cdc20 proteins


Summary: Highly conserved proteins that specifically bind to and activate the anaphase-promoting complex-cyclosome, promoting ubiquitination and proteolysis of cell-cycle-regulatory proteins. Cdc20 is essential for anaphase-promoting complex activity, initiation of anaphase, and cyclin proteolysis during mitosis.

Top Publications

  1. Goh P, Lim H, Surana U. Cdc20 protein contains a destruction-box but, unlike Clb2, its proteolysisis not acutely dependent on the activity of anaphase-promoting complex. Eur J Biochem. 2000;267:434-49 pubmed
    ..This suggests the existence of proteolytic mechanisms in G1 that can degrade destruction-box containing proteins, such as Cdc20, in an APC-independent manner. ..
  2. Lee S, Rodriguez Bravo V, Kim H, Datta S, Foley E. The PP2AB56 phosphatase promotes the association of Cdc20 with APC/C in mitosis. J Cell Sci. 2017;130:1760-1771 pubmed publisher
    ..A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2AB56, modulates APC/CCdc20 assembly. These results elucidate the contributions of PP2AB56 towards completion of mitosis. ..
  3. Kim T, Lara Gonzalez P, Prevo B, Meitinger F, Cheerambathur D, Oegema K, et al. Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates. Genes Dev. 2017;31:1089-1094 pubmed publisher
    ..The microtubule attachment status of kinetochores therefore optimizes mitotic duration by controlling the balance between opposing Cdc20 fates. ..
  4. Hein J, Hertz E, Garvanska D, Kruse T, Nilsson J. Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis. Nat Cell Biol. 2017;19:1433-1440 pubmed publisher
    ..Altogether, the findings of our work reveal that the inherent residue preference of a protein phosphatase can provide temporal regulation in biological processes. ..