. 2009;126:511-20 pubmed publisher
    ..Among the six cases with heterozygous 9p deletions, we found that the remaining CDKN2A and CDKN2B alleles were hypermethylated at CpG islands. ..
  18. Paul T, Bies J, Small D, Wolff L. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. Blood. 2010;115:3098-108 pubmed publisher
    ..These data indicate that AML cells with p15INK4b DNA methylation have an altered histone methylation pattern compared with unmethylated samples and that these changes are reversible by epigenetic drugs. ..
  19. Deneberg S, Grövdal M, Karimi M, Jansson M, Nahi H, Corbacioglu A, et al. Gene-specific and global methylation patterns predict outcome in patients with acute myeloid leukemia. Leukemia. 2010;24:932-41 pubmed publisher
    ..We conclude that global and gene-specific methylation patterns are independently associated with the clinical outcome in AML patients. ..
  20. Wemmert S, Bettscheider M, Alt S, Ketter R, Kammers K, Feiden W, et al. p15 promoter methylation - a novel prognostic marker in glioblastoma patients. Int J Oncol. 2009;34:1743-8 pubmed
  21. Cunnington M, Santibanez Koref M, Mayosi B, Burn J, Keavney B. Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression. PLoS Genet. 2010;6:e1000899 pubmed publisher
    ..Our study suggests that modulation of ANRIL expression mediates susceptibility to several important human diseases. ..
  22. Hashikata H, Liu W, Inoue K, Mineharu Y, Yamada S, Nanayakkara S, et al. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. Stroke. 2010;41:1138-44 pubmed publisher
    ..None of these SNPs had linkage disequilibrium with rs1333040 and was associated with IA. A region between introns 7 and 15 of CDKN2BAS carrying the rs1333040-T allele may confer risk for IA. ..
  23. Brito E, Lyssenko V, Renstrom F, Berglund G, Nilsson P, Groop L, et al. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes. 2009;58:1411-8 pubmed publisher
    ..015 and 0.0068, respectively). Our observations suggest that the genetic predisposition to hyperglycemia is partially dependent on a person's lifestyle. ..
  24. Han H, Zhong C, Zhang X, Liu R, Pan M, Tan L, et al. Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells. Nutr Cancer. 2010;62:641-7 pubmed publisher
    ..Moreover, selective estrogen receptor modulators did not affect genistein induced growth inhibition. These findings provide new insights into the potential intervention of NPC with genistein. ..
  25. Wang X, Sun W, Bai J, Ma L, Yu Y, Geng J, et al. Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma. Mol Biol Rep. 2009;36:861-9 pubmed publisher
    ..Thus, we conclude that TGF-beta/Smads signaling pathway play a important role on cell growth and metastasis potential in OSCC. ..
  26. Hong H, Jeon W, Bae E, Kim S, Lee H, Kim S, et al. 14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1. Mol Cells. 2010;29:305-9 pubmed publisher
    ..Taken together, our findings indicate that dysregulation of 14-3-3 sigma or 14-3-3 zeta contributes to TGF-beta1 resistance in cancer cells. ..
  27. Senturk S, Mumcuoglu M, Gursoy Yuzugullu O, Cingoz B, Akcali K, Ozturk M. Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology. 2010;52:966-74 pubmed publisher
    ..Moreover, TGF-beta-induced senescence in vivo is associated with a strong antitumor response against HCC. ..
  28. He J, Kallin E, Tsukada Y, Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol. 2008;15:1169-75 pubmed publisher
    ..Alteration of Jhdm1b level affects Ras-induced neoplastic transformation. Collectively, our results indicate that Jhdm1b is an H3K36 demethylase that regulates cell proliferation and senescence through p15(Ink4b). ..
  29. Lefever T, Pedersen E, Basse A, Paus R, Quondamatteo F, Stanley A, et al. N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways. J Cell Sci. 2010;123:128-40 pubmed publisher
    ..These data identify the actin nucleation regulator N-WASP as a novel element of hair-cycle control that modulates the antiproliferative and pro-apoptotic TGFbeta pathway in keratinocytes in vivo and in vitro. ..
