cdh1 proteins


Summary: Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.

Top Publications

  1. Kim J, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, et al. Lack of epithelial PPAR? causes cystic adenomatoid malformations in mouse fetal lung. Biochem Biophys Res Commun. 2017;491:271-276 pubmed publisher
    ..Taken together, PPAR? may play an important role in fetal lung development via alveolar cell-to-cell adhesion system. ..
  2. Till J, Yoon C, Kim B, Roby K, Addai P, Jonokuchi E, et al. Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. Cancer Res. 2017;77:5349-5359 pubmed publisher
    ..This model offers a valuable tool to investigate gastric adenocarcinoma subtypes where RAS/MAPK pathway activation and E-cadherin attenuation are common. Cancer Res; 77(19); 5349-59. ©2017 AACR. ..
  3. Hein J, Hertz E, Garvanska D, Kruse T, Nilsson J. Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis. Nat Cell Biol. 2017;19:1433-1440 pubmed publisher
    ..Altogether, the findings of our work reveal that the inherent residue preference of a protein phosphatase can provide temporal regulation in biological processes. ..
  4. Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
    ..Our data identify a novel axis through which epithelial cells control local Treg cell subsets, which may be activated during intestinal tumorigenesis. ..
  5. Garzón J, Rodríguez R, Kong Z, Chabes A, Rodríguez Acebes S, Méndez J, et al. Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene. 2017;36:5808-5818 pubmed publisher
    ..These observations highlight the relevance of APC/C-Cdh1 activity during G1 to ensure an adequate supply of dNTPs to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis. ..