Summary: Cdh1 is an activator of the anaphase-promoting complex-cyclosome, and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.
Kim J, Yamaori S, Tanabe T, Takagi M, Matsubara T, Okamoto M, et al
. Lack of epithelial PPAR? causes cystic adenomatoid malformations in mouse fetal lung. Biochem Biophys Res Commun. 2017;491:271-276 pubmed publisher
..Taken together, PPAR? may play an important role in fetal lung development via alveolar cell-to-cell adhesion system. ..
Till J, Yoon C, Kim B, Roby K, Addai P, Jonokuchi E, et al
. Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. Cancer Res. 2017;77:5349-5359 pubmed publisher
..This model offers a valuable tool to investigate gastric adenocarcinoma subtypes where RAS/MAPK pathway activation and E-cadherin attenuation are common. Cancer Res; 77(19); 5349-59. ©2017 AACR. ..
Hein J, Hertz E, Garvanska D, Kruse T, Nilsson J. Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis. Nat Cell Biol. 2017;19:1433-1440 pubmed publisher
..Altogether, the findings of our work reveal that the inherent residue preference of a protein phosphatase can provide temporal regulation in biological processes. ..
Meinicke H, Bremser A, Brack M, Akeus P, Pearson C, Bullers S, et al
. Tumour-associated changes in intestinal epithelial cells cause local accumulation of KLRG1+ GATA3+ regulatory T cells in mice. Immunology. 2017;152:74-88 pubmed publisher
..Our data identify a novel axis through which epithelial cells control local Treg cell subsets, which may be activated during intestinal tumorigenesis. ..
GarzÃ³n J, RodrÃguez R, Kong Z, Chabes A, RodrÃguez Acebes S, MÃ©ndez J, et al
. Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1. Oncogene. 2017;36:5808-5818 pubmed publisher
..These observations highlight the relevance of APC/C-Cdh1 activity during G1 to ensure an adequate supply of dNTPs to the replisome, prevent replication stress and the resulting chromosomal breaks and, ultimately, suppress tumorigenesis. ..