  30. Huang Q, Cheung A, Zhang Y, Huang H, Auersperg N, Leung P. Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation. Am J Physiol Endocrinol Metab. 2009;296:E1344-53 pubmed publisher
    ..GDF-9 stimulates hLG cell proliferation by stimulating cyclin D(1) and E and suppressing p15(INK4B) and p16(INK4A) via both Smad-dependent and Smad-independent pathways. ..
  31. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, et al. Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes. 2009;58:1690-9 pubmed publisher
    ..The strength of association was more prominent in the Japanese population than in Europeans for more than half of the confirmed type 2 diabetes loci. ..
  32. Sarfraz S, Hamid S, Ali S, Jafri W, Siddiqui A. Modulations of cell cycle checkpoints during HCV associated disease. BMC Infect Dis. 2009;9:125 pubmed publisher
    ..The information presented here highlights the potential of identified proteins as predictive factors to identify patients with high risk of cell transformation and HCC development. ..
  33. Mun G, Lee S, An S, Kim I, Boo Y. Differential gene expression in young and senescent endothelial cells under static and laminar shear stress conditions. Free Radic Biol Med. 2009;47:291-9 pubmed publisher
    ..The genes identified in this study are expected to facilitate improvements in our current level of understanding regarding endothelial physiology in association with age-associated vascular disease. ..
  34. Trabosh V, Divito K, D Aguda B, Simbulan Rosenthal C, Rosenthal D. Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis. Carcinogenesis. 2009;30:1252-9 pubmed publisher
    ..These results tie together the previously observed misregulation of Id2 with a novel mechanism for tumorigenesis. ..
  35. Bailey V, Easwaran H, Zhang Y, Griffiths E, Belinsky S, Herman J, et al. MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Res. 2009;19:1455-61 pubmed publisher
    ..The direct application of MS-qFRET on clinical samples offers great promise for its translational use in early cancer diagnosis, prognostic assessment of tumor behavior, as well as monitoring response to therapeutic agents. ..
  36. Jeong J, Jeong H. 2-Methoxy-4-vinylphenol can induce cell cycle arrest by blocking the hyper-phosphorylation of retinoblastoma protein in benzo[a]pyrene-treated NIH3T3 cells. Biochem Biophys Res Commun. 2010;400:752-7 pubmed publisher
    ..Our results suggest that 2M4VP induce growth arrest of BaP-treated NIH 3T3 cells by blocking the hyper-phosphorylation of Rb via regulating the expression of cell cycle-related proteins. ..
  37. Pechlivanis S, Scherag A, Mühleisen T, Mohlenkamp S, Horsthemke B, Boes T, et al. Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort. Arterioscler Thromb Vasc Biol. 2010;30:1867-72 pubmed publisher
    ..This differential association pattern underlines the potential of endophenotypes, such as CAC, to extend the scope of disease outcome associations. ..
  38. Zhang Y, Bailey V, Puleo C, Easwaran H, Griffiths E, Herman J, et al. DNA methylation analysis on a droplet-in-oil PCR array. Lab Chip. 2009;9:1059-64 pubmed publisher
    ..These results were consistent with standard MSP protocols, yet the simplicity of the droplet-in-oil microfluidic PCR platform provides an easy and efficient tool for DNA methylation analysis in a large-scale arrayed manner. ..
  39. Ohashi S, Natsuizaka M, Wong G, Michaylira C, Grugan K, Stairs D, et al. Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors. Cancer Res. 2010;70:4174-84 pubmed publisher
  40. Doré A, Kilkenny M, Rzechorzek N, Pearl L. Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation. Mol Cell. 2009;34:735-45 pubmed publisher
    ..Biochemical analysis reveals a single repair enzyme-binding site on 9-1-1 that can be blocked competitively by the PCNA-binding cell-cycle regulator p21(cip1/waf1). ..
  41. Agnihotri S, Wolf A, Picard D, Hawkins C, Guha A. GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system. Oncogene. 2009;28:3033-46 pubmed publisher
    ..Collectively, we show that GATA4 is expressed in the embryonic and adult CNS and acts as a negative regulator of astrocyte proliferation and growth. ..
  42. Stanganelli C, Arbelbide J, Fantl D, Corrado C, Slavutsky I. DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance. Ann Hematol. 2010;89:191-9 pubmed publisher
  43. Liu W, Liu J, Ao L, Zhou Z, Zhou Y, Cui Z, et al. Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol Lett. 2009;189:5-13 pubmed publisher
    ..These results suggest that DNA methylation alterations are an early event in tumorigenesis and play an important role during MCA/DEN-induced multistep rat lung carcinogenesis. ..
  44. Shimoyama T, Hiraoka S, Takemoto M, Koshizaka M, Tokuyama H, Tokuyama T, et al. CCN3 inhibits neointimal hyperplasia through modulation of smooth muscle cell growth and migration. Arterioscler Thromb Vasc Biol. 2010;30:675-82 pubmed publisher
    ..CCN3 belongs to the CCN family, which constitutes multifunctional secreted proteins that act as matrix cellular regulators. We investigated the pathophysiological roles of CCN3 in the vessels...
  45. Mittelman M, Oster H, Hoffman M, Neumann D. The lower risk MDS patient at risk of rapid progression. Leuk Res. 2010;34:1551-5 pubmed publisher
    ..In summary, some patients, classified as "low risk MDS" carry PPF. An appropriate therapeutic approach is indicated. Future updated classifications and prospective trials may lead to a better outcome. ..
  46. Kim M, Oh B, Kim S, Park H, Hwang S, Kim T, et al. p15INK4b methylation correlates with thrombocytopenia, blast percentage, and survival in myelodysplastic syndromes in a dose dependent manner: quantitation using pyrosequencing study. Leuk Res. 2010;34:718-22 pubmed publisher
    ..8% vs. 4.1%, p=0.036, respectively). The survival of patients with >7% MtL was worse than patients with <7% MtL (p=0.031). Heavy p15INK4b methylation in MDS is associated with IPSS predictors of poor prognosis and adverse survival. ..
  47. Kim M, Yim S, Cho N, Kang S, Ko D, Oh B, et al. Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study. Cancer Genet Cytogenet. 2009;195:59-65 pubmed publisher
    ..The difference in incidence, distribution, and prognostic effect of homozygous deletion in children and adults may explain the prognostic disparity. ..
  48. Kanellou P, Zaravinos A, Zioga M, Spandidos D. Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in basal cell carcinoma. Br J Dermatol. 2009;160:1215-21 pubmed publisher
    ..Basal cell carcinoma (BCC) is a locally aggressive slowly growing tumour that rarely metastasizes and is mostly seen in older members of the population...
  49. Cheung M, Pei J, Pei Y, Jhanwar S, Pass H, Testa J. The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival. Oncogene. 2010;29:1633-40 pubmed publisher
    ..These data indicate that deletions of PLZF are a common occurrence in MM and that downregulation of PLZF may contribute to MM pathogenesis by promoting cell survival. ..
  50. Holdt L, Beutner F, Scholz M, Gielen S, Gäbel G, Bergert H, et al. ANRIL expression is associated with atherosclerosis risk at chromosome 9p21. Arterioscler Thromb Vasc Biol. 2010;30:620-7 pubmed publisher
    ..Our data provide robust evidence for an association of ANRIL but not CDKN2A, CDKN2B, C9orf53, and MTAP, with atherosclerosis and Chr9p21 genotype in a large cohort. ..
  51. Yalcin A, Serin M, Emekdas G, Tiftik N, Aslan G, Eskandari G, et al. Promoter methylation of P15(INK4B) gene is possibly associated with parvovirus B19 infection in adult acute leukemias. Int J Lab Hematol. 2009;31:407-19 pubmed publisher
    ..To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia. ..
  52. Tudzarova S, Trotter M, Wollenschlaeger A, Mulvey C, Godovac Zimmermann J, Williams G, et al. Molecular architecture of the DNA replication origin activation checkpoint. EMBO J. 2010;29:3381-94 pubmed publisher
  53. Rodriguez C, Borgel J, Court F, Cathala G, Forné T, Piette J. CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus. Biochem Biophys Res Commun. 2010;392:129-34 pubmed publisher
    ..We propose that CTCF is an essential factor for transcription of the INK/ARF locus and that abrogation of its binding by DNA methylation contributes to the permanent silencing of several genes of the locus in tumors. ..